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      • ULSI DRAM의 BIST 알고리즘을 위한 제어회로 설계

        온정근,김대익,도경주,이영훈,이창기,전병실 전북대학교 전자산업개발연구소 1991 전자산업연구 Vol.2 No.-

        Lately, more developed semiconductor technolgy is, higher integration per one chip is rapidly. Mow 64 Mb DRAM is used 0.3㎛ techonology. This very large integration is caused faults of new type, and exhaused much time for test. So algorithms which distiguish at higher faults coverage. less time and cost of test is reported. In this paper control circuit of Built-In Self Test(BIST) Algorithm was designed for ULSI DRAM and simulated with MYCAD. This control circuit is carried out steps of algorithm, controlled generation of test patterns and data, generated control signals of parallel test.

      • ULSI DRAM의 BIST 알고리즘을 위한 패턴발생회로 설계

        온정근,김대익,도경주,이영훈,이창기,전병실 전북대학교 전자산업개발연구소 1991 전자산업연구 Vol.2 No.-

        Lately, more developed semiconductor technolgy is, higher integration per one chip is rapidly. Mow 64 Mb DRAM is used 0.3㎛ techonology. This very large integration is caused faults of new type, and exhaused much time for test. So algorithms which distiguish at higher faults coverage. less time and cost of test is reported. In this paper control circuit of Built-In Self Test(BIST) Algorithm was designed for ULSI DRAM. This circuit generates patterns of the algorithm by input clocks.

      • KCI등재
      • A simple and easily available nostril retainer using syringe

        ( Jungyoon Ohn ),( Yun Seon Choe ),( Jung Won Shin ),( Chang Hun Huh ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

        A 62-year-old Korean woman presented with waxy plaques with telangiectasia on left nasal ala of 6-month duration, histopathologic finding of which was basal cell carcinoma. Full-thickness excision was performed leaving defect of the ala and alar rim. This defect was reconstructed by Spear’s nasolabial flap. Nostril retainer was in situ for two weeks, which was made from a syringe by cutting it apart on bed-side. The subcutaneous pedicled nasolabial flap transferring skill was described as a useful method for reconstructing full-thickness defects of nasal ala by Spear et al. It is suitable for not only ensuring structural integrity but also preventing the “valve” movement without cartilage grafts. Also, additional usage of nostril retainer could aidthem. In this case, the barrel part of a syringe was used as a nostril retainer. It is made from a common medical supply, a syringe, not only easy to get but also very cheap (8 cents). In addition to its accessibility, it adequately performs its role, preventing “valve” effect of reconstructed nasal ala. In conclusion, this simple nasal retainer can be used as an alternative to ready-made products in ala reconstruction patient.

      • Enhancing the Working Memory of Stroke Patients Using tDCS :

        Jo, Jung Mi,Kim, Yun-Hee,Ko, Myoung-Hwan,Ohn, Suk Hun,Joen, Bohyun,Lee, Kwang Ho Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2009 AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITA Vol.88 No.5

        <P>OBJECTIVES: We investigated whether anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex affected the working memory performance of patients after a stroke. DESIGN: Ten patients (mean age 47.7 yrs) with cognitive deficits after a first-ever stroke participated in this single-blind, crossover, and sham-controlled experiment. Each patient was randomly assigned to undergo two transcranial direct current stimulation sessions: anodal dorsolateral prefrontal cortex and sham stimulation within 48 hrs of a washout period. All participants performed a two-back working memory task before and after the administration of the transcranial direct current stimulation. Accuracy (correction rate), recognition accuracy (correction rate-commission error rate), and response time were measured during each experiment. RESULTS: Repeated-measures analysis of variance indicated a significant interaction effect of transcranial direct current stimulation type and time on the recognition accuracy. Post hoc analyses revealed a significant difference between prestimulation and poststimulation in the anodal stimulation group but not in the sham stimulation group. Regarding the accuracy, the paired t test indicated significant improvement only after anodal transcranial direct current stimulation without a significant interaction effect between the two transcranial direct current stimulation types. The response time was not significantly different in the anodal and sham stimulation groups. CONCLUSION: Our results demonstrated that anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex was associated with enhanced working memory performance as indexed by the recognition accuracy in patients after a stroke.</P>

      • 미세혈관 협심증 환자의 임상상 및 지표에 관한 연구

        박상호,온영근,김현정,이태훈,길효욱,김현건,박수진,송해정,한대희,방덕원,신원용,이내희,김성구,권영주 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

        Background : Microvascular angina or syndrom X is heterogenous and encompasses different pathogenetic entities. Several studies suggest that microvascular angina have good prognosis and occurs predominantly in postmenopausal women. Lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and fibrinogen are the independent risk factor of acute coronary syndrome and are the chief underlying cause of atherosclerosis. We investigated clinical characteristics and markers in patients with microvascular angina. Methods : We studies 23 patients diagnosed with microvascular angina and 16 control group with negative treadmill exercise test and no significant coronary angiogram. We investigated clinical characteristics in patients group and evaluated symptom during a follow-up period of 4.2± 2.5 month. Exercise time in treadmill exercise test was compared between patients and control group. We assessed the level of markers, such as lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and ESR in two groups. Results : There is no difference in age between two groups. Patients group had a tendency to increase in female, hypertension, DM, and smoking history, but there was no statistical significance difference. Exercise duration time was significantly decreased in patients with microvascular angina (p<0,05). Serum lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholestrol, Triglyceride, ESR, Fibrinogen and Homocystein value were no significant difference between microvascular angina and control group. Only CRP was significantly high in patients with microvascular angina (p<0.05). Conclusion : There was no statistical significance difference in age, sex, hypertension, DM and smoking history between two groups but patients group had a tendency to increase the prevalence in hypertension, DM and smoking history, female. Also, Symptom improvement and disappearance in follow-up was presented in 11 patients of 19(57.9%). Exercise tolerance was worse in patients group than control group. CRP value was significantly higher in patients group than control group. There was no statistical significance difference in lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, ESR and Fibrinogen between two groups.

      • KCI등재

        Role of bicarbonate and volume therapy in the prevention of acute kidney injury in rhabdomyolysis: a retrospective propensity score-matched cohort study

        김혜원,Kim Sejoong,Ohn Jung Hun,Kim Nak-Hyun,Lee Jong-chan,김은선,Lim Yejee,Cho Jae Ho,박희선,류지원,Kim Sun-wook 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

        Background: Although bicarbonate has traditionally been used to treat patients with rhabdomyolysis at high risk of acute kidney injury (AKI), it is unclear whether this is beneficial. This study compared bicarbonate therapy to non-bicarbonate therapy for the prevention of AKI and mortality in rhabdomyolysis patients. Methods: In a propensity score-matched cohort study, patients with a creatine kinase (CK) level of >1,000 U/L during hospitalization were divided into bicarbonate and non-bicarbonate groups. Patients were subgrouped based on low-volume (<3 mL/kg/hr) or high-volume (≥3 mL/kg/hr) fluid resuscitation in the first 72 hours. Logistic regression analyses were used to identify the impacts of bicarbonate use and fluid resuscitation on AKI risk and need for dialysis. The Kaplan-Meier method was used to estimate survival. Volume overload and electrolyte imbalances were assessed. Results: Among 4,077 patients, we assembled a cohort of 887 pairs of patients treated with and without bicarbonate. Bicarbonate group had a higher incidence of AKI, higher rate of dialysis dependency, higher 30-day mortality, and longer hospital stay than the non-bicarbonate group. Further, patients who received high-volume fluid therapy had worse renal outcomes and a higher mortality than those who received low-volume fluids regardless of bicarbonate use. Bicarbonate use, volume overload, and AKI were associated with higher mortality. Volume overload was significantly higher in the bicarbonate group than in the non-bicarbonate group. Conclusion: Bicarbonate or high-volume fluid therapy for patients with rhabdomyolysis did not reduce AKI or improve mortality compared to non-bicarbonate or low-volume fluid therapy. Limited use of bicarbonate and adjustment of fluid volume may improve the short- and long-term outcomes of patients with rhabdomyolysis.

      • Yin and Yang of disease genes and death genes between reciprocally scale-free biological networks

        Han, Hyun Wook,Ohn, Jung Hun,Moon, Jisook,Kim, Ju Han Oxford University Press 2013 Nucleic acids research Vol.41 No.20

        <P>Biological networks often show a scale-free topology with node degree following a power-law distribution. Lethal genes tend to form functional hubs, whereas non-lethal disease genes are located at the periphery. Uni-dimensional analyses, however, are flawed. We created and investigated two distinct scale-free networks; a protein–protein interaction (PPI) and a perturbation sensitivity network (PSN). The hubs of both networks exhibit a low molecular evolutionary rate (<I>P</I> < 8 × 10<SUP>−12</SUP>, <I>P</I> < 2 × 10<SUP>−4</SUP>) and a high codon adaptation index (<I>P</I> < 2 × 10<SUP>−16</SUP>, <I>P</I> < 2 × 10<SUP>−8</SUP>), indicating that both hubs have been shaped under high evolutionary selective pressure. Moreover, the topologies of PPI and PSN are inversely proportional: hubs of PPI tend to be located at the periphery of PSN and vice versa. PPI hubs are highly enriched with lethal genes but not with disease genes, whereas PSN hubs are highly enriched with disease genes and drug targets but not with lethal genes. PPI hub genes are enriched with essential cellular processes, but PSN hub genes are enriched with environmental interaction processes, having more TATA boxes and transcription factor binding sites. It is concluded that biological systems may balance internal growth signaling and external stress signaling by unifying the two opposite scale-free networks that are seemingly opposite to each other but work in concert between death and disease.</P>

      • SCISCIESCOPUS

        Carnitine induces autophagy and restores high-fat diet-induced mitochondrial dysfunction

        Choi, Jin Woo,Ohn, Jung Hun,Jung, Hye Seung,Park, Young Joo,Jang, Hak Chul,Chung, Sung Soo,Park, Kyong Soo W.B. Saunders Co. [etc.] 2018 Metabolism, clinical and experimental Vol.78 No.-

        <P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Autophagy is suppressed in skeletal muscle and the liver with insulin resistance induced by a high-fat diet. Autophagy is essential for maintaining mitochondrial function, and dysfunctional mitochondria are associated with insulin resistance. As carnitine treatment is well known to improve insulin resistance by promoting mitochondrial function, we investigated if carnitine affects autophagy in the skeletal muscle of a high-fat diet-induced rodent model of obesity.</P> <P><B>Results</B></P> <P>After 6weeks on a high-fat diet (48kcal% fat), mice developed glucose intolerance, and the gastrocnemius muscle showed a decrease in insulin signaling and mitochondrial function, which was reversed after carnitine (100mg/kg/day) treatment by oral gavage for 2weeks. Swollen mitochondria with destroyed cristae were observed in the skeletal muscle of high-fat diet-fed mice but were not there after carnitine treatment. High-fat diet decreased LC3B-II, a marker of autophagosome formation, and increased sequestosome 1 (SQSTM1), expression of which was reversed after carnitine treatment. In C2C12 myotubes, prolonged treatment with palmitate suppressed autophagy, which was relieved by carnitine treatment. However, the induction of autophagy by carnitine in C2C12 myotubes was not observed after knock-down of peroxisome proliferator-activated receptor γ (PPARγ), which is known to regulate autophagy.</P> <P><B>Conclusion</B></P> <P>We conclude that the removal of dysfunctional mitochondria by induction of autophagy through PPARγ may be a novel mechanism by which carnitine improves insulin resistance and mitochondrial dysfunction in obesity.</P>

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