제2형 당뇨병환자에서 ApoB/ApoA-I Ratio와 대사증후군 및 대사증후군 각 요소와의 관계

김정은 ( Jung Eun Kim ),김화영 ( Wha Young Kim ),이윤정 ( Yoon Jung Lee ),박지은 ( Ji Eun Park ),최영주 ( Young Ju Choi ),허갑범 ( Kap Bum Huh ),황지윤 ( Ji Yun Hwang ) 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.2

연구배경: Apolipoprotein B/apolipoprotein A-I 비율(ApoB/ApoA-I)은 대사증후군의 중요한 임상적 지표이다. 하지만, 한국인 제2형 당뇨병환자들을 대상으로 ApoB/ApoA-I과 대사증후군의 관련성을 살펴본 연구는 미미하다. 따라서 본 연구에서는 ApoB/ApoA-I과 ApoB/ApoA-I 사분위에 따른 대사증후군 및 대사증후군 각 요소별 위험도를 보았다. 방법: 대상자는 서울의 당뇨병 전문 클리닉 허내과를 방문한 제2형 당뇨병환자 812명 (남자 424명, 여자 388명)이다. 이들을 성별로 ApoB/ApoA-I의 사분위에 따라 네 군으로 나누었다(가장 낮은 군:Q1-가장 높은 군:Q4). 체위, 혈액성상 및 식품섭취 빈도조사지를 통한 식이섭취량이 측정되었다. 결과: 대사증후군의 유병률은 남자 47.9%, 여자 66.5%였다. 대사증후군과 대사증후군의 각 위험요소에 대한 OR은 남녀 모두 ApoB/ApoA-I의 Q2에서 Q4로 갈수록 유의하게 증가했다(남자: OR=5.37; 95% CI=2.98-9.65 and OR=7.41; 95% CI=4.04-13.6; 여자: OR=2.57; 95% CI=1.28-5.15 and OR=8.49; 95% CI=4.28-16.8). 이러한 경향은 남녀 모두에서 연령, 당뇨 유병기간, 공복 혈당, 대량영양소를 보정한 후에도 변하지 않았다(남자: OR=5.24; 95% CI=2.80-9.24 and OR=7.98; 95% CI=4.09-15.6; 여자: OR=3.54; 95% CI=1.84-6.81, OR=4.41; 95% CI=2.26-8.61, and OR=8.29; 95% CI=3.85-17.8). 결론: 본 연구에서는 당뇨병환자에서 가장 중요한 인자 중 하나인 다량 영양소 섭취량을 포함한 대사증후군의 위험요인을 보정하기 전과 후 모두 ApoB/ApoA-I이 증가 할수록 대사증후군 및 대사증후군 각 요소의 위험도가 증가했다. 향후, ApoB/ApoA-I 증가와 대사증후군 및 대사증후군 각 요소의 위험도에 대한 정확한 평가를 위해 ApoB/ApoA-I과 관련한 식이위험요인에 대한 전향적인 연구가 필요할 것으로 사료된다. Background: The Apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I) is a powerful clinical indicator of metabolic syndrome. However, few studies have searched for an association between ApoB/ApoA-I and metabolic syndrome in Korean patients with type 2 diabetes. We investigated the relation between ApoB/ApoA-I and the risk of metabolic syndrome and its components. Methods: Subjects were 812 (424 males and 388 females) Korean patients who were being treated for type 2 diabetes at Huh`s Diabetes Center in Seoul. The patients were classified into quartiles (lowest:Q1- highest:Q4) of ApoB/ApoA-I by gender. Anthropometric and hematological characteristics and dietary intake using a food frequency questionnaire were assessed. Results: The prevalence of metabolic syndrome in our sample was 47.9% in males and 66.5% in females. The odds ratios (OR) for metabolic syndrome and for having its components were significantly increased from Q2 to Q4 quartiles of ApoB/ApoA-I in males (OR = 5.37; 95% CI = 2.98-9.65 and OR = 7.41; 95% CI = 4.04-13.6) and females (OR = 2.57; 95% CI = 1.28-5.15 and OR = 8.49; 95% CI = 4.28-16.8). These trends withstood adjustment for age, duration of type 2 diabetes, fasting blood glucose levels, and macronutrient intake both in males (OR = 5.24; 95% CI = 2.80-9.24 and OR = 7.98; 95% CI = 4.09-15.6) and in females (OR=4.41; 95% CI = 2.26-8.61 and OR = 8.29; 95% CI = 3.85-17.8). Conclusion: ApoB/ApoA-I appeared to be independently associated with risk of having metabolic syndrome and its components in Korean patients with type 2 diabetes after adjustment for putative risk factors including macronutrient intake, a particularly important lifestyle factor for patients with type 2 diabetes. A follow-up study of this population should evaluate the mechanisms underlying the relation between ApoB/ApoA-I and metabolic syndrome and its components. (Korean Diabetes J 33:143-154, 2009)

ApoB/ApoA-I ratio is independently associated with carotid atherosclerosis in type 2 diabetes mellitus with well-controlled LDL cholesterol levels

( Ji Eun Jun ),( Young Ju Choi ),( Yong-ho Lee ),( Dae Jung Kim ),( Seok Won Park ),( Byung Wook Huh ),( Eun Jig Lee ),( Sun-ha Jee ),( Kyu Yeon Hur ),( Sung Hee Choi ),( Kap Bum Huh ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.1

Background/Aims: This study aimed to investigate whether the apolipoprotein (Apo) B/ApoA-I ratio is associated with carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) subjects with low density lipoprotein cholesterol (LDL-C) levels less than 100 mg/dL. Methods: This cross-sectional study included 845 subjects aged with T2DM 40 to 75 years who had visited Huh’s Diabetes Center in Seoul, Republic of Korea for CIMT measurement. Traditional fasting lipid profiles, ApoB and ApoA-I levels were examined. CIMT was measured at three points on the far wall of 1 cm long section of the common carotid artery in the proximity of the carotid bulb. The mean value of six measurements from right and left carotid arteries were used as the mean CIMT. In this study, carotid atherosclerosis was defined as having a focal plaque or diffuse thickening of the carotid wall (mean CIMT ≥ 1.0 mm) Results: The prevalence of carotid atherosclerosis increased with ApoB/ApoA-I ratio. The ApoB/ApoA-I ratio, expressed as both quartiles (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.21 to 3.79; p for trend = 0.014) and continuous values (OR, 10.05; 95% CI, 3.26 to 30.97; p < 0.001), was significantly associated with a higher risk for carotid atherosclerosis, regardless of conventional cardiovascular disease risk factors. The optimal ApoB/ApoA-I ratio cutoff value for detecting carotid atherosclerosis was 0.57, based on receiver operating characteristic curve analysis with a sensitivity of 58.0% and a specificity of 55.1%. Conclusions: A high ApoB/ApoA-I ratio was significantly associated with carotid atherosclerosis in T2DM patients with LDL-C levels less than 100 mg/dL.

고추 탄저병 저항성 중간모본 ‘원예 100005호 ’,‘원예 100006호’ 육성

양은영,김수,채영,채수영,조명철,문지혜,박태성,이우문,곽정호 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

Owing to frequent heavy rain due to abnormal weather, the occurrence of pepper anthracnose has recently increased, which affects the supply and demand of pepper. As a result, the price of red pepper powder in 2011, for example, increased three times compared to the average year. Although anthracnose of pepper plants has been controlled by fungicides until now, it is important to develop new resistant cultivars because of the reduction of the labor force in rural area and occurrence of new anthracnose strains resistant to fungicides. National Institute of Horticultural and Herbal Science developed two pepper lines, ‘Wonye 100005’ and ‘Wonye 100006’ that are resistant to pepper anthracnose. These lines were developed by continuous selection of progenies from a cross between ‘Wonye AR1’, which were developed from interspecific hybridization and ‘TF68’. The anthracnose resistance level of the two lines was higher than that of commercial cultivars and similar to check varieties showing highest level of anthracnose resistance.

비동맥류성 자발성 지주막하 출혈을 예측할 수 있는 뇌전산화 단층촬영 소견

조용은,허승곤,서정호,이규창 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.5

Fourty-seven patients with non-aneurysmal spontaneous subarachnoid hemorrhage were reviewed retrospectively. Attention was directed to the distribution and amount of subarachnoid hemorrhage on computerized tomography scans. Though the hemorrage could be distributed in all cisterns, the frequency and amount of hemorrhage were higher in infratentorial cisterns than in supratentorial cisterns. Among infratentorial cisterns, the hemorrhage was distributed to cisterns around the brainstem mainly and it had a predilection for interpeduncular cistern. Also the telangiectasia of thalamoperforating artery might be one of the causes of non-aneurysmal spontaneous subarachnoid hemorrhage.

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

말라리아 감염 환자에서 관찰되는 항핵항체

조성은,허정원,정환순 대한임상병리학회 2001 대한임상병리학회지 Vol.21 No.5

Neuropeptide γ의 구조 및 생리활성

구희정,서정길,김은희,허민도,정준기,박장수,강신원,박남규 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

생리활성을 지닌 신경펩타이드의 구조와 활성간의 관계를 규명하기 위하여 고상법으로 합성한 세종류의 neuropeptide γ(mammalian-,trout- 그리고 goldfish-neuropeptide γ)를 사용하여 연구하였다. Circular dichroism spectra에 의하면 mammalian-,trout- 와 goldfish-neuropeptide γ는 완충액 조건하에 모두 random한 구조를 나타내었다. 중성 및 산성 지질 존재 하에서, mammalian-과 trout- neuropeptide γ는 여전히 random한 구조를 취하였다. 그러나, goldfish-neuropeptide γ는 중성 및 산성지질하에서 부분적으로 α-helix구조를 나타내었다. 장관 수축활성에 있어서는 carp 장관, guinea-pig 회장 그리고 rat십이지장에 대하여 비교하였다. Carp에 대해서는 goldfish-neuropeptide γ= trout- neuropeptide γ>mammalian-neuropeptide γ순으로 활서이 나타났다. 그러나, guinea-pig 회장과 rat십이지장에 대해서 mammalian-neuropeptide γ는 어류 유래성 neuropeptide g들 보다 높은 수축활성을 나타내었다. 이러한 결과들은 neuropeptide γ들이 종-특이적인 활성을 나타낸다는 것을 제시한다. The relationship between structure and biological activity was studied on the three neuropeptides(mammalian-,trout- and goldfish-neuropeptide γ)that were syntheized by the solid-phase method. Circular dichroism spectra showed that mammalian-,trout- and goldfish-neuropeptide γadopted an undered structure in buffer solution. In the presence od neutral and acidic liposomes, mammalian-and trout- neuropeptide γ also took a random structure. However, goldfish-neuropeptide γ took an α-helical structure in acidic liposomes. The intestinal motility response was investigated with carp interstines, guinea-pig ileums and rat duodenums. In case of carp intestine, contractine activity was as follows:goldfish-neuropeptide γ= trout- neuropeptide γ> mammalian-neuropeptide γ. On the other hand, the contracile activity of mammalian-neuropeptide γ was more potent than trout- and goldfish-neuropeptide γ in the guinea-pig ileums and rat duodenums. these results suggest that neuropeptide γs showed the species-specific activity.

서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

Effects of the immobilization of heparin and rhPDGFBB to titanium surfaces for the enhancement of osteoblastic functions and anti-inflammation

Jung-Bo Huh,Jeong-Yol Lee,Kyung-Lae Lee,Sung-Eun Kim,Mi-Jung Yun,Ji-Suk Shim,June-Sung Shim,Sang-Wan Shin 대한치과보철학회 2011 The Journal of Advanced Prosthodontics Vol.3 No.3

PURPOSE This study was to investigate the effects of recombinant human platelet-derived growth factor (rhPDGF-BB) and heparin to titanium surfaces for enhancement of osteoblastic functions and inhibition of inflammation activity. MATERIALS AND METHODS The anodized titanium discs, not coated with any material, were used as a control group. In heparinized- Ti group, dopamine was anchored to the surface of Ti substrates, and coated with heparin. In PDGF-Ti group, rhPDGF-BB was immobilized onto heparinized Ti surface. The surface morphologies were investigated by the scanning electron microscope in each group. The release kinetics of rhPDGF-BB were analyzed, and cytotoxicity tests for each group were conducted. The biocompatibilities were characterized by measuring cell proliferation, alkaline phosphatase activity, and calcium deposition using MG-63 cells. Statistical comparisons were carried out by one-way ANOVA tests. Differences were considered statistically significant at *P<.05 and **P<.001. RESULTS The combination of rhPDGF-BB and heparin stimulated alkaline phosphatase activity and OCN mRNA expression in osteoblastic cells (*P<.05 and **P<.001). MG-63 cells grown on PDGF-Ti had significantly higher amounts of calcium deposition than those grown on anodized Ti (**P<.001). Heparinized Ti was more anti-inflammatory compared to anodized Ti, when exposed to lipopolysaccharide using the transcript levels of TNF-α and IL-6 of proinflammatory cytokine (*P<.05 and **P<.001). CONCLUSION The result of this study demonstrated that the incorporation of rhPDGF-BB and heparin onto Ti surface enhanced osteoblastic functions and inhibited inflammation.

Predictive Factors for Incidental Contralateral Carcinoma in Patients with Unilateral Micropapillary Thyroid Carcinoma

Huh, Jung Eun,Kim, Sang Soo,Kang, Ji Hyun,Choi, Bo Gwang,Lee, Byung Joo,Lee, Jin Choon,Jeon, Yun Kyung,Kim, Bo Hyun,Wang, Soo Geun,Kim, Yong Ki,Kim, In Joo Korean Endocrine Society 2012 Endocrinology and metabolism Vol.27 No.3