http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과
류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-
Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.
뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열
장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-
Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.
초등학교 과학교실 및 과학동아리 관련 현장 조사 및 프로그램 개발 모형 설정
임청환,김남일,권성기,고한중,이성호 한국과학교육학회 2005 한국과학교육학회지 Vol.25 No.2
본 연구의 목적은 과학 교실 및 과학반, 과학동아리 활동과 관련하여 일선 학교 현장에서는 어떤 문제점을 갖고 있으며 어떤 요구가 있는지 조사연구를 통해 알아보고 그 결과를 바탕으로 활동 프로그램을 개발하기 위한 개발 모형을 제시하는 것이었다. 146개 초등학교의 과학 관련 교사를 대상으로 설문 조사하였으며 조사결과, 교사들은 다양한 문제점과 해결 덜'간을 제시하였는데 다음과 같은 시사점을 얻을 수 있었다. 첫째, 다양한 과학 활동에 대한 행·재정적 지원이 절실히 필요하다. 둘째, 과학비전공 교사도 쉽게 다룰 수 있는 활동 프로그램의 제공이 필요하다. 셋째, 재미있는 활동으로 구성된 프로그램이 있어야 한다. 넷째, 프로그램은 준비가 용이한 활동으로 이루어져야 한다. 다섯째, 탐구 활동 중심의 평가 방법이 제시되어야 한다. 이러한 조사 결과를 바탕으로, 교사, 학생, 운영 환경을 축으로 하는 프로그램 개발 맥락을 설정하고 주제 설정, 활동구성, 차시구성, 활동지 구성, 교사용 지침서 구성의 단계로 이루어진 개발 모형을 제안하였다. The purpose of this study was to investigate the needs of elementary school teachers on extra-science programs and to suggest development model for extra-science program. Survey research was conducted on 146 science-related teachers all over the country. As the result, teachers presented several problems and solutions on extra-science activities and programs. The suggestions from the results are as follows. First, more administrative and financial supports are required. Second, it must be the programs with which any teachers, regardless of their major fields, can execute easily. Third, the programs should be interesting for students to do. Fourth, it should be easy to prepare activities and materials, Finally, the inquiry-focused assessment method should be presented in each program. Based on these suggestions, the context of development of programs was established. Three axises of, students, teachers, and environment, were included in the context. The model of development of programs was set up based on the context. It was constructed with six process steps, Confirmation of theme, Composition of work frame, Organization of each period, Worksheets for students, Guidebook for teachers, Completion, and one or two assessment criteria in each process steps. It must be useful to development of extra-science programs that is appropriate to the need of teachers.
Glycoprotein extraction from Laminaria japonica promotes IEC-6 cell proliferation.
Go, Hiroe,Hwang, Hye-Jung,Nam, Taek-Jeong D.A. Spandidos 2009 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.24 No.6
<P>The brown alga Laminaria japonica is frequently consumed in Korea, Japan and China, and has been used for more than a thousand years as a drug in traditional Chinese medicine. In this study, we isolated a novel glycoprotein from L. japonica that stimulates the growth of the IEC-6 normal murine intestinal epithelial cells. We also identified the mechanism by which this glycoprotein, referred to as LJGP, stimulates cell growth. After 24 h of exposure to LJGP, cell proliferation increased in a dose-dependent manner. To further explore the mechanism associated with LJGP-induced cell proliferation, we treated cells for various times with LJGP. We focused on the epidermal growth factor receptor (EGFR) signaling pathway, which is involved in the regulation of cellular proliferation and differentiation, during LJGP-induced cell growth. The results showed that LJGP induced EGFR and Akt activation. Furthermore, LJGP stimulated Shc/Grb2 binding and ERK activation, but inhibited JNK phosphorylation. These results indicate that LJGP stimulates gastrointestinal cell growth by activating the EGFR signaling pathway.</P>
Ultra Fast Flash Observatory to observe the prompt photons from Gamma Ray Bursts
Nam, Ji-Woo,Boggs, Steven,Ripov, G.,Grossan, Bruce,Jeon, Jin-A,Jin, Joo-Young,Jung, Ae-Ra,Kim, Ji-Eun,Kim, Min-Soo,Kim, Yong-Kweon,Klimov, P.,Khrenov, B.,Lee, Chang-Hwan,Lee, Jik,Na, Go-Woon,Nam, Shin 한국우주과학회 2009 한국우주과학회보 Vol.18 No.1
( Nam-ho Keum ),( Taek Lee ),( Jung-been Lee ),( Hoh Peter In ) 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.4
As mobile devices such as smartphones and tablet PCs become more popular, users are becoming accustomed to consuming a massive amount of multimedia content every day without time or space limitations. From the industry, the need for user satisfaction investigation has consequently emerged. Conventional methods to investigate user satisfaction usually employ user feedback surveys or interviews, which are considered manual, subjective, and inefficient. Therefore, the authors focus on a more objective method of investigating users’ brainwaves to measure how much they enjoy their content. Particularly for multimedia content, it is natural that users will be immersed in the played content if they are satisfied with it. In this paper, the authors propose a method of using a portable and dry electroencephalogram (EEG) sensor device to overcome the limitations of the existing conventional methods and to further advance existing EEG-based studies. The proposed method uses a portable EEG sensor device that has a small, dry (i.e., not wet or adhesive), and simple sensor using a single channel, because the authors assume mobile device environments where users consider the features of portability and usability to be important. This paper presents how to measure attention, gauge and compute a score of user’s content immersion level after addressing some technical details related to adopting the portable EEG sensor device. Lastly, via an experiment, the authors verified a meaningful correlation between the computed scores and the actual user satisfaction scores.
( Go Woon Choi ),( Nam Ju Lim ),( Jung U Shin ),( Hee Jung Lee ),( Moon Soo Yoon ),( Dong Hyun Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Psoriasis can be treated successfully with biologics in a fixed dosing interval. However, there are limited data on the treatment outcomes of biologics with irregular dosing interval in psoriasis. Objectives: This study aimed to compare treatment outcomes of biologics with regular and irregular dosing interval in psoriasis. Methods: This was a retrospective single-center study. Patients diagnosed with plaque psoriasis who were treated with biologics between 1 January 2014 and 31 December 2019 were included. We compared the demographics, treatment regimen, and treatment outcomes for each regular and irregular dosing interval group. Results: Among 95 patients, 63 (66.3%) patients were treated with biologics with regular dosing interval, and 32 (33.7%) with irregular dosing interval. No significant difference regarding final Psoriasis Area Severity Index (PASI) (1.4 vs. 1.6; p=0.40) and percentage of PASI improvement from baseline (-89.6% vs. -90.7%; p=0.63) was found between two groups. The number of switching biologics was not significantly different but higher in irregular group than regular group (8 (12.7%) vs. 9 (28.1%); p=0.06). Conclusion: In this study, noninferiority was not demonstrated for irregular dosing interval of biologics based on the PASI in patients with psoriasis compared with regular dosing interval. However, irregular biologic dosing interval may increase the number of switching biologics.