노년기 우울성 가성치매 환자군에서의 뇌 단일광자방출 전산화 단층촬영 소견

이동우,이명철,정준기,이동수,곽철은,이재성,조경형,조맹제 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.6

연구 목적 : 우울성 가성치매 환자군의 Tc-HMPAO SPECT영상 소견을 정상 대조군, 인지기능장애가 없는 우울증 환자군 및 알쯔하이머형 치매 환자군과 비교함으로써 노년기 우울성 가성치매의 병태생리의 일부를 알아 보았다. 연구 방법: 9명의 알쯔하이머형 치매 환자군, 7명의 인지기능장애가 없는 우울증 환자군, 7명의 우울성 가성치매 환자군, 4명의 정상대조군을 대상으로 하였다. 우울증 환자군은 DSM-III-R의 우울증의 진단 기준에 의해 진단되었고, 알쯔하이머형 치매 환자군은 DSM-III-R의 진단기준과 NINCDS-ADRDA의 알쯔하이머형 치매의 진단 기준에 의해 진단되었다. 모든 대상자가 해밀턴 우울증 척도 및 MMSE-K에 의해 평가되었다. 모든 대상자에 대해 99m-HMPAO SPECT를 시행하였고, 각 대상군의 영상을 Friston의 통계적 매개변수 지도 방법을 이용, 매 복셀(voxel) 단위로 비교분석하였다. 결과 : 결과는 아래와 같다. 1) 알쯔하이머형 치매 환자군은 대조군에 비해 우측 전두엽, 우측 측두엽, 양측 두정엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 2) 우울증 환자군은 대조군에 비해 좌측 전두엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 3) 우울성 가성치매 환자군은 대조군에 비해 우측 측두엽과 좌측 두정엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 4) 우울성 가성치매 환자군은 우울증 환자군에 비해 우측 측두엽과 양측 두정엽에서 유의한 혈류감소 소견을 보였다.(p<0.05). 결론 : 우울성 가성치매 환자군은 측두-두정엽의 혈류감소 소견을 보였고, 이는 알쯔하이머형 치매와 유사한 소견이었다. 이러한 결과는 우울성 가성치매가 초기의 원발성 치매 환자군을 포함한다는 가설을 지지해준다. 0bjects : Through comparison of the Tc-HMPAO SPECT image ofdepressive pseudo-dementia group with those of control group(depression group free from cognitive impairment)and DAT(Dementia of Alzheimer's type). we tried to see part of pathophysiology of she depressive pseudodementia of the elderly. Methods : The subjects consisted of 9 patients with dementia of Alzheimer type(DAT group),7 patients with depression free from cognitive impairment(depression group),7 patients with depressive pseudodementia(depressive pseudodementia group), and 4 normal controls. De-pression patients were diagnosed according to DSM 111-R DAT patients were diagnosed by DSM 111-R and N1NCDS-ADRDA criteria of DAT. All were rated with Hamilton Rating Scale for Depression and Mini Mental State Exam. All underwent 99m-HMPAO SPECT scan. The images of each group were analysed using SPM of Friston, which compares the images on voxel-by-voxel basis. Results : The results were as follows : 1) DAT group showed significant decrease in cerebral blood flow (CBF) compared with controls in the right frontal region, the right temporal region, and both temporal regions(p<0.05). 2) Depression group showed significant decrease in CBF in the left frontal region(p<0.05). 3) Depressive pseudodementia group showed significant decrease in CBF compared with controls in the right temporal region and the left parietal region(p <0.05). 4) Depressive pseudodementia group showed significant decrease in CBF compared with depression group in the right temporal region and both parietal regions(p<0.05). Conclusion : Depressive pseudodementia group showed decreased CBF in temporo-parietal region, similar to that of the DAT group. This result supports the hypothesis that depressive psuedodementia includes a subgroup of patients with early-stage primary dementia.

Ⅲ-Ⅴ족 반도체의 연구 : GaAs의 합성, 단결성 및 특성 Crystal Growth and Characterization of GaAs

이형재,김영기,신영진,박해용,정양준,최춘태,김병호,김진성 全北大學校 基礎科學硏究所 1982 基礎科學 Vol.5 No.1

Temperature of 618 and 1250℃ at As and Ga sities respectively in the horizontal Bridgman furnace and growht speed of 0.7cm/h were found to be optimal for the production of single crystalline GaAs. Self-seeded and unintentionally doped GaAs crystals showd n-type characteristics with Hall mobillity of ∼0.75㎡/V-sec and carrier density of ∼10^19 m^-3 when the mesurements were made right after the growth. About three month later it was found that the same samples were converted to p-type GaAs. The analysis on the p-type sample showed that impurity scattering is dominant at around room temperature and thus the measured Hall mobility was 0.0065㎡/V-sec at 300K. 7.4±0.6 eV was obtained for acoustic deformation potential in the heavy hole band by fitting the theoretical conductivity and Hall coefficient to the corresponding experimental data. The value is very much higher than the theoretically estimated value, 3.6eV. The carrier density variation with temperature obtained from the present analysis gave 0.38 and 0.17 eV respectively for the activation energies of donor and acceptor.

치아 이상의 발생 빈도와 양상에 관한 연구

이제호,손홍규,전승준,최형준 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

An object definition of the anomaly is not avaliable and most investigators define the term differently or fail to describe their criterion.Because dental anomaly may lead to many complications,early detection and diagnosis of dental anomalies are essential steps in the evaluation of the child patient and in treatment planning.These procedures require detailed medical and dental histories,through clinical examination and the use of radiographs.So,this study was designed to find out the prevalece of dental anomalies.The clinical and roentgenographic examination was undertaken for 8,054 children at age from 0 to 15 years and statistical analysis was done.The results were as follows: 1.Among the examined subjects 2,134 subjects(26.5%) showed dental anomalies.The prevalance of individure dental anomalies were as as follows:Supernumerary teeth 15.6% congenitally missing teeth 6.6%,fusion 2.2%,odontoma 0.35%,microdontia 1.2%,macrodotia 0.05%,gemination 0.22%,talon cusp 0.36%,dens evaginatus 0.24%,dens invaginatus 0.15%,dilaceration 0.27%,taurodontism 0.09%,abnormal tooth position 1.7%,natal $ neonatal teeth 0.92%,amelogenesis imperfecta 0.01%. 2.Significant correlations between the groups with individual dental anomalies were as follows:between groupⅠand other groups,there was nagative correlation,especially groupⅠ and groupⅡ.And the correlation coefficient between male and female showed differences. 3.For the supernumerary teeth group,the prevalence of male was higher than female(p<0.001).While for the congenitally missing teeth,macrodontia,microdontia,abnormal tooth position group,the prevalence of female was greater than male(p<0.001). 4.For the congenitally missing teeth group,the mandibular primary lateral incisor showed the highet incidence in primary dentition,while mandibular lateral incisor in permanent dentition.In the mandible(72.5%),this site showed higher prevelence than in maxilla.In this case with deciduous congenitally missing teeth,the prevelence of successive permanent congenitally missing teeth was about 33.9%,the incidence was highet in mandibular lateral incisors. 5.Most supernumerary teeth existed on middle area and showed inverted position and unerupted state.In addition,supernumerary teeth showed higher incidence on maxilla(99.3%). 6.In the case with deciduous fused teeth,the prevelence of successive permanent congenitally missing teeth was 39.9%,while that of successive permanent fused teeth was 2.7%.And the highet rate of the prevalence(40.3%) appeared in fusion of mandibular deciduous lateral incisor and canine. 7.In the case of odontoma,the prevelence was higher in maxilla(78.6%) and anterior region(82.7%) the mandible and posterior region.

??의 전기전도 특성 및 에너지 밴드구조

정양준,박문규,이형재 木浦大學校基礎科學硏究所 1988 基礎科學硏究誌 Vol.6 No.-

Experimental measurement of electrical conductivity and Hall coefficient have been made as a function of temperature on n-type five ?? alloys which had as component ratio of 0.02, 0.11, 0.21, 0.275, 0.32 respectively. Theorical calculation of electrical conductivity and Hall coefficient have been made on a three band model using the method of Fletcher and Butcher and the resulting values fitted to the experimental measured data. Where unknown parameters were energy of L₁and X₁band edge, and the compensated acceptor density. The resulting analysis show the band gap variation given by ?? and ?? at room temperature. Various scattering mechanisms are also discussed in this work.

InSb의 결정성장 및 특성

정양준,양순철,이형재 木浦大學校基礎科學硏究所 1989 基礎科學硏究誌 Vol.7 No.-

InSb crystals, both doped and undoped, were grown using the zone-refining technique in vacuum. The unintentionally doped crystals exhibit n-type conduction with the lowest carrier concentration of ??. The pure crystals show intrinsic characteristics even at very low temperatures. Hence very heavily doped n-type crystals were grown in an effort to determine the electron behaviors, not disturbed by the other bands over a wide temperature range. All the InSb crystals prepared in this work were self-seeded along the (111) direction, and the volatilization turned out to be very efficient in reducing the residual impurities during the growing process. The electrical conductivity and Hall coefficient were measured as a function of temperature from 90 to 570K. Theoretical calculations were carried out using a three-band model with the ?? and two hole bands taking into account scattering mehanisms. The results were consistently fitted to the experimental data with the adjustable parameters used in describing the temperature variation of band gap, heavy hole effective mass??, deformation potential??. The final fitting was obtained with the following values, ??, ??, ??. At high temperatures polar optical scattering is dominant for electron scattering and electron-hole scattering becomes very important.

반복 용체화처리에 의해 조직제어된 Ti-6Al-4V 합금의 인장성질

조형준,임영호,이준희 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.2

The purpose of the present study is to improve the tensile properties of the beta-quenched with little strain due to processing, only by heat treatment. Control of volume fraction, morphology and distribution of alpha is of great importance in achieving desired mechanical properties with a good combination of strength and elongation. Accordingly, a cyclic solution treatment has been proposed to obtain bimodal structures of equiaxed and acicular alphas. The microstructures of the specimens subjected to the Cyclic Ⅲ solution treatment consisted of nearly equiaxed and acicular alphas with the matrix of the tempered martensite. As a result, the tensile properties became almost equivalent to the specimens of the double solution treatment in the α+β region.

NK/T 세포 림프종 환자에서 시행된 비골수제거성 조혈모세포이식

정준원,김진석,장준호,서형찬,이승태,김현옥,양우익,민유홍,한지숙,고윤웅 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

저자 등은 맹장, 충수돌기 및 흉막을 침범한 고위험군 NK/T 세포 림프종 환자에서 비골수제거 조혈모세포이식을 시행한 후 이식연관 합병증 없이 무병생존하였기에 보고하는 바이다. NK/T cell lymphoma is a rare type of non-Hodgkin"s lymphomas. It has the histological features of angiocentric lymphoma characterized by prominent angio-invasion by tumor cells, and commonly presents in nasal and paranasal structures. Non-nasal form of NK/T cell lymphoma involves skin, gastrointestinal tract, or liver. With conventional chemotherapy and/or radiotherapy, NK/T cell lymphoma shows poor response rate and seldom results in long term survival. Especially, non-nasal form has more aggressive clinical manifestations and grave outcome than nasal form. We report a case of NK/T cell lymphoma presenting with small bowel perforation and malignant pleural effusion due to lymphoma infiltration, transplanted with allogeneic peripheral blood stem cells from HLA identical sibling donor after fludarabine-based nonmyeloablative chemotherapy. After transplantation, the patient achieved an enduring tri-lineage hematological complete response without any evidence of relapse for 10 months.

금속 촉매를 이용한 poly-Si의 결정화에 관한 연구

金善浩,李秀京,金泰延,康娜榮,金亨駿 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-

Nickel induced crystallization of amorphous silicon (a-Si) has been studied by selective deposition of Ni on a-Si thin films. The kinetics of crystallization for MIC was found to be greatly enhanced than that of SPC. Ni-induced crystallization is a promising technique for low-temperature fabrication of poly-Si thin-film transistors needed for large area applications. Lateral growth of polycrystalline silicon mediated by the formation of nickel silicide, has been successfully employed for the fabrication of high-performance TFTs. A-Si thin films on which Ni films were deposited with various thickness were crystallized as a function of annealing temperatures. Throughout the thesis work, wise choice of both the thickness of Ni and the annealing temperature was found to produce poly-Si films with high quality, thus potentially resulting in the production of TFTs with high performance.

T1b 병기의 신세포암에서 수술 후 예후를 예측할 수 있는 임상 및 병리학적 인자에 대한 연구

오승용, 김영원, 윤형윤, 서성필, 이상근, 김원태, 윤석중, 이상철, 김원재, 김용준 충북대학교 의과대학 충북대학교 의학연구소 2014 忠北醫大學術誌 Vol.24 No.1

연구목적: T1병기의 국소신세포암(localized clear-cell renal cell carcinoma)은 근치적신적출술이 나 부분신절제술이 표준치료이며 수술 후 타 병기에 비해 양호한 예후를 보인다. 하지만, 많은 수의 환 자에서 추적관찰 중 재발 및 사망이 발생하는데, 이는 T1b 병기에서 더 높게 보고되고 있다. 본 연구 에서는 국소신세포암 중 T1b 병기의 신세포암에서 표준적 치료 후 환자의 예후에 영향을 주는 임상 및 병리학적 인자에 대하여 알아보고자 하였다. 대상 및 방법: 1999년부터 2011년 까지 5개 기관에서 근치적신적출술이나 부분신제술을 시행 받은 3567명의 국소신세포암 환자들 중 병리학적 병기가 T1b로 확진 된 702명을 대상으로 하였다. 이들 환자가 가지는 임상 및 병리학적 특성 [연령, 성별, 고혈압, 당뇨, 비만도, European Cooperative Oncology Group(ECOG) 수행도, 증상유무, 수술방법, 종양크기, 분화도, 조직학적 형태 등]을 이용 하여 환자의 예후 [무재발생존율(relapse-free survival), 암특이생존율(cancer-specific survival) 및 전체생존율(overall survival)]에 영향을 미치는 인자에 대하여 다양한 방법으로 비교분석 하였다. 결과: 추적 관찰 기간은 34.0개월 (중앙값, 0-152개월)이었으며, 이 기간 중 재발, 사망 및 암특이사 망은 각각 72례 (10.3%), 57례 (8.1%) 및 24례 (3.4%)에서 발생하였다. 단변량 및 다변량 Cox 비례위험회귀분석에서 다양한 인자들이 무재발생존율(당뇨 유무, 종양크기 및 Fuhrman등급), 암특이 생존율(나이, 체질량지수, 당뇨 유무, 종양크기) 및 전체생존율(나이, 체질량지수, ECOG 수행도, 종 양크기)에 영향을 줄 수 있는 독립적 예후인자였다. 결론: 본 연구결과 국소신세포암의 예후를 예측할 수 있는 다양한 임상 및 병리학적 인자를 확인 할 수 있었다. 이러한 위험인자를 가지고 있는 환자는 보다 적극적인 추적관찰을 통하여 재발을 조기에 발 견한다면 이들의 생존율 향상에 많은 기여를 할 수 있을 것으로 생각한다.

비개흉 심근 경색 동물모델을 이용한 심근 경색의 자기공명영상에 관한 연구

임명관,박재형,이활,정진욱,이동수,정준기,최영희 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11