Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

전국체육고등학교 투척선수들의 운동 상해에 관한 연구

배성완,강주혁,문주흠 목포대학교 스포츠산업 연구소 2006 스포츠 산업연구소 논문집 Vol.5 No.-

The purpose of this research is to work out the injury time, injury place, injury part, cause of injury, medical treatment, preventions against weight throwers at national physical education high schools and management and protection of them and advance of competence. As a result of questioning total 148 persons of shot putters (M20, F17), discus throwers(M21, F20), javelin throwers(M22, F20) and hammer throwers(M18, F10) who are registered at the Korean Amateur Athletic Federation, we come to the following conclusions. 1. As a result of comparison and analysis of the training programme where weight throwers were frequently injured by the event, the meaningful difference was obtained. Javelin throwers were injured most frequently while throwing training. 2. As a result of comparison and analysis of the meaningful difference of part which injury happened most frequently while throwers trained usually, the meaningful difference was obtained. Javelin throwers’ elbow injury was very frequent. 3. As a result of comparison and analysis of most frequently injured part by the event while weight throwing, the meaningful difference was obtained. Discus throwers’ waists were mostly injured while throwing. 4. As a result of comparison and analysis of frequently injured part by the event while weigh throwing training, the meaningful difference was obtained. Injury in waist part happened more frequently in rotary motion event than rectilineal motion event while weight throwing. 5. As a result of comparison and analysis of the event that throwers were injured frequently by sex while weight training, the meaningful difference was obtained. Women weight throwers were injured while jump squat training. 6. As a result of comparison and analysis of treatment period after injury by sex, the meaningful difference was obtained. It took women 4 weeks more to cure up and it was not short. 7. That difference that keep in mind method that can protect Shanghai when saw as exercise injury experience according to comparative analysis result by item appeared and rectilineal movement item selected most by method that mental power can protect Shanghai both item beam egg number It Eotda. 8. As a result of comparison and analysis of the season when thrower were injured frequently by experience, the meaningful difference was obtained. Throwers with below 1-4 year experience were injured frequently in summer. 9. As a result of comparison and analysis of the training time when weight throwers were injured frequently by result, the meaningful difference was obtained. Weight throwers who have never won the prize were injured frequently while training in the afternoon. 10. As a result of comparison and analysis of throwing motion when weight throwers were injured frequently by experience while throwing training, the meaningful difference was obtained. Throwers with below 1-4 year experience were injured frequently on waist twisting motion in the finish motion.

Polyamide Membrane with Tro?ger’s Base Intrinsic Structure Nanofiltration through Interfacial Polymerization

Jun Hyeok Kang,Ho Bum Park 한국막학회 2023 한국막학회 총회 및 학술발표회 Vol.2023 No.05

Timing for a laparoscopic myomectomy during the menstrual cycle

( Jun Hyeok Kang ),( Woo Young Kim ),( Kyo Won Lee ),( Kye Hyun Kim ),( Tae Jong Song ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

Public perception of risk-reducing salpingectomy for preventing ovarian cancer

( Jun Hyeok Kang ),( Se Hyun Nam ),( Taejong Song ),( Woo Young Kim ),( Kyo Won Lee ),( Kye Hyun Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.4

Objective: The fallopian tube is considered as the site of origin of serous ovarian cancer, and risk-reducing salpingectomy (RRS) has been proposed as a new and safe strategy for preventing ovarian cancer. However, little is known about the public perception of RRS. Methods: We performed a questionnaire survey of 100 healthy female volunteers in November 2014. Questionnaire for this survey included questions on demographics, medical history, knowledge of and belief about RRS, and barrier to its application. Results: Among 100 respondents, 71% did not realize the seriousness of ovarian cancer, 79% were unaware of the fact that salpinx was the origin of ovarian cancer, and 87% stated that they had never heard of RRS as a preventive method for ovarian cancer. Also, 98% of respondents replied that they had the right to be informed about RRS and the choice given. The respondents’ fears about RRS included increased risk of surgical complications (68%), no benefit (8%), and increased surgical costs (3%). Conclusion: Most general women were unaware of RRS as a method for preventing ovarian cancer in women at average risk. Therefore, physicians should discuss RRS with patients and consider this procedure at the time of abdominal or pelvic surgery.

GG-04 : Single-port laparoscopically assisted-transumbilical ultraminilaparotomic myomectomy (SPLA-TUM)

( Jun Hyeok Kang ),( Doo Haeng Lee ),( Jung Hun Lee ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

The aim of current study was to describe the surgical technique and our initial experience with single-port laparoscopically assisted transumbilical ultraminilaparotomic myomectomy (SPLA-TUM) and to assess the safety and feasibility of this procedure. A prospective observational study was performed from July 2012 to August 2012. Fifteen women underwent SPLA-TUM, and we compared the results of this study and our preliminary report on single port laparoscopic myomectomy (SP- LM). In SPLA-TUM, the mean operating time, hemoglobin change, return of bowel activity, and length of hospital stay were 64.9 ± 9.5 minutes, 1.2 ± 0.5 g/dL, 32.8 ± 3.5 hours, and 3.1 ± 0.4 days, respectively. Because SPLA-TUM did not provide a satisfactory surgical field, SPLA-TUM was converted to single-port laparoscopic myomectomy in one woman (6.7%). In comparison of SPLA-TUM and SP-LM, there was no significant difference in the clinical characteristics and operative results, except operating time (64.9 ± 9.5 and 81.6 ± 21.5 minutes, respectively). SPLA-TUM, which was designed by integrating the surgical techniques of single-port laparoscopy and laparotomy, can reduce the operating time compared with SP-LM by permitting comfortable suturing and reliable knotting while maintaining the advantages of single-port laparoscopy. SPLA-TUM is a feasible alternative in selected patients with symptomatic myoma.

Life Science : Effects of solid carriets on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS)

( Jun Hyeok Kang ),( Dong Hoon Oh ),( Yu Kyoung Oh ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

In order to investigate the effects of solid carriers on the crystalline properties, dissolution andbioavailability of flurbiprofen in a solid self-nanoemulsifying drug delivery system (solid SNEDDS), different solid SNEDDS formulations were prepared by spray-drying the solutions containing liquid SNEDDS and various carriers. The liquid SNEDDS, composed of Labrafil M 1944 CS/Labrasol/Trasncutol HP (12.5/80/7.5%) with 2%w/v flurbiprofen, gave a z-average diameter of about 100 nm. Silicon dioxide, a hydrophobic solid carrier, produced an excellent conventional solidSNEDDS with a nanoemulsion droplet size of less than 100 nm, similar to the liquid SNEDDS and smaller than the other solid SNEDDS formulations. The drug was in an amorphous state in this solidSNEDDS. Furthermore, it greatly improved the dissolution rate and oral bioavailability of flurbiprofen in rats because it allowed the spontaneous formation of an interface between the oil droplets and the water. Magnesium stearate, a hydrophobic carrier, produced a solid SNEDDS with the largest diameter. However, it greatly enhanced the dissolution rate and oral bioavailability due to the formation of a simple eutectic mixture. The hydrophilic carriers such as polyvinyl alcohol (PVA), sodium carboxymethyl cellulose (Na-CMC) and hydroxypropyl-β-cyclodextrantrin (HP-β-CD) did not form asolid SNEDDS but rather a solid dispersion (or microcapsule). HP-β-CD improved the dissolution rate but did not improve the oral bioavailability as much as the hydrophobic polymers. PVA and Na-CMC hardly improved the dissolution rate but maintained constantly high plasma levels in rats for a long period. Thus, the selection of carrier is an important factor in the development of solid SNEDDS, since the carriers had significant effects on the crystalline properties, dissolution and oral bioavailability offlurbiprofen and on the formation of solid SNEDDS.ⓒ 2011Elsevier B.V. All rights reserved.

Analysis of Multiple Fin-type Vertical GaN Power Transistors based on Bulk GaN Substrates

Jun Hyeok Heo,Sang Ho Lee,Jin Park,So Ra Min,Geon Uk Kim,Ga Eon Kang,Jaewon Jang,Jin-Hyuk Bae,Sin-Hyung Lee,In Man Kang 대한전자공학회 2023 Journal of semiconductor technology and science Vol.23 No.1

In this study, the multiple fin-type vertical GaN power transistor based on the GaN-on-GaN were analyzed using the two-dimensional technical computer-aided design (2-D TCAD) simulations. In the field of the electric vehicle systems requiring a high operation voltage of 1,000 V or more, the power devices have a large device area because of the long distance between the gate region and the drain region. This problem can be addressed by using the fin-type vertical GaN power transistor, which can reduce the device area due to its vertical channel. For the high current performance, the multiple fin-type structure was required. Thus, we investigated characteristics depending on the number of fin (Nfin). By comparing the on-state drain currents (Ion), the breakdown voltages (BV), and the on-resistances (Ron) with different Nfin, this study provides an understanding of the electrical properties of the multiple fin-type vertical GaN power transistor affected by Nfin.

Film Session Q&A 1 : A new surgical technique, single-port laparoscopically assisted-transumbilical ultraminilaparotomic myomectomy (SPLA-TUM)

( Jun Hyeok Kang ),( Doo Haeng Lee ),( Jung Hun Lee ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Teach a new procedure A 41 years old Korean women with 8.7 × 5.2 cm intramural myoma on the anterior corpurs underwent Single-port laparoscopically assisted- transumbilical ultraminilaparotomic myomectomy (SPLA-TUM) using Gel-Port portrepalcement system through a 2 to 2.5 umbilical incision. In the laparoscopic phase, a dilute solution of vasopressin was injected into the tissue around the uterine myoma. A vertical or transverse incision over the fibroid, made with monopolar articulating Metzenbaum scissors, was extended down to the avascular myoma plane. Conventional 10 mm laparoscopic claw forceps, conventional 5 mm laparoscopic forceps or articulating laparoscopic graspers were then used to grasp the myoma and create countertraction and the myoma was dissected out of the uterus. In the transumbilical laparotomic phase, after decoupling the GelPort from the wound retractor, the umbilical incision was pulled caudally with an Army-Navy retractor. Then, the cut edge of the uterine incision was grasped with Allis clamps .The defect in the myometrial and serosal layers was repaired in one layer with figure-of-8 sutures of 1-0 Vicryl just above or below the wound retractor. The morcellation and extraction of the resected myoma was performed with a scalpel through the umbilical incision. After the Gel-Port was latched to the retractor and following intraabdominal irrigation, the incision site of the uterus was covered with an absorbable adhesion barrier. Operating time, hemoglobin change, return of bowel activity and hospital stay were 60 minutes, 1.1 g/dL, 46.5 hours and 3 days, respectively. SPLA-TUM might be an effective and feasible alternative in selected patients with symptomatic myoma.

Development of Matlab-Based IPMSM Model Considering Fault Modes of xEV Platform for SILS

Heo Jun-Hyeok,Kang Jun-Kyu,Hur Jin 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.6

Building a motor fault model through software-in-the-loop simulation (SILS) proposes the control state of the test object as an effective platform. Therefore, in this paper, the motor characteristics considering motor fault based on equations and numerical analysis are applied to the Matlab model. This presents the excellence of evaluating the characteristics of the motor that contributes to the vehicle characteristics in advance at the vehicle level simulation without directly manufacturing the motor.