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강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-
Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.
박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.
CRISPR/Cas9-mediated knockout of NKX3.1 leads to adenoma and hyperplasia in prostate of C57BL/6 mice
Jin Ju Park,Ji Won Park,Ji Eun Kim,Mi Rim Lee,Jun Young Choi,Bo Ram Song,Hye Ryeong Kim,Byeong Cheol Kang,Dae Youn Hwang,Mi Ju Kang,Su Ji Bae,Hyeon Jun Choi,Yu Sang Choi,Young Ju Lee,Jun Go 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.1
Yoon, Hyun Ju,Ahn, Youngkeun,Park, Jeong Bae,Park, Chang Gyu,Youn, Ho Joong,Choi, Dong Ju,Shin, Joon-Han,Kim, Dong-Woon,Rim, Se Joong,Bae, Jang Ho Informa Healthcare 2010 Clinical and experimental hypertension Vol.32 No.7
<P>Patients with masked hypertension (MH) tend to have a higher risk than those with white-coat hypertension (WCH). Therefore, we evaluated the characteristics of MH and WCH in Korean patients receiving medical treatment for hypertension. We enrolled 1019 outpatients (56 ± 10 y, 488 males) with diagnosed hypertension who had not changed oral anti-hypertensive medication for 6 months. Clinic blood pressure (CBP) was checked by a nurse and doctor twice per visit. Home BP (HBP) was checked every morning and evening for 1 week. In the MH patients, mean CBP was 130/80 mmHg, whereas HBP was 137/86 mmHg. In the WCH patients, mean CBP was 149/86 mmHg by physician and 143/85 mmHg by nurse and mean HBP was 124/75 mmHg. Age and gender did not differ between the groups. Waist and hip circumferences and the level of fasting glucose were higher in patients with MH than in patients with WCH (p = 0.008, 0.016, 0.009, respectively). Metabolic risk factors were more frequent in patients with WCH, MH, and uncontrolled hypertension than in patients with controlled hypertension. The incidence of metabolic risk factors, however, did not differ between patients with WCH and MH. Heart damage was more frequent in MH than in WCH (p = 0.03). The incidence of metabolic risk factors did not differ between patients with WCH and those with MH. Target organ damage was more closely related to MH than to WCH. Home BP measurement was a useful tool for discriminating WCH and MH in patients with hypertension.</P>
Long term effects of fluoride administration on the chemical compositions of rat bones
Do, Young Ju,Kim, Hye Young,Choi, Youn Hee,Song, Keun Bae 대한구강보건학회 2002 大韓口腔保健學會誌 Vol.26 No.3
불소는 체내 대사 중 칼슘대사에 영향을 미쳐 골 광물화 기전에 관여함으로써 인체 경조직 내에 축적된다. 또한 적절한 농도에서는 골의 형성과 흡수를 촉진하고 골밀도를 증가시킬 수 있다고 알려져 있다. 본 연구는 불소 투여가 백서 골강도 및 화학적 조성에 미치는 영향을 알아보기 위하여 여러 농도의 불소를 실험백서에 최장 30주 동안 장기간 투여하였다. 실험동물은 생후 4주경의 체중 80-100gm내외의 Sprague-Dawley계 자성백서 30마리를 15주군 15마리,30주군 15마리로 하여 각 군 당 체중을 평균 1gm내외로 균등하게 조정하고 다시 각각 3마리씩 5개의 소군으로 나누었다. 제 1소군은 대조군으로 불소를 첨가하지 않은 Q-water를 투여하고, 제 2소군은 1 ppmF, 제 3소군은 5 ppmF, 제 4소군은 10 ppmF 및 제 5소군은 20 ppmF의 불소를 실험 15주 및 30주 동안 식수대신 무제한 공급하였으며, 또한 체중변화를 매주마다 동물천평으로 측정하여 체중차이 즉 자연적인 성장에 의한 골의 변화를 최소화하였다. 실험최종일 백서를 회생하여 대회골, 경골, 하악골 및 척추골을 채취하여 각종 골의 압축강도와 표면미세경도 및 칼슘, 무기인 그리고 마그네슘 둥의 무기이온들을 Instron과 Victor's micrordness tester 및 Induced Coupled Plasma Emission Speorophotometer (ICP)로 측정 및 분석하였다. 각 군별로 수합된 모든 자료들은 SAS 6.12외 t-test와 일원변량분산분석법을 이용하여 투여되는 불소의 농도와 기간에 따른 체중변화와 골표면미세경도 및 무기이온 농도의 장기간 평균차이를 검정하였으며, 통계적으로 유의한 경우에 사후검정법으로 다중비교점정 (Duncan's multiple range test)을 실시하여 다음과 같은 결과를 얻었다. 1. 실험 15주 및 30주 모두에서 투여되는 불소 농도가 증가될수록 백서 대퇴골의 압축강도는 증가되었다. 2. 백서 대퇴골, 경골 및 하악골의 표면경도는 실험 15주 및 班주군에서 동일하게 대조군에 비해 1 ppm부터 20 ppm까지 투여되는 불소 농도가 증가될수록 통계적으로 유의하게 증가하였다 3. 15주 및 30주 동안 0,1,5,10 및 20 ppm불소투여 시 대퇴골, 하악골 및 요추 내의 칼슘, 마그네슘 및 무기 인의 함량은 불소 투여량에 따라 증가 양상을 나타내었으며 , 칼슘과 인의 결합비는 각 시료간에 유의한 차이는 없었으나 하악골과 요추에 비해 대퇴골에서 약간 더 높은 결합비를 나타내었다. 이상의 결과를 종합하면 수돗물불소화에 사응되는 1ppm 정도의 불소는 불소가 투여되지 않는 대조군에 비해 골 내에 무기이온의 축적을 증가시킴으로써 골 건강에 도움을 줄 수 있지만 불소농도가 더욱 증가될 때 더 많은 무기 이온이 축적됨에 따라 골의 성질에 어떤 영향을 미치는 지에 대해서는 계속적인 연구가 뒤따라야 하겠다
Bae, Insung,Kang, Seok Ju,Park, Youn Jung,Furukawa, T.,Park, Cheolmin Elsevier 2010 Current Applied Physics Vol.10 No.1
<P>Among the many ferroelectrics polymers, poly(vinylidene fluoride-co-trifluoroethylene) [P(VDF-TrFE)] has drawn a great attention with its promising memory properties such as large remanent polarization, good fatigue and retention properties. Since the ferroelectric layer plays a critical role in the operation of memory device, it is important to control the structure of ferroelectric thin film. In order to improve the performance of a ferroelectric device, in this contribution we employed P(VDF-TrFE) layers blended with various compositions of an amorphous poly(methyl methacrylate) (PMMA) from 0 wt.% to 20 wt.%. In metal/ferroelectric/metal capacitor structure, we observed the decrease of remanent polarization from 9.13 mu C/cm(2) to 4.7 mu C/cm(2) and increase of coercive voltage from 9.5 V to 15.2 V with PMMA. Polarization switching time of the ferroelectric blend films estimated from the switched polarization vs. time curves increases with the amount of PMMA. Furthermore, ferroelectric field-effect transistors (FeFETs) based on ferroelectric P(VDF-TrFE) and PMMA blend films with single-crystalline tri-isopropylsilylethynyl pentacene (TIPS-PEN) channels show that both ON and OFF currents of the transistors are maintained with the PMMA contents despite the reduction of remanent polarization of P(VDF-TrFE)/PMMA films. (C) 2009 Elsevier B.V. All rights reserved.</P>