Telomere의 기능 손실에 의한 Telomerase 결핍 세포의 성장 억제에 대한 연구

주연진,박정은,전경미,김창민,김상훈,박원봉,이기호 대한암예방학회 2002 Journal of cancer prevention Vol.7 No.3

(2-Cyano-2-Carboethoxy-1-Ethyl)Phenoxyacetic Acid들의 가수분해에 대한 반응속도론적 연구

이주연,허태성 가톨릭대학교 자연과학연구소 1990 자연과학논문집 Vol.11 No.-

넓은 pH범위에서 (2-cyano-2-carboethoxy-1-ethenyl)phenoxyacetic acid들의 가수분해속도상수를 자외선 분광광도법으로 측정하였고 이 결과로부터 넓은 pH범위에 적용되는 반응속도식을 구하였다. 이 속도식과 실험사실로부터 이 물질의 가수분해반응 메카니즘을 제안하였다. pH10 이상에서는 전체반응속도는 수산화이온 농도에 직접 비례하며 pH7 이하의 산성용액에서는 물분자가 직접 첨가된다. The rate constants of the hydrolysis of (2-cyano-2-carboethoxy-1-ethenyl) phenoxyacetic acids were determined by ultraviolet spectrophotometer at various pH and the rate equation which can be applied over a wide pH range were obtained. Therefore the reaction mechanism was proposed. Above pH10, the over-all rate is depend upon concentration of hydroxide ion, below pH7, the reaction are initiated by the attack of a water molecule on the double bond. At pH 7-10, the competitive reaction between a water molecule and hydroxide ion is anticipated to occur.

산국의 수량과 유효성분에 대한 NPK의 효과

이경동,양민석,정연규,손보균,조주식,이성태,김필주 한국농화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.2

본 연구는 3요소(N-PO_2O_5-K_2O)처리가 산국(Chysanthemum boreale M.)의 수량과 유효성분에 미치는 효과를 조사하여 효과적인 재배시스템을 개발하고자하였다. 처리구는 무처리, NPK(250-160-160), NK(250-0-160), PK(0-160-160kg/ha)의 5처리로 설정하여 산국을 재배한 결과, 건물수량은 NPK처리구가 PK처리구에 비하여 4.0배의 증수가 있었으며, 다른 처리구보다 무기이온의 흡수율, 생육 및 수량에서 NPK처리구가 가장 우수하였다. 식용으로 많이 쓰이는 꽃의 주요 아미노산은 proline, glutamic acid과 aspartic acid이였고, 다른 처리구들에 비하여 NPK처리구가 높은 함량을 보였다. 혈압강하효과가 우수한 cumambrin A는 PK처리구에 비하여 NPK처리구가 6.2배의 증수효과가 있었다. NK처리구는 NP처리구보다 cumambrin A의함량을 높이기 위해서는 인산의 시용보다 칼리의 시용이 더 요구되며, 야외포장에서의 인산과 칼리의 적정 시비량의 설정이 필요하다고 판단된다. To establish the fertilization condition to increase the productivity of Chrysanthemum boreale M. with high quality, the effects of three nutrients (N, P, K) on the yields and the effective components were investigated in the pot scale. NPK was applied by chemical fertilizers with N-P_2O_5-K_2O = 250-160-160 kg/ha as a main treatment, and NP (N-P_2O_5 = 250-160 kg/ha), NK (N-KO = 250-160 kg/ha), and PK (PO_2-KO_5 = 160-160 kg/ha) treatments were settled as comparison. Dry yields of C. boreale M. was increased significantly to 4 fold higher by nitrogen. Nitrogen increased apparently plant growth and inorganic nutrient uptake. In the flower, which is most useful and edible part as a herbal medicine, main amino acids were glutamic acid and aspartic acids, and the total content was increased significantly by three elements of application. In addition, the content of cumambrin A, which is known to have the effect of blood-pressure reduction, was increased source to 6.2 times by nitrogen higher than that in PK treatment. Potassium was more effective in biosyndiesis of cumatnbrin A than phosphorus, but the biological pathway was not clear, still.

수종 식물추출물의 항히스타민작용

이신웅,이윤주,손종근 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

The antihistaminic action of eighteen herbal medicines was investigated by the radioligand binding and functional assays. The hexane fractions of Trichosanthis radix, Mori cortex radicis and Evodiac fructus dose-dependently inhibited [³H]mepyramine binding to H, receptor in guinea-pig brain homogenates and histamine-induced contraction of isolated guinea-pig ileum. Antihistaminic action of the hexane and ethyl acetate fractions of Mori cortex radicis and the hexane fraction of Evodiae fructus was more potent than their antimuscarinic action evaluated from the inhibition of [³H]QNB binding and carbachol response. The ethyl acetate and chloroform fractions from Scutcllariae radix also inhibited histamine-induced contraction, but antihistaminic potencies of these fractions were almost identical with their antimuscarinic potencies. The hexane fractions of Mori cortex radicis and Evodiae fructus inhibited selectively the increase of histamine-induced cutaneous vascular permeability in the rat dorsal skins. However, the ethyl acetate fraction from Scutellariae radix inhibited eqipotently the effects of histamine and serotonin on the vascular permeability. These results demonstrate that the hexane and ethyl acetate fractions of Mori cortex radicis and the hexane fraction of Evodiae fructus have the selective histamine H₁ receptor blocking activity.

갑상샘암 수술환자의 심리 및 신체적 불편감에 미치는 정보교육 프로그램 효과

이양희,정영,박연주,최길순,정지연 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

본 연구는 정보교육 프로그램이 갑상샘암 수술 환자의 심리 및 신체적 불편감 감소에 미치는 효과를 검정하기 위해 실시된 비동등성 대조군 전,후 시차 설계의 유사 실험연구이다. 자료수집 기간은 2006년 6월 17일 부터 9월 19일 까지 3개월간 이었으며, 연구 대상자는 일개 종합병원에 갑상샘암 수술을 받기위해 입원한 환자 가운데 6월 17일 부터 8월 3일 까지 입원환자 29명을 대조군으로 하였고, 8월 5일 부터 9월 19일 까지 입원환자 30명을 실험군으로 하였다. 연구도구는 심리적 불편감을 측정하기 위해 Derogatis 등(14)이 개발한 ‘자기보고식 다차원 증상목록(Multidimensional Symptom Inven- tory)검사를 사용하였고, 신체적 불편감 측정은 McCorkle & Young(16)이 개발한 도구를 사용하였다. 본 연구의 결과는 다음과 같다; 1) 정보교육 프로그램을 받은 실험군은 정보교육 프로그램을 받지 않은 대조군에 비해 심리적 불편감 정도의 차이는 통계적으로 유의한 차이를 보이지 않았다(p= .135). 다만 ‘근심 걱정’요인에서 유의한 불편감 감소효과를 보였다(p= 0.49) . 2) 정보교육 프로그램을 받은 실험군과 정보교육 프로그램을 받지 않은 대조군은 두군 모두 신체적 불편감 정도가 사후 유의한 수준으로 증가함을 보였다(p= 0.90). 결론적으로 본 연구를 위해 만들어진 정보교육 프로그램은 갑상샘암 수술 환자의 신체적 불편감 감소에는 효과적이지 못하였으나 심리적 불편감의 근심걱정 요인을 감소시키는데는 효과가 있음을 알게 되었다. Objectives: This study was designed as a non-equivalent control group pre and post-test quasi-experimental study to examine the effects of education program using information on the psychological and physical discomfort of patients undergoing operation for cancerous thyroid glands. Methods: The study covered for three months from June 17, 2006 to September 19, 2006. The subjects of this study were selected from those patients who were admitted in one of the general hospitals in order to receive the operation for cancerous thyroid glands. They include 29 control group patients who were hospitalized during the period of Jun 17th to August 3rd 2006, and 31 experimental group patients who were hospitalized during the period of August 5th to September 19th, 2006, respectively. The instruments utilized for conducting this study includes the Multidimensional Self-Report Symptom Inventory test originally developed by Derogatis & et al. (1983) for measuring psychological discomfort. And for measuring physical discomfort, the tools developed by McCorkle & Young (1978) was utilized. Results: 1) Hypothesis 1 “The level of psychological discomfort of the experimental group who completed the information education program would be decreased comparing with that of the control group who didn't complete the program” was partly supported (Worry & Anxiety factor: p= .049). 2) Hypothesis 2 “The level of physical discomfort of the experimental group who completed the information education program would be reduced comparing with that of the control group who didn't complete the program” was not supported (p= -.90). Conclusion: The information program provided for this study was proved to be not effective for decrease physical discomfort of the patients undergoing operations for cancerous thyroid glands but proved to be effective for decrease the anxiety factor of psychological discomfort.

다량의 하부위장관출혈이 병발된 Vibrio vulnificus 패혈증 1예

최주연,유진홍,한석원,이대훈,최민호,박순민,김연식,김선우,신완식,강문원,강성구 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

최근 저자들은 Vibrio vulnificus 감염에 의해 패혈증 및 이차성 피부 병변을 보인 42세의 남자 환자의 치료중 하부 위장관 출혈이 병발된 1예를 경험하였기에 보고하는 바이다. We experienced a case of Vibrop vulnificus septicemia which showed an unusual manifestation such as hematochezia. The patient was a 42-year-old man with chronic liver disease. The blood and wound culture revealed the organism. During intensive care, he suffered from massive hematochezi for several days. Colonoscopy and abdominal CT showed findings suspicious of ischemic colitis. To our knowledge, this is the first unusual case of V.vulnificus infection which showed massive lower gastrointestinal bleeding.

불소인식정도에 대한 조사보고

김미라,백병주,김재곤,이승익,양연미 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

저자는 1998년 6월과 7월에 전북대학교병원 소아치과에 내원한 초진환자중 설문지에 응답할 수 있는 환자 50여명과 보호자 100명을 대상으로 불소에 대해 어느정도 인식하고 있는지 알아보고자 설문지를 이용하여 조사하여 다음과 같은 결론을 얻었다. 1. 불소의 치과에서의 사용여부에 대한 인식정도는 환자 26%, 보호자 51%, 전체적으로 42.7%를 보였다. 2. 불소의 우식예방효과에 대한 인식정도는 환자 86%, 보호자 85%, 전체적으로 85.7%의 높은 비율을 보였다. 3. 이에 반해 불소도포희망 여부에 대하여 환자 46%, 보호자 44%만이 긍정적으로 답하였다. 4. 불소를 이용하거나 도포한 경험은 환자 60%, 보호자 55%로 낮은 비율을 보였다. 5. 불소의 우식예방효과에 대한 인식여부와 실제이용 정도는 일치하지 않았다. 이에 치과 종사자 및 대중매체를 통해 보다 적극적인 불소사용의 교육이 이루어진다면 불소이용은 증가할 것이다. At the department of Pediatric Dentistry in Chonbuk National University Hospital, authors conducted a survey of 50 new patients and 100 new parents regarding fluoride in order to discover what they think about fluoride. The results obtained were as follows ; 1. It answered patients 26%, parents 51% and total 42.7% in knowledge about the use of fluoride in dental clinics. 2. The knowledge about caries prevention effect of fluoride is high ; patients 86%, parents 85% and total 85.3% 3. The patients and parents who wanted to use fluoride are 46%, 44% respectively 4. The patients and parents who experienced fluoride are 60%, 55% respectively 5. It is not correspond the knowledge about caries prevention effect of fluoride and the practical method of application These results suggest that the number of patients and parents who use fluoride will increase if we advise them adequately

한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

Original Article : Impact of immunosuppressant therapy on early recurrence of hepatocellular carcinoma after liver transplantation

( Ju Yeun Lee ),( Yul Hee Kim ),( Nam Joon Yi ),( Hyang Sook Kim ),( Hye Suk Lee ),( Byung Koo Lee ),( Hye Young Kim ),( Young Rok Choi ),( Geun Hong ),( Kwang Woong Lee ),( Yung Suk Suh4 ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2

Background/Aims: The most commonly used immunosuppressant therapy after liver transplantation (LT) is a combination of tacrolimus and steroid. Basiliximab induction has recently been introduced; however, the most appropriate immunosuppression for hepatocellular carcinoma (HCC) patients after LT is still debated. Methods: Ninety-three LT recipients with HCC who took tacrolimus and steroids as major immunosuppressants were included. Induction with basiliximab was implemented in 43 patients (46.2%). Mycophenolate mofetil (MMF) was added to reduce the tacrolimus dosage (n=28, 30.1%). The 1-year tacrolimus exposure level was 7.2 ± 1.3 ng/mL (mean ± SD). Results: The 1- and 3-year recurrence rates of HCC were 12.9% and 19.4%, respectively. Tacrolimus exposure, cumulative steroid dosages, and MMF dosages had no impact on HCC recurrence. Induction therapy with basiliximab, high alpha fetoprotein (AFP; >400 ng/mL) and protein induced by vitamin K absence/antagonist-II (PIVKA-II; >100 mAU/mL) levels, and microvascular invasion were significant risk factors for 1-year recurrence (P<0.05). High AFP and PIVKA-II levels, and positive 18fluoro-2-deoxy-d-glucose positron-emission tomography findings were significantly associated with 3-year recurrence (P<0.05). Conclusions: Induction therapy with basiliximab, a strong immunosuppressant, may have a negative impact with respect to early HCC recurrence (i.e., within 1 year) in high-risk patients. (Clin Mol Hepatol 2014;20:192-203)