노인 당뇨병환자의 운동수행에 영향을 미치는 요인

박인순(In-soon Park),김창숙(Chang-sook Kim),김란(Ran Kim),김영재(Young-jae Kim),박명희(Myung-hee Park),정영주(Young-ju Jung) 대한환경위생공학회 2009 대한환경위생공학회지 Vol.24 No.4

The purpose of this study was to identify the factors influencing the Exercise Performance of elderly patients with diabetes. The subjects were 153 elderly patients with diabetes who were selected from the public health center in Gwang ju. The data collected was analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation and stepwise multiple regression. This study found that approximately 52.9% of the subjects were exercising regulary. Exercise performance was significantly different according to education level, family income by month, and level of diabetes education. Significant factors influencing exercise performance were exercise self-efficacy, exercise social support and exercise benefits. The most powerful predictor of exercise performance was exercise self-efficacy(34.2%). This study suggests that nurses should emphasize exercise social support. and exercise benefits as well as reinforce exercise self-efficacy to improve exercise performance of the elderly patients with diabetes.

일자리 참여 프로그램이 노인의 자아존중감과 생활만족도에 미치는 영향

민순 ( Soon Min ),주리애 ( Ree Aie Ju ),정현필 ( Hyon Pil Jung ),정영주 ( Young Ju Jung ),김미란 ( Mi Ran Kim ),김윤경 ( Yun Gyung Kim ) 경희대학교 동서의학연구소 2008 동서간호학연구지 Vol.14 No.2

본 연구는 G시 D복지관에 있는 60세 이상 된 노인 70명을 대상으로 일자리 참여 프로그램이 노인들의 자아존중감과 생활만족도에 미치는 영향을 파악하고자 한다. 단일군 전후 원시실험설계로 노인들의 대조군이 없는 현실적인 문제를 갖고 있어 비교할 수 없는 제한점을 갖고 있지만 노인들에게 일자리를 참여시키므로 그들을 돕는데 의미를 두고 있으며, 본 프로그램에서 얻어진 결과를 토대로 논의하고자 한다. 일자리 프로그램에 참여하기 전 자아인식의 평균이 참여 전3.31에서 참여 후 3.50으로, 자아가치는 참여 전 평균이 3.04에서 참여 후 3.46으로, 자아존중 정도도 참여 전 평균 3.31에 참여 후 3.48로 모두 유의하게 향상되었다. 이는 저소득 노인의 자아존중감이 낮다는 Shim (2005)의 연구결과와 일치했고, 월 사용 지출액에 따라 자아존중감이 차이가 있다는 Kim2003)의 연구 결과와 월수입이 많은 사람 즉 경제적으로 나은사람이 자아존중감이 높다는 Kim (2002)의 연구 결과 및 일자프로그램 참여를 여가활동으로 여겨 이에 참여하는 사람이참여하지 않는 경우보다 자아존중감이 높다고 한 Kim (2007)연구 결과와도 유사한 결과를 보였다. 노인에게 자아존중감은 정신건강을 결정짓는데 중요한 요소로, 자아존중감은 노인의 우울과 역상관관계가 있는데(Park,1993), 본 연구에서 노인들이 일자리에 참여하므로 자존감 향상에 긍정적인 영향을 미치는 것으로 나타난 바, 이는 노후에노인 대상자들에게 여가활동과 소정의 수익을 통해 용돈이나기초생활에 필요한 경비를 조달받게 된 것이 자아존중감을 높인 것으로 사료된다.그러므로, 본 연구에서도 일자리 참여 프로그램이 노인들의 자아존중감을 향상시키는 점을 볼 때, 노인의 일자리 참여는 자신들의 소득을 확보하려는 경제적인 측면뿐 아니라 사회참여의 욕구도 포함하고 있어 노인에게 일자리 참여는 매우 중요한 의미를 지니고 있고, 소일거리와 여가선용 차원에서도 노인에게 일자리 참여의 기회를 제공해주는 것은 노후의 경제적인 자립생활은 물론 사회적으로도 바람직한 방안이라 할 수 있어 일을 통해 보람도 얻고, 단체 활동을 통한 소속감을 가지고 경제활동도 할 수 있는 방안도 모색해야 할 것이다.일자리 참여 프로그램 전과 후의 생활만족도의 변화에서, 일자리 프로그램에 참여하기 전 평균 3.04점이었고, 일자리 프로그램에 참여한 후 평균 3.24점으로 유의하게 향상하였는데, 이는 일자리 참여자와 비참여자들을 비교 연구한 Kim (2007)과Seo (2007)의 연구 결과와 일치하였고, 시니어클럽에 참여하고 있는 노인이 참여하지 않고 있는 노인보다 생활만족도가 유의하게 높게 나타난 Bang (2005)의 연구 결과와도 일치하였다.노인들의 생활만족도에 관한 선행연구를 고찰한 결과 노인의 생활만족도는 배우자가 있는 경우, 주관적 건강상태가 좋을수록, 경제수준이 높을수록, 교육정도가 높을수록 생활만족도가 높다고 보고되고 있으며, 노인의 사회적 지지나 자아존중감이 높을수록 생활만족도가 높다고 하였다(Jang, 2006; Kim,2005; Park & Lee, 2006).노인들이 일자리 프로그램에 참여하므로 생활만족도에 긍정적인 영향을 미치는 것으로 나타난 바, 이는 노인대상자들에게일자리를 통해 심리적, 경제적 여건에 도움이 된 것으로 여겨지며, 이로 인해 생활만족 정도를 높인 것으로 사료된다. 노후의시간활용 방법에 대한 2004 전국 노인생활실태 및 복지욕구조사 결과에서 가장 선호되는 것이 소득창출 27.8%, 취미활동16.3%, 소일거리 14.5%, 자원봉상활동 3.1%, 자아계발 활동2.4%로 나타났다(Jung et al, 2005). 그러나 노인의 일자리 참여는 여러 가지 문제에 봉착하게 된다. 우선 노인시장에 유입되는 신규 노동력의 과잉과 기업의 인사정체, 그리고 노인취업에 대한 잘못된 인식으로서 기능주의적 사회격리이론은 인간의 노화를 기능주의적으로 이해하려는 사회적 편견인데 노인이 반드시 체계적, 생물학적으로 또는 정신적으로 결함이 있다는 편견으로 인해 노인인력 활용가능성을 근본적으로 저해하는 요인이 된다(Jung, 2007). 또한 본 연구 대상자들에게 연구일자리 프로그램 유형에 따른 생활만족도와 자아존중감 정도를 분석한 결과에서는 유의하지 않았는데 노인들에게 일자리 참여 자체가 생활만족과 자아존중감 정도에 영향을 주는 것이지 유형별로는 큰 의미가 있는 것은 아닌 것으로 보인다. 본 연구 결과를 종합하여 볼 때 어떤 형태이든 간의 노인의 일자리 참여는 고령화 사회에서 나타나는 심각한 노인문제를 해결하고 노후 생활에 대한 적응력을 높이며, 노년기의 역할변화에 따른 적절한 대응을 통해 역할상실에 대한 대비를 할 수 있을 뿐만 아니라 노인 스스로의 자아존중감과 생활만족도 향상을 위해 필요하다. Purpose: The effects of job participation on self-esteem and life satisfaction were investigated. Methods: Seventy residents of D welfare center located in G city who were >60 yr-of-age were selected for the study. The SERS research tool (Nugent and Thomas,1993; modified by Koh, 2002) was used to assess self-esteem before and after a job participation program. The Cronbach`s αvalue-based reliability of this tool was 0.923 and 0.920 before and after the job participation program, respectively. Cronbach`s αvalue-based life satisfaction as measured according to Choi (1986) was 0.932 and 0.933 before and after the job participation program, respectively. Results: The hypothesis that job participation program increases self esteem was supported by the results. The mean self esteem of subjects before and after the job program, 3.31 and 3.48, respectively, represented a significant increase. The hypothesis that the job participation program increases life satisfaction was supported by the results, The mean life satisfaction index of subjects before and after the program, 3.04 and 3.24, respectively, represents a significant increase. Conclusions: Increased job opportunities and income guarantee for adults, particularly the elderly, can increase self-esteem, life satisfaction, and emotional stability.

심리적 연습이 아동의 폐쇄기능 수행 및 학습에 미치는 영향

김상규,김성문,류상구,조주란 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

The purpose of this thesis is, through the positive study, to clarify the effects of mental practice on performance and learning to the closed skill of children, what differences there are between mental practice and physical practice, whether or not the mental practice is effective in case it is performed simultaneously with physical practice, and when the effects of mental practice come out. The subjects are all right-handed elementary school students who are in the fifth grade and divided into four groups through four-step preliminary test. The subjects throw balls toward the five-meter apart target whose center is one meter high from the ground with their feet stuck on the ground. The points are treated 'ANOVA with repeated measured'-practice conditions(four variables) times practice periods(four variables)- making use of PC-SAS. If meaningful differences are found, they are put under the afterward identification - 'Turkey's HSD.' The material analysis brought the following conclusions. First, the skill performance effects are not found according to the practice conditions, but the practice performance effects are found according to the practice period. Second, the learning effects are not found according to the practice conditions, but the skill learning effects are found according to the practice period. Third, in the latter part of the practice period are the learning effects of the mental practice found.

구강내 연조직 질환과 구강점막 각화도와의 관계

송주종,김병국,최홍란 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1

To investigate the relationship between several intraoral soft tissue lesions(hairy tongue, lichen planus, recurrent aphthous stomatitis, oral candidiasis, glossitis and oral herpetic lesion) and oral mucosal keratinization, exfoliative cytological smear on intraoral mucosal surfaces were performed on each number of patients and 25 controls keratinization cell(yellow-stained cell) ratio was then measured. In hairy tongue, there was no significant difference between patient group and control group in all kind of cells. Only blue cell ratio of wemen was more than of men in patient group. In inchen planus, there was no difference between patient and control group in yellow cell ratio. Red cell ratio in the control group was more than in the patient group. Blue cell ratio in the patient group was more than that in control group. But there was no sex predilection between both groups in the ratio of all kind of cells. In recurrent aphthous stomatitis, Yellow cell ratio in the control group was more than that in the patient group. Red cell ratio in the control group was more than that in control group. Blue cell ratio in the patient group was more than that in control group. But there was no sex predilection between both groups in the ratio of all kind of cells. In oral candidiasis, Yellow cell ratio in the control group was more than that in the patient group. Red cell ratio in the control group was more than that in control group. Blue cell ratio in the patient group was more than that in control group. There was no sex predilection between both groups in yellow cell ratio. Red cell ratio of wemen was more than of men in patient group. Blue cell ratio of men was more than of wemen in patient group. In herpetic lesions, there was no difference between patient and control group in yellow cell ratio. Red cell ratio in the control group was more than in the patient group. Blue cell ratio in the patient group was more than that in control group. Yellow cell ratio of wemen was more than of men in control group. Red cell ratio of men was more than of wemen in control group. Blue cell ratio of men was more than of wemen in patient group. In glossitis, Yellow cell ratio in the control group was more than in the patient group. There was no difference between patient and control group in red cell ratio. Blue cell ratio in the patient group was more than that in control group. Yellow cell ratio of wemen was more than of men in control group. Red cell ratio and blue cell ratio of men were more than of wemen in control group. According to above results, the ratio of keratinized cell in atrophic, ulcerated, or pseudomembranous lesions was lowered than in control, but the ratio of keratinized cell in keratotic, vesicular or lesions on keratinized surface lesions had no difference to control group. Thus, keratotic, vesicular or lesions on keratinized surface lesions have not closely relation to mucosal keratinization. And, there was a little sex predilection between men and wemen in mucosal keratinization.

Characterizing affinity epitopes between prion protein and b-amyloid using an epitope mapping immunoassay

Mino Kang,Su Yeon Kim,안성수,Young Ran JU3 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.8

Cellular prion protein, a membrane protein, is expressed in all mammals. Prion protein is also found in human blood as an anchorless protein, and this protein form is one of the many potential sources of misfolded prion protein replication during transmission. Many studies have suggested that b-amyloid1–42 oligomer causes neurotoxicity associated with Alzheimer’s disease, which is mediated by the prion protein that acts as a receptor and regulates the hippocampal potentiation. The prevention of the binding of these proteins has been proposed as a possible preventative treatment for Alzheimer’s disease;therefore, a greater understanding of the binding hot-spots between the two molecules is necessary. In this study, the epitope mapping immunoassay was employed to characterize binding epitopes within the prion protein and complementary epitopes in b-amyloid. Residues 23–39 and 93–119 in the prion protein were involved in binding to b-amyloid1–40 and 1–42, and monomers of this protein interacted with prion protein residues 93–113 and 123–166. Furthermore, b-amyloid antibodies against the C-terminus detected bound b-amyloid1–42 at residues 23–40, 104–122 and 159–175. b-Amyloid epitopes necessary for the interaction with prion protein were not determined. In conclusion, charged clusters and hydrophobic regions of the prion protein were involved in binding to b-amyloid1–40 and 1–42. The 3D structure appears to be necessary for b-amyloid to interact with prion protein. In the future, these binding sites may be utilized for 3D structure modeling, as well as for the pharmaceutical intervention of Alzheimer’s disease.

면접조사를 통한 초등학생의 영양교육 실태 및 실천도 조사

오유진,이영미,김정현,안홍석,김정원,박혜련,서정숙,김경원,권오란,박혜경,이은주,성현이 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

This study investigated the experience and practice of elementary school students on nutrition education. The data were collected from 217 male and female students attending 5-6th grade elementary schools in Seoul and Kyunggi-Do from March to June 2007, interviewing face to face by a nutrition teacher and 3 interns of a nutrition teacher. The results were as follows: 86.5% of the subjects learned about ‘Table etiquette’, ‘Reasons for eating fruits and vegetables’ (78.7%), ‘Food waste and environment’ (72.3%), ‘Healthy snacks’ (55.7%), ‘Food sanitation’ (52.3%), ‘Food culture of foreign countries’ (48.1%). Nutrition education experience was significantly different by gender. A total of 43.5% boys responded that they never learned about ‘basic food preperation’ (p < 0.01). They had learned ‘Nutrients for body’ and ‘Food waste and environment’ in school, ‘Healthy weight loss’, ‘Food culture of foreign countries’, ‘Food circulation’ on television, Most content (‘Table etiquette’, ‘Simple cooking’, ‘Food sanitati n’, ‘Eating behaviors for health’, ‘Reasons for eating fruits and vegetables’, ‘Healthy snacks’) was learned from parents. The practice after nutrition education was higher in ‘Table etiquette’ (2.14), ‘Eating fruits and vegetables’ (2.07) than others compared with education experience. The most reason of non-practice on nutrition information was ‘Troublesome’. In ‘Nutrients for body’, a boy answered ‘Difficult for practice’ 20.0%, a girl answered ‘Difficult to understand’ 32.6%, showing a significant difference between the gender groups (p < 0.001). They remembered the ‘Nutrients for body’ (49.6%), ‘Food sanitation’ (44.5%) because of ‘important content’,‘Basic food preparation’ (40.6%), ‘Food culture of foreign countries’ (36.3%) because of ‘interesting content’, ‘Healthy weight loss’ (52.0%), ‘Eating behavior for health’ (44.5%) and ‘Healthy snacks’ (33.7%) because of ‘need for my health’.

Differentiation of Dopaminergic Neurons from Mesenchymal-Like Stem Cells Derived from Human Umbilical Cord Vein

Kim Ju-Ran,Lee Jin-Ha,Jalin Anjela Melinda,Lee Chae-Yeon,Kang Ah-Reum,Do Byung-Rok,Kim Hea-Kwon,Kam Kyung-Yoon,Kang Sung-Goo 한국발생생물학회 2009 발생과 생식 Vol.13 No.3

One of the most extensively studied populations of multipotent adult stem cells are mesenchymal stem cells (MSCs). MSCs derived from the human umbilical cord vein (HUC-MSCs) are morphologically and immunophenotypically similar to MSCs isolated from bone marrow. HUC-MSCs are multipotent stem cells, differ from hematopoietic stem cells and can be differentiated into neural cells. Since neural tissue has limited intrinsic capacity of repair after injury, the identification of alternate sources of neural stem cells has broad clinical potential. We isolated mesenchymal-like stem cells from the human umbilical cord vein, and studied transdifferentiation-promoting conditions in neural cells. Dopaminergic neuronal differentiation of HUC-MSCs was also studied. Neural differentiation was induced by adding bFGF, EGF, dimethyl sulfoxide (DMSO) and butylated hydroxyanisole (BHA) in N2 medium and N2 supplement. The immunoreactive cells for -tubulin III, a neuron-specific marker, GFAP, an astrocyte marker, or Gal-C, an oligodendrocyte marker, were found. HUC-MSCs treated with bFGF, SHH and FGF8 were differentiated into dopaminergic neurons that were immunopositive for tyrosine hydroxylase (TH) antibody. HUC-MSCs treated with DMSO and BHA rapidly showed the morphology of multipolar neurons. Both immunocytochemistry and RT-PCR analysis indicated that the expression of a number of neural markers including NeuroD1, -tubulin III, GFAP and nestin was markedly elevated during this acute differentiation. While the stem cell markers such as SCF, C-kit, and Stat-3 were not expressed after neural differentiation, we confirmed the differentiation of dopaminergic neurons by TH/-tubulin III positive cells. In conclusion, HUC-MSCs can be differentiated into dopaminergic neurons and these findings suggest that HUC-MSCs are alternative cell source of therapeutic treatment for neurodegenerative diseases.

3,5-Di-C- <i>β</i> - _{<small>D</small>} -glucopyranosyl phloroacetophenone, a major component of <i>Melicope ptelefolia</i> , suppresses fibroblast activation and alleviates arthritis in a mouse model: Potential therapeutics for rheumatoid arth

Kim, Hyun Jong,Choi, Ji Hyun,Hwang, Jung-Hwan,Kim, Kyong-Shim,Noh, Jung-Ran,Choi, Dong-Hee,Moon, Sung Je,Kim, Hyun-Yong,Kim, Sang-Woo,Choi, Sangho,Eum, Sang Mi,Bach, Tran The,Rho, Jaerang,Lee, Ju Yong UNKNOWN 2018 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.42 No.5

<P><I>Melicope ptelefolia</I> has been traditionally used to treat rheumatism and fever. The present study aimed to investigate the therapeutic effect of 3,5-di-C-<I>β</I>-<SUB><SMALL>D</SMALL></SUB>-glucopyranosyl phloroacetophenone (βGP), a main component of <I>M. ptelefolia</I>, on rheumatoid arthritis (RA). A model of collagen-induced arthritis (CIA) was established in mice using the RAW 264.7 murine macrophage cell line and mouse embryonic fibroblasts (MEFs). The clinical scores of arthritis, swelling, histopathological findings, and micro-computed tomography in CIA mouse paws were assessed. The levels of anti-type II collagen antibody and cytokines were determined in the plasma and cell culture supernatant, respectively. Protein and gene expression levels were analyzed by western blot and reverse transcription-quantitative polymerase chain reaction analyses. βGP significantly decreased the gross arthritic scores of CIA mice and joint swelling, and decreased articular inflammation, cartilage degradation and bone erosion. However, βGP did not exert any effect on anti-type II collagen immunoglobulin G plasma levels or inflammatory cytokine expression in macrophages. βGP significantly suppressed the expression of interleukin-6 and leukemia inhibitory factor and decreased the phosphorylation of signal transducer and activator of transcription 3, and expression of receptor activator of nuclear factor-κB ligand in tumor necrosis factor-α-stimulated MEFs and in CIA mouse paws. Osteoclast-related gene expression was significantly reduced in CIA mouse paws. Taken together, βGP suppressed the development of RA by regulating the activation of synovial fibroblasts.</P>

<i>Hominis placenta</i> Suppresses Acute Lung Inflammation by Activating Nrf2

Kim, Tae Ho,Choi, Jun-Yong,Kim, Kyun Ha,Kwun, Min Jung,Han, Chang-Woo,Won, Ran,Lee, Jung Ju,Kim, Jong-In,Joo, Myungsoo World Scientific Publishing Company 2018 The American journal of Chinese medicine Vol.46 No.4

<P><I>Hominis placenta</I> (HP), a dried human placenta, has been known to target liver, lung, or kidney meridians, improving the functions associated with these meridians in traditional Chinese or Asian medicine (TCM). Since recent studies implicate an HP extract in suppressing inflammation, we investigated whether an aqueous HP extract can ameliorate inflammation that occurred in the lungs. When administered with a single intratracheal lipopolysaccharide (LPS), C57BL/6 mice developed an acute neutrophilic lung inflammation along with an increased expression of pro-inflammatory cytokine genes. However, this was diminished by the administration HP extract via an intraperitoneal route 2 h after LPS treatment. Western blot and semi-quantitative RT-PCR analyses revealed that while suppressing the activity of a proinflammatory factor NF-<TEX>$ \kappa $</TEX>B marginally, the HP extract strongly activated an anti-inflammatory factor Nrf2, with concomitant expression of Nrf2-dependent genes. Mechanistically, the HP extract suppressed the ubiquitin-mediated degradation of Nrf2, functioning similarly to a 26S proteasome inhibitor, MG132. Collectively, these results suggest that the HP extract suppresses inflammation in mouse lungs, which is in part related to the HP extract perturbing the ubiquitin-dependent degradation of Nrf2 and thus increasing the function of Nrf2.</P>

Induction of Neuron and Glia Cells from Human Umbilical Cord Mesenchymal Cells in Ovariectomized Female Brain

Ju Ran Kim,Seong Jin Yu,Hee Gyoung Kang,Byung Rok Do,Seong Ho Koh,Kyung Suk Kim,Seung Hyun Kim,Seah park,Hae Kwan Kim,Sung Goo Kang 한국동물생명공학회(구 한국동물번식학회) 2004 발생공학 국제심포지엄 및 학술대회 Vol.2004 No.1