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장성동,이은희,홍명엽,문성진,김주혁,이윤관,김영준 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
This study is purposed to analyse the effects of long-term & one-time 10km running exercise from bone metabolic marker change on bone metabolism. 7 male members(18.6±1.08) from a marathon club were subjected to the study. They were allowed to do long-term 10 km running training once a week for 6 months. And bone metabolism mark was determined according to the respective times : before/after 6 months training, before/after 10 km race, one day after the race, 3 days after the race. The examination items of bone metabolism mark were serum calcium, phosphorus, paratyroid hormone, osteocalcin, calcitonin, alkaline phosphatase in blood and calcium, phosphorus, deoxypyridinolin in urine. The results of study were as follows; 1) There was no change in deoxypyridinolin and alkaline phosphatase but there was significant change in calcitonin, paratyroid hormone and osteocalcin(p<.01). 2) There was no change of Calcium in serum and urine but there was significant change of phosphorus in blood(p<.01). To make a conclusion, it is determined that long-term 10 km running at low intensity and low frequency tends to restrict bone metabolism circulation, but exercise at a little high level activates bone metabolism into building up bones and absorbing bones and finally shows up high bone metabolism circulation, which is inferred to have an effective influence on bone health. It is considered there is a possibility that different exercise intensity, even same kind of exercise, influences on bone metabolism sdifferently.
Inhibitory Effects of Chicken Egg Yolk Antibody on Infection of Escherichia coli in Macrophage
Jin-Ju Lee,Dong-Hyeok Kim,Jeong-Ju Lim,Dae-Geun Kim,Gon-Sup Kim,Won-Gi Min,Hu-Jang Lee,Man-Hee Rhee,Hong-Hee Chang,Suk Kim 경상대학교 농업생명과학연구원 2012 농업생명과학연구 Vol.46 No.2
The present study evaluated the potential use of immunoglobulin prepared from egg yolk of chickens immunized with Escherichia coli K88 (IgY-Ec) in the control of E. coli K88 infection in RAW 264.7 murine macrophage. The binding activity of IgY-Ec against E. coli K88 surface protein was more specific and increased than control IgY. In infection assay of E. coli in macrophage, the specific IgY-Ec to E. coli K88 remarkably inhibited the phagocytic activity comparing to nonspecific IgY (p<0.001). In adherence assay, bacterial adhesion on macrophage cells was definitely reduced by preincubation of IgY-Ec compared with nonspecific IgY (p<0.05). These findings suggested that IgY-Ec have the protective effects against pathogens and IgY-based diets may have potential benefits for preventing or treating various infections in domestic animals.
Lee, Chang Hyeok,Lim, Hyo Jin,Park, Jae Hyoung,Kim, Jung Hyun,Kim, Jung Soo,Jeong, Min Joon,Song, Min Kyung,Kim, Si Hwan,Hwang, Su Min,Eom, Tae Kang,Lee, Min Jung,Lee, Yang,Ryu, Sung Ju The Kangwon-Kyungki Mathematical Society 2013 한국수학논문집 Vol.21 No.3
We continue the study of power-Armendariz rings over IFP rings, introducing $k$-power Armendariz rings as a generalization of power-Armendariz rings. Han et al. showed that IFP rings are 1-power Armendariz. We prove that IFP rings are 2-power Armendariz. We moreover study a relationship between IFP rings and $k$-power Armendariz rings under a condition related to nilpotency of coefficients.
Lee, Ji Young,Kim, Hyo Jeong,Yoon, Nal Ae,Lee, Won Hyeok,Min, Young Joo,Ko, Byung Kyun,Lee, Byung Ju,Lee, Aran,Cha, Hee Jeong,Cho, Wha Ja,Park, Jeong Woo Oxford University Press 2013 Nucleic acids research Vol.41 No.11
<P>Tristetraprolin (TTP) and <I>let-7</I> microRNA exhibit suppressive effects on cell growth through down-regulation of oncogenes. Both TTP and <I>let-7</I> are often repressed in human cancers, thereby promoting oncogenesis by derepressing their target genes. However, the precise mechanism of this repression is unknown. We here demonstrate that p53 stimulated by the DNA-damaging agent doxorubicin (DOX) induced the expression of <I>TTP</I> in cancer cells. TTP in turn increased <I>let-7</I> levels through down-regulation of <I>Lin28a</I>. Correspondingly, cancer cells with mutations or inhibition of p53 failed to induce the expression of both <I>TTP</I> and <I>let-7</I> on treatment with DOX. Down-regulation of <I>TTP</I> by small interfering RNAs attenuated the inhibitory effect of DOX on <I>let-7</I> expression and cell growth. Therefore, TTP provides an important link between p53 activation induced by DNA damage and <I>let-7</I> biogenesis. These novel findings provide a mechanism for the widespread decrease in TTP and <I>let-7</I> and chemoresistance observed in human cancers.</P>
Lee, Jin Ju,Kim, Dong Hyeok,Kim, Dae Geun,Lee, Hu Jang,Min, Wongi,Rhee, Man Hee,Cho, Jae Youl,Watarai, Masahisa,Kim, Suk American Society for Microbiology 2013 Infection and immunity Vol.81 No.7
<P><I>Brucella abortus</I> is an intracellular pathogen that uses a crafty strategy to invade and proliferate within host cells, but the distinct signaling pathways associated with phagocytic mechanisms of <I>B. abortus</I> remain unclear. The present study was performed to test the hypothesis that Toll-like receptor 4 (TLR4)-linked signaling interacting with Janus kinase 2 (JAK2) plays an essential role in <I>B. abortus</I> phagocytosis by macrophages. The effects of TLR4-JAK2 signaling on <I>B. abortus</I> phagocytosis in murine macrophage RAW 264.7 cells were observed through an infection assay and confocal microscopy. We determined that the uptake of <I>B. abortus</I> was negatively affected by the dysfunction of TLR4 and JAK2. F-actin polymerization detected by flow cytometry and F-actin assay was amplified for <I>B. abortus</I> entry, whereas that event was attenuated by the disruption of TLR4 and JAK2. Importantly, JAK2 phosphorylation and actin skeleton reorganization were suppressed immediately after <I>B. abortus</I> infection in bone marrow-derived macrophages (BMDMs) from TLR4<SUP>−/−</SUP> mice, showing the cooperation of JAK2 with TLR4. Furthermore, small GTPase Cdc42 participated in the intermediate pathway of TLR4-JAK2 signaling on <I>B. abortus</I> phagocytosis. Consequently, TLR4-associated JAK2 activation in the early cellular signaling events plays a pivotal role in <I>B. abortus</I>-induced phagocytic processes in macrophages, implying the pathogenic significance of JAK2-mediated entry. Here, we elucidate that this specific phagocytic mechanism of <I>B. abortus</I> might provide achievable strategies for inhibiting <I>B. abortus</I> invasion.</P>