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New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae
( Phi Hung Nguyen ),( Min Kyun Na ),( Trong Tuan Dao ),( Derek Tantoh Ndinteh ),( Joseph Tanyi Mbafor ),( Jae Young Park ),( Hyeon Sook Cheong ),( Won Keun Oh ) 영남대학교 약품개발연구소 2011 영남대학교 약품개발연구소 연구업적집 Vol.21 No.-
Jang, JunPil,Na, MinKyun,Thuong, Phuong Thien,Njamen, Dieudonné,Mbafor, Joseph Tanyi,Fomum, Zacharias Tanee,Woo, Eun-Rhan,Oh, Won Keun The Pharmaceutical Society of Japan 2008 Chemical & pharmaceutical bulletin Vol.56 No.1
<P>Phytochemical study on an EtOAc-soluble extract of the root bark of <I>Erythrina mildbraedii</I> resulted in the isolation of six prenylated flavonoids 1—6. Based on physicochemical and spectroscopic analyses, their structures were determined to be new natural products licoflavanone-4′-<I>O</I>-methyl ether (1), 2′,7-dihydroxy-4′-methoxy-5′-(3-methylbut-2-enyl)isoflavone (2), and (3<I>R</I>)-2′,7-dihydroxy-3′-(3-methylbut-2-enyl)-2‴,2‴-dimethylpyrano[5‴,6‴ :4′,5′]isoflavan (3), along with three known compounds erythrinin B (4), abyssinin II (5), and parvisoflavone B (6). All the isolates, except for compound 4, inhibited PTP1B activity <I>in vitro</I> with IC<SUB>50</SUB> values ranging from 5.3 to 42.6 μ<SMALL>M</SMALL>. This result further suggests that the prenyl group on the B ring of flavonoids plays an important role in suppressing the enzyme PTP1B.</P>