A case of multinucleate cell angiohistiocytoma: histopathologic findings reflecting its pathogenesis.

( Joongheon Suh ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Multinucleate cell angiohistiocytoma(MCAH) is a peculiar cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on acral regions and face of elderly women. We report a case of 14-year-old man who presented with multiple asymptomatic erythematous papules and single flat brownish plaque on left chest. The brownish plaque was initially a single erythematous papules but brownish color change and size enlargement have been developed over more than 1 year. After that, multiple erythematous papules appeared around the brownish plaque 1 month ago. We performed histologic evaluation at the both site of the papule and the plaque. The brownish plaque lesion histologically showed remarkable proliferation of dilated small vessels in the upper-mid dermis and numerous bizarre-shaped multinucleate cells intermingled with numerous lymphohistiocytes. The erythematous papules, meanwhile, histologically also showed dilated small vessels in the upper-mid dermis and multiple interstitial histiocytic infiltrations but no multinucleate cells were detected. In immunohistochemistry studies, CD68 and vimentin were both positive at the both specimen. Based on the clinico-pathologic findings and immunohistochemistry studies, the diagnosis of MCAH was made. To the best of our knowledge, this is the first documented case of MCAH describing its histologic change, reflecting the mechanism of its pathogenesis.

[P364] A case of eccrine poroma on the ear helix

( Joongheon Suh ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

An eccrine poroma is a solitary neoplasm composed of group of benign eccrine ductal epithelial cells. Although the most common site of the eccrine poroma is the sole or hand, it can also occur on the nose, eyelids, neck and chest as well. We report a patient who presented with slowly growing nodule on the right ear helix. Initially the lesion was clinically thought to be a keloid or a pyogenic granuloma. However, the skin biopsy specimen revealed a relatively well-defined epidermal anastomosing tumor with monomorphous small cuboidal cells containing round basophilic nuclei throughout the epidermis layer and turned out to be an eccrine poroma.

[P363] A case of extramammary Paget`s diseae on the back

( Joongheon Suh ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Ectopic extramammary paget`s disease(EMPD) is a rare variant of EMPD that develops in non-apocrine regions. We present 70-year-old man in whom ectopic extramammary Paget`s disease(EMPD) affected the lower back. Clinical appearance was suggestive of Bowen`s disease. However, the biopsy specimen and immunohistochemical study results were consistent with EMPD features. The lesion was resected with 1cm safety margin, and was covered with a full thickness local skin graft. Ectopic EMPD is so rare that only a few case EMPD on non-apocrine region have been reported. We thought this EMPD case on the back is interesting enough in that there has been no case reported on this location.

Efficacy of ablative fractional CO₂ laser and bleomycin combination therapy on periungual viral warts

( Joongheon Suh ),( Jaeho Lee ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: The treatment of periungual viral warts is a therapeutic challenge. Result of various treatments can be ineffective and may cause various complications, including permanent nail changes, pain and scar formation. Objectives: To investigate the efficacy and safety of a ablative fractional carbon dioxide laser and bleomycin combination therapy in the treatment of periungual warts. Methods: Wart lesions were treated with prior ablative cabon dioxide fractional laser. Immediately after each fractional laser treatment, bleomycin(1U/mL) was applied on the lesions. The patients were treated every 2 weeks until elimination of the lesions. Results: Twenty six lesions(68.4%) achieved a complete clearance. Three lesions(7.8%) had excellent partial response(>75% improvement). There were no recurrences of those warts that had achieved complete clearance during the follow-up period of 6 months. No significant long-term adverse effects were noted. Only one lesion showed postinflammatory hyperpigmentation, which resolved within 1 month, and five patients(29%) had localized moderate pain for 2 to 3 days after the treatment. Conclusion: Combination therapy of ablative fractional laser and bleomycin is an effective and safe modality to treat periungual warts. Further large controlled studies are necessary.

15 years retrospective study of DRESS syndrome : a single center study

( Joongheon Suh ),( Sookyung Lee ),( Hoyoung Kim ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome that involves multi-organ and shows variable clinical presentation. Objectives: The purpose of this study is to investigate the common causative drugs, clinical features and prognosis of DRESS, and compare the differences between the steroid use group and non-use group. Methods: Medical records of patients at the Sanggye Paik hospital from 2001 to 2015 were collected. Results: Totally 65 patients were included. The four most common causative drugs were antibiotics (27.7%), anticonvulsants (20%), antituberculosis (16.9%) and allopurinol (16.9%). The mean incubation period was 4 weeks, significantly shorter for 2 weeks in antibiotics (p<0.001), and longer for 6.5 weeks in anticonvulsants (p=0.033). Sixty-three patients were fully recovered with mean recovery time 3.1 (SD 2.2) weeks, 1 patient had sequelae and 1 patient died. Recovery time tended to increase with longer duration of diagnosis from rash onset (p<0.001) and higher serum AST levels (p=0.024). The mean recovery time was 1 week shorter in steroid use group, but not statistically significant (p=0.056). Conclusion: DRESS may be a heterogeneous syndrome with some particular characteristics related to different drugs. The prognosis of DRESS is relatively good and the role of systemic steroid therapy is unclear.

A case of familial generalized multiple glomangioma

( Joongheon Suh ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Glomus tumor is a benign vascular neoplasm derived from a specialized form of arteriovenous temperature-regulating structure called the glomus body. They often appear as solitary or multiple bluish nodules, and can be either acquired or congenital. Histopathologically, glomus tumors are classified into three different variants: solid glomus tumor, glomangioma, and glomangiomyoma. Of multiple variants, multiple glomangiomas are rare and show stronger genetic tendency than solitary ones. A 52-year-old male was presented with multiple bluish to skin colored papules and nodules on the extremities and the trunk. Some of the lesions were painful and the others were painless. All of his 3 daughters and his mother either have multiple bluish nodules on the trunk, the arm and the thigh. We performed skin biopsy from the one of his lesions with immunohistochemical studies. The biopsy specimen revealed dilated and irregularly branching vascular structures lining with uniformly-sized and round glomus cells. In order to control his painful symptom, painful nodules were removed by excision. The patient refused to proceed genetic evaluation and decided to keep observation.

A case of asymptomatic angioleiomyoma occurring on the sole

( Joongheon Suh ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Angioleiomyoma is a rare and benign smooth muscle tumor derived from the walls of blood vessel. It mainly develops on the lower extremities especially between the knee joint and ankle joint of the middle-aged women. We encountered a 60-year-old man having a 30 year history of a painless 1.5 x 1.5cm-sized flesh to bluish colored subcutaneous nodule on his right sole. Histological examination of the punch biopsy specimen revealed well circumscribed smooth muscle cell proliferation with sporadically remaining vascular structures. Additionally, the specimen was positively stained with smooth muscle actin. On the basis of clinical and histopathological findings, we established the diagnosis of solid type angioleiomyoma. The lesion was removed clearly through the process of punch biopsy. Any recurrence sign or symptom has not been observed over 6 months. Herein, we report an unusual site of angioleiomyoma occurring on the sole.

A case of cutaneous plasmacytosis showing a zosteriform distribution

( Joongheon Suh ),( Hoyoung Kim ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Cutaneous plasmacytosis is a rare skin disorder characterized by multiple reddish brown nodules mainly occurring at the trunk in adults. Histologically, there is a dermal infiltrate of mature plasma cells. A 35-year-old female presented with multiple erythematous to brownish macules and patches at the left side of trunk with a zosteriform distribution. The lesion appeared 4 years ago without any painful or itching symptoms. Histopathological exam revealed the dense dermal patch-like cellular infiltration surrounding the follicles and the nerves. The infiltrate was composed of lymphocytes, histiocytes and plasma cells. Also, the specimen was positively stained with CD138, CD3 and CD20. On the basis of previous findings, we established the diagnosis of cutaneous plasmacytosis. To the best of our knowledge, there has been no cases of cutaneous plasmacytosis occurring in a stripe or on one side of the body, mimicking zosteriform dermatoses. Therefore, we report an unusual case of cutaneous plasmacytosis showing a zosteriform distribution which should be taken into consideration when dermatologists encounter characteristic zosteriform pigmentation lesions in their clinics.

Optimized transmission power control of interrogators for collision arbitration in UHF RFID systems

Joongheon Kim,Wonjun Lee,Eunkyo Kim,Dongshin Kim,Kyoungwon Suh IEEE 2007 IEEE communications letters Vol.11 No.1

<P>The emergence of UHF RFID as one of the dominant technology trends has posed numerous unique challenges to researchers. This letter presents a novel, theoretically-grounded collision arbitration protocol, called TPC-CA, which optimally controls transmission power of RFID interrogators and thereby reducing redundant interrogator collisions</P>

A case of trichilemmal carcinoma

( Hoyoung Kim ),( Joongheon Suh ),( Sookyung Lee ),( Myoungshin Kim ),( Unha Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Trichilemmal carcinoma is a rare adnexal tumor of the outer hair sheath. The pathophysiology is unclear but sun exposure has been considered as a trigger. It appears as a pale tan to reddish epidermal papule, indurated plaque or nodule which may be accompanied by ulceration or crusting. The lesions are rarely locally aggressive and metastases are uncommon. The histopathology shows atypical clear cells resembling those of the outer root sheath. They form solid, lobular or trabecular growth patterns and demonstrate peripheral palisading. Cytologic atypia is prominent and the pagetoid spread of the cells into the epidermis mimicking melanoma can be seen. Herein, we report a rare case of trichilemmal carcinoma. A 84-year-old female was presented with a brownish scaly patch on her nose. The onset of the lesion was unknown. The biopsy specimen revealed infiltrative atypical cells with pale eosinophilic cytoplasm. They formed lobular and trabecular growing pattern with peripheral palisading cells in the lesions. Subsequent excisional biopsy confirmed the diagnosis of trichilemmal carcinoma. Any signs of recurrence were not observed after 1 month at last follow-up session.