시스템분석의 주요변수와 시스템성과와의 상관관계 연구 : 분석기간, 사용자참여 및 통제조직을 중심으로

장시영,최중섭 한국경영과학회 1991 經營 科學 Vol.8 No.2

This study investigates the relationship between some control factors of systems analysis and information systems effectiveness. For this purpose, a research model is set up that consists of three independent variables (duration of systems analysis, user involvement, and control organization/mechanism) and a dependent variable (user satisfaction). Data were gathered from thirty-two industry firms in Korea. The results of data analysis indicate that only user involvement is significantly related to the dependent variable. Among independent variables, the existence of the sign-off procedure and auditing organization is associated with the relative duration of systems analysis. Discussions of the results are presented, followed by the suggestions for future research.

Regulation of toll-like receptors expression in muscle cells by exercise-induced stress

Park, Jeong-Woong,Kim, Kyung-Hwan,Choi, Joong-Kook,Park, Tae Sub,Song, Ki-Duk,Cho, Byung-Wook Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.10

Objective: This study investigates the expression patterns of toll-like receptors (TLRs) and intracellular mediators in horse muscle cells after exercise, and the relationship between TLRS expression in stressed horse muscle cells and immune cell migration toward them. Methods: The expression patterns of the TLRs (TLR2, TLR4, and TLR8) and downstream signaling pathway-related genes (myeloid differentiation primary response 88 [MYD88]; activating transcription factor 3 [ATF3]) are examined in horse tissues, and horse peripheral blood mononuclear cells (PBMCs), polymorphonuclear cells (PMNs) and muscles in response to exercise, using the quantitative reverse transcription-polymerase chain reaction (qPCR). Expressions of chemokine receptor genes, i.e., C-X-C motif chemokine receptor 2 (CXCR2) and C-C motif chemokine receptor 5 (CCR5), are studied in PBMCs and PMNs. A horse muscle cell line is developed by transfecting SV-T antigen into fetal muscle cells, followed by examination of muscle-specific genes. Horse muscle cells are treated with stressors, i.e., cortisol, hydrogen peroxide (H₂O₂), and heat, to mimic stress conditions in vitro, and the expression of TLR4 and TLR8 are examined in stressed muscle cells, in addition to migration activity of PBMCs toward stressed muscle cells. Results: The qPCR revealed that TLR4 message was expressed in cerebrum, cerebellum, thymus, lung, liver, kidney, and muscle, whereas TLR8 expressed in thymus, lung, and kidney, while TLR2 expressed in thymus, lung, and kidney. Expressions of TLRs, i.e., TLR4 and TLR8, and mediators, i.e., MYD88 and ATF3, were upregulated in muscle, PBMCs and PMNs in response to exercise. Expressions of CXCR2 and CCR5 were also upregulated in PBMCs and PMNs after exercise. In the muscle cell line, TLR4 and TLR8 expressions were upregulated when cells were treated with stressors such as cortisol, H₂O₂, and heat. Migration of PBMCs toward stressed muscle cells was increased by exercise and oxidative stresses, and combinations of these. Treatment with methylsulfonylmethane (MSM), an antioxidant on stressed muscle cells, reduced migration of PBMCs toward stressed muscle cells. Conclusion: In this study, we have successfully cultured horse skeletal muscle cells, isolated horse PBMCs, and established an in vitro system for studying stress-related gene expressions and function. Expression of TLR4, TLR8, CXCR2, and CCR5 in horse muscle cells was higher in response to stressors such as cortisol, H₂O₂, and heat, or combinations of these. In addition, migration of PBMCs toward muscle cells was increased when muscle cells were under stress, but inhibition of reactive oxygen species by MSM modulated migratory activity of PBMCs to stressed muscle cells. Further study is necessary to investigate the biological function(s) of the TLR gene family in horse muscle cells.

Laparoscopic Para-aortic Lymphadenectomy (LPAL): Standard Surgical Boundary and Technique

( Joong Sub Choi ),( Jaeman Bae ),( Won Moo Lee ),( Un Suk Jung ),( Jeong Min Eom ),( A Ra Koh ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: Teach a new procedure. 방법: We conducted a retrospective chart review of 324 patients with gynecologic malignancies who had undergone LPAL by a single surgical team between November 2003 and May 2015. 결과: Three hundred seventeen patients underwent LPAL as part of their staging, restaging or debulking surgery. Seven patients with isolated para-aortic lymph node recurrence underwent a repeat LPAL. The median age and BMI were 54 years (range 28-81 years) and 26.0 kg/m2 (range 20.3 -37.2 kg/m2), respectively. The median operating time was 60 minutes (range 24-135 minutes), and the median number of harvested para-aortic lymph nodes was 12 (range 6-49). There were eleven cases of complications: five of major vessel injuries (three IVC, one aorta, and one common iliac vein), two lymphocysts, two cases of chylous ascites, a cisterna chyli rupture, and one case of ureteric injury. There were two conversions to laparotomy: one left common iliac vein laceration that needed to be repaired and removal of an enlarged para-aortic lymph node completely. 결론: It is feasible and efficient to perform LPAL to the left renal vein level for women with gynecologic malignancies by well-trained gynecologic oncology surgeon according to our suggested standard surgical boundary.

선행 질식수술에서 실패한 자궁경관무력증 환자에서 복식자궁경협부원주봉합술 및 변형질식자궁경봉합술의 결과 비교

최중섭 ( Joong Sub Choi ),박민수 ( Min Soo Park ),김영재 ( Young Jae Kim ),배은경 ( Eun Koung Bae ),백지흠 ( Ji Heum Paek ),박문일 ( Moon Il Park ),황정혜 ( Jeong Hyae Hwang ),김승룡 ( Seung Ryong Kim ),문형 ( Hyung Moon ),정성로 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.3

배경 : 임신 제 2삼분기 임신유지 실패의 대부분을 차지하는 자궁경관무력증의 치료방법은 질식자궁경부원주봉합술 (이하 TVC, transvaginal cerclage)과 복식자궁경협부원주봉합술 (이하 TCIC, transabdominal cervicoisthmic cerclage)이 있다. TCIC는 질식수술을 한번 이상 시행하여 실패한 경력이 있는 경우, 자궁경부가 매우 짧거나 선천적 기형이 있는 경우, 자궁경부의 질환으로 자궁경부를 제거한 경우 등에 Objective : Incompetent internal os of cervix is one of the most common causes of midtrimester abortion in which interventions such as, transvaginal cerglage and transabdominal cervicoisthmic cerclage (TCIC) have been performed to prolong pregnancy. Trans

수소 인프라용 NBR 실링 소재의 충진제 및 온도에 따른 수소 투과도 특성 연구

Jin-Sub Jang(장진섭),Chun-Joong Kim(김천중),Myung-Chan Choi(최명찬),Nak-Kwan Chung(정낙관) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.06

최근 친환경 에너지로 각광을 받고 있는 수소에너지의 안전한 사용과 보급을 위해서는 고압 수소용 부품 및 재료에 대한 수소 환경 평가가 매우 중요하다. 특히 고압 수소용 실링 부품에 사용되는 폴리머 소재는 온도 변화(- 45 ~ 80 ℃)와 고압 수소 노출에 따른 수축/팽창으로 인해 파손 및 수소 누설의 가능성이 있으며, 이는 자칫 대형사고로 이어질 수 있다. 우리는 수소 인프라에 사용되는 NBR 재료의 투과 특성 향상을 위해 Silica, Carbon Black 등의 filler 를 배합하였고, -20 ~ 80 ℃ 조건에서 수소 투과도를 측정하였다. 그 결과 충진제 함량이 증가함에 따라 확산도가 감소하였고, 결국 수소 투과도가 감소함을 알 수 있었다. 특히, Carbon black(HAF)가 배합된 NBR 시편의 경우, 가장 큰 투과도 감소를 나타내었다. 또한, 온도에 따른 투과 특성 측정을 통해 Activation Energy (E_a)를 측정하였으며, 이를 통해 충진제의 첨가가 저온에서의 투과 특성을 크게 향상시킨다는 것을 알 수 있었다.

The four-trocar method for performing Laparoscopicallyassisted vaginal hysterectomy on Large uteri

최중섭 ( Joong Sub Choi ),( Young Soo Kyong ),( Kye Hyun Kim ),( Kyo Won Lee ),( Jong Sul Han ) 대한산부인과학회 2007 대한산부인과학회 학술대회 Vol.93 No.-

상피성 난소암 환자에서 생존율 분석을 통한 임상병리학적 예후 인자에 대한 고찰

최중섭(Joong Sub Choi),박창수(Chang Soo Park),김병기(Byoung Gie Kim),이제호(Je Ho Lee),배덕수(Duk Soo Bae),김우영(Woo Young Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10

목적 : 본원에 내원한 상피성 난소암 환자의 임상병리학적 특징과 이러한 인자들의 예후 인자로서의 효용성에 대한 가치를 알아보고자 하였다. 연구 대상 및 방법 : 1995년 1월부터 2000년 12월까지 삼성서울병원 산부인과에서 상피성 난소암으로 치료받은 147명의 환자를 대상으로 하였다. 임상병리학적 특징을 포함한 의무기록을 후향적으로 조사하였다. 생존율은 Kaplan-Meier 방법에 의해서 산출하였으며 생존 곡선간의 비교는 log-rank 방법을 이용하였다. 각각의 임상병리학적 인자들에 대한 다변량 분석은 Cox proportional hazard model을 이용하였다. 결과 : 상피성 난소암 환자의 조직학적 분류에 따른 빈도를 보면 다음과 같았다. 장액성 난소암 57.1%, 점액성 난소암 15.0%, 자궁내막양 난소암 15.0%, 투명세포암 9.5%, 혼합성 3.4%이었다. 147명 전체 환자의 FIGO 수술적 병기별 분포는 다음과 같았다. 제 1기: 29.3%, 제 2기: 4.1%, 제 3기: 54.4%, 제 4기: 12.2%. 수술 전 혈중 CA-125의 조직학적 분류에 따른 평균 역치는 장액성이 2,715 mIU/ml (S.E.637), 자궁내막양이 2,002 mIU/ml (S.E.687), 혼합성이 896 mIU/ml (S.E.290), 점액성이 421 mIU/ml (S.E.145), 투명 세포암이 236 mIU/ml (S.E.140) 이었다. 일차 수술 후 67명 (48.9%)에서는 잔류 종양이 없었으며, 16명 (11.7%)에서는 2 ㎝ 미만의 잔류 종양이 남았고, 54명 (39.4%)에서는 2 ㎝ 이상의 잔류 양이 남았다. 전체 환자의 5년 생존율은 46.7%로 나타났으며, 단변량 분석에서는 FIGO stage (p=0.0091), 세포분화도 (p=0.0081), 잔류종괴 용적 (p=0.0038), 조직학적 유형 (p=0.0313)이 통계적으로 유의하였으나 다변량 분석에서는 FIGO 수술적 병기 (p=0.048)만이 통계적으로 유의함을 보였다. 결론 : 이상의 결과에서 본원에 내원한 상피성 난소암 환자의 생존율에 영향을 미치는 가장 중요한 예후인자는 진단 당시 FIGO 수술적 병기인 것으로 확인되었다. Objective : In this retrospective study, we analyzed the clinicopathologic characteristics of epithelial ovarian cancer and evluated the prognostic factors which has an impact on survival of the patients with epithelial ovarian cancer. Patients and Methods : Total 147 patients with epithelial ovarian cancer who were treated at Samsung Medical Center between 1995 and 2000 were included. Medical records including pathologic reports were reviewed to identify clinicopathologic characteristics. Survival was analyzed by Kaplan-Meier method and log-rank test was used for curve comparison. Cox proportional hazards model was used for multivariate analysis. Results : The histopathologic distribution of all the patients was as follows: serous type (57.1%), mucinous type (15.0%), endometrioid type (15.0%), clear cell type (9.5%). mixed type (3.4%). The FIGO stage distribution for invasive epithelial ovarian cancer was stage I (29.3%), stage Ⅱ (4.1%), stage Ⅲ (54.4%), and stage Ⅳ (12.2%). The mean value of pre-operative CA-125 according to histologic type was 2715 IU/ml (S.E. 637) for serous type, 2002 IU/ml (S.E. 687) for endometrioid type, 896 IU/ml (S.E. 290) for mixed type, 421 IU/ml (S.E. 145) for mucinous type, and 236 IU/ml (S.E. 140) for clear cell ovarian cancer. No residual tumor was identified in 67 patients (48.9%) after primary cytoreductive surgery. Sixteen patients (11.7%) exhibited less than 2 ㎝ tumor and 54 patients (39.4%) 2 ㎝ or more macroscopic residual tumor. Second-look laparotomy was undertaken and pathologic residual disease was observed in 12 cases out of 39 (30.7%) patients. The overall 5-year survival rate of all the patients was 46.7%. In univariate analysis, FIGO stage (p=0.0091), grade (p=0.0081), residual volume (p=0.0038) and histologic type (p=0.0313) were significant prognostic factors affecting survival. However, multivariate analysis demonstrated that only FIGO stage (p=0.0048) was identified as a significant independent prognostic factor in this study. Conclusion : This study showed that FIGO stage was identified as a significant independent prognostic factor in the patients with epithelial ovarian cancer of all stages.

Reduced pelvic field sparing anastomosis for postoperative radiotherapy in selected patients with mid–upper rectal cancer

Choi, Seo Hee,Chang, Jee Suk,Kim, Nam Kyu,Lim, Joon Seok,Min, Byung So,Hur, Hyuk,Shin, Sang Joon,Ahn, Joong Bae,Kim, Yong Bae,Koom, Woong Sub JAPAN RADIATION RESEACH SOCIETY 2017 JOURNAL OF RADIATION RESEARCH Vol.58 No.4

<P><B>Abstract</B></P><P>The aim of this study was to report the clinical results of reduced pelvic field radiotherapy (RT), excluding the anastomotic site, after total mesorectal excision in selected patients with rectal cancer. Between 2011 and 2014, 99 patients underwent upfront surgery for clinically less-advanced tumors but were finally diagnosed as pT3/N+. Among them, 50 patients with mid–upper rectal cancer who received postoperative RT with a reduced pelvic field were included in this retrospective review. This group was composed of patients with high seated tumors, complete resection with a clear circumferential resection margin, and no complication during surgery. We investigated treatment outcomes, toxicity and the effect of RT-field reduction on organs-at risk in 5 randomly selected patients. During the median follow-up period of 42 months (range: 15−59 months), tumors recurred in 9 patients (18%). The 3-year overall and disease-free survival were 98% and 81%, respectively. Distant metastasis was the dominant failure pattern (<I>n</I> = 8, 16%), while no recurrences occurred at or near anastomotic sites. No anastomotic complications were found on pelvic examination, images and/or colonoscopy. Reported acute and late RT-related toxicities were mostly mild to moderate, with only small numbers of Grade 3 toxicities. None of the patients developed Grade 4−5 acute or late toxicity. With a caudally reduced field, 64% reduction in absolute anastomotic exposure at the maximum dose was achieved compared with the traditional whole-pelvic field (<I>P</I> = 0.008). The reduced pelvic field RT was able to minimize late anastomotic complication without increasing its recurrence in selected patients with mid–upper rectal cancer in the postoperative setting.</P>

Nodal metastasis in the distal mesorectum : need for total mesorectal excision of rectal cancer

Choi, Jin Sub,Kim, Sei Joong,Kim, Yong Ii,Min, Jin Sik Yonsei University, College of Medicine 1996 Yonsei medical journal Vol.37 No.4

Mapping of lateral pelvic lymph node recurrences in rectal cancer: a radiation oncologist’s perspective

Choi, Seo Hee,Chang, Jee Suk,Yoon, Hong In,Jang, Dong-Su,Kim, Nam Kyu,Lim, Joon Seok,Min, Byung So,Huh, Hyuk,Shin, Sang Joon,Ahn, Joong Bae,Koom, Woong Sub Springer-Verlag 2018 Journal of cancer research and clinical oncology Vol.144 No.6