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반도체 산업에서의 Enterprise Document Management Architecture 구현에 관한 연구
장현성,이영중,송하석,한영준,안정삼 한국경영과학회 2001 한국경영과학회 학술대회논문집 Vol.- No.2
A systematic construction and re-use of technology related to the product development and production has been the most important for the semiconductor industry dependent on process and equipment Therefore, numerous outputs in the form of paper has been produced in the process of information management ranging from the creation to recycling and disposal of technologies. In this research, the technology and documents necessary for the business management in the field of semiconductor manufacturing were classified in an effort to solve problems while the modeling of document management architecture at the enterprise level was performed by properly setting up the security system to prevent the unauthorized disclosure of the product development technology to the third parties. Especially, the product and process specification are designed in such a way as to ensure a real-time response in interface with the production system in order to shorten the development lead-time and improve the productivity. This paper is to discuss the modeling approach, the strategy to construct the system and its results.
Joong Hyun Ahn,Chi Hong Kim,Yong Hyun Kim,Seung Joon Kim,Sook Young Lee,Young Kyoon Kim,Kwan Hyoung Kim,Hwa Sik Moon,Jeong Sup Song,Sung Hak Park,Soon Seog Kwon 대한의학회 2007 Journal of Korean medical science Vol.22 No.6
Although animal models with ovalbumin have been used to study chronic asthma, there are difficulties in inducing recurrence as well as in maintaining chronic inflammation in this system. Using a murine model of house dust mite (HDM)-induced bronchial asthma, we examined the airway remodeling process in response to the chronic exposure to HDM. During the seventh and twelfth weeks of study, HDM were inhaled through the nose for three consecutive days and airway responsiveness was measured. Twenty-four hours later, bronchoalveolar lavage and histological examination were performed. The degree of overproduction of mucus, subepithelial fibrosis, and the thickness of the peribronchial smooth muscle in the experimental group was clearly increased compared to the control group. In addition, HDM-exposed mice demonstrated severe airway hyperreactivity to methacholine. In the bronchoalveolar lavage fluid, the number of total cells and eosinophils was increased; during the twelfth week, the number of neutrophils increased in the experimental group. With regard to changes in cytokines, the concentrations of IL-4, IL- 13, and transforming growth factor-beta (TGF- ) were increased in the experimental group. The data suggest that eosinophils, IL-4, IL-13, and TGF- might play an important role in the airway remodeling process and that neutrophils may be involved with increased exposure time.
DNA methylation predicts recurrence from resected stage III proximal colon cancer
Ahn, Joong Bae,Chung, Woon Bok,Maeda, Osamu,Shin, Sang Joon,Kim, Hyun Soo,Chung, Hyun Chul,Kim, Nam Kyu,Issa, Jean‐,Pierre J. Wiley Subscription Services, Inc., A Wiley Company 2011 Cancer Vol.117 No.9
<P><B>Abstract</B></P><P><B>BACKGROUND:</B></P><P>In colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMP2, and CIMP‐negative. The role of this classification in predicting recurrence and disease‐free survival (DFS) in resected stage III CRC was evaluated.</P><P><B>METHODS:</B></P><P>Sporadic cancers from 161 patients were analyzed. Bisulfite pyrosequencing was used to examine the methylation of 2 global DNA methylation markers (LINE‐1, Alu) and 9 loci (<I>MINT1, MINT2, MINT31, P16, hMLH1, P14, SFRP1</I>, SFRP2, and WNT5A). Mutations in BRAF and KRAS were assayed.</P><P><B>RESULTS:</B></P><P>Gene hypermethylation clustered in discrete groups of patients, indicating the presence of CIMP. K‐means clustering analysis identified 3 discrete subgroups: CIMP1 (n = 22, 13.7%), associated with proximal location and <I>BRAF</I> mutations; CIMP2 (n = 40, 24.8%), associated with <I>KRAS</I> mutations; and CIMP‐negative (n = 99, 61.5%), associated with distal location. In proximal CRC, CIMP1 was correlated with a higher recurrence rate (53% for CIMP1, 18% for CIMP2, and 26% for CIMP‐negative) and a worse DFS (<I>P</I> = .015). Also in proximal CRC, LINE‐1 methylation was lower in patients whose cancer recurred compared with those whose cancer did not recur (<I>P</I> = .049). In multivariate analysis, CIMP1 and low LINE1 methylation were independent prognostic factors for DFS in proximal CRC (<I>P</I> = .008 for classification by K‐means clustering analysis; <I>P</I> = .040 for LINE‐1 methylation status).</P><P><B>CONCLUSIONS:</B></P><P>DNA methylation is a useful biomarker of recurrence in resected stage III proximal but not distal CRC. However, as the number of CIMP1 cases was small in distal CRC, further study is required to validate our findings. Cancer 2011. © 2010 American Cancer Society.</P>
Hyun, Jae-Won,Huh, So-Young,Kim, Woojun,Park, Min Su,Ahn, Suk-Won,Cho, Joong-Yang,Kim, Byung-Jo,Lee, Sang-Hyun,Kim, Su-Hyun,Kim, Ho Jin SAGE Publications 2018 Multiple sclerosis journal: clinical and laborator Vol.24 No.6
<B>Objectives:</B><P> We compared validity of 2010 McDonald and newly proposed 2016 Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) criteria for dissemination in space (DIS) in predicting the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). </P><B>Methods:</B><P> Between 2006 and 2016, we enrolled 170 patients who had a first clinical event suggestive of multiple sclerosis (MS) from seven referral hospitals in Korea. Patients were classified into two groups based on the main outcome at the last follow-up: CDMS converters, who experienced a second attack, and non-converters. </P><B>Results:</B><P> Of 170 patients with mean follow-up duration of 54 months, 51% converted to CDMS. The sensitivity, specificity, accuracy, and positive and negative predictive values of 2010 McDonald criteria were 70.9%, 63.1%, 67.1%, 66.3%, and 67.9%, and those for 2016 MAGNIMS criteria were 88.4%, 46.4%, 67.7%, 62.8%, and 79.6%, respectively. When we excluded 80 patients who underwent disease-modifying therapy before the second clinical event, the specificity increased to 92.3% and 84.6%, but the sensitivity decreased to 58.8% and 82.4% for 2010 McDonald and 2016 MAGNIMS criteria, respectively. </P><B>Conclusion:</B><P> 2016 MAGNIMS magnetic resonance imaging (MRI) criteria for DIS showed higher sensitivity but lower specificity than 2010 McDonald criteria in predicting conversion to CDMS in CIS patients. </P>
GENERALIZED CONDITIONAL YEH-WIENER INTEGRALS FOR THE SAMPLE PATH-VALUED CONDITIONING FUNCTION
Ahn, Joong Hyun,Changz, Joo Sup The Kangwon-Kyungki Mathematical Society 2016 한국수학논문집 Vol.24 No.3
The purpose of this paper is to treat the generalized conditional Yeh-Wiener integral for the sample path-valued conditioning function. As a special case of our results, we obtain the results in [6].
Ahn, Joong Hyun,Song, Jeong Sup THE CATHOLIC UNIVERSITY OF KOREA 1997 Bulletin of The Catholic Research Institutes of Me Vol.25 No.-
Although the pathogenesis of Adult Respiratory Distress Syndrome(ARDS) is undoubtedly complex and poorly understood, several observations point to the important roles of poly-morphonuclear neutrophils(PMN), several cytokines and adhesion molecules. To assess the potential roles of Tumor Necrosis Factor-α(TNF-α) and soluble Intercellular Adhesion MolecuIe-1(sICAM-1) in the pathogenesis and prognosis of ARDS, we measured the plasma levels of TNF-α and sICAM-1 in 10 patients with ARDS serially and in 5 healthy normals as a control by Radioimmunoassay(RIA) and Enzyme-linked immunosorbent assay(ELISA) methods. According to the causes of ARDS, we classified patients into sepsis(n=7) and non-sepsis group(n=3) and made a comparison of plasma levels of TNF-α and sICAM-1 between the two groups. We also compared the plasma levels of TNF-α and sICAM-1 between the survivors and the non-survivors to clinical indicies that have been regarded as prognostic factors of ARDS. The results were as follows; 1. Mean plasma levels of TNF-α in patients with both septic and non-septic ARDS were significantly higher than that of the normal control(F<0.05). 2. Mean plasma level of sICAM-1 in patients with ARDS was higher than that of the normal controls, and significantly higher in the septic ARDS group(P<0.01). 3. However, in patients with ARDS, mean plasma levels of TNF- a and sICAM-1 did not differ significantly between the survivors and the non-survivors(P>0.05). 4. In patients with ARDS, there was a poor correlation between the serial plasma levels of TNF-α and prognosis(r=0.525, P>0.05 in non-survivors; r=-0.898, P>0.05 in survivors respectively). However, in the survivors, serial plasma levels of TNF- a had a tendency to decrease, and in the non-survivors, it had a tendency to increase. 5. In patients with ARDS, there was poor correlation between the serial plasma levels of sICAM-1 and prognosis(r = 0.811, P>0.05 in non-survivors; r=-0.795, P>0.05 in survivors respectively). However, in the survivors, serial plasma levels of sICAM-1 had a tendency to decrease, and in non-survivors, it had a tendency to increase. These results suggest that the plasma levels of TNF- a and sICAM-1 are higher in patients with ARDS, and even more so in septic ARDS patients. But, this elevation is not associated with the clinical severity and the prognosis of ARDS.