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( Han Wook Chung ),( Yu Jin Ko ),( Sang Wook Lee ),( Hyun Woong Lee ),( Hyung Joon Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aims: Quantitative HBsAg (qHBsAg) titers are emerging as useful tools for measuring viral load and predicting predicting virologic response (VR). This study aimed to determine whether serial monitoring of HBsAg levels could predict virologic response to entecavir(ETV) & clevudine(CLV) therapy in treatment-naive patients with CHB Methods: A total of 157 treatment-naive patients with CHB, who visited Chung-Ang University Hospital between January 2007 and December 2008, were enrolled in this study (100 males). 97 patients(69 males, mean age 48) were treated with ETV for average 53 months, and 60 patients (31 males, mean age 43) were treated with CLV for 26months average. HBsAg levels were measured at baseline, week 12, 24, and 48. All patients were assessed for virological response (HBV DNA<140 copies/mL). Serum HBV DNA was quantified using the real time PCR assay (Artus HBV LC PCR Kit, Roche Diagnostics, lower limit of quantification, 140 copies/mL). Results: In 97 ETV-treated patients, the rates of virological response were 56.7% (55/97) at 48months and 60 CLV-treated patients, 30% (18/60) at 24 months, respectively. Mean reduction of baseline HBV DNA was -5.3, and -4.9 log10 copies/mL. In 55 VR patients treated with ETV, 43(78.1%) patients showed early decline of HBsAg titer and 31(56.3%) patients had lower baseline HBsAg levels (< 3.7 log IU/mL). In 18 VR patients treated with CLV, 9(50%) patients showed early decline of HBsAg titer and 11(61.1%) patients had also lower baseline HBsAg levels (< 3.7 log IU/mL) . Conclusions: Early decline of HBsAg was useful for predicting VR, and baseline HBsAg could be indicative as well in CHB patients treated with ETV than patients treated with CLV.
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김승환,김인병,정순미,정성필,장석준 대한외상학회 1999 大韓外傷學會誌 Vol.12 No.1
$quot;Background: Paragliding injuries are increasing recently due to the growing popularity of this sport. This topic has been discussed in numerous journals in the European countries with large mountains, such as Austria, Germany and Switzerland, Those studies gave information regarding the flight phase during which an injury ocurred, the type and site of injury, and suspected reasons for the accidents. This study was done to compare our data to those of other nations and give preventive advices to reduce injuries occurring during paragliding. Method: Nineteen paragliders documented as having injuries during paragliding at Chung-Ju, Korea from 1990 to 1997 were included in the study. Their accident reports including medical records, were analyzed retrospectively. Result: Eighteen of the injured were male with one female and their mean age was 25.6 years old. Five injuries were suffered during take-off, of which technical error was the cause in most cases. Also, 5 injuries occurred during flight due to a sudden change of thermal and wind condi- tions. The majority of injuries were suffered during the landing period, affecting 9 paragliders. They were mostly due to forced landings, unexpected obstacles, and sudden change of wind conditions. Thirty-three percent suffered spine trauma and 29% were involved in injuries of the lower extremities. Upper limb injuries occurred in 19%, and 19% also suffered cerebral concussion or contusion. Conclusion: We have found that spine and ankle injuries were commonly occur during paragliding, especially the landing phase. Proper knowledge of the procedures, adequate training and appropriate foot wear could help in reducing injuries while paragliding.$quot;
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鄭準基 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-
In deep drawing of sheet metal, there are many cases in which the uniform and thin wall thickness of the drawn products is more important than the bottom thickness. In this case, we can not easily get the deep drawn products with the uniform and precise wall thickness by only drawing process. Therefore in general the manufacturing processes which both the drawing and the ironing process are proceeded sequentially are used. But this method has the disadvantages of a cost-up, decrease of productivity and degradation of quality, because the ironing process is added after the drawing process. In this study, in order to improve those problems and to enhance the effect of deep drawing, the combined process of redrawing and ironing for multistep drawing of cylindrical cups is used. In this experiment, we considered the characteristics of the combined process such as the relation between the drawing and ironing rates, the drawing limits and the forces needed for operations. The suggested force prediction shows that it can successfully represent experimental results.
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鄭亨煥,李浚析,金海在 동아대학교 공과대학 부설 한국자원개발연구소 1991 硏究報告 Vol.15 No.1
This paper mainly deals with the problems related to the improvememts of power system stability for an infinite bus-bar system with single machine, which AC and DC transmission line are connected in parallel. We considered about the stable operation region for the steady-state stability of power system with a DC current controller and without one. Specially, we assumed the general coefficients of converters in DC transmission line to be constant and obtained easily the stable limit curve in variations of gain coefficients for DC current controller through the digital computer simulation.
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鄭準基,辛文基 弘益大學校 1990 弘大論叢 Vol.22 No.2
The System Layout of Flexible Manufacturing Cell by computer simulation This paper describes the system layout of flexible manufacturing cell. It was formed part families and machine groups to increase flexibility and productivity. Part families and machine groups were made up by digitizing analysis. In this paper information of machine tool, quantity of part and machining time are used for the purpose of manufacturing cell matrix. Somewhat manufacturing cell is composed by 0.1 method instead of machining time among input information. As a result, it is made manufacturing cell of idential type. Therefor it possesses the advantage of noncounting machining time one by one. Another benefit is more easily grouping than any other GT(Group chnology) methods. Besides, the existing algorithm is developed a new algorithm to avaiable personal computer.
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鄭準基 弘益大學校 1989 弘大論叢 Vol.21 No.2
. High speed and heavy cutting performed for improving the surface quality and productivity, are often prevented due to chatter phenomena. Chatter is a violent relative vibration between workpiece and tool in machining of metals, and is an important limiting factor of production rate and surface quality, and reduces the tool life and the dynamic performance of machine tool itself. In this study, in order to suppress the chatter, a modified tool-post combined with the spring and damper was designed and used in the actual cutting test. The results of this study are summerized as follows; The spring and damper adopted in the modified tool-post have the suppressing effects of chatter, and there exists an optimum combination between spring constant and damping ratio.
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鄭準基 弘益大學校 1988 弘大論叢 Vol.20 No.2
In this study, the method determining chatter threshold was investigated experimentally. For the exact discrimination of the chatter threshold, the variations of the tool acceleration, cutting force, horizontal deflection of the workpiece, vibration amplitude of the workpiece, and surface roughness of the finished workpiece surface at the chatter threshold were observed. Its critical value was determined by making a comparative study of abrupt changes of the above quantities. By the experimental study, the following results are obtained. The chatter threshold can be discriminated exactly by measuring the variation of the tool acceleration which reacts more sensitively than the above other methods. And the critical value of the tool acceleration was 0.4g at all the cutting condition used in this experiment.
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