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RISS 인기검색어
- 검색키워드
- 저자 : ( Joohyeon Hong ) (검색결과 3 건)
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Son, Sung Yun,Kim, Jae Won,Lee, JooHyeon,Kim, Guan-Woo,Hong, Jisu,Kim, Jin Young,Park, Taiho The Royal Society of Chemistry 2018 Journal of materials chemistry. A, Materials for e Vol.6 No.47
<P>Morphologies and optoelectronic/mechanical properties of semiconducting polymers are significantly affected by their configurations. In this study, thiophene units are introduced into the backbone of a semiconducting polymer in either a regular (PffBT-T4) or a random (PffBT-RT4) manner to determine whether the resulting semiconducting polymers are suitable for developing efficient polymer solar cells. The energy levels of both polymers are highly similar because they share the same ratio of subunits in their backbones; however, PffBT-RT4 has lower crystallinity than PffBT-T4 due to its random configuration. Microstructural analyses indicate that PffBT-RT4 exhibits a shorter π-π stacking distance than PffBT-T4. Since short π-π stacking distance benefits interchain charge transport, PffBT-RT4 shows higher space-charge-limited current mobility, and PffBT-RT4 solar cells exhibit higher power conversion efficiency (PCE; 8.84%) than their PffBT-T4 counterparts (7.25%). In addition, PffBT-RT4 solar cells with active layers, prepared using a green solvent without any additive, show an encouraging PCE of 7.23%. Moreover, flexible solar cells based on PffBT-RT4 are much more stable during bending cycles than PffBT-T4 flexible solar cells. Therefore, this study demonstrates that the random configuration approach is a promising design strategy to realize semiconducting polymers for efficient, green-solvent-processable flexible polymer solar cells.</P>
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Lee, Jungryun,Song, Kiyeong,Lee, Kyoobin,Hong, Joohyeon,Lee, Hyojung,Chae, Sangmi,Cheong, Eunji,Shin, Hee-Sup National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.50
<P>T-type Ca<SUP>2+</SUP> channels in thalamocortical (TC) neurons have long been considered to play a critical role in the genesis of sleep spindles, one of several TC oscillations. A classical model for TC oscillations states that reciprocal interaction between synaptically connected GABAergic thalamic reticular nucleus (TRN) neurons and glutamatergic TC neurons generates oscillations through T-type channel-mediated low-threshold burst firings of neurons in the two nuclei. These oscillations are then transmitted from TC neurons to cortical neurons, contributing to the network of TC oscillations. Unexpectedly, however, we found that both WT and KO mice for <I>Ca<SUB>V</SUB>3.1</I>, the gene for T-type Ca<SUP>2+</SUP> channels in TC neurons, exhibit typical waxing-and-waning sleep spindle waves at a similar occurrence and with similar amplitudes and episode durations during non-rapid eye movement sleep. Single-unit recording in parallel with electroencephalography in vivo confirmed a complete lack of burst firing in the mutant TC neurons. Of particular interest, the tonic spike frequency in TC neurons was significantly increased during spindle periods compared with nonspindle periods in both genotypes. In contrast, no significant change in burst firing frequency between spindle and nonspindle periods was noted in the WT mice. Furthermore, spindle-like oscillations were readily generated within intrathalamic circuits composed solely of TRN and TC neurons in vitro in both the KO mutant and WT mice. Our findings call into question the essential role of low-threshold burst firings in TC neurons and suggest that tonic firing is important for the generation and propagation of spindle oscillations in the TC circuit.</P>
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Lee, Kyung-Tae,Byun, Hyo-Jeong,Jung, Kwang-Woo,Hong, Joohyeon,Cheong, Eunji,Bahn, Yong-Sun American Society for Microbiology 2014 EUKARYOTIC CELL Vol.13 No.6
<P>Protein tyrosine phosphatases (PTPs) serve as key negative-feedback regulators of mitogen-activated protein kinase (MAPK) signaling cascades. However, their roles and regulatory mechanisms in human fungal pathogens remain elusive. In this study, we characterized the functions of two PTPs, Ptp1 and Ptp2, in <I>Cryptococcus neoformans</I>, which causes fatal meningoencephalitis. <I>PTP1</I> and <I>PTP2</I> were found to be stress-inducible genes, which were controlled by the MAPK Hog1 and the transcription factor Atf1. Ptp2 suppressed the hyperphosphorylation of Hog1 and was involved in mediating vegetative growth, sexual differentiation, stress responses, antifungal drug resistance, and virulence factor regulation through the negative-feedback loop of the HOG pathway. In contrast, Ptp1 was not essential for Hog1 regulation, despite its Hog1-dependent induction. However, in the absence of Ptp2, Ptp1 served as a complementary PTP to control some stress responses. In differentiation, Ptp1 acted as a negative regulator, but in a Hog1- and Cpk1-independent manner. Additionally, Ptp1 and Ptp2 localized to the cytosol but were enriched in the nucleus during the stress response, affecting the transient nuclear localization of Hog1. Finally, Ptp1 and Ptp2 played minor and major roles, respectively, in the virulence of <I>C. neoformans</I>. Taken together, our data suggested that PTPs could be exploited as novel antifungal targets.</P>
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