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Huh, Joo Ryung,Song, Dong Eun 이화여자대학교 의과학연구소 2008 EMJ (Ewha medical journal) Vol.31 No.1
We have presented a case of unsuspected PBL in a patient who underwent THRA for suspected osteoarthritis. Our findings emphasize the importance of pre- or intraoperative consultation in case of PBL and thorough pathologic examination of all specimens obtained during routine, elective orthopedic surgeries. 원발성 골 림프종은 주변의 림프절의 침윤과 관계없이 한 개의 골격을 침범하거나 혹은 내부 장기나 림프절의 침윤없이 여러 개의 골격들을 침범한다. 원발성 골 림프종의 방사선 소견은 매우 다양하고 비 특이적이며, 대개 병리학적 검사 이전에는 진단되지 않는다. 관절을 침범하는 경우에는 골관절염과 유사하게 표현될 수 있다. 원발성 골 림프종은 뼈를 침범하는 다른 악성 종양에 비해 양호한 생존율을 보이므로, 적합한 치료를 위해 정확하고 빠른 진단이 매우 시급하다. 여기서 우리는 일년 동안 지속된 고관절 통증을 주소로 내원하여 방사선적으로 골관절염 의심 하에 전 고관절 치환 관절성형술 후에 진단된 원발성 골 림프종 1예를 문헌고찰과 함께 보고한다. 병리학적 검사결과 미만성 대세포성 B-세포림프종으로 진단되었다. 본 증례는 비 특이적인 방사선 소견과 임상 특성 때문에 원발성 골 림프종을 먼저 의심하기가 어렵다는 점과 진단에 있어 수술 중 자문의 중요성을 강조하는 증례이다.
( Kyoung Chan Park ),( Hae Ryung Choi ),( Jung Im Na ),( Hyun Joo Cho ),( Kyung Mi Nam ),( Jee Woong Choi ),( Se Young Na ),( Chang Hun Huh ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.1
Dermal cells from neonatal mice can initiate the formation of hair follicles (HFs) when combined with adult mouse epidermal cells and transplanted subcutaneously into athymic mice. In the present study, the effects of dermal cells on HF formation were tested in terms of total cell number and the time course of cell harvest. Results demonstrated that the number of dermal cells is critical to the formation of HF. Furthermore, hair forming ability is rapidly decreasing as the neonatal mice age. To examine potential differences in gene expression, cDNA array was performed. Results demonstrate that numerous molecules which are directly involved in receptor and signaling correlated with decreased hair inductivity in early time points after delivery. It is reported that bone morphogenic protein (BMP)-6 and Wnt3a treatment increased hair inductivity of dermal papilla cells. But in our study, no changes were observed in the expression levels of BMP-6 and Wnt3a. However, several Wnt related genes demonstrate increased or decreased expression levels. Thus, our results suggest that co-ordinated regulation of these molecules will be important in hair neogenesis within our model system. (Ann Dermatol 24(1) 94∼98, 2012)
피하지방층염 양상을 보인 혈관중심성 T / NK - 세포 림프종
장성은,허주령,문기찬,성경제,최지호,고재경,지두현 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.12
Nasal-type T / NK cell lymphoma shows frequent extra-nodal involvement including skin with poor prognosis. Subcutaneous panniculitic T-cell lymphoma which is characterized by subcutaneous nodules, systemic signs and symptoms, and a hemophagocytic syndromes was also identified and must be differentiated with primary cutaneous nasal-type T / NK cell lymphoma. We report a case of subcutaneous angiocentric T / NK cell lymphoma in a 77-year-old man who had multiple deep ulcers on the extremities. Strong CD56 positivity and EBV RNA by in situ hybridization were demonstrated in the angiocentric infiltrates of the subcutis. The skin lesions were resistant to combination chemotherapy and pancreatic involvement of lymphoma developed. One year after onset of the skin lesions, he had a rapid downhill course.
피부 원발성 CD 30 양성 림프구증식 질환 1예 : 림프종양 구진증과 악성 림프종의 중간형 Borderline case
장성은,허주령,문기찬,성경제,최지호,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.3
Primary cutaneous CD30-positive large cell lymphoma and lymphomatoid papulosis; both entities are characterized by CD30-positive large atypical cells predominantly of T cell origin. We report a borderline case between CD30-positive large cell lymphoma and lymphomatoid papulosis in a 57-year-old woman presenting as a spontaneous disappearing and recurrent solitary erosive nodule on the right upper eyelid. Histopathological findings of two biopsies from each lesion showed mixed CD30-positive large atypical cells, many eosinophils and neutrophils histologically. The nodule disappeared after chemotherapy and subsequent radiotherapy. She is well without recurrence for a follow-up of 9 months.
다수의 반, 구진, 결절로 나타난 원발성 피부 CD30 양성 퇴형성 대세포림프종 1예
장성은,허주령,문기찬,성경제,최지호,고재경,박일중 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.11
We report an unusual case of primary cutaneous CD30+ anaplastic large cell lymphoma in a 58-year-old man who presented with disseminated hyperpigmented patches, papules, and nodules. Our case is also unusual in that the patient did not respond to an intensive chemotherapy regimen in contrast to previously reported cases of primary cutaneous CD30+ anaplastic large cell lymphoma.