마미증후군 환자의 요천추 신청근 손상 및 회복양상

손현주,김경민,한지의,장재혁,신용범,고현윤 부산대학교 병원 암연구소 2007 부산대병원학술지 Vol.- No.21

Purpose: Numbers and severity of the injured segments and neurological recovery patterns are both vague and confused following cauda equina syndrome (CES). We evaluated the characteristics of CES according to the causes of the injuries resulting in CES. Subjects and Methods: Thirty-nine cases of CES diagnosed by clinical features and electrophysiological studies were recruited. We investigated segments or roots involved, muscle strength grades of key muscles, external anal sphincter tones, and changing patterns of theses findings. Their characteristics were compared according to the traumatic and non-traumatic lesions. Results: In traumatic lesions, lower segments, such as sacral roots, were involved more frequently and severely (p<O.OOl). In non-traumatic lesions, L5 and Sl roots were more injured and S2,3,4 roots were less injured (p<O.05). However, there was no significant difference of severity among the injured segments in non-traumatic disorders. There was no typical recovery pattern in both traumatic and non-traumatic cases. Conclusions: In traumatic CES, lower segments or roots were injured more prevalently and severely. Relatively, upper segments were more affected in non-traumatic CES.

일차성 식도이완불능증의 풍선확장술후 치료효과의 객관적 평가지표

손영해,나호영,조성범,주영은,김현수,최성규,유종선,김세종 全南大醫大 2001 전남의대학술지 Vol.37 No.2

(초)고층 아파트 거주자의 주거환경 스트레스 인식에 관한 연구

손광제,김주현,정준현 대구대학교 과학기술연구소 1998 科學技術硏究 Vol.5 No.4

The purpose of this study is to analyze about the stress for the residential and it's degree of resident's cognition for high-rised living and then to provide the basic data which contribute to improving the quality of the residental environment. This study was conducted to investigate the stressing of resident from residental environment of high-rised apartment on Taegu area. This investigation was achieved by the questionary field-surveying for housewives of the super high-rised apartments. The Spatial extents of residental environment ware limited by the housing unit plan, the clustered open space and the neighborhood environment. In the result of study was produced that the degrees of residental environment are relative to the human, at factor of residents and the physical factor of residental environment, and are evaluated as the mutual relation between it's variables.

관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

신경인성 과반사성 배뇨근에 대한 배뇨근 내보툴리눔 독소 A 주사

고현윤,신용범,손현주,장재혁,이경미,문혜정,하용훈 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

Local injections of botulinum toxin A have been reported in the treatment of neurogenic bladder dysfunctions including detrusor sphincter dyssynergia and detrusor overactivity. We reports a case of intradetrusor injection of botulinum toxin type A in acervical cord injured patient with neurogenic overactive detrusor refractory to high dose anticholinergic medication. Botulinum toxin A (200 units) was injected cystoscopically into the detrusor in 40 sites over the bladder with sparing the trigone. Urodynamic studies were performed at baseline, and eight days, four weeks, and eight weeks after intradetrusor injection. There was marked improvement of the urodynamic parameters including maximum cystometric capacity and maximum detrusor pressure after intradetrusor botulinum toxin injection.

유아의 과학적 탐구능력 증진을 위한 과학교육 프로그램 개발 : “물”에 대한 발견과 발명

이현옥,한정희,손지현,손여민,정은주,김소리 서울여자대학교 2006 아동연구 Vol.12 No.-

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경막 외 스테로이드 주사에 반응 없는 추간판성 요통에 대한 추간판 내 시술 효과

신용범,고현윤,손현주,장재혁,박형욱,신명준,김수연 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

Objective: To determine the effect of intradiscal therapy with discography in patients with back pain of no effect using epidural steroid. Subject and methods: Thirty patients with herniated nucleus pulposus (HNP) who had not have any improvement using repeated epidural steroid were studied. Degree of disc degeneration, provocation pain and intradiscal pressure were evaluated in 41 discs. Intradiscal triamcinolone was injected to degenerated discs and intradiscal electrothermal therapy (IDET) was performed to the patients who had no improvement using intradiscal steroid. Patients were asked to report pain according to a visual analogue scale (VAS). Results: Thirty of 41 discs showed significant degeneration. In 19 of 30 (63.3%) patients, VAS was reduced over 50% after intradiscal steroids. Low intradiscal pressure without provocation pain and ruptured discs were significantly higher in these patients (p<0.05). After IDET, 8 of 9 patients noted over 50% reduction of VAS. Conclusions: In patients with discogenic back pain combined with radicular pain, intradiscal therapy according to discography may be helpful in patients with no improvement using epidural steroid.

척추손상 쥐의 지방유래 줄기세포와 미노사이클린의 운동기능 회복효과

장재혁,고현윤,차영선,박형욱,신용범,손현주 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

신경인성방광으로 인한 방광요관역류에서 임계 배뇨근압 및 용량

장재혁,고현윤,신용범,손현주 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

Purpose: We investigated relationships of detrusor pressure and bladder volume at the onset of vesicoureteral reflux (VUR) with other urodynamic and clinical parameters in neurogenic bladders after spinal cord injury. Materials and Methods: Videourodynamics were performed in 15 patients with spinal cord injury. Neurological levels of spinal cord injuries were categorized as cervical in 6 cases, thoracic in 6 cases, and lumbosacral in 3 cases. The interrelationships of detrusor pressure and bladder volume at the onset of VUR, bladder comp Hanco maximum detrusor pressure, and maximum bladder capacity were assessed. Results: A weak correlation existed between detrusor pressure and bladder volume at VUR (r=0.493, p=0.062). Detrusor pressure at VUR and bladder compliance presented an inverse correlation (r=-0.525, p=0.044). Pressure-volume index at VUR had a strong correlation with bladder volume at VUR divided bladder capacity (r=0.861, p<0.00l). Conclusions: Detrusor pressure and bladder volume at the onset of VUR appeared to have relationships with other factors associated with VUR in neurogenic bladders after spinal cord injury. Further studies acquiring additional patient data and follow-up data about reflux resolution permit to develop the management guide and prognostic factor of the secondary VUR in neurogenic bladders after spinal cord injury.

RT-QUIC detection of PrPCWD in CSF of CWD infected cervid

Hyun Joo Sohn(Hyun Joo Sohn),Kyung Je Park(Kyung Je Park),In Soon Roh(In Soon Roh),Hyo Jin Kim(Hyo Jin Kim),Hoo Chang Park(Hoo Chang Park),Hae Eun Kang(Hae Eun Kang) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-