일개 대학병원에서 치료중인 만성질환자의 금연,절주 및 운동 실천 정도

손혜숙,전진호,이종태,정귀원,김성준,엄상화,유병철 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.3

Background: Many chronic diseases are associated with the lifestyle such as smoking, alcohol drinking and exercise. Attention is increasingly paid on the effect of exercise for the management of chronic disease these days. Objective: The purpose of this study was to evaluate the status of the smoking habit, alcohol drinking and physical exercise of the patients with chronic diseases. Methods: Total 793 persons(normal:422, chronic disease patients:371) in a hospital were questioned regarding the habits of smoking and alcohol drinking, and a practice of physical exercise in 1999. The patients with chronic illness were divided into three groups(Group I included the patients of hypertension and diabetes mellitus. Group II includes respiratory disease and cancer. Group III included liver disease ). The rate of exercise, the rate of smoking cessation and the rate of abstinence were assessed. In logistic regression analysis with each independent variables in each disease groups(I, II and III), odds ratio for the presence of disease was controlled for age and education. Results: The rate of exercise, the rate of smoking cessation and the rate of abstinence was 31.5%, 27.3% and 9.5% in the patients with chronic disease, respectively. In control group, those were 31.5%, 21% and 2.1%, respectively. In logistic regression analysis with exercise as independent variable, odds ratios(95% CI) for age and education were significantly high, with smoking cessation, odds ratio for age was high and with abstinence, odds ratio for disease was high in all disease groups. Conclusion : It was suggested that an effort for proper changes of lifestyle related to disease such as smoking, alcohol drinking and exercise should be intervened in the patients with chronic diseases.

메티실린 내성 황색 포도알균에 의한 연조직 및 골 감염에 대한 전환요법으로서의 경구 Rifampin의 유용성

손종원,김신우,하상우,이응갑,정덕원,장현하,이종명,김능수 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 메티실린 내성 황색 포도알균에 의한 연조직및 골 감염의 치료 시 glycopeptide약물의 정주 요법에 이은 경구 항생제로의 처방 전환이 요구되는 경우가 많으나 마땅한 경구 약제의 선택이 어려운 실정이다. 이에 경구 rifampin을 메티실린 내성 황색 포도알균에 의한 연조직 및 골 감염에 사용하여 치료한 경우를 분석하여 그 유용성 정도와 실패한 경우 실패의 위험인자를 알아보고자 하였다. 재료 및 방법 : 2001년 1월부터 2004년 9월까지 메티실린 내성 황색 포도알균에 의한 연조직 및 골 감염 환자를 대상으로 rifampin을 그 치료 목적으로 사용한 44명의 환자를 의무 기록과 X선 사진을 통해 후향적으로 분석하였다. 기초 자료를 분석하였고 감염이 재발하여 치료 실패로 판정된 환자들에 대해 치료 실패의 원인이 될 만한 주요 변수에 대한 Chi-square 검증과 로지스틱 회귀분석을 시행하였다. 결과 : 치료 후 재발은 20.5% (8/39)였으며 재발 예와 사망에 대한 위험요소에 대한 단변량 분석에서 고관절 보형물이 있는 경우 흔하였으나 통계적 차이에는 미치지 못하였다(P=0.065). 고관절 보형물 외에 동반된 질환들, 쇼크의 동반, 균혈증의 동반, 경구 시 ciprofloxacin과 rifampin의 병합 복용 기간 등을 혼란 변수로 사용한 다변량 로지스틱 회귀분석에서는 고관절 보형물 만이 통계적으로 유의하였다(P=0.044). 결론 : 메티실린 내성 황색 포도알균에 의한 연조직및 골 감염에 rifampin과 다른 약제를 병합하여 치료하는 경우 재발은 적었다. 치료 실패의 경우는 고관절 부위 감염과 같이 보형물을 쉽게 제거하기 어려운 상황과 관계되는 것을 보여준다. Background : Rifampin is sometimes used in combination with other anti-staphylococcal agents to treat methicillin-resistant Staphylococcus aureus (MRSA) infections but few reports are available about the usefulness of rifampin against MRSA infections, especially in soft tissue and bone infections. Thus, we evaluated the efficacy of rifampin as switch therapy for soft tissue and bone infections caused by MRSA and assessed the risk factors for treatment failure. Materials and Methods : We retrospectively studied 44 patients who had soft tissue and bone infections caused by MRSA and were treated with rifampin in combination or as monotherapy as switch therapy from January 2001 to September 2004. Results : The mean age of the subjects was 50.2 years and the number of male and female were 34 and 10, respectively. Median duration of rifampin use was 32 days and 25% of the patients had artificial prostheses. Thirty one patients (79.5%, 31/39) were cured with parenteral glycopeptide followed by rifampin in combination or as monotherapy. Eight patients (8/39) recurred after the completion of treatment. The presence of hip prosthesis was the only significant risk factor (P= 0.027) in multivariate logistic regression test. Rifampin was tolerable in all cases. Conclusion : Rifampin as switch therapy for soft tissue and bone infection caused by MRSA was effective in 79.5% (31/39) of sujects. The treatment failure seems to be associated with unremovable infected prosthesis.

減壓 貯藏中 Tomato果實의 Ribonucleic Acid와 Ribonuclease 活性의 變化

崔相源,崔鍾旭,孫泰華 COLLEGE OF AGRICULTURE KYUNGPOOK NATIONAL UNIVERSI 1984 慶北大農學誌 Vol.2 No.-

The process of ripening and senescence of tomato fruits has been studied in terms of storage temperature and pressure. Ribonucleic acid(RNA) content, Ribonuclease (RNase) activity, RNase properties and electrophoretic pattern of RNase were investigated during the storage. Total RNA content was decreased during ripening and senescence. The decreasing rate was greater at room temperature (R) than at low temperature (L), and under normal atmospheric pressure (NAP) than under sub-atmospheric pressure (SAP). RNase activity was increased during the period of climacteric rise and in accordance with developing color score. RNase activity was obviously higher at R than L, and under NAP than SAP. Consequently, RNase activity of NAP-R treatment was the highest among the treatments. The optimum temperature and pH of RNase activity were 70℃and pH 6.7, respectively. RNase activity was the most stable at pH 5.0 and retained 50% of its activity when treated at 90℃ for 10min. RNase activity was inhibited by cations and, markedly by zinc. Both treatment of NAP-R and SAP-L showed one band of RNase on gel electrophoresis in the early stage of storage. With the lapse of storage, the number of RNase band increased, showed 3 bands in the 7th day of NAP-R treatment and 2 bands in the 34th day of SAP-L treatment.

유합 상악 측절치의 외과적 처치에 관한 증례보고

김기원,손흥규,이종갑 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.2

Fusion of teeth is a morphological anomaly that is often observed along with missing or supernumerary teeth, and it causes many problems in periodontal, restorative, andesthetic aspects. The incidence of fusion is less than 1 % ; it occurs most often between a incisor and a canine, and no prevalence exists between maxilla and mandible. The exact etiology factor of fusion is unknown, but genetic and environmental factors seem to be related. Differential diagnosis of gemination and fusion is accomplished by the number of roots and/or canals, but when a supernumerary tooth is involved, the differential diagnosis becomes more complicated. In the show-case, the patient expressed chief complaints of abnormal morphology and cross bite caused by a fusion between maxillary left lateral incisor and supernumerary tooth ; the supernumerary tooth was surgically removed and apexification was performed for the lateral incisor that showed irrevesible pulpitis. During the surgical extraction, the least amount possible of buccal bone should be removed, and pulp treatment for the exposed pulp should be performed as soon as possible. The most important determinant in successful surgical treatment is location of fusion ; the treatment time can be delayed until the root formation is completed and until pulp chamber size has decreased to lessen possibility of pulp exposure. In the show-case, however, the labially erupted supernumerary tooth caused mastiatory and esthetic problems, and thus the treatment was performed immediately.

수 종의 치과재료에서 유리된 불소측정 및 인장 강도에 관한 실험적 연구

김기원,손홍규,이종갑 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.1

In this study, three kinds of glass ionomer cement(FujiⅡ, Vitrebond, XR-Ionomer)were evaluated for fouoride release and change of tensile strength. Measurements of fluoride concentration released in solution from disc(2.5 ×4.0mm)made of selected materials and tensile strength were performed 1hr, 24hrs and 30days after the experiment. The results of this study were as follows. 1.The amount of fluoride release from all of the three materials increased during the experimental period, and there was a statistical significance between them. 2.FujiⅡ,XR-Ionomer showed slight increase in tensile strength as time passed; however,no statistical significance was found between them(P<0.01). 3.Vitrebond showed a decrease in tensile strength as the time passed;the result obtained after 24hours and 30days(P<0.01). from these studies, glass ionomer cement showed tensile strength that did not decrease through the time. Also, its continuous release of fluoride qualifies goass ionomer cement as a useful material to be used in restoration of primary dentition with high carious cativity.

급성충수돌기염으로 발현된 방선균증 2예

조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.

한국에서 분리한 사람 Caliviviruses의 RnA-dependent RNA Polymerase 유전자의 다양성

최종환,한동표,이현우,손준,김현원 연세대학교 원주의과대학 1997 원주의대논문집 Vol.10 No.1

지방식이가 Rat 간 Epoxide Hydrolase 활성에 미치는 영향

김은주,손기호,최종원 慶星大學校 環境問題硏究所 1991 環境硏報 Vol.1 No.1

간 microsomal epoxide hydrolase 활성과 bromobenzene에 의해 유도된 간 독성에 미치는 지방식이의 영향에 대한 실험을 통하여 다음과 같은 결과를 얻었다. 간 microsomal cytochrome p-450 및 aniline hydroxylase 활성에 지방식이 (20%)를 섭취케 한 군에서는 본 효소의 활성이 다소 증가되었으나 bromobenzene을 동시에 투여함으로 두 효소의 활성이 유의성 있게 증가되었다. Bromobenzene 단독 투여에서는 두 효소의 활성에 별다른 영향이 없었다. Epoxide hydrolase 활성에서는 bromobenzene 투여로서 감소 되었으며 지방식이를 섭취게 하고 bromobenzene을 투여함으로 bromobenzene 단독 투여보다 약 25% 현저하게 감소하였다. 지방식이를 섭취게 하고 bromobenzene을 투여한 군에서의 간 손상의 지표를 생화학적 측면(s-AST,sALT) 및 간 조직의 과산화 지질 함량에 미치는 영향에서 bromobenzene 단독 투여보다 지방식이를 섭취케 하고 bromobenzene을 투여함으로 현저하게 증가되었다. We have the mecdied the mechanism by examining the effect of fat diet on the epoxide hydrolase activity and bromobenzene-induced hepatotoxicity. Activities of anivities of aniline hydroxylase and cytochrome p-450 as epoxide generating enzymes were singificantly increased by the treatment with fat diet and bromobenzene treatment with fat diet and bromobenzene decreased show any changes on the activities of the epoxide scavenging enzyme such as epoxide hydrolase Furthermore, fat diet elevated against bromobenzene-inducible hepatotoxicity in rats as evidenced by the increased formation of lipid peroxidation, highered serum alanine and aspartate aminotrnsferase activities. Therfore, it can be concluded that the mechanism for the observed elevative effect of fat diet against bromobenzene-induced hepatotoxicity was due to the inhibition of epoxide hydrolase which related with metabolism of these materials.

Equisetum arvense L.이 Streptozotocin유발 당뇨성 쥐의 항당뇨작용에 미치는 영향

이현자,김석환,손기호,최종원 慶星大學校 環境問題硏究所 1993 環境硏報 Vol.3 No.1

The present study was undertaken in order to elucidate the effects of pretreatment with Equisetum arvense L.(EM) on change in serum lipid compositions and pancreatic enzymes induced by streptozotocin(STZ) in rats with pancreatic histopathology. 1. Total serum lipid and triglyceride levels in the STZ-induced diabetic rats were significantly higher than those in the control group, and those in the group pretreated with EM but the phopholipid serum level was not significantly different in any of the group. 2. In the STZ-induced diabetic group, the total serum cholesterol, VLDL-and LDL-cholesterol levels, and the atheroscerotic index were higher, while the HDL-cholesterol level was lower when compared to the control group. HOwever, these changes were slightly prevented by EM. 3. Pancreatic lipase and trypsin activities were increased, but amylase activity was decreased by STZ, and pretreatment with EM slightly prevented these STZ-induced changes, in the histological changes of the pancreatic β-cell. These results suggest that EM pretreatment slightly supresses STZ induced changes in the serum lipid compositions and pancreatic enzyme via maintenance of prevent of β-cell destruction by STZ.

Equisetum arvense L.이 고혈당 쥐의 혈중 포도당 농도에 미치는 영향

이현자,김석환,손기호,강우규,최종원 慶星大學校 環境問題硏究所 1992 環境硏報 Vol.2 No.1

The effect of methanol extract of Equisetum arvense L.(EM) on blood glucose level in streptozotocin-induced diabetic rat and acute toxicity of EM were investigated. Male Sprague-Dawley rats(200∼250g), with free access to commercial rat chow and water, were divided into four groups: Group 1 served as control; Group 2 received STZ only: Group 3 received EM only; Group 4 received pretreatment with EM followed by STZ administration. EM did not affect the normal blood glucose level and LD50 was about 6,250㎎/㎏. EM pretreatment in STZ-induced diabetic rats slightly inhibited Weight loss and water consumption. EM pretreatment in STZ-induced diabetic rats slightly inhibited the rise of serum glucose concentration. Serum transaminase(AST, ALT) and sorbitol dehydrogenase(SDH) were slightly increased by STZ induced changes in the serum glucose level.