체내 카드뮴 농도에 따른 신세뇨관 미세손상 유병률

임동혁, 문선인, 엄상용, 김용대, 강종원, 김헌 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

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젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

복합 적층 박판의 열응력 파손에 대한 진동 활용 비파괴평가

이성혁,이정기,최낙삼 韓國非破壞檢査學會 1999 한국비파괴검사학회지 Vol.19 No.5

두께 1mm의 얇은 복합적층판의 자유경계단부에서 열응력으로 인해 발생하는 미세손상을 진동거동과 관련된 비파괴평가의 가능성을 연구하였다. 유한요소 열응력해석을 통해 예상되는 손상발생영역을 초음파 C-스캔과 광학현미경을 이용하여 관찰하였다. 사인 스윕시험을 이용한 적층보 시험편의 횡진동 해석결과, 미세한 내부손상으로 인해 고유주파수가 확실히 감소하였으며 감쇠비도 상당히 증가하였다. 길이가 짧은 적층보 시험편과 2차 모드의 공진주파수를 이용하여 얇은 적층판에서 열응력으로 유기된 미세손상을 매우 민감하게 평가할 수 있음을 알았다. A feasibility investigation on vibration-based nondestructive evaluation of thermal stress-induced micro failure in the free edge region of thin composite laminates(1mm thick) has been carried out. The failure occurrence and damage zone, which were predicted by the three-dimensional finite-element thermal stress analysis, were observed using the ultrasonic C-scan and optical microscopy. Analysis of the vibration spectrum measured from the laminate beam specimens by the vibration sweep test exhibited that the obvious decrease in resonancy frequency and some considerable increase in damping factor were associated with the micro-failure formation. The vibration technique utilizing short beam and high resonant frequency was found to be very sensitive to the thermal stress-induced damage in the thin laminates.

유전자 재조합 사람 IFN-beta인 제네베타와 베네세린의 생물학적 활성의 비교

하종천,이협준,박봉환,김진숙,유대근,남상윤 전주대학교 자연과학종합연구소 2003 전주대학교 자연과학연구소 학술논문집 Vol.15 No.1

Background: Recombinant IFN-beta products have been approved for the treatment of several diseases. Recently, Inbionet, Co. has successfully developed rhIFN-beta product, Genebeta. This study was performed in a purpose of confirming the biological activity of Genebeta by comparison with another recombinant IFN-beta, Beneserin which was already approved. Methods: In vitro antiporliferative activity, regulation of MHC class I expression, antiviral activity, regulation of natural killer cell cytotoxicity were studied for functional comparison of these two rhIFN-beta products. Results: Proliferation assay data showed that two recombinant IFN-beta inhibited T cell and Daudi cell proliferation to a similar extent. When antiviral activity was compared, there was no significant difference between them. The treatment of these two rhIFN-beta also resulted in a similar level of upregulation of class I expression on the surface of A549 cells. Cytotoxicity experiment against tumor cells revealed that both of rhIFN-beta could enhance NK cell cytotoxicity to comparable level. Conclusion: All comparison data indicated that rhIFN-beta products, Genebeta and Beneserin have comparable potentials as a biological response modifier.

Urechis unicinctus 난세포의 인공수정에 의한 구조적 변화

권혁제,김완종,신길상 순천향대학교 1994 논문집 Vol.17 No.3

The artificial insemination in Urechis unicinctus oocyte revealed some fine structural changes under electron microscope. The degradation of surface coat, retraction of microvilli, fusion of cortical granules with oocyte membrane are the events of fine structural changes after the fertilization. At fertilization, the cortical granules of oocyte are transported from the inner cortex toward oocyte membrane. After the fusion, the contents of cortical granules are discharged into the perivitelline space, the extracelluar space which in future develops into fertilization membrane. There are some indications that the fertilization occur on the microvillous tip in U. uicinctus. Under light microscope, one of the evidences on the fertilization was the formation of fertilization cone, which seemed to sperm entry site, on membrane of round mature oocyte.

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

모티리움 엠정(말레인산돔페리돈 12.72 mg)에 대한 한미 돔페리돈정의 생물학적 동등성

곽손혁,우종수,황성주 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-

Bioequivalence of two domperidone maleate tablets, test drug (Hanmi Domperidone^ⓡ tablet: Hanmi Pharmaceutical Co.) and reference drug (Motilium-M^ⓡ tablet: Jassen Korea Pharm. Co.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male volunteers were divided randomly into two groups and administered the drug orally at the dose of 20㎎ as domperidone in a 2×2 crossover study. There was a week washout period between administrations. Blood samples were taken at predetermined time intervals for 48hr and the plasma concentration of domperidone was determined by a HPLC method. AUC_0-48hr (area under the plasma concentration-time curve from time zero to 48hr), C_max (maximum plasma drug concentration) and T_max, (time to reach C_max) were estimated from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed no difference in AUC_0-48hr, C_max and T_max between two products. The apparent differences of these parameters between two products were less than 20% (i.e., 1.047, -0.416 and 9.347% for AUC_0-10hr, C_max and T_max, respectively). The powers (1-β) for AUC_0-48hr, C_max and T_max were over 0.99. Minimal detectable differences (Δ) at α=0.05, 1-β=0.8 were less than 20% (i.e. 11.15, 10.21 and 18.13% for AUC_0-10hr, C_max and T_max respectively). The 95% Confidence intervals (δ) for these parameters were also within ±20% (i.e. -5.49≤δ≤7.58, -6.39≤δ≤5.57 and -1.28≤δ≤19.95 for AUC_0-10hr, C_max and T_max, respectively). These results satisfied the criteria of KFDA guidelines for bioequivalence, indicating the two tablets of domperidone maleate were bioequivalent.

목제품만들기 단원의 수행평가를 위한 포트폴리오 자료 개발

이종오,이상혁 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.2

The purpose of this study was to develop and identify the effects of portfolio materials for performance assessment on the unit of wooden ware making practical arts in the primary school. In this study, the researcher was analyzed the literatures which was related to portfolios, and created the elements and items of performance assessment, and developed portfolio materials. The results of the study were as follows: (1) After the portfolio materials of practical arts applied to lesson of the woodenware making unit, the results of learning achievement test showed a level by averages 80.8%. The portfolio materials improved the efficiency of performance assessment, and effected on the increasing performance ability in practical arts. (2) After using portfolios, in the results of the learning attitude test of students, seven items of affective domain consist of pleasure during the practical arts education, value of nature, attitude of using tools safely, feeling of satisfaction in the result of practices, confidence in the working of wood-working tools, continuous practice of the practical exercise, attitude of make and using goods of life, which used portfolio materials effected on the increasing learning achievement level.

ZMP를 이용한 굴삭기의 안정성에 관한 연구

최종환,엄혁,임태형,김승수,양순용,이병룡,안경관 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

The hydraulic excavator has been a popular research object for automation because of its multi-workings and economic efficiency. When it works crane tasks, most of disasters happen. The stability of the excavator having crane function has a close relation with excavator's posture, motion and load. In this paper, the stability of tipping-over has been analysed using Zero Moment Point(ZMP),

사람 뇌척수액중 Transthyretin의 항산화작용

양성렬,최기오,박종근,류문희,홍석노,김수한,안봉환,이제혁,이민화 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.4

Protective effects of human cerebrospinal fluid antioxidants against enzyme inactivation caused by metal-catalyzed oxidation systems were investigated. When purified glutamine synthetase(GS) was incubated with human cerebrospinal fluid(CSF), the enzyme was progressively inactivated. Catalase and EDTA could inhibit the enzyme inactivation by 50-80%. Small-molecular(Mr< -10,000) fraction of CSF inactivated the exogenous GS, but large-molecular(Mr> -10,000) fraction did not. The GS inactivation by the small-molecular fraction was also markedly inhibited by catalase and EDTA. These results suggested that metal-catalyzed oxidation is involved in the GS inactivation by the small-molecular fraction of CSF. Dithiothreitol(DTT) was shown to inhibit almost completely the oxidative inactivation of GS by CSF. However, DTT inhibited only partially the oxidative inactivation of GS caused by small-molecular fraction of CSF. When large-molecular fraction of CSF was separated by anion-exchange HPLC chromatogrpahy, there was a peak of antioxidant activity inhibiting the small-molecular fraction-induced GS inactivation in the presence of DTT. The antioxidant activity was neutralized by monoclonal antibodies to transthyretin. Purified transthyretin was found to efficiently inhibit ascorbate/Cu^(2+)-induced GS inactivation in the presence of DTT. Uric acid and glucose did not show any protective effect on the GS inactivation in the same condition. The above results suggest that metal-catalyzed oxidation occurs normally in human CSF, and that transthyretin may play an important role as a CSF antioxidant in protecting proteins from metal-catalyzed oxidation.