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변영남,정필훈,윤영호,김종철 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4
Angiolymphoid hyperplasia with eosinophilia(ALHE) is benign subcutaneous lesion that primarily affects head and neck region. It is characterized by single or multiple nodules in the subcutaneous tissue associated with eosinophilia in the peripheral blood. Kimura's disease, originally reported by Kimura et al., is similar lesion with ALHE in the clinical and histopathological aspects. There has been considerable controversy about the relation between Kimura's disease and ALHE. IN Korea, 26 cases of Kimura's disease and ALHE have been reported since 1975. We present a case of recurred ALHE occurring on the left cheek in a 58-year-old woman. Including this case, we summarized all cases that were reported as Kimura's disease or ALHE in Korea through literature review. We also give an outline of clinical and histopathological characteristics of cases reported in Korea.
CMI와 THI에 의한 서울시내 개인택시 사업장에 근무하는 근로자의 신체적 자각증상에 관한 연구
손종렬,변상훈,김경은,최달웅 대한위생학회 2003 대한환경위생공학회지 Vol.18 No.4
This paper investigated Taxi drivers physical subjective symptoms and what factors were interviewed caused the symptoms. The 600 owning taxi-drivers in Seoul during four months from August 1st, 2003 to November 30th, 2003. 1. The average age of the owning taxi-drivers was generally quite high 54 years old. It was very high index compared with the Todai Health Index(THI) and Cornell Medical Index(CMI) of health check tables. 2. According to the age in THI health check table, the complains of mental subjective symptom by reason of age was high among 31 to 40 years old. People who belonged that age group showed high fabrication(L), digestion(C) and aggressiveness(F). The results showed the complains of mental subjective symptom. All items except tiredness(I), melancholia(N), and hypersensitivity(P) were commonly reported by people in their sixties. On the other hand, melancholia(N) and hypersensitivity(P), people in their forties were investigated highly. Statistically, the items of heart·blood stream(C) and digestion(D) systems were similar between the two ages, but anger(Q) was diferent. (p<0.05) 3. From the complains of mental and physical subjective symptoms about work satisfaction on the THI health check table, all items except eye·skin trouble(B) showed strong dissatisfaction. From the complains of mental and physical subjective symptoms about work satisfaction on the CMI health check table, the items of respiratory system(B), digestion(D), nervous system(G), miscellaneous(K), inadequancy(M), and anger(Q) showed similar results. Otherwise, heart·blood stream(C) showed statistically different. 4. From the complains of mental and physical subjective symptoms on salary satisfaction in the THI health check table, in the case of people receiving around 1 million won, the complains of physical symptoms showed high among all items except for the respiratory(A) and digestion(C) systems. The eye·skin trouble(B) item showed statistical similarity. The complains of mental and physical subjective symptoms according to a salary degiee on the CMI health check table was completely different from the above results. In people received around 1~l.5million won, all items except anxiety(O) showed high. The hypersensitiyity(P) item showed statistically different.
Clinical usefulness of kidney biopsy in liver transplant recipients with renal impairment
( Jong Hoon Lee ),( Yul Hee Cho ),( Seung Jee Ryu ),( Sin Seung Kim ),( Youn Hee Lee ),( In Ae Jang ),( Bum Soon Choi ),( Jong Young Choi ),( Dong Goo Kim ),( Yeong Jin Choi ),( Chul Woo Yang ),( Byun 대한신장학회 2013 Kidney Research and Clinical Practice Vol.32 No.4
Background: Chronic kidney disease is a common complication after liver transplantation. In this study, we analyzed the results of kidney biopsy in liver transplantation recipients with renal impairment. Methods: Between 1999 and 2012, 544 liver transplants were performed at our hospital. We retrospectively analyzed the clinical and histological data of 10 liver transplantation recipients referred for kidney biopsy. Results: The biopsies were performed at a median of 24.5 months (range, 3-73 months) after liver transplantation. The serum creatinine level was 1.8170.5 mg/dL at the time of kidney biopsy. There were no immediate complications. The most common diagnosis was glomerulonephritis (GN), such as immunoglobulin A nephropathy (n¼4), mesangial proliferative GN (n¼1), focal proliferative GN (n¼1), and membranous GN (n¼1). Typical calcineurin inhibitor (CNI)-induced nephrotoxicity was detected in three cases (30%). Chronic tissue changes such as glomerulosclerosis, interstitial fibrosis, and tubular atrophy were present in 90%, 80%, and 80% of cases, respectively, and mesangial proliferation was detected in 40% of cases. We began treatment for renal impairment based on the result of kidney biopsy; for example, angiotensin-receptor blockers or steroids were prescribed for GN, and the CNI dosewas reduced for CNI nephrotoxicity. As a result, eight of 10 patients showed improvement in glomerular filtration rate, but two progressed to end-stage renal disease. Conclusion: Kidney biopsy is a safe and effective method for determining the cause of renal impairment after liver transplantation. Management of patients based on the result of kidney biopsy may improve renal outcomes.
Short Segment Hiatal Hernia: Is It a Clinically Significant Entity?
( Jong Jin Hyun ),( Ji Hoon Kim ),( Jong Eun Yeon ),( Jong Jae Park ),( Jae Seon Kim ),( Kwan Soo Byun ),( Young Tae Bak ) 대한소화기기능성질환·운동학회 2010 Journal of Neurogastroenterology and Motility (JNM Vol.16 No.1
Introduction: Hiatal hernia (HH) is a well-known contributory factor of gastroesophageal reflux disease (GERD). However, studies on the clinical significance of simple small HH are Lacking. We conducted a study to clarify the clinical significance of short segment HH (SSHH) in relation to GERD. Methods: 4,592 consecutive cases (male/female: 2,076/2,516, median age: 49 years) examined with diagnostic esophagogastroduodenoscopy for the first time were enrolled. During the insertion of endoscope, presence of HH was determined and the Length was measured, if present. The relationships between gender, age, presence of erosive esophagitis, and columnar-lined esophagus (CLE) and the Lengths of HH were analyzed. Results: Among 4,592 cases, HH was present in 428 cases (9.3%); SSHH was found in 255 cases (5.6%) and Long segment HH (LSHH) in 173 cases (3.8%). HH was more frequent among males and patients with LSHH tended to be older. Erosive esophagitis was observed in 4.8%, 22.0%, and 37.0% of no HH, SSHH, and LSHH group, respectively (p 0.05). CLE was observed in 14.4%, 36.5%, and 24.3% of no HH, SSHH, and LSHH group, respectively (p 0.05). Conclusions: SSHH is not a clinically silent and innocent entity, but rather a condition with a significant pathologic significance similar to LSHH in regard to GERD.(J Neurogastroenterol Motil 2010;16:35-39)
슈퍼와파린(Superwarfarin) 중독으로 진단된 원인미상의 응고장애 2례
변종규 ( Jong Kyu Byun ),맹치훈 ( Chi Hoon Maeng ),변자민 ( Ja Min Byun ),엄유진 ( Yu Jin Um ),김진숙 ( Jin Sug Kim ),이철현 ( Cheol Hyun Lee ),이태인 ( Tae In Lee ),윤휘중 ( Hwi Joong Yoon ),조경삼 ( Kyung Sam Cho ),김시영 ( Si Y 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.1
브로디파쿰은 강력한 항응고억제작용을하여 장기간 지속되는 응고장애를 유발하는 살서제로 이로 인한 중독은 비교적 흔히 보고되나 원인이 밝혀지지 않은 중독은 드물게 보고 되고 있다. 본 증례에서는 와파린이나 살서제의 복용력이 없었으나 무통성 혈뇨를 주소로 내원한 환자에서 후천성 비타민 K 의존성 혈액응고인자의 결핍을 보여 브로디파쿰 중독을 의심하였고 혈청 브로디파쿰 농도 측정 결과 이로 인한 중독에 의한 응고장애로 진단되어 비타민 k로 혈액응고 장애를 교정하고 치료하였다. 본 사례에서와 같이 임상적으로 유의한 응고장애를 보이는 환자에서 노출 병력이 명확하지 않은 경우에도 살서제 중독을 원인으로 고려하여 혈청 농도 측정을 하고 진단시 장기간의 비타민 K 투여를 통한 치료를 통하여 치료 중단으로 인한 재출혈이 없도록 주의해야 한다. superwarfarins are popular and are readily accessible, they are associated with intoxication, leading to prolonged and sometimes life-threatening coagulopathies. We report our experience managing 2 patients who had clinical evidence of superwarfarin intoxication at Kyung Hee Medical Center in Seoul, Korea. Superwarfarin exposure or poisoning is an important public health concern in South Korea, affecting those of all ages. The diagnosis of superwarfarin poisoning is usually straightforward in cases of acute poisoning, but because many cases present with obscure history of exposure, clinical suspicion is the key to early diagnosis and timely intervention. Prolonged treatment with large doses of vitamin K is needed for superwarfarin intoxication.
경추부 융합척추(block vertebra)를 동반한 경추통 환자 증례보고
변장훈(Jang-Hoon Byun),김민규(Min-Kyu Kim),신예슬(Ye-Sle Shin),박상원(Sang-Won Park),성익현(Ik-Hyun Sung),이갑수(Kap-Soo Lee),김원우(Won-Woo Kim),정재훈(Jae-Hwan Lee),이재환(Jung-Jae Hoon),안용준(Yong-Jun An),이종환(Jong-Hwan Lee) 척추신경추나의학회 2014 척추신경추나의학회지 Vol.9 No.2
Objective : To report a case of cervical block vertebra with neck pain successfully treated with conservative Korean Traditional Medicine treatment with Thoracic Chuna Manipulation. Methods : A patient diagnosed with block vertebra was treated with Thoracic Chuna manipulation, acupuncture, pharmacoacupuncture, and herbal medicine. Numeric Rating Scale(NRS) and Neck Disability Index(NDI) scores were collected before and after treatment for comparison. Results : There was a significant decrease in NRS and NDI scores. The mean NRS score decreased from 8 to 1, and NDI from 50 to 8. Conclusion : Conservative Korean Traditional Medicine treatment appears to be effective for treatment of cervical block vertebra.
( Jong Eun Yeon ),( Kyun Hwan Kim ),( Ji Hoon Kim ),( So Young Kwon ),( Gum Yong Kang ),( Joo Young Bang ),( Eugene C. Yi ),( Hyung Soon Park ),( Kwan Soo Byun ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: AFP (alpha-fetoprotein), as a commonly used serum biomarkers for HCC, often elevated in non-cancerous condition and not elevated in as many as 40% of HCC. The sensitivity and specificity of ultrasonography have been reported to be 71%, 78%, respectively. Other serum markers such as DCP, GP73 levels are known to be elevated in late stage of HCC or advanced liver disease. Aims of our study were to analyze the serum proteins in the processes of hepatocarcinogensis and to identify and validate the HCC specific potential serum biomarkers for the early detection of HCC using multiplexed proteomic techniques such as nano-LC/MS/MS and MRM (multiple reaction monitoring) in HBV infected HCC patients. Methods: Pooled sera from liver cirrhosis and HCC with normal or elevated AFP were used for analysis. Differentially expressed proteins in HCC patients were identified through the intensive protein profiling of serum proteomes using nano- LC/MS/MS and the selected multiple biomarkers were validated quantitatively and simultaneously by using triple quadruple mass spectrometer. Results: A total of 267 proteins were identified and quantified in the sera of HCC patients, of which 28 proteins and 86 proteins showed abundance changes of at least two fold elevations or reduction, respectively in the pooled sera of HCC. Through the gene ontology analysis of differentially expressed proteins in HCC patients, many of the identified proteins were categorized into the inflammatory response, wound healing, acute phase response, defense response, response to stress, localization, immune process, cellular developmental process, complement activation and so on. Selected target proteins among the differentially expressed proteins were validated with extended cases of patients`` sera by MRM method. Conclusions: With the advantage of multiplexed proteomic approach and MRM, we discovered several serum biomarker candidates associated with HCC, which could be developed as potential biomarkers for early diagnosis of HCC.
Prostatic acid phosphatase의 전립선 암에서의 역할
Hoon Young Kong(공훈영),Hak Jong Lee(이학종),Jonghoe Byun(변종회) 한국생명과학회 2011 생명과학회지 Vol.21 No.6
Prostatic acid phosphatase (PAP)는 전립선 암의 진단에 널리 사용되는 표지자로서 1935년 처음으로 동정되었고 인체 전립선에 가장 많이 존재하는 탈 인산화효소이다. PAP는 prostate epithelial cells에서 합성되는 전립선 특이적인 효소로서, 산성 환경에서 효소활성을 띠는 acid phosphatase 그룹에 속한다. PAP는 전립선액에 풍부히 존재하여 수정, 정자부족증, 만성통증의 감소에 관여한다. 그러나 가장 눈에 띄는 기능은 ERK1/2와 MAPK 경로에 관계된 HER-2와 PI3P의 탈 인산화를 유도하여 세포 성장 신호를 억제하고 전립선 암의 억제자로 작용하는 것이다. 최근 PAP DNA 백신을 이용하는 임상시험이 현재 진행 중이고, PAP를 이용한 immunotherapy를 통해 전립선 암을 치료하는 방법이 FDA의 승인을 받아 시행되고 있다. 이러한 PAP의 임상적 중요성에도 불구하고 현재까지 PAP의 분자적 조절기작에 대한 이해는 제한적이라 PAP에 대한 많은 연구가 필요한 실정이다. PAP는 NF-κB, TNF-α, IL-1 및 androgen과 androgen receptor에 의하여 promoter region이 조절된다고 알려졌다. 본 총설에서는 현재까지 밝혀진 PAP 유전자 및 단백질의 특징들과 더불어 전립선 암에서의 PAP의 기능, 발현 조절, 역할들을 종합하였다. Prostatic acid phosphatase (PAP) is one of the widely used biomarkers in the diagnosis of prostate cancer. It was initially identified in 1935 and is the most abundant phosphatase in the human prostate. PAP is a prostate-specific enzyme that is synthesized in prostate epithelial cells. It belongs to the acid phosphatase group that shows enzymatic activity in acidic conditions. PAP is abundant in prostatic fluid and is thought to have a role in fertilization and oligospermia. It also has a potential role in reducing chronic pain. But one of the most apparent functions of PAP is the dephosphorylation of macromolecules such as HER-2 and PI3P that are involved in the ERK1/2 and MAPK pathways, which in turn leads to inhibition of cell growth and tumorigenesis. Currently, clinical trials using PAP DNA vaccine are underway and FDA-approved immunotherapy using PAP is commercially available. Despite these clinically important aspects, molecular mechanisms underlying PAP regulation are not fully understood. The promoter region of PAP was reported to be regulated by NF-κB, TNF-α, IL-1, androgen and androgen receptors. Here, the features of PAP gene and protein structures together with the function, regulation and roles of PAP in prostate cancer are discussed.
Emerging Roles of Human Prostatic Acid Phosphatase
( Hoon Young Kong ),( Jong Hoe Byun ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.1
Prostate cancer is one of the most prevalent non-skin related cancers. It is the second leading cause of cancer deaths among males in most Western countries. If prostate cancer is diagnosed in its early stages, there is a higher probability that it will be completely cured. Prostatic acid phosphatase (PAP) is a non-specific phosphomonoesterase synthesized in prostate epithelial cells and its level proportionally increases with prostate cancer progression. PAP was the biochemical diagnostic mainstay for prostate cancer until the introduction of prostate-specific antigen (PSA) which improved the detection of early-stage prostate cancer and largely displaced PAP. Recently, however, there is a renewed interest in PAP because of its usefulness in prognosticating intermediate to high-risk prostate cancers and its success in the immunotherapy of prostate cancer. Although PAP is believed to be a key regulator of prostate cell growth, its exact role in normal prostate as well as detailed molecular mechanism of PAP regulation is still unclear. Here, many different aspects of PAP in prostate cancer are revisited and its emerging roles in other environment are discussed.