사상규칙과 소함수를 이용한 간호정보시스템의 스키마 사상 모듈의 설계 및 구현

김대희,전종훈 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

Data interchange module for data sharing in a distributed database system envirionment is indispensible. Especially, inconsistency problem incurred by heterogeneous schema and database management system are known to be the most difficult one. This paper proposes a schema mapping method for data interchange between nursing information system and hospital information system. The method is based on the use of rule map and mini functions and the former is for providing schema mapping information and the latter is tailored for each individual database management system. The rule map and mini function resolves mismatch problem, which in turn makes it possible to implement effective data interchange module.

정신분열증 환자의 출생과 계절과의 관계

김정기,장대식,김종길 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.3

In this study, to find out the seasonality of schizophrenic birth and to analyze the relationship between schizophrenic subgroups and their birth seasonality, we compared the monthly and seasonal birth distribution of 367 schizophrenic inpatients, admitted in the neuropsychiatric department of Maryknoll General Hospital from March 1982 to February 1987, to those of the general population as control group. And the monthly births of the subgroups classified according to the clinical subtype and course were also compared. The results of this study were as follows; 1) Comparing with the general population, the birth rates of schizophrenics were higher in November through March and the excess of birth rate during these months was 8.6%. In statistical analysis, there were significant excess of birth in January and significant deficit in June. And there were significant excess of birth in late autumn through early spring, especially in winter. The excess of winter birth rate was 4.6%. 2) In comparisions of the monthly births of each subgroups classified according to the clinical subtype and course (including 4 comparisions; paranoid type Vs. non-paranoid type, paranoid type plus schizoaffective Vs. the rest of the types, schizophrenia Vs. schizophreniform disorder, subchronic schizophrenia Vs. chronic schizophrenia), there were no statistically significant differences in any comparisions. Therefore we confirmed the seasonality of schizophrenic births that there was an excess of winter or spring births among schizophrenics but the hypothesis that seasonality of birth is associated with an increased risk for a subtype of schizophrenia was not supported.

Epidermal Growth Factor가 人體纖維芽細胞 增殖에 미치는 影響

金友濟,鄭豆泳,金良均,梁鍾大 朝鮮大學校 附設 醫學硏究所 1985 The Medical Journal of Chosun University Vol.10 No.1

The effects of epidermal growth factor(EGF) on the cell proliferation were estimated in normal human fibroblast and established adenovirus type 12-simian murine sarcoma virus 40 hybrid virus-transformed human fibroblast. In the presence of culture medium containing 1.0ng per ㎖ epidermal growth factor had more effect on the cell proliferation of transformed cell lines than normal cell lines. The data suggest that epidermal growth factor stimulates cell proliferation in additive manner of virus-transformed human fibroblast.

Hydrocortisone이 변이형 인체포피세포의 성장에 미치는 영향

김경진,양종대,정두영,고광삼 조선의대 1985 The Medical Journal of Chosun University Vol.10 No.1

Nortropinone 유도체로부터 Nortropane Spirohydantoin 유도체의 합성

정대일,박유미,박종훈,김윤영,정두희,김인식 東亞大學校 1998 東亞論叢 Vol.35 No.-

The nortropinones 11 (tropinone lla, N-isopropylnortropinone 11b, N-Carbethoxynortropinone 11c, N-furfurylnortropinone 11d, N-(p-methoxyphenyl)nortropinone 11e) were respectively synthesized by the treatment of acetonedicarboxylic acid 8 with, 2, 5-dimethoxytetrahydrofurane 9 in various amines 10 (methylamine 10a, N-isopropylamine 10b, ethylcarbamate 10c, furfurylamine 10d, p-anisidine 10e). The nortropane spirohydantoins 14 (tropane spirohydanttoin 14a, N-isopropylnortropane spirohydantoin 14b, N-Carbethoxynortropane spirohydantoin 14c, N-furfurylnortropane spirohydantion 14d, n_(p-methoxyphenyl) nortropane spirohydantoin 14e) were respectively synthesized by the treatment of synthesized nortropinones 11 (tropinone 11a 54%, N-isopropylnortropinone 11b 50%, N-Carbethoxynortropinone 11c 58%, N-furfurylnortropinone 11d 31%, N-(p-methoxyphenyl) nortropinone 11e, 70%) with potassium cyanide 12, ammonium carbonate 13.

Swanson의 주의력결핍 장애척도의 한국판 표준화

이종범,박성찬,정성덕,김진성,서완석,배대석,주열 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2

연구목적 : 한국판 Swanson의 주의력 결핍 장애 척도(이하 SNAP)의 신뢰도와 타당도를 검증하고, 이를 국내 실정에서 주의력결핍 과잉행동장애 환자를 선별할 수 있는 평가용 도구로서 적합한지 여부와 연구에 사용할 수 있는지를 알아보고자 하였다. 방 법 : 1998년 7월 1일부터 2001년 9월 30일까지 영남대학교 의료원 신경정신과 외래를 방문한 주의력결핍 과잉행동장애 환자 392명과 정상대조군 432명을 대상으로 SNAP을 시행하였다. 결 과 : 남녀 간의 SNAP 척도 점수비교에서, 환자군에서는 유의한 차이가 없었으나 정상 대조군에서는 남자가 유의하게 높게 나타났다(p<.01 ∼ .001). 검사-재검사 신뢰도 검증에서 신뢰도 계수는 각 하위 척도에서 .85에서 .92로 모두 만족할 만큼 높았다(p<.05). 내적일관성에 의한 신뢰도 검증에서 정상 및 환자군에서 각 하위척도별로 Cronbach α값이 .80(p.05)이상으로 나타났고, 반분신뢰도는 정상 및 환자군에서 각 하위척도별로 0.731에서 .866사이였다(p<.05). 주의결핍장애 평가 척도-가정관(Attention Deficit Disorder Evaluation Scale-Home Version) 및 소아기 집중력 문제 척도(Childhood Attentin Problem Scale)와의 준거 타당도는 ADHD 환자군에서 .342에서 .713사이였고(p<.05), 정상 대조군에서 .551에서 .789였다(p<.05). 요인분석을 해 본 결과 본 척도는 3개의 요인으로 분류되었는데, 부주의(inattention) 요인, 충동성/과잉행동(impulsivity/hyperactivity)요인, 또래 관계(peer interaction)요인으로 구분되었다. 본 척도가 정상인과 환자를 감별할 수 있는 척도인가를 알아보기 위한 감별 타당도 검사를 해본 결과 87.5%를 분류하여 높게 나타났다. 환자와 정상인을 구분하는 점수인 절단점은 표준편차 1.5를 절단점으로 잡을 때 이는 백분율로 93percentile에 해당하는 점수로서 각 소척도 점수에서 남자(0.98∼1.65)와 여자(0.64∼1.38)의 절단점이 다르게 나타났으며 남자가 높게 나타났다. 결 론 : 이상의 결과에서 볼 때 한국판 SNAP 평가 척도의 신뢰도와 타당도가 입증되었고 환자를 판별하는 능력이 우수하여 향후 ADHD 연구에 유용한 도구로 사료된다. Objectives : The purpose of this study was to examine reliability and validity of Swanson's attention deficit disorder sacale(SNAP). Method : SNAP was administered to 432 elementary school students and 392 patients who were diagnosed as attention deficit hyperactivity disorder in Yeungnam university hospital from 1998 July to 2001 September. Results : In the reliability test, the test-retest reliability coefficient was significantly high and that of inattention was 0.85, that of impulsivity was 0.90, that of hyperactivity was 0.90 and that of peer interaction was 0.92(p<.05). In the reliability test by internal consistency, the Cronbach α coefficient was above 0.80 at each subscale in both patients and normal control group(p<.05). The split-half reliability coefficient by first-second half method showed high correlation and those of each scales were from 0.731 to 0.866 in both patients and normal control group(p<.05). The criterion validity of SNAP with Attention Deficit Disorder Evaluation Scale-Home Version(ADDES-HA) and Childhood Attention Problem Scale(CAP) scale was from 0.342 to 0.713 in patients group, from 0.551 to 0.789 in normal control group(p<0.05). The discriminant ability between ADHD and normal subjects by SNAP was 87.5%. Conclusion : In this point of view, SNAP scale showed high reliability and validity in applying to Korean subjects and was proved to be useful screening tool for attention deficit hyperactivity disorder reserch.

구조화된 평가척도와 신경심리검사를 이용한 외상성 뇌 손상 환자의 주관적 증상 연구

이종범,김오룡,김진성,서완석,배대석 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2

본 연구에서는 외상성 뇌 손상 환자의 주관적인 증상의 특성을 알아보기 위하여 그 주관적인 증상의 정도와 관련한 인구동태학적 요인, 뇌 손상의 특성, 신경심리학적 평가결과 및 MMPI 성적을 비교한 뒤 주관적인 정신증상의 정도와 추정된 장애정도와의 일치정도에 따른 특성을 알아보고자 하였다. 1999년 3월 1일부터 2003년 8월 31까지 두부외상 후 정신과적인 증상을 나타내어 진료를 받았거나 자문이 의뢰된 경우 및 후유장애 평가를 위해 내원한 환자 498명 중 배제기준에 해당하지 않는 18세 이상 성인 281명에게 SCL-90-R, K-WAIS, K-MAS, K-BNT 및 MMPI를 실시하였다. 주관적 정신과적 증상 정도에 따른 특성을 알아보기 위해 연구대상자는 SCL-90-R의 표출증상의 문항당 평균점수를 바탕으로 주관적인 정신과적 증상이 경미한 집단(minimal distress group), 경한 집단(mild distress group), 증등도 집단(moderate distress group), 심한 집단(severe distress group)으로 구분하고, SCL-90-R을 수행하지 못한 집단을 불능집단(failed group)으로 구분하여 그 성적을 비교하였다. 그리고 SCL-90-R을 비롯한 신경심리검사 및 MMPI를 온전히 수행한 180명을 대상으로 주관적 증상의 정도와 추정된 장애 정도를 비교하여 주관적 증상의 정도와 추정된 장애정도가 일치하는 집단(no difference group), 주관적 증상의 정도에 비해 추정된 장애정도가 심한 집단(faking good group) 그리고 주관적 증상의 정도에 비해 추정된 장애정도가 약한 집단(faking bad group)으로 구분하여 성적을 비교하였다. 첫 번째, 주관적 증상의 정도에 따라 SCL-90-R의 성적을 비교한 결과에서, 주관적 증상의 정도에 따라 SCL-90-R의 하위척도 및 전체지표에서 유의한 차이(p<.001)가 있음이 확인되었다. 주관적 증상과 추정된 손상정도의 일치정도에 따른 구분에서도 각 집단 간에 하위척도 및 전체지표에서 유의한 차이(p<.001)가 있었지만 공포불안 척도의 점수가 다른 척도 점수에 비해 높은 프로파일 형태를 보이고 있었다. 두 번째, 주관적인 증상의 정도에 따라 신경심리검사 성적을 비교한 결과에서, 지능의 경우 주관적인 증상이 심할수록 사고 후 지능수준이 낮은 것으로 나타났으며, 주관적 증상을 과소평가한 집단은 차이가 없는 집단과 동일하거나 더 나은 지적능력을 유지하고 있는 것으로도 나타났다. 세 번째, 주관적인 증상정도에 따른 기억능력을 비교한 결과 주관적 증상이 심할수록 기억능력이 저하되어 있는 것으로 나타났지만, 주관적인 증상을 과소평가한 집단의 수행이 다른 집단에 비해 우수한 것으로 나타났으며, 한국판 이름대기 검사에서도 이와 동일한 수행성적을 보이고 있었다. 네 번째, MMPI에서는 주관적 증상의 정도 혹은 추정된 손상의 일치정도와는 상관없이 주관적 증상을 경미하게 호소하고 있는 집단을 제외하고는 외상성 뇌 손상 환자들이 기본적인 신경증적인 증상을 경험하고 있었으며, 주관적 증상의 정도가 심할수록 정신병적 증상들을 주로 호소하고 있었다. 본 연구에서는 외상성 뇌 손상의 주관적 증상이 심하던 그렇지 않던 혹은 추정된 손상정도의 일치여부와는 상관없이 이들이 신경증적인 증상을 공통적으로 경험하고 있음이 확인되었으며, 증상의 과대호소를 위하여 주로 정신증적 증상을 사용하고 있었다. 그리고 외상성 뇌손상이 있은 뒤 인지적 기능수준이 나을수록 자신의 정신과적 증상을 과소평가할 수 있음을 확인할 수 있었다. Objectives : To search for the character of subjective symptom among traumatic brain injury patient, we tried to investigate the level of subjective symptoms and the character of the discrepancy between subjective symptoms and suggested disability. The factors such as demographic factors, characteristics of head trauma, the score of neuropsychological test and MMPI were compared for those subjective symptoms. Methods : SCL-90-R, K-WAIS, K-MAS, K-BNT and MMPI was conducted for 281 patients who are suitable for this study with age over 18, out of 498 patients who visited hospital for their psychiatric symptoms after traumatic brain injury or disability evaluation after requesting consult from Mar 1, 1999 to Aug 31, 2003. Subjects were categorized based on the positive symptom total in SCL-90-R as four groups such as minimal distress group to observe character depending on the subjective symptoms level. Mild distress group, moderate distress group, and severe distress group and compared with failed group which couldn't perform SCL-90-R. And 180 patients of all of tests conducted, were divided to the three groups such as no difference group, faking good group, and faking bad group by comparing the level of subjective symptoms to suggested disability and assessed its results. Results : In the result of SCL-90-R depending on the subjective symptom level, there was significant difference (p<.001) in subscale and global index of SCL-90-R. There was also significant difference(p<.001) in the division depending on the discrepancy between subjective symptoms and suggested disability on subscale and global index in each group. However, the score in phobic anxiety scale was high other than subscale score. The result of neuropsychological test depending on the level of subjective symptoms represented more severe in subjective symptoms and lower in intelligence after traumatic brain injury. But, even or better intellectual capability was possessed in faking good group by comparing to no difference group. Memory ability is reduced as subjective symptoms severe and faking good group was superior in its performance. The same result was shown in K-BNT. Regardless of the level of subjective symptoms or discrepancy of the subjective symptoms between suggested disability, traumatic, brain injury patients(except the group appealed minimal distress) experienced basic neurotic symptoms and they appealed psychotic symptoms as the level of subjective symptoms is severe in MMPI. Conclusion : In this research, All the patient commonly have experienced neurotic symptom weather the symptom of traumatic brain injury patients is severe or not. Psychotic symptoms was mainly used for the faking bad of symptom and proved that they underestimated their psychiatric symptoms with better cognitive function level after traumatic brain injury.

韓牛 末梢血液 淋巴球의 在來山羊 赤血球 Rosette形成

宋憙鍾,金鍾冕,姜明大,蔡孝錫 全北大學校 附設 畜産開發硏究所 1988 畜産開發硏究報告 Vol.2 No.-

In order to enumerate the T lymphocytes in bovine peripheral blood lymphocytes(PBL) by E rosette assay, KGRBC were treated with various concentration of 2-aminoethylisothiouronium bromide hydrobromide(AET) and dextran(Dex), singte or combination. The PBL from 10 clinically normal Korean native cattle were formed as low percentage of spontaneous E rosette(6.7±2.4%) in control group, whereas KGRBC treated with 0.1M AET for 20 minutes and 8%Dex were formed as 37.3±2.7% and 45.1±2.1%, respectively. And the synergistic effects were noted no less than 66.5±5.6% when the KGRBC treated with 0.1M AET and 8% Dex subsequently. These results suggest that the KGRBC would be a useful agent for the enumeration of T tymphocytes by E rosette assay in bovine PBI.

乳房炎 乳汁에서 分離된 原因菌의 抗菌劑 感受性

崔民淳,金鍾冕,趙正坤,蔡孝錫,姜明大,宋熹鍾 全北大學校 附設 畜産開發硏究所 1987 畜産開發硏究報告 Vol.1 No.-

A total of 189 strains (Streptococcus agalactiae and non-Streptococcus agalactiae 110, Staphylococcus aureus 63, and E. coli 16) isolated from bovine mastitie milk samples by "The Connecticut Mastitis Control Program" in dairy herds were examined for drug susceptibility to 8 drugs and analysed the rate of multiple resistant patterns. 1. All of the isolates were resistant to antimicrobial agents such as penicillin (PC), streptomycin (SM), kanamycin(KM), carbenicillin (CA), lincomycin (LM), gentamicin (GM), and tetracycline (TC), singly or multiply. The isolates were more susceptible to CA (84.1%),PC (78.9%), and SM (78.4%) than the the other drugs such as GM (51.8%), KM (48.7%), TC (19.6%) and LM (19.0%) in order. 2. The multiple resistant isolates (96.3%) were more than those of singly resistant isolates (3.7%) and 58 different drug resistant patterns were observed. Among 7 singly resistant isolates, CP was the commonest. While among 182 multiple resistant isolates, CP-KM-LM-TC-GM, CP-LM-TC, CP-LM-TC-GM, PC-CP-SM-LM-TC-GM, CP-KM-LM-TC, and CP-LM patterns were frequently encounted. 3. The strains of streptococcus spp. were more susceptible to CA (90.1%) and SM (82.9%) than the other drugs such as KM (43.2%), GM (38.7%), LM (13.5%), CP (10.8%) and TC (10.8%). Among them CP-KM-LM-TC-CM pattern was frequently encounted. 4. The strains of Sta. aureus were more susceptible to PC (74.6%),CA (69.8%), SM (65.1%) and GM (63.5%) than the other drugs such as KM (46.0%), CP (22.2%), TC (15.9%) and LM (9.5%). Among them CP-LM-TC pattern was commonly encounted. 5. The strains of E. coli were more susceptible to CA (100%) and KM (75.0%) tnan TC (9.5%). But the other drugs such as PC, SM, GM, CP and LM were not. Among them PC-CP-SM-LM-TC-GM pattern was commonly encounted.

알쯔하이머형 치매환자 뇌파의 시공간적 패턴분석 : Karhunen-Loeve 방법을 통한 뇌파분석의 임상적용을 위한 예비연구

고효진,김형래,김대진,김수용,박성종 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 뇌파의 시공간적 패턴분석(spatio-temporal pattern analysis)방법을 이용하여 알쯔하이머형 치매의 진단 특히 초기 치매환자의 진단에 대한 예비연구를 하고자 하였다. 방법: 알쯔하이머형 치매환자 10명과 정상대조군 10명을 대상으로 하여 Karhunen-Loeve 분해법을 이용한 시공간적 패턴분석을 통하여 비교하였다. 결과: 첫째, 세가지 주요패턴 중 가장 많은 빈도를 보인 으뜸패턴에서 알쯔하이머형 치매환자는 좌우측 비대 칭성이 정상대조군에 비해 뚜렷해지는 형태를 보였다. 둘째, 으뜸패턴을 비교하여 뇌의 각 부분에 대한 차이를 보았을 때 알쯔하이머형 치매환자는 대조군에 비해 주로 좌측 두정부와 측두엽 부위에서 고유값의 유의한 차이가 있었다. 셋째, 으뜸패턴 전개계수의 Fourier amplitued spectrum 분석을 통하여 알쯔하이머형 치매환자 10명중 6명에서 상당히 큰 진폭의 상승부분을 관찰할 수 있었으며 정상대조군에서는 이러한 진폭의 이상소견이 관찰되지 않았다. 결론: 본 연구의 결과는 알쯔하이머형 치매으 병태생리적 위치가 좌측 측두-두정엽에 있음을 시사하였으며 앞으로 시공간적 패턴분석 방법이 알쯔하이머형 치매환자의 진단에 유용하게 사용될 수 있도록 추후연구가 필요할 것으로 생각하였다. Objectives: We introduce a novel analysis method of spatio-temporal pattern analysis of EEG. Using it, we presents a results discriminating severe Alzheimer's disease patients from normal subjects. Methods: To the groups of 10 Alzheimer's disease patients and 10 normal aged subjects, we applied the Karhunen-Loeve decomposition method and observed their principal patterns and time-varying dynamics. Results: First, there was a first primaty pattern of the eigenvector in Alzheimer's disease patients that showed opposite polarities at the left and the right hemispheric regions. Second, the Alzheimer's disease patients had significantly different average values of the eigenvector at the left parieto-temporal area than the normal controls did. Third, some Alzheimer's disease patients had one, coherent frequency component in the Fourier amplitude spectrum of the first pattern expansion coefficient. Conclusions: Our results suggest that the pathophysiologic site of Alzheimer's dementia may be left temporo-parietal area in brain and further studies need to evaluate whether the spatio-temoral pattern analysis could be used to diagnose Alzheimer's dementia patients.