흰쥐에서 Paraquat 독성에 미치는 Seleniun의 영향

차종희,정미숙,천영욱 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.1

색시톡신에 의한 마비독성 패류 중독 2예

최상천,박종석,정윤석 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Paralytic shellfish poisoning results from consumption of mollusks that have fed on dinoflagellates capable of producing neurotoxins such as saxitoxin. The saxitoxin is concentrated in the shellfish and acts by decreasing sodium-channel permeability, thereby blocking neuronal transmission in skeletal muscles. Symptoms including paresthesia, perioral numbness, perioral tingling, nausea, vomiting, extremity numbness, extremity tingling, dizziness, ataxia, dysphagia, and weakness have been reported. In serious cases, respiratory hold may occur up to 6∼24 hours after ingestion. Generally, the treatment for paralytic shellfish poisoning is supportive care, but mechanical ventilation is needed in serious cases acompanied by respiratory hold. We experienced two cases of paralytic shellfish poisoning. Respiratory hold was presented in one case and only mild paresthesia in the other case. After supportive management, including mechanical ventilation in former case, both patients were discharged without sequalae.

흰쥐에서 Paraquat 독성에 미치는 Selenium의 영향

차종희,정미숙,천영욱 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

In order to investigate effects of selenium on paraquat-induced toxicities. we measured the enzymes involved in the glutathione metabolism, which Includes glutathione s-transferase, r-glutamylcysteine syntheatse and r-glutamyltranspeptidase, and the contents of glutathione in the paraquat-treated and paraquat plus seleniun-treated groups, respectively. 1. The survival rate was great)y diminished in paraquat plus selenium-treated group compared with paraquat-treated group. 2. The content of 81utathione in paraquat plus selenium-treated group was also reduced to 17.5% and 31.7% in liver and kidney, respectively as compared to the corresponding control values. 3 The activity of r-glutamylcysteine synthetase in paraquat-plus selenium group was significantly increased in liver but not affected in the kidney. 4. The activities of glutathione s-transferase in liver and kidney were not affected in both groups. 5. The activity of r-glutamyl transpeptidase in kidney in was increased to 54% in the paraquat plus selenium groups as compared to that of the control group. These results taken together suggest that the coadministration of selenium and paraqua enhances paraquat-induced toxicities, which appear to be associated with the decreased level of glutathione in liver and kidney.

노령의 대퇴 전자간 골절 치료에서 압박고 나사못의 안정성 및 유용성

김종오,노권재,윤여헌,고영도,유재두,정준모,방한천,정재학 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 노령의 대퇴 전자간 골절에서 압박고 나사못의 안정성에 영향을 주는 인자들간의 상관 관계와 골절 양상에 따른 술후 고관절 기능을 평가 및 분석하였다. 대상 및 방법: 압박고 나사를 이용하여 수술적 치료를 시행한 231명의 환자 중 6개월 이상 추시가 가능하였던 60세 이상 84명의 환자들을 대상으로 했다. 방사선적 계측은 압박고 나사못의 활강 길이 및 내반각, 가압 나사 위치, 정복 상태, 원위 골편의 내측 전위를 측정하였으며 술후 기능은 Clawson의 기능 평가표로 하였고 골절 양상에 따라 방사선 계측과 기능 회복과의 상관 관계를 평가하였다. 결 과: 임상 결과는 불안정 골절에서 양호가 10례, 불량이 23례, 안정 골절에서는 양호 40례, 불량이 11례로 안정 골절에서 임상 결과가 좋았고(p<0.001), 압박고 나사 활강은 10 ㎜ 이상일 때 양호가 4례, 불량이 21례, 10 ㎜ 이하에서 양호가 46례, 불량이 13례로 10 ㎜ 이상 활강시에 술후 결과가 불량했다(p<0.001). 다르 방사선적 계측 요인은 결과에 의미있는 차이를 보이지 않았다. 또한, 불안정 골절 중에서 전위 양상 골절의 경우 10㎜ 이상 활강이 12례, 10㎜ 이하 활강이 8례, 분쇄 양상 골절의 경우는 10㎜ 이상이 11례, 10㎜ 이하가 2례로 분쇄 양상의 불안정 골절에서 10㎜ 이상 활강이 의미있게 많았다 (p<0.001). 결 론: 10㎜ 이상의 지연 나사 활강은 고관절 기능 회복 약화를 유발시킬 수 있으며 불안정 골절 분쇄 양상 골절은 이런 지연 나사의 활강이 과도하게 유발될 수 있으므로 불안정 분쇄 양상 골절에서 압박고 나사의 단독 사용은 재고해 보아야 할 것이다. Purpose: To evaluate the relationship between fracture stability and functional results, and analyze the correlation between stability factors and the outcome in intertrochanteric fracture of the elderly. Materials and Methods: Of the 231 patients, 84 patients with age above 60 were able to follow up for minimum 6 months. We measured the sliding length of the lag screw, varus degree, position of lag screw, reduction status and medialization of distal fragment radiologically. The functional outcome of the treatment was evaluated with the Clawson's result classification and we evaluated the correlation between the radiological results of measurement and the functional recovery depending on the Evans fracture classification. Results: There were good results in 40 cases out of 51 stable fractures, and in 10 cases out of 33 unstable fractures (p<0.001). In case of sliding of lag screw more than 10㎜, good results were obtained in 4 cases, and poor in 21. And in case of sliding less than 10㎜, good results were obtained in 46, and poor in 13. (p<0.001).But there was no relationship between other radiologic factors and clinical results. In unstable type, there were 12 cases with lag screw sliding more than 10㎜ and 10 cases with less than 10㎜. In comminuted type, there were 11 cases with lag screw sliding more than 10㎜ and 2 cases with less than 10㎜(p<0.001). Conclusion: The sliding of lag screw more than 10㎜ may result in poor outcome. As in comminuted unstable pattern, sliding of lag screw might be excessive, the use of compression hip screw alone is not good treatment option.

한국인 인슐린비의존형 당뇨병환자에서 엔지오텐신 1-전환효소 유전자의 다형성과 당뇨병성 만성합병증 및 관상동맥질환과의 관계

정민영,천남일,이창훈,조동혁,강호철,정동진,정명호,강정채,박종태,양승원 全南大醫大 2001 전남의대학술지 Vol.37 No.3

中風의 治法 중 潛陽法에 대한 문헌고찰

閔健祐,朴鍾赫,鄭智天 동국대학교 한의학연구소 2000 東國韓醫學硏究所論文集 Vol.9 No.-

潛陽法은 平肝治法의 일종으로 刊陽이 上亢해서 나타나는 頭目昏暈, 수족추휵, 구안괘사, 舌乾語澁, 頭痛不止, 猝然倒地 등의 症狀에 쓰는 治法이며 中風의 標實證을 다스리는 목적으로 多用되고 있다. 中風에서의 活用은 淸代에 이르러 본격화되었는데, 葉天士는 "자액식풍, 濡養營絡, 補陰潛陽"을 사용하였고, 張伯龍은 "潛鎭攝納" 하는 치료법을 사용하였다. 中風의 病理가 本虛標實하므로 항상 滋陰, 補水하는 治法과 相互補完的으로 사용되고 있다. 潛陽法이 多用된 병증은 刊胃陰虛, 風陽上擾로 인한 中經絡證과 中腑證 중에서 陽閉證이며, 脫證의 일부와 中風日久로 因한 癲癎에도 사용 되었다. 潛陽藥 중 珍珠母, 石決明, 玳瑁, 牡蠣, 見齒, 龜板, 鱉甲 등 介類의 효력이 뛰어나고, 治方으로는 鎭肝??風陽, 虎潛丸, 固本丹, 復脈湯, 天麻鉤藤飮, 羚羊角湯 등이 활용되고 있다. The methods of checking the exuberance of yang (潛陽法) are a kind of medical treatments Lvhich cure various symtoms caused by hyperactivity of liver-yang, at the same time used for treating apoplexy. Thus, I investigated the application of checking the exuberance of yang to treat stroke. The conclusions are as follows. We can find application of checking the exuberance of yang to apoplexy on Synopsis of the Gold Chamber. After Ye Gui who persisted the theory of endogenous wind, many physicians applied the method of checking the exuberance of yang and this method has usually applied with nourishing yin. The methods of checking the exuberance of yang are concretely applied as follows. 1) a portion of apoplexy involving the channels and collaterals, which is caused by deficiency of \-in and wind-fire pathogen. 2) excessive-syndrome of coma accompanied by heat syndrome. 3) epilepsy caused old apoplexy. The majority of shells for example abalone shell, hawksbill shell, oyster shell, tortoise-shell etc. are the most frequent use of herbal drug which check the exuberance of yang. The precriptions of checking the exuberance of yang are Ho-jam-hwan(虎潛丸), Ko-bon-dan(固本丹), Cheon-ma-gu-deung-eum(天麻鉤藤飮), Chin-gan-sik-pung-tang(鎭肝湜風湯) etc.

음식물쓰레기 관리의 최적화 방안 연구 : 창원, 마산, 진해시를 중심으로 Focused on Changwon, Masan, Jinhae City

이명희,박증석,김종오,백병천 國立 麗水大學校 環境問題硏究所 1998 環境硏究論文集 Vol.1 No.-

Limited landfill area and finance as well as a huge generation of waste, have called for systematic approaches towards potential cost savings. In this study, the management system of food wastes generated from the residential and commercial sources was considered in three citied; Changwon, Masan, and Jinhae city. Total thirteen alternatives were established and compared by applying the WRAP (Waste Resource Allocation Program). The following results were obtained: 1. While relatively small amounts were generated form the commercial sources such as cafeteria, restaurants, and market facilities, almost 80% of food wastes were generated from the residential sources. 2. Unit costs for food waste management in three cities were different according to their present situation, and the highest cost appeared in Jinhae city due to the most expensive construction of coastal landfill site. 3. Considering proper revenue, the whole conversion of food waste into animal feed was selected as the optimal alternative and represented 60% to 74% of management cost of the whole landfill alternative in all cities. Comparing the other alternatives, composting of food waste was more economical than the landfill alternative and the incineration was the most expensive alternative.

위암 환자에서 절제된 림프절 수의 차이와 관련이 있는 인자

정귀애,박정희,변익건,김경종,장정환,김권천,민영돈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Purpose: By the definition of UICC TNM classification (fifth edition), the nodal stage of gastric cancer is based on the number of metastatic lymph nodes, which is influenced by the number of resected lymph nodes. And individual differences in the number of resected lymph nodes had been observed in patients with gastric cancer. The aim of this study is to verify the factors which are associated with the difference in the number of resected lymph nodes in patients with gastric cancer. Methods: We reviewed 613 patients with gastric cancer who underwent curative resection and D2 lymph node dissection with 15 or more resected lymph nodes. The number of resected lymph nodes was analyzed according to the characteristics of patients, the types of operation and prognostic factors of gastric cancer. Results: The mean number of resected lymph nodes per patient was 33.0 (median: 31.0, range: 15-88). The number of resected lymph nodes was significantly associated with the types of operation, the location and size of tumor, macroscopic types, depth of tumor invasion and the number of metastatic lymph nodes. Patient's age, gender and the histopathological finding's had no relationship with the number of resected lymph nodes. Conclusions: The number of resected lymph nodes from gastric cancer was different in each patient despite of same D2 lymph node dissection and it was associated with several prognostic factors of gastric cancer.

수축저감제와 혼화재를 병용한 콘크리트의 공학적 특성

金光華,김종,한민철,정평유,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The objective of this paper is to investigate the physical and mechanical properties of concrete incorporating shrinkage reducing admixture(SRA) and mineral admixture(MA) such as fly ash and blast furnace slag powder. According to results, for fresh concrete properties, increase of SRA content leaded to reduce the fluidity and air content sharply. For setting time, use of SRA caused concrete to accelerate setting time, and compared with plain concrete it retarded by incorporating MA. Compressive strength decreased with an increase in SRA content, and when incorporating MA, compared with plain concrete, it shows lower compressive strength in early age but similar or increase by the elapse of age due to the pozzolanic and latent hydration reaction. For drying shrinkage, concrete shows decline tendency with an increase in SRA content due to the relaxation effect at the capillary tension in concrete by SRA. In the scope of this paper, it is found that the use of SRA with 1.0% has optimum effects on the various properties of concrete, and the combinations of SRA and fly ash will ensure the stability for drying shrinkage.

두가지 혈류 유발방법에 의한 새로운 심폐소생술(이중 혈류 유발 심폐소생술)장치의 개발

황성오,김현,조준휘,오범진,임종천,최경훈,윤정한,이승환,김영식,이강현,이윤선 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: There have been many efforts to augment blood flow during cardiopulmonary resuscitation. These efforts have focused on maximizing the effect of cardiac pump or thoracic pump alone. However, considering that the heart is the biggest blood reservoir and increase of intrathoracic pressure can generate blood flow, simultaneous exploitation of both mechanisms may have synergistic effect. We hypothesized that simultaneous chest constriction in addition to sternal compression by standard CPR may have additive hemodynamic effects by preventing deformation of the chest and increase of intrathoracic pressure. Methods and results: we built a new mechanical device to perform compression and thoracic constriction simultaneously. The device consists of two main elements. Piston in the center is to depress the sternum. Strap is to constrict the thorax circumferentially. Strap is attached to both sides of the piston. When the piston is pushed down, it depresses the sternum and pulls on the thoracic strap. To determine strap width to produce optimal hemodynamic effect, we measured hemodynamic parameters with variable widths of strap in two dogs after induction of ventricular fibrillation. Result of the experiment showed that 10cm wide strap was determined to be most effective. We also determined optimal depth of compression to produce maximal hemodynamic effect with animal experiments using two dogs. Animal experiments showed that the highest aortic pressure could be generated when the stemum was depressed to 5 cm. Cardiopulmonary resusciation using a new device could generate higher systolic aortic pressure, coronary perfusion pressure and end-tidal carbon dioxide tension in comparison with standard cardiopulmonary resuscitation in a pilot animal study using two dogs. Conclusion: New cardiopulmonary resuscitation method using a mechanical device designed by us could perform sternal compression and simultaneous thoracic constriction, and generate better hemodynamic effects than standard cardiopulmonary resuscitation in pilot animal experiments.