안면마비 환자의 표면근전도와 신경전도검사에서 안면근육활동성의 상관관계

( Nam Joon Yang ),( Jin Ah Yeo ),( Jinmann Chon ) 대한임상병리사협회 2013 임상생리검사학회 발표자료집 Vol.2013 No.-

배경(Background): For the diagnosis of facial palsy, the needle Electromyography(nEMG), blink reflex, and motor nerve conduction study(NCS) have been gold standard. But, they are invasive and uncomfortable techniques. For these reasons, we investigated the possible role of surface electromyography(sEMG) in the study of facial palsy. sEMG is a noninvasive technique whereby surface electrodes are placed on the skin to measure the activity of the underlying muscle. The aim of this study is to assess correlation between the root mean square(RMS) values of sEMG and electrodiagnostic severity according to the amplitude of compound muscle action potential(CMAP) in patients with facial nerve palsy. 방법(Methods): Forty-three patients with unilateral facial palsy confirmed by conventional electrodiagnostic studies were enrolled. sEMG signals were recorded from bilaterally facial muscle (including Frontalis, Obicularis oris, Nasalis, Orbicularis oris muscle) using small surface electrode(silver, 10mm diameter) while performing each facial muscle contraction. During maximal voluntary contractions, to characterize the sEMG amplitude, peak RMS values were obtained from the non-smoothed sEMG periodograms. Then we calculated the ratio of decreased RMS values of sEMG compared to unuffected side (RsEMG) and ratio of decreased CMAP amplitude compared to unuffected side(RCMAP). 결과(Results): Total 43 patients consisting of House-Brackmann Grade Ⅱ:22, Ⅲ:12, Ⅳ:8 ⅴ:1 were enrolled with a mean age of 48.7±14.5 years. Pearson’s correlation coefficient between the RsEMG and the RCMAP was 0.773 at Frontalis, 0.771 at Orbicularis oculi, 0.772 at Nasalis, and 0.724 at Orbicularis oris. RsEMG showed increasing trend across increasing RCMAP. 고찰(Discussion): This study demonstrated significant correlation between facial muscle activities on sEMG and conventional EMG in patients with facial palsy. Therefore, the functional deficitis in facial muscle activation in patients suffering from facial palsy may also be characterized by means of sEMG as comfortable diagnostic tool. We supposed that sEMG could be used to additional , less painful and less time consuming diagnostic tool of the facial palsy.

Efficacy of Ultrasonography Guided Stellate Ganglion Blockade in the Stroke Patients with Complex Regional Pain Syndrome

유승돈,Sang Soo Jung,김희상,윤동환,김동환,Jinmann Chon,Dong Whan Hong 대한재활의학회 2012 Annals of Rehabilitation Medicine Vol.36 No.5

Objective To compare the efficacy of ultrasonography guided stellate ganglion block (US-SGB) with that of blind SGB in management of the stroke patients with complex regional pain syndrome (CRPS) type 1.Method Forty-two patients with post-stroke CRPS were randomly assigned to either US-guided SGB (22 patients) or blind SGB group (20 patients). The mean age of US-guided SGB and blind SGB groups was 61.3±5.6 years and 59.1±4.5 years. We performed two blockades at 7-day intervals on the affected side of patients with CRPS. Pain intensity, using a visual analog score (VAS), score of CRPS clinical severity, and the amounts of affected hand swelling with a hand volumeter were assessed before, 2 weeks and 4 weeks after treatment. Results In both groups, VAS and the amount of hand swelling were significantly decreased after 2 weeks and after 4 weeks. Between two groups, VAS difference of US-guided SGB group and that of blind SGB group were 2.61±1.09, 1.88±0.62 at 2 weeks and 3.67±1.03, 3.13±0.62 at 4 weeks, respectively. US-guided SGB group showed more significant improvement in mean change of VAS compared to the blind SGB group (p-value<0.05). Conclusion Both US-guided SGB and blind SGB techniques were effective in relieving pain in subacute stroke patients with CRPS. US-guided SGB was better in pain relief but has no advantages in reduction of hand swelling in this study.

Changes in collagen fibril pattern and adhesion force with collagenase-induced injury in rat Achilles tendon observed via AFM.

Lee, Gi-Ja,Choi, Samjin,Chon, Jinmann,Yoo, Seungdon,Cho, Ilsung,Park, Hun-Kuk American Scientific Publishers 2011 Journal of nanoscience and nanotechnology Vol.11 No.1

<P>The Achilles tendon consists mainly of type I collagen fibers that contain collagen fibrils. When the Achilles tendon is injured, it is inflamed. The collagenase-induced model has been widely used to study tendinitis. The major advantages of atomic force microscopy (AFM) over conventional optical and electron microscopy for bio-imaging include its non-requirement of a special coating and vacuum, and its capability to perform imaging in all environments. AFM force-distance measurements have become a fundamental tool in the fields of surface chemistry, biochemistry and materials science. Therefore, the changes in the ultrastructure and adhesion force of the collagen fibrils on the Achilles tendons of rats with Achilles tendinitis were observed using AFM. The changes in the structure of the Achilles tendons were evaluated based on the diameter and D-banding of the collagen fibrils. Collagenase-induced Achilles tendinitis was induced with the injection of 30 microl crude collagenase into 7-week-old male Sprague-Dawley rats. The animals were each sacrificed on the first, second, third, fifth and seventh day after the collagenase injection. The normal and injured Achilles tendons were fixed in 4% buffered formalin and dehydrated with increasing concentrations of ethanol. AFM was performed using the non-contact mode at the resolution of 512 x 512 pixels, with a scan speed of 0.8 line/sec. The adhesion force was measured via the force-distance curve that resulted from the interactions between the AFM tip and the collagen fibril sample using the contact mode. The diameter of the collagen fibrils in the Achilles tendons significantly decreased (p < 0.05) after the collagenase injection, and the pattern of the D-banding of the collagen fibrils was similar to that of the diameter changes. The adhesion force decreased until the fifth day after the collagenase injection, but increased on the seventh day after the collagenase injection (p < 0.0001).</P>

Introduction of Fall Risk Assessment (FRA) System and Cross-Sectional Validation Among Community-Dwelling Older Adults

Woo-Chul Park,Miji Kim,Sunyoung Kim,Jinho Yoo,Byung Sung Kim,Jinmann Chon,Su Jin Jeong,Chang Won Won 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.1

Objective To predict the risk of falls, Fall Risk Assessment (FRA) system has been newly developed to measure multi-systemic balance control among community-dwelling older adults. The aim of this study was to examine the association between FRA and fall-related physical performance tests. Methods A total of 289 community-dwelling adults aged 65 years and older participated in this cross-sectional study. All participants underwent FRA test and physical performance tests such as Short Physical Performance Battery (SPPB), Berg Balance Scale (BBS), and Timed Up and Go Test (TUG). Results Participants who were younger, male, highly educated, living with family members, having high body mass index, having high appendicular lean mass index, and having no irritative lower urinary tract syndrome were more likely to have higher FRA scores. SPPB (β=1.012), BBS (β=0.481), and TUG (β=-0.831) were significantly associated with FRA score after adjusting for the variables (all p<0.001). Conclusion FRA composite score was closely correlated with SPPB, BBS, and TUG, suggesting that FRA is a promising candidate as a screening tool to predict falls among community-dwelling elderly people.

Association of Toll-like receptor 2 polymorphisms with National Institute of Health Stroke Scale scores of ischemic stroke patients.

Park, Hae Jeong,Kim, Su Kang,Yun, Dong Hwan,Kim, Dong Hwan,Chon, Jinmann,Kim, Jong Woo,Chung, Joo-Ho Birkhäuser Boston 2012 Journal of molecular neuroscience Vol.46 No.3

<P>Toll-like receptor 2 (TLR2) has been shown to have an important role in the postischemic inflammatory response and to contribute to ischemic brain damage. In this study, we investigated whether coding region single nucleotide polymorphisms (SNPs) of the TLR2 gene were associated with ischemic stroke (IS) and with clinical phenotypes in IS patients. We genotyped two SNPs (rs3804099 [Asn199Asn] and rs3804100 [Ser450Ser]) using direct sequencing in 202 IS patients and 291 control subjects. No SNPs of the TLR2 gene were found to be associated with IS. However, in analysis of clinical phenotypes, we found that rs3804099 was associated with the National Institute of Health Stroke Scale (NIHSS) scores of IS patients in codominant (TC vs. TT, p?=?0.0005; CC vs. TT, p?=?0.0007) and dominant models (TC/CC vs. TT, p?=?0.0001). Also, rs3804100 revealed significant association in codominant (TC vs. TT, p?=?0.0002; CC vs. TT, p?=?0.008) and dominant models (TC/CC vs. TT, p?<?0.0001). In allele frequency analysis, we also found that the C alleles of rs3804099 and rs3804100 were associated with higher NIHSS scores (p?=?0.0003 in rs3804099; p?=?0.0001 in rs3804100). Our results suggest that TLR2 may be related to severe IS.</P>

The Shoulder Gradient in Patients with Unilateral Shoulder Impingement Syndrome

김희상,Dae Gyu Hwang,Jong Ha Lee,윤동환,Jee-Sang Yun,Yong Won Shin,Jinmann Chon 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.5

Objective To investigate the relationship between the shoulder gradient and acromiohumeral interval of both shoulders in patients with unilateral shoulder impingement syndrome. Method Using the angulometer, we measured the shoulder gradient in patients with unilateral shoulder impingement syndrome in a standing position. Using the radiography, we measured the acromiohumeral interval and the angle between a vertical line and a line connecting a superior angle with an inferior angle of the scapula. Results In patients with unilateral shoulder impingement syndrome, the frequency of shoulder impingement syndrome was 76.2% (16 of 21) on the side of the relatively lower shoulder. The mean acromiohumeral interval on the side of the lower shoulder was 10.03±1.28 mm, compared with 10.46±1.50 mm for the higher shoulder. Th e angle between a vertical line and a line connecting a superior angle with an inferior angle of the scapular of the side of the lower shoulder was -0.31±3.73 degrees, compared with 3.85±4.42 degrees for the higher shoulder. Conclusion The frequency of shoulder impingement syndrome was significantly higher on the side of the relatively lower shoulder, and there is no signifi cant diff erence in the acromiohumeral interval between the side of the lower shoulder and that of the higher shoulder. In patients with unilateral shoulder impingement syndrome,the scapular on the side of lower shoulder was more rotated downward than on the side of the higher shoulder.

압력센서가 내장된 보행 분석기를 통한 아치 형성 보행의 생역학적 변수의 특성

이배열 ( Bae Youl Lee ),유승돈 ( Seung Don Yoo ),이승아 ( Seung Ah Lee ),전진만 ( Jinmann Chon ),김동환 ( Dong Hwan Kim ),정용설 ( Yong Seol Jeong ),노성규 ( Seong Gyu Noh ),이미애 ( Mi Ae Lee ),이우진 ( Woo Jin Lee ),김은혜 ( Eun 대한스포츠의학회 2016 대한스포츠의학회지 Vol.34 No.1

The objective of study was to compare biomechanical parameters between normal and arch building gait in healthy subjects. A total of 40 feet from 20 healthy adults were evaluated in this study. The participants were asked to walk on a treadmill comfortably at 2 km/hr for 30 seconds. Then, they were asked to walk after making arch building through raising arches with their feet by pulling the big toe toward the heel. Gait parameters such as geometry, center of pressure, maximum force, and maximum pressure were measured in normal and the arch building gait using a gait analysis system equipped with pressure sensor. Arch building gait demonstrated significantly (p<0.01) decreased forefoot maximum force but significantly (p=0.024) increased heel maximum force compared to normal gait. Maximum pressures of the midfoot and heel were also significantly (both p<0.01) increased. However, the maximum pressures of the forefoot were not significantly (p>0.05) different between the two conditions. Geometry, phase, and time parameters were not significantly (p>0.05) different between the two conditions, either. Although forefoot and midfoot maximum force were significantly decreased in arch building gait compared to those in normal gait, the maximum pressure of forefoot was not significantly changed, indicating decreased area of forefoot contact during arch building gait. The arch building gait moves the center of presser to the hind foot and redistributes the contact area, thus changing the distribution of maximum pressure.

The role of lactose carrier on the powder behavior and aerodynamic performance of bosentan microparticles for dry powder inhalation

Lee, Hyo-Jung,Lee, Hong-Goo,Kwon, Yong-Bin,Kim, Ju-Young,Rhee, Yun-Seok,Chon, Jinmann,Park, Eun-Soek,Kim, Dong-Wook,Park, Chun-Woong Elsevier 2018 European journal of pharmaceutical sciences Vol.117 No.-

<P><B>Abstract</B></P> <P>In this study, we prepared carrier-based formulations for dry powder inhalers by mixing bosentan microparticles with carrier, prepared in three separate types of lactose. Spray-dried, milled and sieved lactose resulted in formulations with various shapes, surface morphology and particle size distributions. In the spray-dried lactose, the micronized bosentan particles were trapped and strongly interlocked in the rugged surface of spray-dried lactose, whereas in the milled and sieved lactose they exhibited lower binding affinity onto the smooth surface of carrier. In all of the carrier-based formulations, the flow properties were improved compared with bosentan microparticles alone, in the following order spray-dried, sieved and milled lactose. The aerodynamic characteristics of each were evaluated by particle image velocimetry and Andersen cascade impactor™. Depending on the lactose carrier type, particle dispersion showed different flow characteristics. In the spray-dried lactose, the formulation was dispersed fast in the only frontal direction, while the milled and sieved lactose formulations formed a relatively slower S-shaped and fountain-shaped flow stream, respectively. In addition, milled and sieved lactose formulations showed that the drug particles were readily liberated from the lactose carrier, and demonstrated significantly higher aerosol performance than spray-dried lactose.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Spiral mouthpiece design in a dry powder inhaler to improve aerosolization

Lee, Hyo-Jung,Kwon, In-Ho,Lee, Hong-Goo,Kwon, Yong-Bin,Woo, Hye-Min,Cho, Sang-Min,Choi, Youn-Woong,Chon, Jinmann,Kim, Kibum,Kim, Dong-Wook,Park, Chun-Woong Elsevier 2018 International journal of pharmaceutics Vol.553 No.1

<P><B>Abstract</B></P> <P>This study presents the effect of a spiral mouthpiece design in a carrier-based dry powder inhalation on particle aerosol characteristics. Two kinds of mouthpieces, with spiral and non-spiral shaped flow channels, were fabricated by 3D-printing; particle image velocimetry and Anderson cascade impactor were performed to evaluate the drug aerosol characteristics. The obtained experimental results were in agreement with the simulation results of the computational fluid dynamics analysis. The spiral channel created a strong swirl motion of the air flow emitted from the mouthpiece exit, which produced angular momentum rather than the axial flow velocity in the forward direction. This is beneficial in terms of liberating the micronized drug particles from the carrier surface, and leads to more effective delivery of these drug particles to the peripheral target regions of the respiratory system. The spiral device could produce drug particles with significantly smaller mass median aerodynamic diameters and higher fine particle fraction than the non-spiral device.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>