Flaw Detection in LCD Manufacturing Using GAN-based Data Augmentation

( Jingyi Li ),( Yan Li ),( Zuyu Zhang ),( Byeongseok Shin ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2

Defect detection during liquid crystal display (LCD) manufacturing has always been a critical challenge. This study aims to address this issue by proposing a data augmentation method based on generative adversarial networks (GAN) to improve defect identification accuracy in LCD production. By leveraging synthetically generated image data from GAN, we effectively augment the original dataset to make it more representative and diverse. This data augmentation strategy enhances the model's generalization capability and robustness on real-world data. Compared to traditional data augmentation techniques, the synthetic data from GAN are more realistic, diverse and broadly distributed. Experimental results demonstrate that training models with GAN-generated data combined with the original dataset significantly improves the detection accuracy of critical defects in LCD manufacturing, compared to using the original dataset alone. This study provides an effective data augmentation approach for intelligent quality control in LCD production.

Removal and fate of carbamazepine in the microbial fuel cell coupled constructed wetland system

Jingyi Xie,Haixiao Li,Shiyu Wang,Hao Chen,Wei Jiang,Lin Zhang,Lianjie Wang,Yufeng Wu,Lirong Li,Xueqiang Lu 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.3

Carbamazepine (CBZ), which is difficult to remove in the wastewater treatment system and easily forms toxic transformation products during the treatment process, is one of the priority pollutants of pharmaceuticals and personal care products (PPCPs). Increasing attention has been paid to explore their treatment technology without side effects from the treatment products. This study aims to reveal the removal and transformation of CBZ in the microbial fuel cell coupled constructed wetland (CW-MFC) system. The CW-MFC system was operated continuously at room temperature for nearly 80 days. The results show that CW-MFC system can effectively remove CBZ with an average removal rate of 97%. Three transformation products were identified by liquid chromatography−high-resolution mass spectrometry: 2-(2-oxoquinazolin-1(2H)-yl) benzoic acid (TP267), methyl 2-(2-oxoquinazolin-1(2H)-yl) benzoate (TP281), 2-(2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl) benzoic acid (TP283). Except TP281 in the influent, the other transformation products were formed in the system, which indicated that TP267 and TP283 were the main transformation products of CBZ. The formation pathway of transformation products could be explained by reactions including oxidation, hydrolysis, bond rupture and intramolecular reaction. The results also indicate that the CW-MFC system might be a promising technology for PPCPs treatment.

Updated Bayesian Network Meta-Analysis of Adjuvant Targeted Treatment Regimens for Early Human Epidermal Growth Factor Receptor-2 Positive Breast Cancer

Xinyan Li,Litong Yao,Mozhi Wang,Mengshen Wang,Xiang Li,Xueting Yu,Jingyi Guo,Haoran Dong,Xiangyu Sun,Yingying Xu 한국유방암학회 2020 Journal of breast cancer Vol.23 No.4

Purpose: Combining targeted agents with adjuvant chemotherapy prolongs survival in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients, but also increases the risk of adverse effects. The updated results of 3 randomized controlled trials (RCTs) were reported in 2019. Given the lack of adequate head-to-head pairwise assessment for anti-HER2 agents, network meta-analysis facilitates obtaining more precise inference for evidence-based therapy. Methods: RCTs comparing at least 2 anti-HER2 regimens in an adjuvant setting for HER2- positive early-stage breast cancer (EBC) were included. Hazard ratios for overall survival (OS) and disease free survival (DFS), with respective 95% confidence intervals were pooled for assessment of efficacy. A Bayesian statistical model was used, and odds ratios (ORs) for adverse events (AEs) were used to pool effect sizes. Results: We demonstrated that 1-year trastuzumab plus chemotherapy had increased efficacy compared to shorter or longer treatment duration. The OR of cardiac events gradually increased from 6 months to 1 and 2-year trastuzumab arms, relative to chemotherapy only. Compared to trastuzumab plus chemotherapy, dual HER2-targeting therapies increased DFS, especially for hormone receptor negative patients. Dual anti-HER2 blockade regimens revealed an increased probability of gastrointestinal reactions. As a second agent, pertuzumab showed significantly higher DFS and OS. Conclusion: We conclude that 1-year adjuvant trastuzumab should remain as the standard treatment for HER2-positive EBC patients, as it has greater efficacy and a manageable proportion of AEs. Clinical efficacy can be increased for hormone receptor-negative tumors by including a second HER2-targeted agent to the treatment regimen. For hormone receptor-positive cases with basal disease, it is acceptable to reduce the risk of cardiotoxicity by shortening the duration of trastuzumab.

Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion

Zhao Jingyi,Li Bingyan,Ren Yongxia,Liang Tiansong,Wang Juan,Zhai Suna,Zhang Xiqian,Zhou Pengcheng,Zhang Xiangxian,Pan Yuanyuan,Gao Fangfang,Zhang Sulan,Li Liming,Yang Yongqiang,Deng Xiaoyu,Li Xiaole,C 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Compelling evidence has indicated the vital role of lysine-specific demethylase 4 A (KDM4A), hypoxia-inducible factor-1α (HIF1α) and the mechanistic target of rapamycin (mTOR) signaling pathway in nasopharyngeal carcinoma (NPC). Therefore, we aimed to investigate whether KDM4A affects NPC progression by regulating the HIF1α/DDIT4/mTOR signaling pathway. First, NPC and adjacent tissue samples were collected, and KDM4A protein expression was examined by immunohistochemistry. Then, the interactions among KDM4A, HIF1α and DDIT4 were assessed. Gain- and loss-of-function approaches were used to alter KDM4A, HIF1α and DDIT4 expression in NPC cells. The mechanism of KDM4A in NPC was evaluated both in vivo and in vitro via RT-qPCR, Western blot analysis, MTT assay, Transwell assay, flow cytometry and tumor formation experiments. KDM4A, HIF1α, and DDIT4 were highly expressed in NPC tissues and cells. Mechanistically, KDM4A inhibited the enrichment of histone H3 lysine 9 trimethylation (H3K9me3) in the HIF1α promoter region and thus inhibited the methylation of HIF1α to promote HIF1α expression, thus upregulating DDIT4 and activating the mTOR signaling pathway. Overexpression of KDM4A, HIF1α, or DDIT4 or activation of the mTOR signaling pathway promoted SUNE1 cell proliferation, migration, and invasion but inhibited apoptosis. KDM4A silencing blocked the mTOR signaling pathway by inhibiting the HIF1α/DDIT4 axis to inhibit the growth of SUNE1 cells in vivo. Collectively, KDM4A silencing could inhibit NPC progression by blocking the activation of the HIF1α/DDIT4/mTOR signaling pathway by increasing H3K9me3, highlighting a promising therapeutic target for NPC.

Interaction Between Serum/Glucocorticoid-Regulated Kinase 1 and Interleukin-6 in Chronic Rhinosinusitis

Lai Yuting,Hu Li,Yang Lu,Hu Xianting,Song Xiaole,Yang Jingyi,Li Hongbin,Chen Kun,Li Huabin,Wang Dehui 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.5

Purpose: Serum/glucocorticoid-regulated kinase 1 (SGK1) has recently emerged as a critical regulator of inflammatory diseases. In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS). Methods: Immunohistochemistry, western blotting, Bio-Plex assay, enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction were performed to assess protein and gene expression levels. The mRNA expression levels of SGK1 and interleukin-6 (IL-6) were extracted from a CRS database to perform correlation analysis. Stable cell lines with SGK1 overexpression (16HBE) and knockdown (A549) were constructed to investigate the interaction between SGK1 and IL-6 in vitro. Results: SGK1 exhibited strong cytoplasmic and nuclear staining in the epithelial layers and the lamina propria of nasal polyps (NPs) and in the mucosal tissues of CRS without nasal polyps (CRSsNP). The mRNA and protein expression levels of SGK1 and IL-6 were significantly increased in NPs and CRSsNP tissues, compared to control tissues. SGK1 phosphorylation was significantly greater in NPs than in CRSsNP tissues (P < 0.01). The mRNA levels of SGK1 and IL-6 were significantly correlated (P < 0.001, r = 0.649). Exposure to IL-6 significantly increased SGK1 expression in cultured dispersed NP cells, 16HBE cells, and A549 cells. IL-6 expression was significantly down-regulated in SGK1-overexpressing 16HBE cells (P < 0.01) and significantly up-regulated in SGK1-knockdown A549 cells (P < 0.05). Administration of GSK650394, a SGK1 inhibitor, significantly increased IL-6 self-induced mRNA expression in cultured dispersed NP cells and 16HBE cells. Conclusions: The interaction between SGK1 and IL-6 may play an anti-inflammatory role in IL-6-induced inflammation in the pathogenesis of CRS.

Investigation on the Storage Method of Blurred Art Image with Retrieval and Processing

Jingyi bo,Yubin Wang,Yu Xiang Li 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.7

For the Chinese ancient art, stone carving experiences the etching of the natural environment and become blurred. How to process and store their images becomes a quite important problem. In this paper, an image process and storage method have been proposed. In this method, the blurred image will be firstly pretreated. Then, relative images which have high similarity with the blurred image will be retrieved in the database. Thirdly, blurred images are processed with template matching method to improve the clarity. Finally, processed images and the original images are stored in the dataset with classification. A blurred art image is used as the example to verify the validity of the method. The blurred image contains a person and a door. The query method is proposed with higher speed and precision, which is due to the pretreatment and mixed subgraph method. The pretreatment can improve the precision of the query content, while the mixed subgraph method can provide the completeness of the query content. Both the mechanism improves the retrieval precision. The blurred images excavated in the soil are often with pitting and rust, which is corresponding to the noise in the image process. In the image process step, the image is fixed up when the blurry points are big enough. The verification confirms the validity of the method.

Bone Marrow Mononuclear Cells Transfer for Patients after ST-Elevated Myocardial Infarction: A Meta-Analysis of Randomized Control Trials

Jingyi Zhang,Li Lin,Wenxia Zong 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.5

Purpose: Results on the clinical utility of cell therapy for ST-elevated myocardial infarction (STEMI) are controversial. This studysought to analyze the efficacy of treatment with intracoronary bone marrow mononuclear cells (BMMC) on left ventricular (LV)function and remodeling and LV diastolic and systolic function in patients with STEMI. Materials and Methods: Literature search of PubMed and EMBASE databases between 2004 and 2017 was performed for randomizedcontrolled trials in STEMI patients who underwent successful percutaneous coronary intervention and received intracoronaryBMMC therapy. The defined end points were left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume(LVEDV), and left ventricular end-systolic volume (LVESV). Also, sensitivity analysis and several subgroup analyses basedon follow-up duration, timing of injection, doses of cells, and imaging modalities were conducted to strengthen the statistic powerof the study. Results: A total of 22 trials with 1360 patients were available for the current meta-analysis. The pooled statistics showed a significantimprovement in LVEF {2.58 [95% confidence interval (CI), 1.32, 3.84]; p<0.001}, LVEDV [-3.73, (95% CI, -6.94, -0.52), p=0.02],and LVESV [-4.67, (95% CI, -7.07, -2.28), p<0.001] in the BMMC group, compared with the control group. However, in sensitivityanalysis, a significant reduction in LVEDV disappeared, while the outcomes of LVEF and LVESV remained unchanged. The sameresults were presented in the subgroup analysis adjusting for imaging modalities and timing of cells injection. Conclusion: BMMC transplantation in patients with STEMI was found to lead to improvement in LVEF, LVEDV, and LVESV parameters,indicating that cell therapy has a potential beneficial effect on LV remodeling and function.

Research on the design of shooting shoes for air rifle athletes in standing position

Yisong Li,Jingyi Hu,Yao-Hua Wang 한국디자인학회 2022 한국디자인학회 학술발표대회 논문집 Vol.2022 No.11

Predictive and Prognostic Roles of Pathological Indicators for Patients with Breast Cancer on Neoadjuvant Chemotherapy

Xinyan Li,Mozhi Wang,Mengshen Wang,Xueting Yu,Jingyi Guo,Tie Sun,Litong Yao,Qiang Zhang,Yingying Xu 한국유방암학회 2019 Journal of breast cancer Vol.22 No.4

Currently, neoadjuvant chemotherapy is a standard therapeutic strategy for breast cancer, as it can provide timely and individualized chemo-sensitivity information and is beneficial for custom-designing subsequent treatment strategies. To accurately select candidates for neoadjuvant chemotherapy, the association between various immunohistochemical biomarkers of primary disease and tumor response to neoadjuvant chemotherapy has been investigated, and results have shown that certain pathological indicators evaluated after neoadjuvant chemotherapy are associated with long-term prognosis. The Food and Drug Administration (FDA) has recommended that complete pathological response can be used as a surrogate endpoint for neoadjuvant chemotherapy, which is related to better prognosis. Considering that residual tumor persists in the majority of patients after neoadjuvant chemotherapy, the value of various pathological indicators of residual disease in predicting the long-term outcomes is being extensively investigated. This review summarizes and compares various predictive and prognostic indicators for patients who have received neoadjuvant chemotherapy, and analyzes their efficacy in different breast cancer subtypes.

Study of the Electric Field Screening Effect for Field Emitter Arrays

Nannan Li,Fei Yan,Shucai Pang,Lei Chen,Dazhi Jin,Wei Xiang,De Zhang,Jingyi Dai,Baoqing Zeng 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.8

Understanding the influence of the interaction of emitters on the field emission performance of a field emitter array is of great importance for the design of a multi-emitter device. In this work, a screening factor S is defined to quantify the effect of electric field screening due to the interaction of emitters in an array. A three-dimensional finite integration technique is used to study the electric field screening effect for Spindt-type field emitter arrays which have potential applications in flatscreen displays and high-power vacuum electronics. The dependences of the electric field screening on the tip-to-tip spacing, half-angle of the emitter, height of the emitter and radius of the tip’s curvature are analyzed. The effects of the variations in the size of the emitter’s geometry on the most efficient arrangement to achieve maximum emission efficiency in an array are discussed.