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( Zhen Zhen Lian ),( Xiao Jing Yin ),( Hua Li ),( Li Li Jia ),( Xiu Zhen He ),( Yong Bo Yan ),( Nai Hua Liu ),( Ka Yiu Wan ),( Xiao Kun Li ),( Shao Qiang Lin ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.1
Background: Diabetic wounds are a major clinical challenge, because minor skin wounds can lead to chronic, unhealed ulcers and ultimately result in infection, gangrene, or even amputation. Studies on bone marrow derived mesenchymal stem cells (BMSCs) and a series of growth factors have revealed their many benefits for wound healing and regeneration. Platelet-rich plasma (PRP) may improve the environment for BMSC development and differentiation. However, whether combined use of BMSCs and PRP may be more effective for accelerating diabetic ulcer healing remains unclear. Objective: We investigated the efficacy of BMSCs and PRP for the repair of refractory wound healing in a diabetic rat model. Methods: Forty-eight rats with diabetes mellitus induced by streptozotocin were divided into four groups: treatment with BMSCs plus PRP, BMSCs alone, PRP alone, phosphate buffered saline. The rate of wound closure was quantified. A histopathological study was conducted regarding wound depth and the skin edge at 7, 14, and 28 days after surgery. Results: Wound healing rates were significantly higher in the BMSC plus PRP group than in the other groups. The immunohistochemistry results showed that the expression of platelet/endothelial cell adhesion molecule 1, proliferating cell nuclear antigen, and transforming growth factor-β1 increased significantly in the BMSC plus PRP group compared to the other treatment groups. On day 7, CD68 expression increased significantly in the wounds of the BMSC plus PRP group, but decreased markedly at day 14 compared to the controls. Conclusion: The combination of BMSCs and PRP aids diabetic wound repair and regeneration. (Ann Dermatol 26(1) 1∼10, 2014)
Muscle fatigue: general understanding and treatment
Jing-jing Wan,Zhen Qin,Peng-yuan Wang,Yang Sun,Xia Liu 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general understanding and describe potential therapies for muscle fatigue, we summarize studies on muscle fatigue, including topics such as the sequence of events observed during force production, in vivo fatigue-site evaluation techniques, diagnostic markers and non-specific but effective treatments.
Fotemustine, Teniposide and Dexamethasone in Treating Patients with CNS Lymphoma
Wu, Jing-Jing,Wang, Xin-Hua,Li, Ling,Li, Xin,Zhang, Lei,Sun, Zhen-Chang,Fu, Xiao-Rui,Ma, Wang,Chang, Yu,Zhang, Xu-Dong,Han, Li-Juan,Zhang, Ming-Zhi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Purpose: We developed and evaluated a regimen including fotemustine, teniposide and dexamethasone (FTD) for treating patients with central nervous system (CNS) lymphoma based on pharmacokinetic properties of individual agents and in combination. Patients and Methods: In a comparison study, 8 patients with primary CNS lymphoma (PCNSL) and 8 with secondary CNS lymphoma (SCNSL) were treated with FTD (comprising fotemustine 100 mg/m2, 1h infusion, day 1; teniposide 60 mg/m2, >0.5 h infusion, on day 2, 3, 4; dexamethasone 40 mg, 1h infusion, on day 1, 2, 3, 4 and 5; and methotrexate 12 mg, cytosine arabinoside 50 mg plus dexamethasone 5 mg intrathecally, on day 2 and 7). Cycles were repeated every 3 weeks. After response assessment, patients received whole brain radiotherapy. Results: Of the 8 PCNSL patients, 4 (50%) achieved CR and 3 (38%) PR, an overall response rate of 88%. Four patients (50%) were in continuing remission at the end of this study after a median follow-up of 30 months (range 10 to 56 months). Of the 8 SCNSL patients the overall response rate was 63% (CR+PR: 38%+25%). All responses were achievable with predictable toxicity mainly reflecting reversible myelosuppression. Conclusion: This study suggests that FTD could be an effective treatment for CNS lymphoma, and is worthy of further evaluation.
Zhou, De,Xie, Wan-Zhuo,Hu, Ke-Yue,Huang, Wei-Jia,Wei, Guo-Qing,He, Jing-Song,Shi, Ji-Min,Luo, Yi,Li, Li,Zhu, Jing-Jing,Zhang, Jie,Lin, Mao-Fang,Ye, Xiu-Jin,Cai, Zhen,Huang, He Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Aim: To analyze the significance of different clinical factors for prognostic prediction in diffuse large B-cell lymphoma (DLBCL) patients. Methods: Two hundred and twenty-seven DLBCL patients were retrospectively reviewed. Patients were managed with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen or rituximab plus the CHOP (RCHOP) regimen. Results: Lactate dehydrogenase (LDH), ${\beta}2$-microglobulin (${\beta}2$-M), B symptoms, Ann Arbor stage and genetic subtypes were statistically relevant in predicting the prognosis of the overall survival (OS). In the CHOP group, the OS in patients with germinal center B-cell-like (GCB)(76.2%) was significantly higher than that of the non-GCB group (51.9%, P=0.032). With RCHOP management, there was no statistical difference in OS between the GCB (88.4%) and non-GCB groups (81.9%, P=0.288). Conclusion: Elevated LDH and ${\beta}2$-M levels, positive B symptoms, Ann Arbor stage III/IV, and primary nodal lymphoma indicate an unfavorable prognosis of DLBCL patients. Patients with GCB-like DLBCL have a better prognosis than those with non-GCB when treated with the CHOP regimen. The RCHOP treatment with the addition of rituximab can improve the prognosis of patients with DLBCL.
Mechanical analysis for prestressed concrete containment vessels under loss of coolant accident
Zhen Zhou,Chang Wu,Shao-ping Meng,Jing Wu 사단법인 한국계산역학회 2014 Computers and Concrete, An International Journal Vol.14 No.2
LOCA (Loss Of Coolant Accident) is one of the most important utmost accidents for Prestressed Concrete Containment Vessel (PCCV) due to its coupled effect of high temperature and inner pressure. In this paper, heat conduction analysis is used to obtain the LOCA temperature distribution of PCCV. Then the elastic internal force of PCCV under LOCA temperature is analyzed by using both simplified theoretical method and FEM (finite element methods) method. Considering the coupled effect of LOCA temperature, a nonlinear elasto-plasitic analysis is conducted for PCCV under utmost internal pressure considering three failure criteria. Results show that the LOCA temperature distribution is strongly nonlinear along the shell thickness at the early time; the moment result of simplified analysis is well coincident with the one of numerical analysis at weak constraint area; while in the strong constrained area, the value of moments and membrane forces fluctuate dramatically; the simplified and numerical analysis both show that the maximum moment occurs at 6hrs after LOCA.; the strain of PCCV under LOCA temperature is larger than the one of no temperature under elasto-plastic analysis; the LOCA temperature of 6hrs has the greatest influence on the ultimate bearing capacity with 8.43% decrease for failure criteria 1 and 2.65% decrease for failure criteria 3.
Novel Mutation of the NCSTN Gene Identified in a Chinese Acne Inversa Family
( Jing Wu ),( Huiyao Ge ),( Yiming Fan ),( Qi Zhen ),( Lili Tang ),( Liangdan Sun ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.3
Acne inversa is a chronic inflammatory follicular disease with autosomal dominant inheritance. In recent years, many functional mutations in the NCSTN genes have been identified as the cause of familial acne inversa. Herein, we recruited four patients and seven unaffected individuals from a Chinese family and performed Sanger sequencing of the NCSTN gene. One novel frameshift mutation, c.450_459del (p.Ser 151GlnfsX48), was identified in exon 5 of the NCSTN gene. Three normal-looking children carrying the mutation were proven to be patients. We also presented a literature review from previous studies of acne inversa, suggesting that NCSTN is a hotspot gene for acne inversa. Most affected individuals experienced onset in adolescence. We confirmed the diagnosis in this family based on the mutation. This finding will help expound the relationship between the NCSTN gene and the pathogenesis of acne inversa and emphasize the value of genetic diagnosis in monogenic disorder. (Ann Dermatol 32(3) 237∼242, 2020)
Formation Control with Multiple Leaders via Event-triggering Transmission Strategy
Jing Liu,Jian-an Fang,Zhen Li,Guang He 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.6
Event-triggering formation control with multiple leaders in second-order nonlinear multi-agent systems is investigated in this paper. This novel distributed formation control strategy allows the event-triggering condition to be intermittently examined at sampling instants, where the data transmission is driven by an event-triggering control protocol. Based on this strategy, two different formation control protocols are presented. Then, some sufficient conditions are given to ensure the second-order nonlinear multi-agent systems converge to the desired formation shape. Finally, examples are given to show the effectiveness of theoretical results.
Jing Liu,Jian-an Fang,Zhen Li,Guang He 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.4
This paper addresses the problem of time-varying formation tracking for a kind of second-order multiagent systems with a switching topology, in which the dynamics of agents are modeled by double integrators and harmonic oscillators respectively. The control input of each agent is subject to saturation. First, depending on the low-gain state feedback technique, an algorithm is designed to solve semi-global time-varying formation tracking problem, where feasibility condition of formation tracking is introduced. Then, by utilizing the Lyapunov function and low-gain feedback theory, it is proved that second-order multi-agent system with a switching topology achieves the specified semi-global time-varying formation tracking if some sufficient conditions hold. Further, as an extension, jointly connected switching topology is considered, and the corresponding formation tracking problem is also explored. Subsequently, several simulation examples is worked out for illustration.
Coloring mechanism of celadon glazes from Yaozhou kiln
Zhen Sang,Fen Wang,Xiaojuan Yuan,Shurui Shen,Jing Wang,Xiaohong Wei 한양대학교 청정에너지연구소 2022 Journal of Ceramic Processing Research Vol.23 No.6
The Five Dynasty sky-green, Song dynasty olive-green and Jin dynasty moon-white glazes are three typical glazes of theYaozhou celadon. In this work, the coloring mechanism of the three celadon glazes were compared and analyzed by usingcolorimeter, EDXRF, XRD, XPS and Raman spectrometer. The results indicate that the content of Fe2O3 is proportional tothe depth of the glaze colors. The Raman Ip value indicates that the firing temperature of the Song dynasty olive-green glazewas the highest, followed by the Five Dynasty, and then the Jin dynasty. The lower firing temperature and dense bubbles areimportant causes of the high opacification of the Jin moon-white glaze. The ratio of Fe2+ to Fe3+ in the glaze is directlyproportional to the b* value, which is the main reason for why the Yao celadon glaze colors are yellow-green in Song, butbluish in the Five Dynasty and Jin dynasty.