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( Jiehyun Jeon ),( Joo Ha Kim ),( Chang Kyu Lee ),( Chil Hwan Oh ),( Hae Jun Song ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.5
Background: Skin infections with Gram-negative bacteria are sometimes challenging to treat, because these bacteriashow multidrug resistance against commonly used antibiotics and patients with Gram-negative bacterial infection overall have deteriorated in conditions in many cases. Studies have shown that epigallocatechin gallate (EGCG) and green tea extracts (GTE) inhibit the growth of several Gram-positive bacteria species. Objective: The purpose of this study was to investigate the minimum inhibitory concentrations (MICs) of EGCG and GTE in Pseudomonas aeruginosa and Escherichia coli, and assess the use of these chemicals as an alternative or adjunct topical antimicrobial agent against P. aeruginosa and E. coli with multidrug resistance. Methods: The MICs of EGCG, GTE, and other tested antibiotics were measured and compared to determine the antibacterial efficacy and the differences in pattern of resistance. Results: The P. aeruginosa and E. coli strains used in this study showed multidrug resistance. EGCG inhibited the growth of P. aeruginosa at a MIC level of 200∼400 μg/ml. The MIC of GTE was a 1 : 16 dilution for P. aeruginosa. EGCG showed antimicrobial activity against E. coli at a MIC of 400 μg/ml. In the case of GTE, the MIC was a dilution between 1:8 and 1:4 for E. coli. Conclusion: EGCG and GTE showed potential as alternative or adjunct topical antimicrobial agents for infections that are resistant to traditional antibiotic therapy. (Ann Dermatol 26(5) 564∼569, 2014)
( Jiehyun Jeon ) 한국피부장벽학회 2023 한국피부장벽학회지 Vol.25 No.1
The skin barrier is a complex, multilayered structure that serves as the primary defense against external environmental factors and maintains homeostasis within the body. Itch, or pruritus, is a distressing sensory experience that often arises from dysfunction or disruption of the skin barrier. The skin barrier consists of the stratum corneum, epidermis, dermis, and underlying hypodermis, all working together to protect against dehydration, mechanical stress, and microbial invasion. Essential components of the skin barrier include lipids, such as ceramides, cholesterol, and free fatty acids, which form a lipid matrix that prevents water loss and maintains structural integrity. When the skin barrier is compromised, either due to external factors (e.g., harsh chemicals, allergens, or physical trauma) or internal factors (e.g., genetic mutations or underlying skin conditions), it can lead to increased permeability and inflammation. This disruption triggers the release of pruritogens from keratinocytes and other inflammatory cells and sensory nerve endings become activated. Understanding the relationship between the skin barrier and itch has led to the development of novel therapeutic approaches. Targeting the restoration of the skin barrier function through the application of emollients, moisturizers, and topical barrier repair agents has shown promise in alleviating itch symptoms. Additionally, modulating the activity of pruritogenic receptors and neurotransmitters involved in itch transmission has emerged as a potential strategy for itch management.