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( Ji Young Yhi ),( Ji Yong Moon ),( Dong Won Park ),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: While physical inactivity is suggested to have a link to metabolic syndrome, the association of metabolic syndrome with physical activity in patients with COPD or restrictive lung diseases remains controversial. Objective: We aimed to explore the relationship of metabolic syndrome with physical activity according to the presence of airway diseases in Korean adult population. Methods: Using the data from Korean National Health and Nutrition Examination Survey (KNHANES) in 2008-2012, we enrolled 17,094 subjects who aged over 40 years and had spirometric data. spirometry pattern and presence of metabolic syndrome were checked for classification. Physical activity was evaluated by questionnaire. Results: After adjusting for age, gender, body mass index, smoking status, energy intake, percentage of carbohydrates in energy intake, household income, high-risk drinking frequency, and education, multivariate logistic regression analysis found that physical inactivity was significantly associated with metabolic syndrome (odd ratio [OR], 1.347; 95% confidence interval [CI], 1.187 - 1.529; P-value < 0.001). Whereas the association was also significant in subjects with normal (OR, 1.348; 95% CI, 1.167 - 1.558) and restrictive pattern of spirometry (OR, 1.412; 95% CI, 1.019 - 1.957), there was no significant association of physical inactivity with metabolic syndrome in those with obstructive airway disease (OR, 1.228; 95% CI, 0.813 - 1.856). Conclusion: The association of physical inactivity with metabolic syndrome might vary with the presence of airway disease.
( Ji Young Yhi ),( Dong Won Park ),( Hyun Jung Kwak ),( Ji Yong Moon ),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Dong Ho Shin ),( Sung Soo Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Endobronchial actinomycosis is a rare form of pulmonary actinomycosis. Actinomyces can colonize bronchial tree infiamed by broncholith, foreign body or infection leading to narrowing or occlusion of the affected lumen. As anaerobes, these bacteria grow rapidly in anaerobic environment created by the combined infections of various pathogens. While endobronchial actinomycosis can lead to obstructive pneumonia, mycoplasma co-infection has not been reported yet. We report a case of endobronchial actinomycosis associated with mycoplasma pneumonia. Case: A 75-year-old woman presented with chronic cough for two months. Chest radiographs and chest CT revealed the bronchial narrowing of right lower lobe (RLL) and consolidation in the distal lung parenchyma. Bronchoscopy found yellowish mucus plug in RLL bronchus and the pathologic examination of the bronchoscopy biopsy specimen showed sulfur granules of Actinomyces Israelii. In the serologic evaluation, the level of Mycoplasma Pneumoniae antibody was very high (1:20480 in dilution) suggesting the presence of mycoplasma pneumonia.
( Ji Young Yhi ),( Dong Won Park ),( Hyun Jung Kwak ),( Ji Yong Moon ),( Tae Hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Dong Ho Shin ),( Sung Soo Park ),( Hyun Joo Pai ),( Sang Heon Kim ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Pneumocystis jirovecii pneumonia (PCP) is a frequent opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). It usually presents as diffuse ground glass opacities and may lead to life-threatening pulmonary complication. However, patients with AIDS may have variable radiographic manifestation including unilateral infiltration, nodules, cavities, and pleural effusions. To date, PCP presenting with disseminated pulmonary nodules has been rarely reported. We describe the case of a 33-year-old man with AIDS showing disseminated pulmonary nodules with cavities on chest radiograph and CT. We found PCP organism on the bronchoalveolar lavage specimen and confirmed the diagnosis of PCP based on open lung biopsy, which revealed granuloma with cysts of pneumocystis jirovecii. In patients with AIDS, early clinical suspicion of PCP is important since immediate treatment is required to prevent clinical deterioration. PCP should be included in the differential diagnosis of disseminated cavitary nodules in such cases.
Free Paper Presentation : OS-79 ; Associations of Obesity with Asthma and Atopy in Korean Adults
( Ji Yong Moon ),( Sang Heon Kim ),( Ji Young Yhi ),( Dong Won Park ),( Hyun Jung Kwak ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Sung Soo Park ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: While obesity is suggested to increase the risk of asthma and atopic diseases, the associations between obesity and asthma varies depending on the study populations. In Asian countries including Korea, the prevalence of obesity based on body mass index (BMI) is relatively low and the impacts of obesity on asthma is not so evident. Objective: To explore the relationship of obesity with asthma and atopy in Korean adult population Methods: We used the data from Korean National Health and Nutrition Examination Survey (KNHANES) in 2010. Based on the definition of obesity in Korea, the study population aged 19 or older were divided into 4 BMI groups: normal (BMI <23), overweight (23-25), obese (25-30) and very obese (=30). Multivariate logistic regression analysis was performed to examine the associations of obesity with asthma and atopy adjusting for age, sex and smoking status. Results: The prevalence of asthma, determined by current wheeze, in the BMI groups was 5.3%, 6.2%, 9.0% and 9.6%. BMI was significantly associated with asthma (P = 0.004), with significant association in obese (adjusted OR 1.63, 95% CI 1.19-2.24) and very obese group (aOR 1.96, 95% CI 1.11-3.46). In addition, there was significant relationship between BMI groups with atopy, determined by serum levels of the specific IgE to Dermatophagoides farinae, cockroach or dog. Conclusion: Obesity is significantly associated with asthma in Korean adult population. The effect of obesity on asthma may be mediated with atopic sensitization.
( Ji Yong Moon ),( Sung Jun Jung ),( Gun Woo Koo ),( Ji Young Yhi ),( Dong Won Park ),( Hyun Jung Kwak ),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Sung Soo Park ),( Ho J 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Bronchial hyperresponsiveness is a pathophysiologic feature of asthma and can be evaluated by means of bronchial challenge. Mannitol is a pharmacologicagonist of an indirect bronchial provocation test. It has been suggested that small airway obstruction is an early marker of bronchial impairment. The correlation between small airway dysfunction and responsiveness to mannitol has not been studied. Objective: To determine whether forced expiratory fi ow between 25% and 75% of vital capacity (FEF25-75%) as a surrogate measure of small airways function is associated with airway responsiveness to mannitol. Methods: We compared the baseline FEF25-75% (presented as percent of predicted) with the other spirometric parameters including forced expiratory volume in 1 second(FEV1) percent predicted, forced vital capacity (FVC) percent predicted and ratio of FEV1 to FVC (FEV1/FVC), in regard to predicting the result of the subsequent mannitol bronchial provocation test in 428 consecutive patients. Statistical analyses were carried out using the area under the receiver operating characteristic curve (AUC) with comparisons using the DeLong method. Results: The rate of bronchial hyperresponsiveness to mannitol (defi ned by a PD15 of < 635 mg) was 20.3 percent. AUC analysis showed that FEF25-75% had signifi cantly higher AUC value (0.772; 95% confi dence interval [CI], 0.729-0.811) than FEV1 % predicted (0.666; 95% CI, 0.619-0.710; P < 0.0001) and FEV1/FVC (0.741; 95% CI, 0.697- 0.782; P = 0.0469). Similar results were obtained after excluding subjects with low FEV1 % predicted (< 80) or low FEV1/FVC (< 70).Conclusions: FEF25-75% showed signifi cantly better association with responsiveness to mannitol compared to the other spirometric indices even in the patients with a normal spirometry, suggesting that small airway dysfunction could be a sign of bronchial hyperresponsiveness.
Park, Dong Won,Yhi, Ji Young,Koo, Gunwoo,Jung, Sung Jun,Kwak, Hyun Jung,Moon, Ji-Yong,Kim, Sang-Heon,Kim, Tae Hyung,Sohn, Jang Won,Shin, Dong Ho,Park, Sung Soo,Yoon, Ho Joo The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3
Invasive pulmonary aspergillosis (IPA) is rarely reported in patients who have normal immune function. Recently, IPA risk was reported in nonimmunocompromised hosts, such as patients with chronic obstructive pulmonary disease and critically ill patients in intensive care units. Moreover, influenza infection is also believed to be associated with IPA among immunocompetent patients. However, most reports on IPA with influenza A infection, including pandemic influenza H1N1, and IPA associated with influenza B infection were scarcely reported. Here, we report probable IPA with a fatal clinical course in an immunocompetent patient with influenza B infection. We demonstrate IPA as a possible complication in immunocompetent patients with influenza B infection. Early clinical suspicion of IPA and timely antifungal therapy are required for better outcomes in such cases.
( Hyun Jung Kwak ),( Ji Young Yhi ),( Dong Won Park ),( Ji Yong Moon ),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Dong Ho Shin ),( Sung Soo Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Postoperative venous thromboembolism (VTE) is a fatal condition in patients undergoing surgical procedure. The incidence of VTE and the usefulness of Caprini risk scoresfor predicting VTE in head and neck surgery have not been well established in Korean patients. Methods: In a prospective design, we enrolled subjects who underwent head and neck surgery from January to March 2013. Clinical characteristics and Caprini score were assessed at the day of operation. The development of VTE was monitored for the following 3 months after surgery. Results: Of 364 enrolled subjects, nine patients were identified to have VTE. The 3-month incidence rate of VTE in head and neck surgery was 2.5%. Three of these patients were in fatal condition requiring emergency embolectomy and one of them underwent extracorporeal membrane oxygenation before embolectomy. Caprini score in VTE patients was signifi cantly higher than those without VTE (8.1 ± 5.1 vs. 3.9 ± 1.9, P = 0.048). Receiver-operating characteristic curve analysis revealed that the diagnostic accuracy of Caprini score was high with an area under the curve of 0.868 ±0.035. Conclusion: The incidence of VTE in patients with head and neck surgery was 2.47%. The Caprini risk score was useful in selecting high risk patients for VTE in head and neck surgery.
( Dong Won Park ),( Ji Young Yhi ),( Gunwoo Koo ),( Sung Jun Jung ),( Hyun Jung Kwak ),( Ji Yong Moon ),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Sung Soo Park ),( Ho Jo 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Invasive pulmonary aspergillosis (IPA) is rarely reported in patients with normal immune function. Recently, nonimmunocompromised hosts such as patients with chronic obstructive pulmonary disease and critically ill patients in intensive care units are reported to be at risk of IPA. Infiuenza infection is also believed to be associated with IPA among immunocompetent patients. However, most reports of IPA with infiuenza infection involved infiuenza A infection including pandemic infiuenza H1N1, and IPA associated with infiuenza B infection was scarcely reported. Here, we report probable IPA with a fatal clinical course in an immunocompetent patient with infiuenza B infection. We demonstrate IPA as a possible complication in immunocompetent patients with infiuenza B infection. Early clinical suspicion of IPA and timely antifungal therapy are required for better outcomes in such cases.
( Dong Won Park ),( Ji Young Yhi ),( Gun Woo Koo ),( Sung Jun Jung ),( Hyun Jung Kwak ),( Ji Yong Moon ),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Sung Soo Park ),( Ho J 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3
Invasive pulmonary aspergillosis (IPA) is rarely reported in patients who have normal immune function. Recently, IPA risk was reported in nonimmunocompromised hosts, such as patients with chronic obstructive pulmonary disease and critically ill patients in intensive care units. Moreover, influenza infection is also believed to be associated with IPA among immunocompetent patients. However, most reports on IPA with influenza A infection, including pandemic influenza H1N1, and IPA associated with influenza B infection were scarcely reported. Here, we report probable IPA with a fatal clinical course in an immunocompetent patient with influenza B infection. We demonstrate IPA as a possible complication in immunocompetent patients with influenza B infection. Early clinical suspicion of IPA and timely antifungal therapy are required for better outcomes in such cases.
( Dong Won Park ),( Ji Young Yhi ),( Gun Woo Koo ),( Sung Jun Jung ),( Hyun Jung Kwak ),( Ji Yong Moon ),( Sang Heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Dong Ho Shin ),( Sung Soo Park ),( Ho J 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Invasive pulmonary aspergillosis (IPA) is rarely reported in patients with normal immune function. Recently, nonimmunocompromised hosts such as patients with chronic obstructive pulmonary disease and critically ill patients in intensive care units are reported to be at risk of IPA. Influenza infection is also believed to be associated with IPA among immunocompetent patients. However, most reports of IPA with influenza infection involved influenza A infection including pandemic influenza H1N1, and IPA associated with influenza B infection was scarcely reported. Here, we report probable IPA with a fatal clinical course in an immunocompetent patient with influenza B infection. We demonstrate IPA as a possible complication in immunocompetent patients with influenza B infection. Early clinical suspicion of IPA and timely antifungal therapy are required for better outcomes in such cases.