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( Chang Yoon Sim ),( Ji Yeoun Sin ),( Seung Min Lee ),( Hyun Jo Kim ),( Young Lip Park ),( Kyu Uang Whang ),( Sung Yul Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Radiofrequency (RF) devices of various delivery systems have been reported to be clinically effective in treating various dermatologic conditions. Howevere, there are few histological studies for identifying mechanism and therapeutic effect. Objectives: To evaluate histologic change and compare wound repair after radiofrequency irradiation to non-invasive bipolar fractional radiofrequency (FRF) and non-insulated microneedle bipolar FRF. Methods: We irradiated the skin of an albino rat (Sprague-Dawley, 200∼250 g) using a non-invasive bipolar FRF and a non-insulated microneedle bipolar FRF device. Biopsy specimens of the irradiated skin were collected on the first, third, seventh and fourteenth day after irradiation. For histological analysis, the skin samples were stained with hematoxylin and eosin and Masson’s trichrome. Results: After non-invasive bipolar FRF irradiation, the skin sample showed epidermal ablation and pyramidal shape of dermal heat damage zone. In contrast, non-insulated microneedle bipolar FRF made coagulation column around needle without epidermal damage. Conclusion: Both radiofrequency devices make heat damage on collagen, but there are difference in pattern of damage. We confirmed that radiofrequency irradiated by microneedle, although that was non-insulated, didn’t make damage in epidermis, when irradiated in very short time. In addition, pulsed-type radiofrequecy irradiation gave damage to perivascular area of upper dermis.