Monocyte Chemoattractant Protein-1[MCP1] -2518 유전자 다형성과 주요 우울장애

배치운,이지현,신윤경,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Object : This study was designed to examine the association between monocyte chemoattractant protein-l (MCPl) -2518poly morphism and major depressive disorder (MDD). Methods : Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results : Genotype and allele distributions in patients with MDD were significantly different from those of the controls, In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion : The present study suggests that the MCPl -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

하악에 전이된 위 선양암종

이지운,권기정,안현숙,고광준 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.3

Metastatic tumors to the jaw bones are uncommon. The most common metastatic tumors to the jaw bones are the breast, lung and kidney. In the jaw bones, the common location of the lesions is the mandible, and the posterior area of the mandible is more commonly affected. The radiographic appearance is quite variable. In this report, a very rare case of metastatic gastric adenocarcinoma to the mandible is presented. The patient had undergone a gastrectomy 3 years ago.

로이 애스콧(Roy Ascott)의 디지털 아트를 통해 살펴본 ‘테크노에틱’(Technoetic) 개념

이지언 이화여자대학교 이화인문과학원 2014 탈경계인문학 Vol.7 No.2

This paper explores Roy Ascott (1934- ) and his conceptual world of “technoetic art,” including his artistic and aesthetic projects and concepts. I argue Ascott is one of the important harbingers of digital art aesthetics in the 1960s, even though he didn’t call his works digital art, because for Ascott the important features to develop in art and aesthetics are interactivity and co-creation. These principles place him immediately before a developing late 20th century and early 21st century more digital-based artistry that holds to the same principles. He has written many articles and arranged many artistic projects for over three decades. I focus on explaining his most well-known article, “Is there Love in the Telematic Embrace?”, while exploring his concepts of technoetics, telematics, and consciousness. I think he provides many early insights and important intuitions into later digital art practice that have seldom been discussed by those analyzing digital art. Through this article, I concentrate on his view of how a new communicative environment can change art’s relation to topics like human dignity and the posthuman condition. In short, my main research topic is how well Ascott’s “technoetic” concepts connect to the existing literature and practice of digital art’s aesthetic experience.

Cone beam형 전산화단층촬영법을 이용한 하악과두의 골변화에 관한 연구

이지운,김형섭,송주섭,김경아,고광준 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.3

Purpose : To assess bone changes of mandibular condyle using cone beam computed tomography (CBCT) in temporomandibular disorder (TMD) Patients. Materials and Methods : 314 temporomandibular joints (TMJs) images of 163 TMD patients were examined at the Department of Oral and Maxillofacial Radiology, Chonbuk National University. The images were obtained by PSR9000N (Asahi Roentgen Co., Japan) and reconstructed by using Asahivision software (Asahi Roentgen Co.,Japan). The CBCT images were examined three times with four weeks interval by three radiologists. Bone changes of mandibular condyle such as flattening, sclerosis, erosion and osteophyte formation were observed in sagittal, axial, coronal and 3 dimensional images of the mandibular condyle. The statistical analysis was performed using SPSS 12.0. Intra-and interobserver agreement were performed by 3 radiologists without the knowledge of clinical information. Results : Osteophyte (2.9%) was found more frequently on anterior surface of the mandibular condyle. Erosion (31.8%) was found more frequently on anterior and medial surfaces of the mandibular condyle. The intraobserver agreement was good to excellent(k=0.78-0.84), but interobserver agreement was fair(k=0.45). Conclusion : CBCT can provide high qualified images of bone changes of the TMJ with axial, coronal and 3 dimensional images.

칸트의 숭고미학과 동양의 숭고미학에 관한 비교 고찰

이지언 건국대학교 조형연구소 2004 조형연구 Vol.12 No.-

In the paper of a thesis the sublime concept with new aesthetics value was comparison-interpretation-seen based on argument of Kant by present age fine arts. What is deserving calling that it is the sublime? As for the sublime concept generally accepted, it is universal to have originated from the form of the abstract art understood by modernism as "abstraction" to which a Western reappearance-tradition, is opposed like the concept of abstraction differing from the concept of Western abstraction strictly in however the East which understand sublime quantity in specified form which the sublime concept before. Kant who can obtain that a sublime concept is not in agreement, either can also give other interpretations--the sublime problem which he discussed not only meaning only its sublime problem as a matter of fact but sublime quantity. I will look at our culture. In fact, a Western art concept also has distance with our concept -- so that it may carry out single [ of our culture ] again sublime quantity surely under the religion of Western Europe a problem hierarchical for saying and whose antique problem are not, sweet. However our religion and a historical tradition surely appropriation to which the problem of reappearance will also be hard to be applied in us conversation if only the conversation tradition of East and the West which has only a heterogeneous number unlike a Western thing is seen, Conversation by the tradition of the conversation of our country soul nature. If only the abstraction returned only to modernism-color without abstraction and the form is abstraction in our conversation when seeing in the viewpoint of which was abstract to original on the side in which it embodies, however Western Europe, although there may be no abstraction, soul nature is embodied in us conversation. Nature to copy a meaning Without placing if it is that a writer's view of the world and character appeared in the work, the Korean drawing is an advanced abstract painting. If it sees by non-formed when seeing sublime quantity in a Western viewpoint, by the Korean drawing, he has to understand a picture as embodiment of the moral Utopia. For example "sadaebu", which can see sublime quantity with the same picture as being discovered with the work of "An keoun"-- in the conversation. Therefore the West, if united with reappearance or the substance in the focus, Eastern sublime quantity can do it, if the sublime problem means deep connection nature to people's character.

2-deoxy-D-glucose와 quercetin이 방사선조사 MC3T3-E1 골모세포주의 분화시 bone sialoprotein과 osteocalcin 유전자의 발현에 미치는 영향

이지운,김경아,고광준 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.3

Purpose : To investigate the effects of 2-deoxy-D-glucose (2-DG) and quercetin (QCT) on gene expression of bone sialoprotein (BSP) and osteocalcin (OC) during the differentiation in irradiated MC3T3-E1 osteoblastic cells. Materials and Methods : When MC3T3-E1 osteoblastic cells had reached 70-80% confluence, cultures were transferred to a differentiating medium supplemented with 5 mM 2-DG or 10 μM QCT, and then irradiated with 2, 4, 6, and 8 Gy. At various times after irradiation, the cells were analyzed for the synthesis of type I collagen, and expression of BSP and OC. Results : The synthesis of type I collagen in cells exposed to 2 Gy of radiation in the presence of 2-DG or QCT showed no significant difference compared with the control group within 15 days post-irradiation. When the cells were irradiated with 8 Gy, 2-DG facilitated the irradiation mediated decrease of type I collagen synthesis, whereas such decrease was inhibited by treating with QCT. During MC3T3-E1 osteoblastic cell differentiation, the mRNA expression of BSP and OC showed the peak value at 14 days and 21 days, respectively. 2-DG or QCT treatment alone decreased the level of BSP mRNA, but increased the OC mRNA level only at early time of differentiation (day 7). In the cells irradiated with 2, 4, 8 Gy, the mRNA expression of BSP and OC decreased at 7 days after the irradiation. The cells were treated with various dose of radiation in the presence of 2-DG or QCT, the mRNA level of both BSP and OC increased although this increase was observed at low dose of radiation (2 Gy) and at the early stage of differentiation. However, when the cells were exposed to 4, 6, or 8 Gy, the increase of BSP and OC mRNAs was detected only in cells co-incubated with QCT. Conclusion : This study demonstrates that 2-DG and QCT affect differently the expression of bone formation related factors, type I collagen, BSP, and OC in the irradiated MC3T3-E1 osteoblasic cells, according to the dose of radiation and the times of differentiation. Overall, the present findings suggest that 2-DG and QCT could have the regulatory roles as radiation-sensitizer and -protector, respectively. (Korean J Oral Maxillofac Radiol 2009; 39 : 121-32)

법랑아세포종에서의 p53 및 MIB-1 발현 : 임상 및 병리학적 요인들간의 연관성 Correlation Between Clincopathologic Parameters

이수운,한지용,권창석,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Thirty five patinets' paraffin embedded biops block , which was previously diagnosed ameloblastoma and obtained from oral and maxillofacial surgery dept. of pusan paik hospital and OMS dept of collage dentistry, pusan national university hospital, from January 1994 to march 1999, were performed immunohistochemistry with p-53 and MIB-1. On investigating the expression, correlation between clinical and histologic factor and correlation between prognosis and moleculopathologic property were examined. And we obtained the following results; 1. Age over forty, recurrence rate was 58.5%. 91.4% of the tumor was developed on mandibule, recurrence rate of maxilla area tumor was 66.7% On radiologic and histologic feature, multilocular and follicular type has high recurrence rate but no significance statistical difference was found 2. Expression of p-53 was 25.7%, When underage of forty. location on mandibule, multilocular and plexiform type, the expression of p-53 was somewhat higher and recurred cases of tumor, expression rate was 12.5%. 3. MIB-1 expression rate was 77.1%. When location on mandibule, unilocular, plexiform type tumor and previously recurred case, MIB-1 expression was 87.5% which was somewhat higher than no recurrence case of 74.1%. 4. 33.3.% of positive on MIB-1 have expression of p-53 and all p-53 positive case express MIB-1 positive. All p-53 positive case have high cell proliferation rate. From this result, age and location have closely related with the prognosis of tumor, histologic feature and MIB-1 expression has related with the prognosis of tumor. But p-53 has highly expressed on cell proliferation area, not closely related with the prognosis of tumor.

盲腸에 發生한 Hodgkin氏症 一例

柳志文,李恩泰,李永麟 醫藥係社 1963 綜合 醫學 Vol.8 No.8

震顫을 主 症狀으로 入院한 患者 30例에 對한 臨床的 考察

朴智雲,李相龍 대전대학교 한의학연구소 2001 혜화의학회지 Vol.10 No.1

The clinical study was carried out the 30 patients with tremor who were treated in Daejeon University Oriental Hospital from 1 April 1997 to 31 March 2001. The results were summarized as follows. 1. The ratio of female was higher, especially in the psychosomatic tremor, the ratio of female was higher and in the age distribution the aged over 50 were higher frequence. 2. The case without past history was most, the most ordinary preceding disease was hypertintion and the next was diaetes, dringking history had no concern with tremor, first visit was msot, in the psychosomatic tremor complicaiton by relation was the most inducing factor and both parkinson tremor and essential tremor were no inducing factor. 3. Tremor appeared to be busy in extremities, parkinson tremor appeared to be accompanied with musculoskeletal system symptoms and they were in descending order lower limb weakness, extremities numbness, general body weakness e.t.c. both essential trmor and psychosomatic tremor appeared to be accompanied with psychosomatic symptoms and they were in descending order dizziness, headache e.t.c. 4. In classification of Four Human coporeal constitution the number of patients, Tae-Eum-In(太陰人) was most, the prescription drugs of tranquillizing the liver and relieving anxiety such as GYEJIYONGGOLMORYETANG(桂枝加龍骨牡蠣湯) and nourishing Yin, blood and relieving anxiety such as SAMULANSINTANG(四物安神湯) were used to be busy. 5. The rate of treatment was collectively improved and was higher in the yaung age than in the old age, the period of the clinical history was the shorter within on e month, the rate of improvement was the better

소득작물 전후작지 적응 극단기성 벼 ‘중모 1032’

손영보,이종희,조준현,이지윤,오성환,송유천,박동수,박노봉,김상열,여운상,남민희,권영업 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2