Acaricidal toxicities and synergistic activities of Salvia lavandulifolia oil constituents against Dermatophagoides farinae, D. pteronyssinus, and Tyrophagus putrescentiae

Seon?A Choi,Won-Seok Lee,Yun-Seon Yu,Myung-Ji Lee,Hoi-Seon Lee 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.4

심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

3,4‑Dichloroaniline promotes fatty liver in zebrafish larvae

Ji‑Seon Park,송정아,Jong‑Su Park,이상우,Jieon Lee,Han‑Jin Park,Woo‑Keun Kim,Seokjoo Yoon,Hang‑Suk Chun 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.2

Backgrounds 3,4-Dichloroaniline (3,4-DCA) is a transformation product of herbicides that is commonly used as a reference in developmental toxicity studies (OECD TG 236) (Bonnet et al. in Environ Toxicol 22:78–91, 2007). However, the mechanisms underlying 3,4-DCA-induced hepatotoxicity are not well known. Methods We exposed zebrafish larvae at 72 hpf to 3,4-DCA for 3 days and observed lipid accumulation in liver treated with 10-μM 3,4-DCA using oil red O staining. Subsequently, we performed qRT-PCR analysis to determine the genes involved in the observed lipid accumulation. Results We found that genes related to lipogenesis (srebp1, pparγ, lipin1, and scd1) and ER stress (bip, atf4, ddit3, dnajc3, and edem1) were significantly upregulated. In addition, we found that ROS generation increased in the larvae treated with 10-μM 3,4-DCA. Moreover, glutathione-S-transferase activity in these larvae was increased by 3,4-DCA in a dose-dependent manner, and the expression of the inflammation marker il-1β increased. Conclusion Our results indicated that exposure to 3,4-DCA induced fatty liver in zebrafish larvae and that this, in association with additional factors such as ER stress response, can promote liver damage. We accordingly suggest that 3,4-DCA could be used to induce fatty liver in zebrafish larvae.

가평 전주이씨묘 출토복식 고찰

최연우,박윤미,김윤경,김지희,박양희,이선우,차서연,편나영,황혜남,Choi, Yeon Woo,Park, Yoon Mee,Kim, Yoon Gyung,Kim, Ji Hee,Park, Yang Hee,Lee, Seon U,Cha, Seo Yeon,Pyeon, Na Young,Hwang, Hye Nam 한국의류학회 2017 한국의류학회지 Vol.41 No.5

In 1995, the costumes were restored in an unknown woman's tomb at the Jeonju Lee's family cemetery in Gapyeong, Gyeonggi-Do, and there are currently nine items remaining. In this study, we first introduced these 9 relics to academia and analyzed the morphological characteristics of the costumes. We also estimated the time and person of burial compared with costumes unearthed from other burials. Jeogories (short jacket) are all four items. One of these items was unusual in shape, and the upper part of the seop (gusset) was wrinkled and shaped. This type of Jeogori appears only till the 1520s in other tombs. There are also two skirts, one of which is characterized by a superimposed pattern. The top and bottom / middle part of the skirt were rolled up, and the skirt, which was double-rolled up in this way, was first discovered. An analysis of the shape of Jeogori and skirt indicated that the person buried in the Jeonju Lee's family tomb was believed to have survived until the early 16th century. Based on these estimated periods, as a result of looking at the genealogy of Jeonju Lee's family, it was concluded that the tomb was probably a woman named Lee Geum Myeong (李金命) born in the mid-15C and died between the late 15C and the early 16C.

소학교령기(1895-1905) 관·공립소학교교육의 성격에 대한 고찰

이성은,김정효,정희숙,이해지,허선영 한국초등교육학회 2004 초등교육연구 Vol.17 No.1

본 연구의 목적은 국가 주도의 기초 공교육의 효시가 된 소학교령기(1895-1905) 관, 공립소학교교육의 성격을 탐구함으로써, 우리나라 초등교육기원에서 보여지는 특성을 재조명하려는 데에 있다. 이를 위해 소학교령기의 사회적 상황과 교육적 요구, 초등학교의 교육목적, 교육내용 및 방법, 학습자계층과 교원양성과 처우에 대해 알아봄으로써, 당시 초등학교교육의 성격이 어떠했는지 규명하였다. 연구결과, 이 당시 관, 공립소학교는 사회 통합적이라기보다는 구국적 국민계몽교육의 성격을 띠었으며, 보편적 아동교육 이라기보다는 혁신적 근대교육을 상징하였고, 현실안주적 보통교육 이라기보다는 미래지향적 교육의 성격을 띠었다. 결론적으로 다양한 시대상황적 한계에도 불구하고 교육개혁의 의지는 대단하였던 것으로 평가되어졌다. The purpose of this study was to search for the nature of public primary school education in beginning period Enlightenment in Korea(1895-1905) in terms of the aims, the educational contents and methods, and the learner and teacher. For the purpose, the contemporary governmental documents, the newspapers, and other historic materials were collected and analyzed and the school sites were visited. The nature of public primary school education in beginning period of Enlightenment, was revealed as follows: First, it was not for the social consensus, but for the enlightenment of the people against nationalism. Second, it was not universal child education, but innovational elite education, Third, it did reflect not the present need, but the future need. In conclusion, it can be said that their intention of establishment of modem primary school has been underestimated and that their effort for educational reform should be reevaluated. But the research result suggests that public primary school education needs the balance not only between national needs and individual needs, but also between present needs and the future need.

Treacher Collins 증후군 환아의 증례보고

박지현,김승혜,송제선,김성오,이제호 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

Treacher Collins 증후군(TCS)은 25,000명에서 50,000명당 1명의 빈도로 비교적 드물게 발생하는 난치성 질환이다. 이 질환은 정상적인 부모에게서 돌연변이로 발생하거나 상염색체 우성으로 유전된다고 알려져 있다. 하악과 상악, 협골의 발육 부전, 부정교합, 양측성 이개 기형, 안검렬의 반몽고증 사면(antimongoloid slant)이 특징적이며, 종종 구순열, 구개열, 외이도 폐쇄, 중이와 내이의 기형에 의한 청각소실, 왜소증, 심장과 골격의 이상 등을 동반한다. 또한, 인두의 형성부전, 소구, 거설증, 악골의 기형에 기인하여 수면 중 무호흡증, 만성 폐쇄성 무호흡증 등의 호흡 장애가 있을 수 있으며, 전신마취 유도 시에 기관내 삽관이 어렵다고 보고된 바 있다. 치과의사는 관련 신드롬에 대한 충분한 이해를 통해 환자에게 보다 안전하게 치료를 제공해야 하며 구강 건강 관리 및 선천성 안면 기형에 대한 문제 해결을 돕기 위해 적절한 치료 및 안면 수술에 관련된 가이드를 제시해야 한다. 본 증례는 전반적인 치아우식을 주소로 연세대학교 치과병원 소아치과에 내원하여 외래에서 치아우식 치료를 받은 TCS 환아에 대한 것으로, 문헌 고찰을 통해 얻은 다소의 지견을 함께 보고하는 바이다. Treacher Collins syndrome(TCS) is a rare, incurable condition occurring in approximately 1 of 25,000 to 50,000 births. It may occur as a spontaneous mutation out of genetically normal parents or it may be manifested as an autosomal dominant pattern. TCS is characterized by facial deformities such as, underdevelopment of the maxilla, mandible and zygoma, malocclusion, bilateral deformities of auricles, antimongoloid slant of the palpebral fissures. The syndrome is often associated with cleft lip and palate, ear malformations and hearing loss, short stature, and anomalies of the heart and skeleton. Respiratory difficulty associated with air way obstruction may also be observed, and there is considerable difficulty in airway management during general anesthesia. It is necessary that dentists provide safe dental treatments and guidelines to TCS patients by providing adequate understanding about the characteristics of the syndrome and proper ways of managements. The purpose of this study is to report the dental and medical characteristics of the patient who visited the Department of Pediatric Dentistry, Yonsei University for multiple dental caries treatment and to review the literatures of TCS.

원주지역 정보통신도시 육성 및 추진방안 연구

이희춘,지선수 尙志大學校 生産技術硏究所 1998 生産技術論叢 Vol.- No.4

The purpose of this research is to serve as a base for promoting the growth of an information and communication city by orienting to develop Wonju an information and communication city and to present its prospective models. According to the project, Wonju can be a city of crucially strategical resources by the regional strong economic activities in Wonju areas, which will be able to not only enhance the better life but also lead more job opportunities for the people. Also the plan can make Wonju a clean industry city without pollution problems. Therefore the increase of tax revenues is expected by the population influx to this areas. Information and communicative industry by introducing software industry would help Wonju area be the post of strategic importance with bringing middle and less leveled technology of S/W industry and by proceeding with the forward the scheme of software supporting center and S/W founding and upbring center to Wonju.

공정관리에서 신경망을 이용한 X 관리도의 연구

이희준,지선수 尙志大學校 生産技術硏究所 1997 生産技術論叢 Vol.3 No.-

We propose the control chart to provide a more comprehensive scheme for detecting process mean shifts. In this papers, using the backpropagation, five samples are fed into the trained neural network to provide outputs ranging from -1 to 1. The main advantage of using neural network with control chart is that the neural network has almost no delay in detecting small and systematic patterns in the mean. Simulation results show that the performance of the proposed control chart using the neural network is quite promising.

평가 문항을 통한 중학교 과학영재 학생들의 빛 개념 지식상태 분석

이형재,하지선,박상태 韓國英才學會 2011 영재교육연구 Vol.21 No.4

이 연구에서는 K대학교 영재교육원의 중학교 과학영재 학생들 30명을 대상으로 빛에 관한진단평가 15문항을 개발하여 적용하였다. 그리고 빛에 대한 학생들의 지식상태에 관하여 지식공간론을 활용하여 분석하고 이것으로부터 얻은 위계를 도식화함으로써 중학교 과학영재학생들의 지식상태를 파악함은 물론 교수 학습 방법을 개선하기 위한 기초자료로 활용하고자하였다. 이러한 연구 목적을 달성하기 위하여 중학교 과학영재 학생들의 빛에 대한 지식상태평가결과를 분석하였고, 문항 간 위계구조 및 개별 학생들의 지식상태를 분석하였다. 그 결과학습 집단 내에서 개인별로 서로 다른 지식구조를 갖고 있었고, 이에 따른 학습 진단도 서로다르게 평가해야 함을 알 수 있었으며, 평가 문항과 문항 간의 관계(위계 구조)와 개별 학습자의 지식상태를 알 수 있게 한다는 시사점을 얻을 수 있었다. In this study, we developed and applied 15 evaluation questions about light to 30middle school students in K University Science Education Institute for the Gifted .Then we used the theory of knowledge space and analyzed the middle school ScienceGifted Students' knowledge state about light. By schematizing the hierarchy from it, weintended to not only measure students' knowledge state about light, but use it as thebasic materials to improve teaching methods. To achieve the purpose of this study, weanalyzed the evaluation results and individual knowledge state and hierarchy ofquestions. As a result, there were different knowledge structures in the individual, andwe found that we should diagnose them differently. In addition, we have hadimplications that it has the connection with each questions and the individualknowledge state.

건강한 성인에서 발병한 칸디다와 연관된 위궤양 1례

박지훈,이상혁,김희,이재호,박성재,지삼룡,양성연,박은택,이연재,설상영,정정명,강미선 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Fungus such as Candida albicans is a normal flora that is frequently found in the oral cavity, gastrointestinal tract, genitourinary tract, vaginal mucosa in a normal person. However, candida can cause opportunistic infection in an immune compromised host. Candidiasis has broad spectrum of disease from mucocutaneous infection to invasive or disseminated infection. But, it is rarely reported that candida is associaed with gastrointestinal tract disease in a healthy adult. The case of gastric ulcer associated with candida particularly in a health adult is reported with relevant literature.