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OB-28 : Up-regulation of O-GlcNAc transferas (OGT) mRNA in human preeclamptic placenta tussues
( Jeong Kyu Shin ),( Ji Kwoun Park ),( Won Jun Choi ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: O-GlcNAC transferase (OGT) catalyze the O-GlcNAcyation which is an essential modification factor of cellular proteins and appears to be a important regulator of the cellular hypoxic stress response. In this study, we measured the level of OGT mRNA and expression of O-GlcNAcylation, OGT in human preeclamptic placenta tissues. 방법: Gene level of OGT was measured by RT-PCR. Protein expression of O-GlcNAcylation and OGT were measured by Western blotting analysis and immunohistochemistry. 결과: We found that OGT mRNA was strongly up-regulated in the preeclamptic placenta but hardly detectable in the normal placenta tissue. By immunohistochemistry and Western blotting analysis, protein expression of OGT and O-GlcNAcylation were increased. 결론: Up-regulation of O-GlcNAc transferase (OGT) mRNA in human preeclamptic placenta might be an important role in the hypoxic stress response of preeclampsia, through over-expression of OGT and O-GlcNacylation.
O-GlcNAcylation and Expression of OGT in Ovarian cancer tissues
( Jeong Kyu Shin ),( Ji Kwoun Park ),( Won Jun Choi ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
O-GlcNAcylation is an O-linked β-N-acetylglucosamine (O-GlcNAc) moiety linked to the side chain hydroxyl of a serine or threonine residues of nuclear and cytoplasmic proteins. The O-GlcNAcylation is catalyzed by O-GlcNAc transferase (OGT) and its removal is catalyzed by O-GlcNAc-selective N-acetyl-β-D-glucosaminidase (O-GlcNAcase, OGA). O-GlcNAcylationis becoming increasing realized as having important roles in cancer-relevant processes. However, little is known about the role of aberrant O-GlcNAcylation in ovarian cancer. In this study, level of O-GlcNAcylation and expression of OGT were examined in ovarian cancer tissues Immunohistochemical studies for expression of OGT, OGA and O-GlcNAcylation was performed on ovarian cancer tissues. O-GlcNAcylation, OGT and OGA epression were quantified by Western blotting. Immunohistochemical and the Western blot analysis of OGT and O-GlcNAcylation level were significantly elevated in ovarian cancer tissues compared to normal tissues, while expression OGA from cancer tissues were unvaried. Increased expression of OGT and level of O-GlcNAcylationin might be important role in the pathogenesis of ovarian cancer, and may be a valuable target for diagnosis and therapy of ovarian cancer.
GG-38 : Minimal invasive surgery (LESS) for huge cystic adnexal tumors in whole abdomen
( In Young Choi ),( Ji Hye Lee ),( Mi Hyun Park ),( Ji Kwoun Park ),( Jeong Kyu Shin1 ),( Won Jun Choi1 ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Laparoendoscopic single-site surgery (LESS) is helpful if not an evidence of suspicious malignancy in huge adnexa tumors. This approach might be reasonable alternative to conventional laparoscopic surgery. We report two cases with LESS for huge cystic adnexal tumors in whole abdomen. A 58 years old multigravida woman in menopause underwent removal of a huge cystic adnexal mass that occupied her entire abdomen by LESS.(ca.5200ml aspiration) A 15 years old single nulligravida woman had a huge cystic adnexal tumor in whole abdomen reaching to the level of the xyphoid process. A needle through the transumbilical single port was inserted directly under the mass. Subsequently, 8000 ml of cystic fluid was aspirated without spillage.
( Wan Ju Kim ),( Ji Hye Lee ),( Ji Kwoun Park ),( Jeong Kyu Shin ),( Won Jun Choi ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Rectal duplication cyst is rare and few parts of gastrointestinal duplication cysts. Most of gastrointestinal duplication cysts are congenital anomaly, and it revealed variety lesions and forms in children so difficult to find in adults. By chance, we found a woman who have a huge uterine myoma with rectal duplication cyst. It diagnosed by computed tomography. This case report is uncommon in gynecology.
GO-63 : Adenoid cystic carcinoma of Bartholin`s gland in menopause women
( In Young Choi ),( Jeong Kyu Shin ),( Ji Kwoun Park ),( Won Jun Choi ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Adenoid cystic carcinoma (ACC) of the Bartholi`s gland is a rare histological type malignancy of the external genital tract. Only less than eighty cases have been reported in the literature. A 58-year-old women presented to our clinic with chronic external genital pain. In gynecologic examination, slightly hard and swelled mass was palpated around Bartholin`s gland. Under general anesthesia, we performed left hemivulvectomy, inguinal lymphadnectomy, external iliac lymph node sampling by laparoscopy. Pathologic examination conformed ACC showing positive resection margin without lymph node invasion. Postoperative radiotherapy was performed. We planned long-term follow up to evaluate optimal primary treatment and role of radiotherapy.