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서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
Ji, Hee Chung,Whang, Tae Young,Lee, Ki-Won,Kim, Won Ho,Woo, Jae Hoon,Hong, Ki Hung,Choe, Kuh Wann The Korean Society of Grassland and Forage Science 2019 한국초지조사료학회지 Vol.39 No.3
This experiment was conducted to breed a very early maturing variety of Italian ryegrass (Lolium multiflorum Lam.) in Grassland and Forage Crops Division, National Institute of Animal Science, RDA, Cheonan 2015-2017. The new variety of Italian ryegrass, 'Green call 2ho' is a diploid variety with green in leaf color and has semi-erect growth habit in late autumn and erect growth habit in early spring, 'Green call 2ho' was in heading date as a early-maturing variety April 24. Also 'Green call 2ho' was narrower by 2 mm in flag leaf width, longer by 2.5 cm in flag leaf length and shorter by 3 cm in plant height than those of the control variety, 'Florida 80', respectively. 'Green call 2ho' was also thicker by 0.33 mm in stem thickness and strong in winter hardness. Dry matter (DM) yield (11,688 kg/ha) of 'Green call 2ho' was 7% higher than that of 'Florida 80'. Total digestible nutrient (TDN), crude protein (CP) and relative feed value (RFV) of 'Green call 2ho' were 61.3 %, 9.8 % and 98.2, respectively which are 2.6, 0.6, and 8.4 % higher, respectively than those of 'Florida 80', respectively. Acid detergent fiber (ADF) and neutral detergent fiber (NDF) of 'Green call 2ho' were 34.9 and 58.5 % which are 3.3 and 2.7 % lower than those of 'Florida 80', respectively.
손상골조직의 치유에 영향을 미치는 물질에 관한 연구(Ⅱ)
정수연,최현진,정면우,안미령,최선주,유태무,양지선,성연희,류항묵 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
골절은 일반적으로 뼈의 깨짐물 일컫는 용어로 특별한 처치 없이도 자연치유된다. 그러나 최근 교통사고 등의 외상,골다공증 등 질병으로 인한 뼈의 변화로 인해 골절률이 증가함에 따라』 골절의 빠른 치유를 위해 국소적인 growth factor의 투여, 전기 및 초음파 주극 등에 대한 연구가 진행되고 있으나 ')1의 유용성 여분는 명확하지 않다. 홍화씨는 홍화(Carthamus tinctorius 1,.)웨 씨로서 그 약효 및 성분에 대한 보고가 드프나 민간에서 골절, 골다공증,골형성부전 등 골질환의 치료에 사용되어온 물질이다. 본 연구에서는 홍화씨가 골절의 치유에 미치는 영향을 알아보고자 랫드를 이용하여 골다공증성골절의질, 골절모질 및 fetal parietal bone flracture 모릴에서 골절치운도를 평가하였다. 골다공증성골절모질 및 골절모질에서는 10% 홍화씨혼합사료 형태로 8주간 투여하였으며, fetalparietal bone fractore모질에서는 흥화씨 methanol추출물을 12일간 처리하였다. 골절치유에 대한 효과확인의 지표로서 방사선 사진가골(callus) 부피, urinary hydroxyproline, serum osteocalcin, total alkaline rhosphatase 등을 통하여 확인 하였다. 골다공증성골절모질에시는 시헙기간 8주동안 홍화씨를 투여한 군궤서는 대조군에 비하여 방사선쏘견, 가골부피 , urinary hydroxyproline, serum osteocalcin, total alkaline phi)sphatase의 유의적 인 변화는 관찰I 다. 골절모질에서는 홍화씨를 투여한 군에서 대조군에 준하여 방사선소견상으로는 유의적인 변화가 없었고 2주에서 가골 부피의 증가, urinary hydroxyproline, serum osteocalcin, total :tlkaline phosphatase의 감소가 관찰되었으며 1주, 4주, 6주 8주에는 유의작인 변화를 나타나지 않았다. FeIpal·ietalbonefracture모질에서는 흥로씨 메탄을 추출물이 대조군에 ㅂ1하여 육안 및 조직학적 소견으로 골절치유가 촉진되는 경향이 관찰되었다. 본 실험결과에서 촐다롱증성 골절모질에 홍화뛰를투여하였을 매 대조군에 비하여 골절치유의 전단계에 있어서 홍추씨의 골절치윤에 개산초과는 엄었다. 골절모텔에 홍화씨를 투여하였을 패 대조군에 ㅂ1하여 괄절치유의 전단계에 있어 홍rW의 글절치유에 대한 개션 효과는 없었으나 가골이 형성되는 골절치운 초기단계인 2주체 가골의 형성을 유의하게 촉진,골흡수억제가 화인되었고 fettl parietal Cone fracture 모텔에서 치유가 촉진되는 경향이 관찰되었다. We investigated the effect of safflower-seed on fracture healing of osteoporotic fracture model, fracture model and :fetal parietal bone in rat. Fracture healing was evaluated by examining thedegree of wound healing macroscopically, radiography, bone histomorphometry and biochemical exami-nation. On osteoporotic frarture rat model, callus volume, urina]-y hydroxyproline, osteocalcin and totalalkaline phosphatase did nclt reveal the differeuce in safflower-seed treated group and control group. Onfracture rat model, callets volume increased significaltly(p<0.05) and urinary hydroxyproline,osteocalcin and total alkaline phosphatase decreased significaltly(p< 0.05) in safflower-seed treatedgroup at 2 week after frac·ture. On fetal parietal bone fracture model, fracture healing was acceleratedin safflower-seed treated group. In conclusion, safflower-seed stimulate fracture healing during the iBi-tial healing phase by enharlciBg the callus formation and osteoclast activity inhibition.
Analysis of Expressed Sequence Tags of the Spider, Araneus ventricosus
Chung, Eun-Hwa,Lee, Kwang-Sik,Han, Ji-Hee,Sohn, Hung-Dae,Jin, Byung-Rae Korean Society of Sericultural Science 2001 International Journal of Industrial Entomology Vol.3 No.2
We have constructed a cDNA library from the whole body of the spider, Araneus ventricosus. Sequence analysis of randomly selected cDNA clones was performed to obtain genetic information on the spider A. ventricosus, of which genetic information is currently not available. We have partially sequenced randomly selected 385 clones of the cDNA library constructed from A. ventricosus. This expressed sequence tags (EST) analysis revealed 383 genes had high homologies to known genes in GenBank. In this report, 241 independent genes were analyzed in detail.
Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome
Kim, Ji-Hee,Hwang, Kyu-Hee,Lkhagvadorj, Sayamaa,Jung, Jae Hung,Chung, Hyun Chul,Park, Kyu-Sang,Kong, In Deok,Eom, Minseob,Cha, Seung-Kuy The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.3
Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have been implicated in ccRCC development. Although Klotho suppresses a tumor progression through growth factor receptor signaling including insulin-like growth factor-1 receptor (IGF-1R), the role of Klotho acting on IGF-1R in ccRCC and its clinical relevance remains obscure. Here, we show that Klotho is favorable prognostic factor for ccRCC and exerts tumor suppressive role for ccRCC through inhibiting IGF-1R signaling. Our data shows the following key findings. First, in tumor tissues, the level of Klotho and IGF-1R expression are low or high, respectively, compared to that of adjacent non-neoplastic parenchyma. Second, the Klotho expression is clearly low in higher grade of ccRCC and is closely associated with clinical outcomes in tumor progression. Third, Klotho suppresses IGF-1-stimulated cell proliferation and migration by inhibiting PI3K/Akt pathway. These results provide compelling evidence supporting that Klotho acting on IGF-1R signaling functions as tumor suppressor in ccRCC and suggest that Klotho is a potential carcinostatis substance for ccRCC.
Review of 67 Patients With Autoimmune Pancreatitis in Korea: A Multicenter Nationwide Study
Ryu, Ji Kon,Chung, Jae Bock,Park, Seung Woo,Lee, Jong Kyun,Lee, Kyu Tack,Lee, Woo Jin,Moon, Jong Ho,Cho, Kwang Bum,Kang, Dae Whan,Hwang, Jin-Hyeok,Yoo, Kyo-Sang,Yoo, Byung Moo,Lee, Don Hang,Kim, Hae K Lippincott Williams Wilkins, Inc. 2008 Pancreas Vol.37 No.4
OBJECTIVES:: The ideal diagnostic criteria of autoimmune pancreatitis (AIP) are still challenging. Therefore, we investigated the clinical features of AIP in Korea and assessed the clinical use of new Korean diagnostic criteria. METHODS:: We reviewed 67 patients with AIP enrolled in 16 hospitals via a multicenter study. The diagnosis was confirmed according to the Korean diagnostic criteria that included pancreatic imaging, laboratory findings, histopathology, and response to steroid. RESULTS:: Mean age of the patients was 56 years, and 73% were men. Obstructive jaundice (52%) was the most common symptom, and 14 patients (21%) had other organ involvement. Fifty-four patients (81%) revealed diffuse swelling of the pancreas. Either immunoglobulin (Ig)G or IgG4 was elevated in 76%. According to the Korean criteria, 65 patients had definite diagnostic criteria, and 2 patients had probable criteria. Fifteen patients were fulfilled with image, serological, and histopathologic criteria, and 4 patients could be diagnosed with image and steroid responsiveness. Ten patients experienced recurrent attacks of AIP during the mean 20-month follow-up. CONCLUSIONS:: Among 67 cases of AIP, either IgG or IgG4 was elevated in 76% of patients, and 14 patients (21%) had other organ involvement. New Korean diagnostic criteria are useful for diagnosis of AIP.