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Distinctive clinical features of HPeV-3 infection in 2 neonates with a sepsis-like illness
Yeom, Jung Sook,Park, Ji Sook,Seo, Ji-Hyun,Park, Eun Sil,Lim, Jae-Young,Park, Chan-Hoo,Woo, Hyang-Ok,Youn, Hee-Shang,Lee, Ok Jeong,Han, Tae-Hee,Chung, Ju-Young The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.7
We report a human parechovirus-3 (HPeV-3) infection in 2 neonates who had prolonged fever (>5 days) with palmar-plantar erythema. This distinctive rash was observed 4-5 days after fever onset, just before defervescence. Elevated aspartate aminotransferase, lactate dehydrogenase, and ferritin levels were characteristic laboratory findings in the 2 cases, suggesting tissue damage caused by hypercytokinemia. Case 1 was treated with intravenous immunoglobulin, considering the possibility of severe systemic inflammatory responses. The initial ferritin level was 385 ng/mL (range, 0-400 ng/mL); however, the level increased to 2,581 ng/dL on day 5 after fever onset. Case 2 presented with milder clinical symptoms, and the patient recovered spontaneously. HPeV-3 was detected in cerebrospinal fluid and/or blood samples, but no other causative agents were detected. The findings from our cases, in accordance with recent studies, suggest that clinical features such as palmar-plantar erythema and/or hyperferritinemia might be indicators of HPeV-3 infection in neonates with sepsis-like illness. In clinical practice, where virology testing is not easily accessible, clinical features such as palmar-plantar erythema and/or hyperferritinemia might be helpful to diagnose HPeV-3 infection.
Research notes : Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus
( Ji Hee Yeom ),( In Kyoung Lee ),( Dae Won Ki ),( Myeong Seok Lee ),( Soon Ja Seok ),( Bong Sik Yun ) 한국균학회 2012 Mycobiology Vol.40 No.2
During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to 1H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC50 values of 13.1 and 0.03 uM, respectively.
유치원 교사 핵심역량에 기초한 현직교사교육 연구동향 분석
박지희 ( Ji Hee Park ),조형숙 ( Hyung Sook Cho ),염지숙 ( Ji Sook Yeom ) 한국유아교육학회 2014 유아교육연구 Vol.34 No.5
The purpose of this study was to analyze research trends of studies and journals in teacher education published from 1990 to 2014. For this study, research studies and journals of ‘kindergarten teacher’ and ‘teacher education’ were searched through Korea Education and Research Information Service. 27 studies and 40 journals, in total of 67, dealing kindergarten teacher education based on core competency were selected for subjects of the study. The subjects were examined and analyzed upon four standards of analysis, which are core competence, NURI Curriculum, teaching-learning method and educational type. According to the analysis, kindergarten educations were most heavily dominated in following orders of subjects: developing teacher disposition and professionalism, curriculum operation and relationships and communications. Looking at the analysis results according to sub-content of each core competence, four categories were showed such as passion for teaching, understanding of teachinglearning process, reflective self-development and community awareness and attitude formation. Regarding the portation of sub-areas of NURI curriculum, the areas of nature and inquiry were placed first and social relationships secondly. Lastly, exploration and reflective inquiry-based teaching methods were mostly dealt for teaching method of teacher education apporach. 본 연구는 1990년부터 2014년까지 발행된 유아교육관련 모든 학술지 논문과 학위논문을 대상으로 현직교사교육이 어떻게 수행되었는지 동향을 살펴보고자 하였다. 이를 위하여 한국교육학술정보원에서 ‘유치원교사’와 ‘교사교육’ 검색어로 검색된 모든 연구물을 열어보고 ‘유치원 교사 핵심역량에 기초한 현직교사교육’에 해당하는 학술지논문 40편과 학위논문 27편, 총 67편을 연구대상으로 선정하여 분석하였다. 분석기준은 핵심역량과 누리과정 영역, 교수학습방법, 현직교육유형의 네 가지 영역으로 선정하였다. 연구 결과 유치원 현직 교사교육은 교직인성 및 전문성 개발, 교육과정 운영, 대인관계 및 의사소통 순으로 비중있게 다루어졌다. 각 역량의 세부 내용별 연구의 경향을 보면, 교직에 대한 열정, 교수학습과정에 대한 이해, 반성적 자기개발, 공동체 의식 및 태도형성에 대한 연구가 주를 이루고 있었다. 누리과정영역별 핵심역량 연구의 비중을 살펴보면, 자연탐구영역이 가장 많았고, 사회관계영역이 다음이었다. 마지막으로, 교사교육접근을 위한 교수방법으로 활용된 접근방안의 경향을 보면, 탐구중심과 반성적 교수 방법이 가장 많이 활용되었다.
여대생의 월경특성, 학업스트레스, 내분비계 장애물질 노출행동과 월경전증후군의 관계
이성희(Sung Hee Lee),김윤지(Yoon Ji Kim),정지윤(Ji Yoon Jeong),염지영(Ji Young Yeom),김보람(Bo Ram Kim),조은진(Eun Jin Cho),김수진(Su Jin Kim),배민지(Min Ji Bae),임주연(Joo Yeon Lim),이승아(Seung A Lee) 인문사회과학기술융합학회 2018 예술인문사회융합멀티미디어논문지 Vol.8 No.7
본 연구는 여대생의 월경전증후군의 정도를 파악하고, 이에 영향을 미치는 요인을 알아보기 위해 수행되었다. 2017년 5월 29일에서 6월 30일에 걸쳐 D시 1개 대학 및 2개 전문대학 재학 중인 여대생 800명을 편의 모집하였고, 768부가 통계처리에 사용되었다. 자료는 IBM SPSS 20을 이용하여 Mean±SD, t-test, ANOVA, Pearson s correlation coefficient, multiple logistic analysis. multiple regression을 통해 분석되었다. 연구결과, 월경전증후군에 유의한 영향을 미치는 요인으로는 적은 월경량(β=-.116, p=.004), 적당한 월경량(β=-.100, p=.013), 월경곤란증의 가족력(β=-.085, p=.013), 불만족스러운 수면의 질(β=.232, p<.001), 중등도의 수면의 질(β=.095, p=.017), 카페인 무 섭취(β=-.169,p=.002), 카페인 하루 1잔 섭취(β=-.129, p=.018), 학업스트레스(β=.129, p<.001), 내분비계 장애물질 노출행동(β=.164, p<.001)으로 나타났다. 이들 변수가 여대생의 월경전증후군 전체 모형의 17.3%를 설명하였다. 본 연구결과는 여대생의 수면의 질, 카페인 섭취 습관, 학업스트레스관리 및 내분비계 장애물질 노출행동에 대한 생활습관 개선을 통해 월경전 증후군을 감소시켜 여대생의 건강증진 중재의 개발 및 적용이 필요함을 시사한다. The purpose of this research is to figure out the degree of female college students’ premenstrual syndrome, and factors affecting this disease. The study subjects were 800 female college students in 3 schools located in D city. The data were used in 768 additions and collected by a self-administered questionnaire between May 29 and June 30, 2017. The data was analyzed through Mean±SD, t-test, ANOVA, Pearson s correlation coefficient, multiple logistic analysis. multiple regression, using IBM SPSS 20. The results of this study are as follows. Factors affecting premenstrual syndrome included little(β=-.116, p=.004), or moderate amount of menstruation(β=-.100, p=.013), family history of dysmenorrhea (β=-.085, p=.013), unsatisfied sleep quality(β=.232, p<.001), moderate satisfactory of sleep quality(β=.095, p=.017), non-intake of caffeine(β=-.169, p=.002), intake a cup of caffeine a day(β=-.129, p=.018), academic stress(β =.129, p<.001), exposure to endocrine disruptor(β=.164, p<.001) accounting for 17.3% of total variables. This study suggests that health promoting interventions for female college students need to be developed and adapted, by managing sleep quality, academic stress and improving life habits to decrease premenstrual syndrome.
A case of capecitabine-induced discoid lupus erythematosus
( Ji Hye Heo ),( Han Na Hyun ),( Seon Bok Lee ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Jeonghyun Shin ),( Gwang Seong Choi ),( Ji Won Byun ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
There are a few reports of capecitabine-induced cutaneous lupus erythematosus (CLE), of which most of are subacute CLE. In particular, only one case showed discoid lupus erythematosus (DLE)-like features. Capecitabine is an oral fluoropyrimidine carbamate designed to generate 5-fluorouracil preferentially in tumor tissue through exploitation of higher intratumoral concentrations of thymidine phosphorylase and has less systemic toxicity than 5-fluorouracil administered through intravenous processes. The occurrence of druginduced CLE is related to the use of the drug in a timely manner, followed by the improvement of skin symptoms after discontinuation of the offending drug within several weeks. Stopping implicated medication is the initial management of drug-induced CLE. We report an interesting case of oral capecitabine-induced DLE with discoid and malar rashes, which had not occurred using LF protocol (leucovorin plus 5-fluorouracil) previously, that could not be provoked after changing chemotherapy from a capecitabine (a pro-drug of 5-fluorouracil) to FOLFIRI regimen containing leucovorin, 5-fluorouracil, and irinotecan. This case is meaningful for considering the unknown metabolic components acting on converting capecitabine to 5-fluorouracil of CLE induced by oral capecitabine.
A case of pyoderma gangrenosum-like herpes simplex virus infection
( Ji Hye Heo ),( Seon Bok Lee ),( Hee Seong Yoon ),( Si Hyub Lee ),( Seung Dohn Yeom ),( Ji Won Byun ),( Jeonghyun Shin ),( Gwang Seong Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Herpes simplex virus (HSV) infection tends to be more severe and persistent to treatment in immunocompromised patients. We report a case of HSV infection in an immunocompromised patient mimicking pyoderma gangrenosum. The patient of refractory acute myeloid leukemia had ulcers and vesicles around the anus that started eight months ago. Although she was treated for about a month, symptoms got worse. Skin biopsy showed ulceration with abscess and dermolysis in upper dermis. Ballooning cells with inclusion bodies were shown in epidermis. Immunohistochemical stain for HSV was positive. Tzanck test performed in vesicles was also positive. After antivirals and systemic steroid treatment for 2 months, ulcers completely healed. In this case, clinical manifestations were similar to pyoderma gangrenosum, but histopathologic findings were consistent with HSV infection. Therefore, it was diagnosed as pyoderma gangrenosum-like HSV infection. The constant positive results of Tzanck test from initial and recurrent vesicles also suggest a high probability of the diagnosis. Herein, we emphasize that HSV infection can be recalcitrant and may show atypical clinical findings in immunocompromised patient.
Yeom, Jung Sook,Woo, Hyang Ok,Park, Ji Sook,Park, Eun Sil,Seo, Ji-Hyun,Youn, Hee-Shang The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.9
Kawasaki disease (KD) is an acute febrile illness that is the predominant cause of pediatric acquired heart disease in infants and young children. Because the diagnosis of KD depends on clinical manifestations, incomplete cases are difficult to diagnose, especially in infants younger than 1 year. Incomplete clinical manifestations in infants are related with the development of KD-associated coronary artery abnormalities. Because the diagnosis of infantile KD is difficult and complications are numerous, early suspicion and evaluation are necessary.
( Ji Young Kim ),( Chang Wook Kim ),( Yun Hui Kim ),( Seok Cheon Yeom ),( Su Gyeong Lee ),( Hee Yeon Kim ),( Si Hyun Bae ),( Jong Young Choi ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Natural killer T (NKT) cells can be divided into two types broadly. One of them is invariant NKT cells (iNKT) and these cells have CD1d molecules that were presented from antigen presenting cells. Also, CD1d is generally known to present by inflammatory events in patients with alcoholic liver disease. Thus, we investigated the characteristics of peripheral CD1d-restricted T cell population in patients with severe alcoholic hepatitis (SAH). Methods: Four patients with SAH and four healthy people were enrolled. Peripheral blood mononuclear cells were isolated from these subjects according to time schedule, baseline (W0) and after 1 week (W1). To detect iNKT cells, lymphocytes were stained with CD1d Alpha Gal Cer tetramers (Proimmune, oxford, UK) for 30 minutes. We investigated the difference of CD1d-restricted T cells population with positive CD3 and negative CD19 between SAH patients and healthy controls. Flow cytometric analysis was performed using BD FACSCanto II. Results: The baseline frequencies of peripheral CD1d+, CD3+, CD19- NKT cell in patients with SAH were lower compared to those of healthy controls. There were two types of changing pattern of peripheral CD1d+ NKT cell in patients with SAH. First is increasing pattern of peripheral CD1d+ NKT cell at W1 compared to W0 (SAH 1 group). The second is decreasing pattern of peripheral CD1d+ NKT cell at W1 compared to W0 (SAH 2 group). SAH 1 group showed marked improvement of clinical parameters without steroid therapy but, SAH 2 group needed steroid therapy usually for clinical improvements. Conclusions: Based on above results, we consider that frequency of peripheral CD1d+ NKT cell can be used as biomarker for steroid treatment of patients with SAH patients.