월남전 당시 살포된 고엽제에 의해 발생한 것으로 생각되는 피부 질환

이증훈,김윤동,서기범,박장규 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

Although many dermatologists need adequate information about Agent Orange-related skin lesions, there have been few researches about them. We observed various skin manisfestations from 266 Korean Vietnam veterans who visited Department of Dermatology, Chungnam National University Hospital, inculding seborrheic dermatitis(46%), xerotic eczema(45%), chloracne(30%), generalized pruritus (10%), dermographism (5%), chronic urticaria (4%), photosensitive dermatitis (3%), etc. Among them chloracne is well known as a disease which results from exposure to Agent Orange which was used for a defoliating agent during Vietnam war. It is a refractory acneiform eruption due to halogenated polyaromatic compounds(eg. dioxin, dibenzofurane, polychlorinated biphenyls, etc.). 2,3,7,8-tetrachlorodibenzo-p-dioxin, a kind of dioxin isomer, contained in the Agent Orange which was used for a defoliating agent during Vietnam war. It is characterized by recalcitrant comedones and cysts predominantly in the malar and postauricular area. We concluded that the various skin lesions in Vietnam veterans resulted from probably the chemicals in defoliant and further researches would be required to find out subjective guidelines for the evaluation of the skin lesions.

식물추출물의 Tyrosinase 활성 억제효과

이정숙,채은경,계경채,문석식,조순장,김창덕,박장규,이증훈 大韓皮膚硏究學會 2003 大韓皮膚硏究學會誌 Vol.10 No.4

선천성 후비공 폐쇄증 : 7예의 분석

김창훈,이정권,최윤석,유신영,윤주헌 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.3

都市流域의 開發特性에 따른 流出特性變化

李曾錫,宋時勳 慶一大學校 1999 論文集 Vol.16 No.2

In this study, ILLUDAS model which is a model of runoff analysis in urban area is used to analyze runoff characteristics of urban area according to perpendicular and horizontal side gradients and lanes of a road in road drainage system. Peak flow and total disckarge which are the runoff characteristics of flood are analyzed for the perpendicular and horizontal gradients of each lane for probability years of 20 years using Huff's distribution type Ⅲ.

간접면역형광법을 이용한 쭈쭈가무시병의 혈청학적 진단

이증훈,성열훈 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

To determine the antibody titer for the diagnosis of tsutsugamushi disease by indirect immunof-luorescent test n Korea, the antibody titers of 6572 sera of the residents and 296 sera of the 109 patients confirmed as tsutsugamushi disease in the Cungcheung area were analyzed. At cut-off point of 1:40 specificity was 98% and sensitivity, positive predictive value and negative predictive value were 49%, 90%, 86% during the first week after onset, 85%, 94%, 95% during the second week, and 96%, 95%, 99% during the third week. At cut-off point of 1:80 specificity was 99% and sensitivity, positive predictive value and negative predictive value were 47%, 94%, 86% during the first week, 85%, 97%, 95% during the second week, and 96%, 97%, 99% during the third week. At cut-off point of 1:160 specificity was 100% and sensitivity, positive predictive value and negative predictive value were 31%, 995, 82% during the first week, 69%, 100%, 91% during the second week, and 89%, 100%, 97% during the third week.

아연 전처치가 카드뮴 급성 중독에 미치는 영향에 대한 실험적 연구

이정훈,최정목,강대영 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

In an attempt to elucidate the effects of zinc on rat tissue changes induced by cadmium, the present study was undertaken in male Sprague-Dawley rats. Rats were intraperitoneally pretreated with zinc chloride(15.0mg/kg) for 3 days, and then were intraperitoneally given CdCl_2(3.0mg/kg). The body and organ weights of the experimental rats were weighed on the 1st, 3rd, 7th, 15th, 30th and 60th day after CdC_12 injection. The lungs, livers, kidneys and testes were microscopically illuminated and examined under the electron microscope. The results were as follows: 1. The cadmium induced toxicity were most prominent in the testes. The testes showed diffuse hemorrhage, followed by massive hemorrhagic necrosis, calcification and complete disappearance of normal parenchymal tissue(severe atrophy). 2. In the zinc treated group, there were no specific light microscopic changes in the organs. Marked ultrastructural changes were not observed, however the number of glycogen particles increased. 3. The cadmium toxicity to the lung was proportional to the number of days. The lung changes showed chronic bronchitis and progressive interstitial fibrosis of the alveoli. 4. In the cadmium treated group, the liver showed ultrastructural changes such as mitochondrial swelling, dilatation of rough endoplasmic reticulum, myelin figure formation, and decreased number of glycogen particles. The degree of ultrastructural changes slightly decreased in the zinc pretreated group. Also nuclear membrane irregularity was noted after experimental 30th day. 5. After 30th experimental day in the cadmium treated group, ultrastructural appearence of the proximal convoluted tubules of the kidneys showed detachment of microvilli, absence of basal cytoplasmic membrane invagination and irregular mitochondrial shape. In the zinc pretreated group, the degree of ultrastructural changes were mild compared to those of the cadmium only treated group. In conclusion, these experimental results suggest that cadmium toxicity was most prominent in the testes and can be the cause of infertility, and that zinc reduces ultrastructural cellular damage induced by cadmium in the rat tissues.

10% Sodium Lauryl Sulfate에 의한 피부자극 반응에 대한 연구

이증훈 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

To assess the regional or individual variations of inflammatory response to an irritant, closed patch test with 10% sodium lauryl sulfate was done in nine volunteers. The test was performed at eight sites on the ventral sides of the forearms and on the upper backs of each volunteers. The degree of inflammation was greater on the upper backs than on the forearms. The degree of variations among test sites and subjects was greater on the forearms than on the upper backs.

완선에 대한 항진균제(clotrimazole) 단독 및 스테로이드가 첨가된 복합체(Triamcinolone acetonide and Hydrocortisone)의 치료효과에 관한 비교 연구

이증훈,서우영,김기홍,최종수 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

Although the combination products of antifungal agents and corticosteroids are often used in the treatment of superficial fungal infections, their usefulness is not settled. The combined corticosteroids may promote the spread of fungi. On the other hand, they can bring rapid relief from signs and symptoms and increase the local concentrations of the antifungal agents in the skin due to the vasoconstrictive effect. This study was performed to compare an antifungal agent with its combination products with corticosteroids in the treatment of tinea cruris. Seventy-four patients with tinea cruris, aged 18-26 years, were admitted to the study. All ere soldiers living in the same conditions. Sixty patients completed 2 weeks of therapy : clotrimazole, 19 ; combination with trimacinolone acetonide, 28; combination with hydrocortisone, 13. All treatments almost completely improved the lesions at the end of 2-week period. No specific treatment was significantly better. After 4 weeks the relapse rate was highest in the group treated with clotrimazole combined with triamcinolone acetonide (75%), compared with clotrimazone alone (47%) or its combination with hydrocortisone (50%), but not significant statistically (p<0.05).

정전기력 구동 마이크로 액츄에이터를 이용한 Si 소재 탄성특성의 온도의존성 평가

鄭聖勳,李世昊,鄭增鉉,權東一 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.8

Electrostatically actuated testing devices were used to estimate the elastic modulus of single-crystalline Si for microeletromechanical systems. The devices were moved laterally by alternating electrostatic force at a series of frequencies, and then a resonance frequency was determined, with temperature cycling, by detecting the maximum displacement. The elastic modulus was calculated from the detected resonance frequency by Rayleigh's energy method. The elastic modulus decreased with heating and then increased with cooling, but after thermal cycle the specimen showed a permanent change to a value lower than the initial one. This phenomenon can be explained, to some extent, by the temperature-dependent variation in interatomic force of Si atoms, but the permanent change in elastic modulus implies that it may also be caused by the formation of a thermal oxide layer on the Si with increasing temperature. Composite bending theory was invoked to analyze the oxide effect and the thickness of the oxide layer formed during thermal cycling was estimated from the permanent change in the resonance frequency. The existence of the oxide layer was confirmed by field emission scanning electron microscopy. Finally, the method for compensating the decreasing elastic modulus with increasing temperature were proposed by using the temperature coefficient of elastic modulus.

유두에 발생한 음부 평활근종 1예

계경채,이영,서영준,이증훈,박장규,김진만,김협 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4