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Reference thermal neutron field at KRISS for calibration of neutron detectors
Kim, Yun Ho,Park, Hyeonseo,Kim, Yong Kyun,Kim, Jungho,Kang, Jeongsoo Elsevier 2017 Radiation measurements Vol.107 No.-
<P><B>Abstract</B></P> <P>A reference thermal neutron field has been established at the Korea Research Institute of Standards and Science (KRISS) by using a <SUP>241</SUP>Am-Be neutron source and a high-purity graphite pile constructed by stacking graphite blocks. The properties of the graphite blocks such as impurities, density, and dimensions were studied thoroughly to understand the characteristics of the generated field. The energy spectrum and thermal neutron fractions were simulated with the Monte Carlo N-Particle eXtended code using measured physical parameters. The neutron effective temperature was 308 K, and the fraction of thermal neutrons was approximately 95% at the reference position of the thermal neutron field. The thermal neutron fluence rate was determined by adopting the Westcott convention method based on neutron activation analysis using a gold foil. The Westcott fluence rate for thermal neutron at the reference position was (2326.7 ± 8.4) cm<SUP>−2</SUP>s<SUP>−1</SUP>. The true thermal neutron fluence rate at the reference position in the KRISS thermal neutron field was (2700 ± 29) cm<SUP>−2</SUP>s<SUP>−1</SUP> (at the reference date of June 30, 2014). The response of a spherical proportional counter with He-3 (SP9 neutron detector) was evaluated in the newly established field as (3.083 ± 0.045) cm<SUP>2</SUP> for the reference calibration condition (a parallel neutron beam with a Maxwellian energy distribution having a most probable energy of 0.025 eV).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thermal neutron field was developed for the calibration of neutron detectors. </LI> <LI> A <SUP>241</SUP>Am-Be neutron source and a pure graphite pile were used for the construction. </LI> <LI> Monte Carlo simulation was performed to understand characteristics of the field. </LI> <LI> Thermal neutron fluence rate was determined based on neutron activation analysis. </LI> <LI> The sensitivity of the SP9 detector was calibrated with an uncertainty of ∼3%. </LI> </UL> </P>
Squamous cell carcinoma in situ successfully treated with ingenol mebutate 0.015%
( Jeongsoo Kim ),( Seulki Lee ),( Haryeong Ryu ),( Chulhyun Yoon ),( Jinok Baek ),( Jongrok Lee ),( Jooyoung Roh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Cutaneous squamous cell carcinoma(cSCC) is the second most common skin cancer in the US. Many cSCCs are small low-risk cancers and are usually effectively managed using minor surgical procedures. However, alternative treatment options are sometimes required, for example, when a patient refuses a surgical procedure, surgical treatment is contraindicated due to possible morbidity or cosmetic deformity and patient condition is compromised by age or the presence of comorbidities. Topical therapy is usually preferred by these patients. Ingenol mebutate has a dual mechanism of action involving the rapid induction of cellular death and cellular cytotoxicity triggered by neutrophils and antibodies. And it has limited local side effect and is applied easily. A 92-year-old Asian woman presented at our dermatology clinic with an erythematous, rough, oozing, crusted lesion of the scalp. In 2011, she has been diagnosed with actinic keratosis of the scalp but dropped out. At this presentation the lesion had became more severe and was biopsied under the suspicion of SCC. We decided to treat the lesion with ingenol mebutate gel (0.015%) daily, and administered two cycles of 3 consecutive days per month for two months. One month after the second cycle the lesion had almost resolved and this was confirmed by biopsy. We report a rare case of cSCC in situ that was treated by ingenol mebutate that is considered an alternative to surgery.
Marginal zone B-cell lymphoma associated with MALT lymphoma of parotid gland
( Jeongsoo Kim ),( Seulki Lee ),( Haryeong Ryu ),( Chulhyun Yoon ),( Jinok Baek ),( Jongrok Lee ),( Jooyoung Roh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Cutaneous Marginal zone B-cell lymphoma (CMZL) is known as extranodal mucosa associated lymphoid tissue (MALT) lymphoma arising at skin accounting for 11% of various extranodal organs. CMZL has indolent behavior and excellent prognosis but recurrence is common. Typically, it manifests as single or multiple, clustered erythematous or violaceous papules, plaques, or nodules. The lesions occur most commonly on the trunk and upper extremities. Histologically, CMZL is composed of polymorphous infiltrate that includes centrocyte-like, monocytoid, and lymphoplasmacytoid lymphocytes and plasma cells. CMZL can be managed with either conservative skin-directed strategies, such as surgical excision and topical steroid, or radiotherapy. A 78-year-old male patient presented with round elevated soft plaque on his back for 2 years. He was diagnosed as MZL of the parotid gland, and underwent surgical excision, radiotherapy and chemotherapy (CHOP) 9 years ago. Histopathologic of the skin showed nodular infiltrate of lymphocytes forming dense, irregulary shaped aggregates in the reticular dermis to subcutaneous tissue. Immunohistochemistry findings revealed positive for CD20, Bcl-2, CD5 and negative for Cyclin D1. There was no evidence of recurrence of previous lymphoma and no sign of metastasis with PET-CT. He was treated with radiotherapy. We report a rare case of CMZL that was formed from patient who had been diagnosed as MZL of the parotid gland.
Kim, Young Hoon,Kim, Jeongsoo,Park, Haeil,Kim, Hyun Pyo Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.8
<P>Chalcones belong to the flavonoid family from plant origin and some of them possess anti-inflammatory activity. Recently, several natural and synthetic chalcone derivatives were reported to inhibit inducible nitric oxide synthase (iNOS)-catalyzed NO production in cell cultures. In the present study, to find the optimal chemical structures and to elucidate their action mechanisms, 41 synthetic chalcones having the substituent(s) on A- and B-rings were prepared and their effects on iNOS-catalyzed NO production were evaluated using lipopolysaccharide (LPS)-treated RAW 264.7 cells. When simultaneously added with LPS, 2′-methoxy-3,4-dichlorochalcone (Ch15), 2′-hydroxy-6′-methoxychalcone (Ch29), 2′-hydroxy-3-bromo-6′-methoxychalcone (Ch31) and 2′-hydroxy-4′,6′-dimethoxychalcone (Ch35) among the tested compounds potently inhibited NO production (IC<SUB>50</SUB>s, 7.1—9.6 μ<SMALL>M</SMALL>). The favorable chemical structures were found to be a methoxyl substitution in A-ring at an adjacent position (2′ or 6′) to carbonyl moiety with/without 2′-(or 6′-)hydroxyl group and 3-halogen substitution in B-ring. When the cellular action mechanisms of Ch15, Ch31 and Ch35 were further examined using Western blotting and electrophoretic mobility shift assay, it was revealed that Ch15 and Ch31 clearly down-regulated iNOS expression while Ch35 did not. Moreover, Ch15 and Ch31 were proved to suppress the nuclear transcription factor-κB activation. From the results, it is suggested that certain chalcone derivatives potently inhibit iNOS-catalyzed NO production by the different cellular mechanisms, iNOS down-regulation and/or iNOS inhibition, depending on their chemical structures. These chalcone derivatives may possibly be used as lead compounds for developing new anti-inflammatory agents.</P>