재발성 류마티즘 환자에서 발작의 유발인자

주유철,이동민,양종태,신병철,임태영,서정균,정기영,최동헌,김원,조영신,고희관 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Palindromic rheumatism (PR) is known to be triggered without any obviously inciting events in most patients, although, in a few cases, attacks have been noted to relate to another events such as weather change, childbirth, ingestion of certain foods, or over-exercise. The aim of this study was to characterize the triggering factors on palindromic attacks. Materials and Methods : We evaluated sixty-four patients with PR for the presence of triggering factors and the relationship between attacks and triggering factors by interview of patients. We considered that there was an probable association between episodes and PR, if episodes within 24 hours prior to PR had triggered at least 50% of all attacks and a definite association between episodes and PR, if episodes within 24 hours prior to PR had triggered 100% of all attacks. Results : In 15 patients (35.9%), there was a possible association between episodes of PR and initiating events. In 8 patients (12.5%), there was a definite association between episodes of PR and initiating events. The triggering factors were physical over-activity including exercise (19/64: 29.7%), foods, such as rawfish, crab, and chicken, including alcohol (19/96: 19.8%). However, there were no difference between the groups with and without the triggering factor in sex ratio, duration and onset of PR, the positive rate of rheumatoid factor and involved sites. Conclusion : Our observations showed that PR was triggered by physical over-activity more than in previous reports and hypersensitivity to foods was a causative factor in some patients with PR. However, patients with triggering factors had a similiar clinical profile to patients without triggering factors.

뮤코펙트 정(염산암브록솔 30mg)에 대한 암브렉트 정의 생물학적 동등성

유정연,정선경,최미희,한상범,이경률,이희주 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

A bioequivalence study of Ambrect^(™) tablets (Dong Wha Pharm. Ind. Co., Ltd.) to Mucopect^(™) tablets(Boe-hringer Ingelheim Korea, Ltd.) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the ambroxol hydorchoride dose of 30 ㎎ in a 2×2 crossover study. There was a one-week wash out period between the doses. Plasma concentrations of ambroxol were monitored by a high-performance liquid chromatography for over a period of 24 hours after the administration. Aug_(t)(the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were compilied from the plasma concentraction-time data. Analysis of variance was carried out using logarithmically transformed AUC_(T) and C_(max). No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the AUC_(t) ratio and the C_(max) ratio for Ambrect^(™)/Mucopect^(™) were 0.89-1.01 and 0.89-1.02, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstarated the bioequivalence of Ambrect^(™) and Mucopect^(™) with respect to the rate and extent of absorption.

CCD/LSB 방식의 형상측정시스템의 정밀도 향상 방법

유주상,정규원 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

Since recent production system becomes that of the small quantity, large volume with high quality production, accurate and high speed inspection system is required. In such situation, non contact 3D measurement system which utilized CCD cameras is useful technique in terms of system cost, speed of data acquisition, measuring accuracy and application. However, it has low accuracy compared with contact 3D measurement system because of the camera distortion, non uniformity of laser distribution and so on. For those reasons, in this paper precision enhancement method is studied considering radial camera distortion, and laser distribution. A distortion correction method is applied even to the standard lens. The laser slit beam trajectory is determined by 3 method: based of the Gaussian function signal approximation, the median method, the center of gravity method and the peak point of the Gaussian function method.

항공기 피로수명 예측을 위한 파면해석

정유인,이태주,장영환,김상식 대한금속ᆞ재료학회 2006 대한금속·재료학회지 Vol.44 No.3

9-12%Cr강의 첨가원소 및 열처리에 따른 미세조직거동과 경도변화

주성욱,유정훈,신기삼,허성강,이재현,석진익,김병훈,김정태 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

9-12%Cr steel are getting increasing attention for expanded application as high temperature materials applicable for gas turbine compressors, steam turbine rotors, blade and casing. For efficient and extensive application of 9-12%Cr steel, the data in addition to the improvement of mechanical properties on the correlation of microstructural evolution and mechanical properties are inevitable and thus the investigation in this study is performed for the determination for the specimens heat-treated at 600, 650 and 700℃ for 1000, 3000 and 5000hrs. The microstructure of as-received specimen was tempered martensite, with a high dislocation density and secondary phases. Upon high temperature heat-treatment, the martensite lath got larger and dislocation density decreased resulting the reduction of the strength. In addition, sharp growth of secondary phases was observed in the specimen heat-treated at 700℃ for 5000hrs. A specimen aged at 600℃ and 650℃ Laves phase was observed. The hardness showed close relationship with the secondary phase particle and dislocation density.

흰쥐의 좌골신경 절단손상후 기능회복에 대한 Acetyl-L carnitine의 효과

조주원,이정재,손유리,유영천,유석근 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

A possible therapeutic effect of acetyl-L carnitine (ALCAR) on peripheral nerve injuries and the expression of Jun, the protein products of immediate-early genes(IEGs), in the spinal cord were investigated after sciatic nerve injury in Sprague-Dawley rats. Experimental animals were divided into 3 groups: intact sciatic nerve as a control group, surgical repair alone, and surgical repair with ALCAR treatment. Toe-spreading response, pinprick response, and compound action potential were measured to evaluate the recovery of sciatic nerve injury. Recovery of behavioral function and electrophysiological function both improved in the surgical repair with ALCAR treatment group. Weak basal expression of Jun was shown in the ventral horn the of spinal cord in the control group. In the surgical repair alone group or the surgical repair with ALCAR treatment group, Jun expression persisted until 28 days after injury in the ventral horn of the spinal cord. Moreover, the surgical repair with ALCAR treatment group showed more increased expression of Jun than the surgical repair alone group. These results suggest that ALCAR facilitates the functional recovery after peripheral nerve injury.

수도권 일부 프랑스 레스토랑의 운영 실태 조사

고유정,이희정,주나미 숙명여자대학교 건강·생활과학연구소 2009 生活科學硏究誌 Vol.- No.26

This study is to find the revitalizing method from a survey of overall operation and characteristics of French restaurant in Seoul and Kyeonggido. Sixty-men and women of 20s took part from appointed 60 restaurants in Seoul and Kyeonggido. The statistical analysis conducts by SPSSWIN 12.0 program and the significance level is p<.05, p<.Ol, p<.OO1. The result of operation status of French restaurant is as below. Form of start-up company is popular and the period ofoperation is within 2-5 years. Mostly, restaurant is operated personally. Most of restaurants are located in residential street and apartment complex. 50-100 are most popular in weekdays and weekend customers are more than 100 people in average. So it shows meaningful differences. Most of restaurants carry on business more than 30 days without holidays and open at noon and evening in a day. Monthly rent is popular for form of possession and owners give a weight of passion and interest for applicant when hiring employees and regard management expenses as most important labor cost. Many restaurant get food staff from appointed supplier by competition. Purchase ratio of food staff compared with sales is 25%-30% mostly. 41.7% of people said the future prospect of restaurant is just ''Normal''. Most important thing of menu composition is structure and composition, particularly representative menu and gustatory quality respectively. The important thing is "Taste", sanitation, facilities, menu development, education of employee, price and etc respectively for operation of French restaurant. Sales promotions to attract more customers and relationship with around store are analyzed as less important things. The biggest difficulty is the speedy rising of prime cost for operation of frenches and restaurant, manpower shortage, decreasing customer in this sequence. The difficult for increase offoreign food service and customer complain, decrease of customers is not a big problem in operation of restaurant. This study shows differences from other studies by grasping characteristics of restaurant unlike consideration of simple French dishes and also it is incalculable value to know the overall particulars, importance and difficulties by detailed survey.

건축에서 "Flux"의 의미에 관한 연구

하언정,유인호,김주현 금오공과대학교 2006 論文集 Vol.27 No.-

The purpose of this study is to explore how modem cities and architecture are adapted to the Age of Flow and Change and to clarify the meaning of the growth of modem cities and architecture in quality. Modem society is changing radically and various fields of it are highly interacting each other. Cities and architecture are not exception of this tendency. Different from other area, philosophy plays an important part as a dominant external factor in theoretical discussion on architecture. Therefore, this study investigated. the meaning of "Flux" appeared in modem cities and architecture from the view of "cinema-philosophy" of Gilles Deleuze and considered how it was expressed in modem cities and architecture through a case analysis. As a movie repeats the trace of philosophy which pursues the time, modem cities and architecture also exhibit the characteristics of "time-image." "Time-image" shows both coexistence and discrepancy of factors which can not go together. Subsequently, it forms continuity by denying the organized relation. The distinction of traditional factor such as wall, column and floor and the boarder between vertical and horizontal space becorres unclear. The similarity between these characteristics of "time-image" and modem architecture exhibits that architecture is in the evolutionary process of finding time as philosophy and movies found time. 'Time-image' that was presented as "Flux" in architecture gives us the true shock on the thinking like a movie does.

비 세균성 설사 환아에서 저나트륨 농도의 경구 전해질 용액(Pedialyte^(�)RS)과 lactose free diet(Isomil^(�))의 치료 효과

이종덕,유정애,이주원,김순겸 최신의학사 1985 最新醫學 Vol.28 No.11

소아에서의 급성 파종성 뇌척수염의 임상적 고찰

조수진,박은애,유은선,김혜순,손세정,서정완,이승주,한후재 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

목적: 급성 파종성 뇌척수염은 감염이나 예방 접종 후 발생하는 중추 신경계의 급성 자가 면역 염증성 질환으로 탈수초를 일으킨다. 신경학적인 증상으로 발현되고 대부분 환전히 회복되지만 신경학적 후유증을 남기거나 사망 할 수도 있다. 이에 저자들은 본원에서 발생 한 14명을 분석하여 조기 진단과 치료에 도움을 주고자 하였다. 대상과 방법: 1998년 3월부터 2003년 8월까지 이대목동병원에서 급성 파종성 뇌척수염으로 진단 받은 14명의 의무기록을 후향적으로 조사하였다. 결과: 환자들의 평균 발생 연령은 5±7.8개월이였고, 특정계절이나 연도에 집중되어서 나타나지는 않았다. 선행질환은 주로 비특이적인 상기도 감염이 가장 많았고, 초기증상으로는 경련이 가장 많았다. 그 외에 의식저하나 운동장애도 있었다. 뇌척수액 검사에서 백혈구 증가증이 발견된 경우는 있었으나 단백이 증가된 경우는 없었다. 뇌 자기공명 촬영에서 T2 증강시 뇌백질과 기저핵에 고음영의 다발성 병소가 발견되었고 추적 촬영에서 대부분에서 소실되었다. 뇌파 검사가 시행되었던 경우 전반적인 서파가 가장 많았고 국소적인 극파가 나온 경우도 한 명 있었다. 환자들은 정맥 면역 글로블린과 메틸프레드니졸론으로 치료하였고 치료 시작 후 3~7일내 증상이 호전되었다. 모든 환자를 2달 이상 추적 관찰하였고 항경련제가 지속적으로 필요한 정도의 경련성 질환이 두 명, 신경아교증이 남아잇는 경우가 한 명, 외래에서 다발성 경화증이 의심되는 경우가 한 명 있었다. 결론: 급성 파종성 뇌척수염은 침범 부위에 따라서 다양한 임상 상으로 나타나며 면역 글로블린과 메틸프레드니졸론이 치료에 효과적이였다. 본 연구에서는 대상 환자수가 적어 신경학적 후유증의 위험요소는 밝힐 수는 없으나, 예후는 검사소견과 연관되어 있지는 않았고, 대부분에서 양호하여 완전히 회복되었으나, 신경학적 후유증이 남은 경우도 있었다. Objective:Acute disseminated encephalomyelitis(ADEM) is an acute demyelinating autoimmune inflammatory disease of the central nervous system which develops after infection of vaccination. It may be fatal, and produce a permanent residual static disability or fully recover. We retrospec-tively studied 14 cases to investigate the clinical findings and outcome of ADEM. Methods : 14cases of ADEM diagnosed at Ewha Womans University Mokdong Hospital from 1998 to 2003 were retrospectively reviewed. Results : The age of onset was 5years±7.8 months and no seasonal clustering was found. The time of onset of symptoms was between 3 to 30 days. The preceding events were nonspecific upper respiratory infections in 9 cases, aseptic meningitis in 4 cases, and gastroenteritis in one case..The initial symptoms were seizure, altered consciousness, hemiparesis, fever, headache, and vomiting. Brain MRI showed multifocal high signal intensity lesions on T2 weighted image mainly in the cerebral whith matter, basal ganglia and periventricular white matter. EEG was performed in some cases and showed generalized or focal slow waves and only one case showed focal spikes. Patients were treated with IV globulin and methylprednisolone and the symptoms improved within 3-7 days after treatment. All patients were followed up for more than 2 months and most of them fully recovered except two. Conclusion : ADEM presents in various clinical manifestations depending on its involvement of the brain lesions. Most cases recovered fully but in some cases, residual permanent neurologic sequelae remained.