Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

열 전처리에 의한 섬유소분해효소생산 미생물의 선발

정허진,김훈,김정호 順天大學校 1996 論文集 Vol.15 No.1

30 개의 토양과 퇴비 시료로 부터 섬유소 분해효소를 생산하는 3 종류의 미생물을 분리하였다. 분리는 carboxymethyl-cellulose (CMC)를 함유하는 고체 평판배지를 이용하였으며, 분리된 3 종류 중 2 종류 (H12, H15)는 열 전처리한 시료로 부터, 1 종류 (N01)는 열 전처리하지 않은 시료로 부터 얻어졌다. H12와 H15의 섬유소분해활성은 N01보다 높은 것으로 조사되었다. H12와 H15는 액체배지에서 배양한 경우 37℃와 42℃에서 균체증식과 CMCase 생산이 좋았다. N01은 37℃에서는 잘 자라지 못 하였고, 42℃에서는 H12, H15와 비슷하게 성장하였으나 효소 생성은 거의 없었다. H12와 H15 균주에서 CMC 첨가에 따른 효소 생성의 유도는 전혀 관찰되지 않았다. 분리된 3 균주를 TSB에서 배양한 결과 LB 배지에서 보다 적어도 2배 이상의 많은 CMCase를 생산하였다. 이상의 결과는 시료의 열 전처리가 CMCase를 생산하는 균주를 선발하는 데 보다 좋은 방법일 수 있음을 시사한다. Three microorganisms producing carboxymethyl-cellulase (CMCase) were isolated from 30 soil and compost samples. CMCase activity, on plates containing CMC, of the two isolates, H12 and H15, screened by heat-pretreatment procedure, was higher than that of N01, the one screened by nonheat-treatment procedure. H12 and H15 were able to grow and produce the enzyme well at 37 and 42℃ in liquid culture media. N01 did not grow well at 37℃ but could grow moderately at a little higher temperature, 42℃. However, N01 did not produce CMCase in liquid culture media at 42℃. For H12 and H15, addition of CMC to the media did not increase the production of CMCase at all. All of the three isolates produced at least about 2 times higher CMCase activity in TSB medium than in LB medium. From these results, it is suggested that heat-pretreatment of samples can provide a better way of screening CMCase producing strains.

Water-Mediated Photochemical Treatments for Low-Temperature Passivation of Metal-Oxide Thin-Film Transistors

Heo, Jae Sang,Jo, Jeong-Wan,Kang, Jingu,Jeong, Chan-Yong,Jeong, Hu Young,Kim, Sung Kyu,Kim, Kwanpyo,Kwon, Hyuck-In,Kim, Jaekyun,Kim, Yong-Hoon,Kim, Myung-Gil,Park, Sung Kyu American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.16

<P>The low-temperature electrical passivation of an amorphous oxide semiconductor (AOS) thin-film transistor (TFT) is achieved by a deep ultraviolet (DUV) light irradiation-water treatment-DUV irradiation (DWD) method. The water treatment of the first DUV-annealed amorphous indium-gallium-zinc-oxide (a-IGZO) thin film is likely to induce the preferred adsorption of water molecules at the oxygen vacancies and leads to subsequent hydroxide formation in the bulk a-IGZO films. Although the water treatment initially degraded the electrical performance of the a-IGZO TFTs, the second DUV irradiation on the water-treated devices may enable a more complete metal oxygen metal lattice formation while maintaining low oxygen vacancies in the oxide films. Overall, the stable and dense metal oxygen metal (M-O-M) network formation could be easily achieved at low temperatures (below 150 degrees C). The successful passivation of structural imperfections in the a-IGZO TFTs, such as hydroxyl group (OH-) and oxygen vacancies, mainly results in the enhanced electrical performances of the DWD-processed a-IGZO TFTs (on/off current ratio of 8.65 X 10(9), subthreshold slope of 0.16 V/decade, an average mobility of >6.94 cm(2) s(-1), and a bias stability of Delta V-TH < 2.5 V), which show more than a 30% improvement over the simple DUV-treated a-IGZO TFTs.</P>

Radiologic screening of maternal periodontitis predicts adverse pregnancy and neonatal outcomes

( Jeong Min Kim ),( Youngmi Jeong ),( Ju Sun Heo ),( Jung Soo Park ),( Ho Yeon Kim ),( Geum Joon Cho ),( Soon-cheol Hong ),( Min-jeong Oh ),( Hai-joong Kim ),( Ki Hoon Ahn ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: Dental screening is essential for the women who decide to conceive a baby or who get pregnancy. However, clinical screening such as periodontal probing could be quite time-consuming, highly discomforting, and inaccurate method. The aim of this study was to assess whether the severity of periodontitis classified by radiologic screening in accordance with the 2017 consensus classification was related to the adverse pregnancy and neonatal outcomes. Methods: One-hundred sixty-five mothers who underwent panorama x-rays within five years before and after the time of delivery, and their singleton neonates were included in this study. Their medical records were retrospectively reviewed. Results: Twenty-two mothers (13.3%) had severe periodontitis (SP), and 143 mothers (86.7%) had mild/moderate periodontitis (MP). Multivariate logistic regression analysis revealed that maternal SP was independently associated with uterine leiomyoma (OR: 5.555, 95% CI: 1.371-22.503, P = 0.016) and small for gestational age (OR: 4.488, 95% CI: 1.116-18.058, P = 0.035). Among the preterm infants, infants in the SP group had not only lower birth weight, but also lower z-score of birth weight. Incidences of retinopathy of prematurity (ROP) and treated patent ductus arteriosus (PDA) were significantly higher in the SP group than in the MP group (ROP: 50% vs 0%, P = 0.008, PDA: 33.3% vs 0%, P = 0.046). Conclusion: Radiologic screening of maternal periodontitis can predict adverse pregnancy and neonatal outcomes. It could be a useful screening method for predicting adverse outcomes as well as diagnosing SP in pregnant women.

A Case of Early Onset Alzheimer's Disease Diagnosed by 18F Flutemetamol PET Image

Jeong-Hoon Kim,Eun-Jeong Lee,Sang-Soon Park,Jae-Hyeok Heo 대한치매학회 2018 Dementia and Neurocognitive Disorders Vol.17 No.4

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ACN9 Regulates the Inflammatory Responses in Human Bronchial Epithelial Cells

Jeong, Jae Hoon,Kim, Jeeyoung,Kim, Jeongwoon,Heo, Hye-Ryeon,Jeong, Jin Seon,Ryu, Young-Joon,Hong, Yoonki,Han, Seon-Sook,Hong, Seok-Ho,Lee, Seung-Joon,Kim, Woo Jin The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3

Background: Airway epithelial cells are the first line of defense, against pathogens and environmental pollutants, in the lungs. Cellular stress by cadmium (Cd), resulting in airway inflammation, is assumed to be directly involved in tissue injury, linked to the development of lung cancer, and chronic obstructive pulmonary disease (COPD). We had earlier shown that ACN9 (chromosome 7q21), is a potential candidate gene for COPD, and identified significant interaction with smoking, based on genetic studies. However, the role of ACN9 in the inflammatory response, in the airway cells, has not yet been reported. Methods: We first checked the anatomical distribution of ACN9 in lung tissues, using mRNA in situ hybridization, and immunohistochemistry. Gene expression profiling in bronchial epithelial cells (BEAS-2B), was performed, after silencing ACN9. We further tested the roles of ACN9, in the intracellular mechanism, leading to Cd-induced production, of proinflammatory cytokines in BEAS-2B. Results: ACN9 was localized in lymphoid, and epithelial cells, of human lung tissues. ACN9 silencing, led to differential expression of 216 genes. Pathways of sensory perception to chemical stimuli, and cell surface receptor-linked signal transduction, were significantly enriched. ACN9 silencing, further increased the expression of proinflammatory cytokines, in BEAS-2B after Cd exposure. Conclusion: Our findings suggest, that ACN9 may have a role, in the inflammatory response in the airway.

Improvement Serum IgG, IgA, and Igκ Levels of High-fat Diet-Induced Obese Rats by Prunus mume Sieb. et Zucc (Maesil) Extract

Jeong Hoon Pan,Wan Heo,Hyung Taek Cho,Jin Soo Yuk,Dong Hoon Shin,Young Jun Kim 한국식품영양과학회 2011 한국식품영양과학회 학술대회발표집 Vol.2011 No.10

A Case of Acute ST-segment Elevation Myocardial Infarction with Normal Coronary Arteries after Binge Drinking

Heo, Ran;Kim, Byung-Ok;Kim, Jeong-Hoon;Kang, Mi-Seon;Jang, Won;Seo, Hee-Young;Park, Ji-Young;Park, Sang-Hoon;Cho, Sung-Woo 인제대학교 2011 仁濟醫學 Vol.32 No.-

알코올의 과다 섭취는 심근 경색의 드문 원인으로, 저자들은 알코올의 과다 섭취 후 발생한 ST 분절 상승 심근 경색 환자에서 정상 관상동맥 소견을 보이는 증례를 보고하는 바이다. 70세 남환이 과음 후 반혼수 상태로 내원하였다. 당시 심전도 및 심근 효소치는 정상이었으나, 2일 후 심전도에서 II, III, aVF, V4-6에 ST 분절 상승과 함께 심근 효소치의 상승을 보였다. 관상동맥 조영술에서 이상 병번은 없었으며, 경흉부 심초음파에서 구혈률은 61.7%였고, 국소 벽운동 장애는 관찰되지 않았다. 알코을은 관상동맥의 연축, 혈견 유발 및 혈관 내피 세포 손상과 연관이 있으나, 알코올에 의한 심근 경색의 기전은 명확하지 앉은 상태이다. 본 증례는 기존의 보고와는 달리 고령에서 발생한 첫 증례로서 ST 분절 상승 상태에서도 정상 관상 동맥 및 정상 심기능을 보였다는 점에 특이성이 있다고 할 수 있다.

Clinical Features and Prognosis of Spontaneous Bacterial Peritonitis in Korean Patients with Liver Cirrhosis: A Multicenter Retrospective Study

( Jeong Heo ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Taeho Hahn ),( Sang Hoon Park ),( Sang Hoon Ahn ),( Jun Yong Park ),( Ji Young Park ),( Moon Young Kim ),( Sung Keun Park ),( Mong Cho ),( Soon Ho 대한소화기기능성질환·운동학회 2009 Gut and Liver Vol.3 No.3

Background/Aims: Although early recognition and treatment with effective antibiotics have lead to improvements in the prognosis of patients with spontaneous bacterial peritonitis (SBP), it remains to be a serious complication in cirrhotic patients. This study was designed to evaluate the clinical manifestations and prognosis of patients with liver cirrhosis and SBP in Korea. Methods: This was a multicenter retrospective study examining 157 episodes of SBP in 145 patients with cirrhosis. SBP was diagnosed based on a polymorphonuclear cell count in ascitic fluid of > 250 cells/mm3 in the absence of data compatible with secondary peritonitis. Results: The mean age of the cohort was 56 years, and 121 (77%) of the 157 episodes of SBP occurred in men. Microorganisms were isolated in 66 episodes (42%): Gram-negative bacteria in 54 (81.8%), Gram-positive in 11 (16.7%), and Candida in 1. Isolated Gram-negative organisms were resistant to third-generation cephalosporin in 6 cases (17%), to ciprofloxacin in 11 (20.8%), and to penicillin in 33 (62.3%). The treatment failure and in-hospital mortality rates were 12.1% and 21%, respectively. A high Model of End-Stage Liver Disease (MELD) score, SBP caused by extended-spectrum β-lactamase-producing organisms, and hepatocellular carcinoma were independent prognostic factors of high in-hospital mortality. Conclusions: SBP remains to be a serious complication with high in-hospital mortality, especially in patients with a high MELD score. (Gut and Liver 2009;3:197-204)

Occurrence tendency of the natural enemies of Ceroplastes rubens in citrus on Jeju island

Jeong Hoon Park,Young Min Kim,Moon Hyang Ko,Jeong Heub Song,Tae Hyeon Heo 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04

루비깍지벌레 Ceroplastes rubens는 감귤에 피해를 주는 주요 깍지벌레 중 하나로 연 1회 발생하며 수액을 흡즙하는 직접적인 피해와 분비된 감로로 인한 그을음병 유발의 간접적인 피해가 발생하고 있다. 제주지역에서 루비깍지벌레 천적으로는 루비붉은깡충좀벌 Anicetus beneficus와 애홍점박이무당벌레 Chilocorus kuwanae 2종이 확인되었다. 1975년 일본에서 도입 방사한 천적인 루비붉은깡충좀벌이 현재까지 지속적으로 발생하고 있었으며, 루비깍지벌레 발생 억제에 영향을 미치고 있었다. 2018년 4월부터 12월까지 도내 유기재배 감귤원 (2개소)에서 황색끈끈이트랩을 이용 루비붉은깡충좀벌 성충의 시기별 발생양상을 조사한 결과 월동세대 성충은 5월 중순, 제1세대와 제2세대 성충은 각각 7월 중순과 8월 하순에 발생 정점을 나타내었다. 조사 포장에서 루비깍지벌레의 기생률은 9월 중순에 9.6%와 19.6%이었다.