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류지구,최혁환,차영호,김정헌,조경연 釜慶大學校 1997 釜慶大學校 論文集 Vol.2 No.2
The wide spread of multimedia sysrem deands a large viewing display device which can inform a message to many peoples in open area. This paper is about the design and simulating of a large viewing digital multi-wision control ASIC(Application Specific Integrated Circuit). In this paper. the digital multi-vision ASIC has one channel of imput cideo signal wihich is compliance with CCIR-656 specification and four channels of output video signal which are compliance with CCIR-601 specificarion. It has 2 operating mode. The one is the pass-thro;ugh mode. input vido signal goes to output video signal without any change, and the another one is the expension mode, input video signal is expended by from 2 to 16 times into output video signal. In expension mode. awindow could be programmed and only the input video signal in the window is expended. The 0.6 micron CMOS sEA OF Gate is used to design the ASIC in amount of about 23,000 gates, and it is simulated at 48MHz.
자동화유방초음파 검사시 부위별 gel pad 부착 전후의 통증 평가
김정단(Jeong-dan kim),박용성(Yong-sung Park),차경민(Gyeong-min Cha),최현정(Hyeon-jeong Choi),양정아(Jeong-a Yang),홍완식(Wan-sik Hong),조민연(Min-yeon Cho),김성헌(Seong-heon Kim) 대한초음파의료영상학회 2015 대한초음파의료영상학회지 Vol.6 No.1
목적 : 자동화 유방초음파 검사시 기존 검사에 비해 환자의 통증을 경감시키고자 검사를 시행하고 평가하였다. 대상 및 방법 : 2013년 6월부터 2013년 8월까지 유방외과에 조직검사를 위해 내원했던 환자들 중 유방의 병변부가 피부 가까이에 만져지거나, 유두하인 경우의 환자(115명, 47.7세)를 대상으로 AWUS를 동의서 작성 후 시행했다. 검사는 Anterior-posterior, Lateral, Medial 3방향에서 시행하고, 이후 Gel pad를 부착하여 병변부위만 한번 더 시행하여 검사의 영상을 평가하고, 환자통증을 수치화 하여 통증경감과 검사시 불편했던 사항을 환자와 검사자에게 조사하였다. 결과 : 환자의 통증경감을 나이대별, 유방실질별, 병리학적 검사결과별, 불편했던 부위별, 검사시 자세잡기 어려웠던 해부학적 인자별로 조사하였다. 환자의 객관적 인자로 인한 부착전후 통증경감은 나이대별(40미만, 40이상 50미만, 50이상)에서 P-value 0.001미만, 유방실질별(지방형 유방, 치밀 유방)에서 P-value 0.001미만, 병리학적 검사결과별(고위험, 중위험, 저위험)에서 P-value 0.001이하로 분석되었다. 환자․검사자 주관적 인자로 인한 부착 전후 통증경감은 불편했던 부위별(유두․유륜, 병변, 흉골, 유방전체, 늑골, 어깨)에서 어깨부위를 제외한 P-value 0.02이하, 검사시 자세잡기 어려웠던 해부학적 인자별(크기가 큰 흉곽, 크기가 작은 흉곽, 피부탄력도가 낮은 피부, 피부탄력도가 높은 피부, 마른 체구, 뚱뚱한 체구)에서 P-value 0.05이하로 분석되었다. 전체적인 Gel pad 부착전 평균검사통증 수치는 5.10, 부착후 평균검사통증 수치는 2.73으로 46.5% 경감되어 P-value가 0.001미만이었다. 결론 : 부위별 어깨부위를 제외한 나머지 통계에서 Gel pad를 이용한 검사는 비교적 통증경감에 유의하다. 하지만 병변의 정보 평가가 필요하며, 검사자의 숙련성이 요구되고, 통증경감에 따른 기대효과와 손익적인 측면이 고려되어야 할 것으로 사료된다. Purpose: This examination was conducted and evaluated in order to reduce pain in patients during the automated whole breast ultrasound compared to other existing examination methods. Materials and Methods: After the subjects filled out the consent forms, AWUS was conducted with subjects (115 patients, Mean age: 47.7) who visited the breast center for biopsy between June and August 2013 and who had palpable lesions near the skins of their breasts or subareolar lesions. The examination was conducted in 3 directions (Anterior-posterior, Lateral, Medial) after which the examination was repeated for only the lesion with gel pad applied. By evaluating the images from the examination and quantifying the pain experienced by the patients, pain relief and any inconvenience or discomfort during the examination were studied from the patients and technologist. Results: The pain relief in patients was investigated according to age, breast density, pathological examination results, region of discomfort and anatomical factors regarding difficult body positions during the examination. The P-values for the pain relief after gel pad application in consideration of the objective factors of the patients were analyzed to be as follows: below 0.001 for age group (below 40 y.o., 40 y.o. or older, below 50 y.o., 50 y.o. or older), below 0.001 for breast parenchyma types (fatty breast, dense breast), and 0.001 or below for pathological examination results (high risk, mid-risk, low risk). The P-values for the pain relief after gel pad application in consideration of the subjective factors of the patients and technologist were analyzed to be as follows: 0.02 or below for regions of discomfort (nipple/areola, lesion, sternum, whole breast, ribs, shoulder) except in case of shoulder region, and 0.05 or below for the anatomical factors regarding difficult body positions during the examination (large thorax, small thorax, skin with low elasticity, skin with high elasticity, thin physique, fat physique). In general, the average pain from examination was 5.10 before gel pad application, which decreased by 4.65% to 2.73 after application. The resulting P-value was below 0.001. Conclusion: The examination using gel pad is relatively significant in pain relief according to the statistics except in case of the shoulder region. However, it is considered that the evaluation of the information on the lesion would be needed, trained skills of the technologist are required, and profit/loss aspect and expected effects from pain relief must be reviewed.
차상헌 ( Sang Heon Cha ),이정재 ( Jeong Jae Lee ),최규연 ( Kyu Yeon Choi ),김신아 ( Shin A Kim ),박선영 ( Seon Yeong Park ),정성윤 ( Seong Yun Jeong ),이임순 ( Im Soon Lee ),이권해 ( Kwon Hae Lee ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
목적 : 본 연구는 자궁내 태아사망의 원인을 밝히고 임상적 특성을 분석하여 향후 자궁내 태아사망을 줄이고자 함이다. 연구 방법 : 1998년 1월부터 2003년 4월까지 5년 4개월간 순천향대학교병원 산부인과에 입원 분만한 5,523예의 환자 중 임신 20주 이상에서 자궁내 태아가 사망한 74예의 임상기록을 토대로 발생 빈도, 원인요소, 분만 방법 및 합병증 등을 고찰하였다. 결과 : 전 분만중 자궁내 태아사망이 차지하는 비율은 1.34%였다. 대상 산 Objective : The purpose of this study was to evaluate intrauterine fetal death and elucidate the etiology of intrauterine fetal death. Methods : This is a clinical study of 74 cases of intrauterine fetal death (IUFD) among 5,523 deliveries at Soonchunhyan
Jeong, Hye-Jin,Lee, Seong-Heon,Cho, Soo-Young,Lee, Cha-Sup,Jeong, Cheol-Won,Yoon, Myung-Ha,Kim, Woong-Mo The Korean Pain Society 2011 The Korean Journal of Pain Vol.24 No.4
Background: The analgesic mechanisms of cyclooxygenase (COX)-2 inhibitors have been explained mainly on the basis of the inhibition of prostaglandin biosynthesis. However, several lines of evidence suggest that their analgesic effects are mediated through serotonergic or adrenergic transmissions. We investigated the roles of these neurotransmitters in the antinociception of a selective COX-2 inhibitor at the spinal level. Methods: DUP-697, a selective COX-2 inhibitor, was delivered through an intrathecal catheter to male Sprague-Dawley rats to examine its effect on the flinching responses evoked by formalin injection into the hindpaw. Subsequently, the effects of intrathecal pretreatment with dihydroergocristine, prazosin, and yohimbine, which are serotonergic, ${\alpha}1$ adrenergic and ${\alpha}2$ adrenergic receptor antagonists, respectively, on the analgesia induced by DUP-697 were assessed. Results: Intrathecal DUP-697 reduced the flinching response evoked by formalin injection during phase 1 and 2. But, intrathecal dihydroergocristine, prazosin, and yohimbine had little effect on the antinociception of intrathecal DUP-697 during both phases of the formalin test. Conclusions: Intrathecal DUP-697, a selective COX-2 inhibitor, effectively relieved inflammatory pain in rats. Either the serotonergic or adrenergic transmissions might not be involved in the analgesic activity of COX-2 inhibitors at the spinal level.
Jeong, Jong-Kyou,Lee, Ji-Heon,Han, Byung-Moon,Cha, Han-Ju The Korean Institute of Electrical Engineers 2011 Journal of Electrical Engineering & Technology Vol.6 No.2
This paper proposes a grid-tied power conditioning system for fuel cell, which consists of three-phase current-fed DC-DC converter and three-phase PWM inverter. The three-phase current-fed DC-DC converter boosts fuel cell voltage of 26-48 V up to 400 V with zero-voltage switching (ZVS) scheme, while the three-phase PWM(Pulse Width Modulation) inverter controls the active and reactive power supplied to the grid. The operation of the proposed power conditioning system with fuel cell model is verified through simulations with PSCAD/EMTDC software. The feasibility of hardware implementation is verified through experimental works with a laboratory prototype with 1.2 kW proton exchange membrane (PEM) fuel cell stack. The proposed power conditioning system can be commercialized to interconnect the fuel cell with the power grid.
<i>O</i>-GlcNAcylation of the Tumor Suppressor FOXO3 Triggers Aberrant Cancer Cell Growth
Shin, Heon,Cha, Hyun-Jeong,Na, Keun,Lee, Min Jung,Cho, Jin-Young,Kim, Chae-Yeon,Kim, Eun Kyung,Kang, Chang Moo,Kim, Hoguen,Paik, Young-Ki American Association for Cancer Research 2018 Cancer Research Vol.78 No.5
<P>These findings highlight a posttranslational mechanism for indirect abrogation of the p53 pathway, one that may occur with some frequency in human cancer cells.</P><P>Posttranslational modifications of tumor suppressors can induce abnormal cell growth. Here, we identify site-specific <I>O</I>-GlcNAcylation as a critical block of FOXO3 that may abrogate a part of the p53 pathway, resulting in aberrant cancer cell growth. Of seven <I>O</I>-GlcNAcylation sites identified within the FOXO3 transactivation domain, we found that changes in <I>O</I>-GlcNAcylation at Ser284 modulated p21-mediated cancer cell growth. Overexpression of either <I>O</I>-GlcNAcylated FOXO3 (FOX-OV) or a Ser-to-Ala mutant (S284A) in PANC-1 cells indicated that S284 <I>O</I>-GlcNAc acts as a critical block of the FOXO tumor suppressor and induces proliferation in PANC-1 cancer cells by stimulating the MDM2-p53-p21 axis. Furthermore, S284A mutant cells lacking S284 <I>O</I>-GlcNAc and FOX-OV cells exhibited opposing MDM2-p53-p21 axis expression patterns at both the mRNA and protein levels. Thus, our study provides evidence to support a role for S284 <I>O</I>-GlcNAc as a critical block of FOXO3 to induce subsequent cancer cell growth via abrogation of the p53 regulatory circuit.</P><P><B>Significance:</B> These findings highlight a posttranslational mechanism for indirect abrogation of the p53 pathway, one that may occur with some frequency in human cancer cells. <I>Cancer Res; 78(5); 1214–24. ©2018 AACR</I>.</P>