경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

유산균을 이용한 경구용 항원 단백질 수송능 연구

조희정,최한곤,김정애,오유경 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2

A promising application of Lactococcus lactis is its use as live vehicles for production and delivery of heterologous proteins of vaccines and therapeutic substances. Because L. lactis has GRAS ("generally regarded as safe") status, use tested whether L. lactis could function as the carrier of the L1 protein of human papillomavirus (HPV) type 16. The RNA level expression of L1 gene was detected in L. Laois. The L1 protein was expressed in L. luctis with LI gene. The growth of strains L. lactis with an empty plasmid (pAMJ328) and L. lactis with L1-encoding plasmid (pAMJ328-L1) was slightly decreased in comparison with the growth of strains L. lactis (wild type). However, all the three strains of L lactis maintained the ability to ferment sugars primarily into lactic acid, indicating that L1 protein did not affect the biochemical property of L.. lactis. These results suggest that L. lactis. capable of carrying LI protein, might he further developed as a biocompatible oral protein delivery system.

미맹출된 제1소구치의 외과적 노출과 치은하 견인에 의한 맹출유도에 관한 증례보고

김유정,이광희 大韓小兒齒科學會 1990 大韓小兒齒科學會誌 Vol.17 No.2

This report described the surgical & orthodontic management of a patient with unerupted permanent mandibular 1st premolar. Through surgical exposure and direct bonidng of lingual button, the premolar was brought into proper position with elastic traction subgingivally. This treatment resulted in good periodontal health and excellent ethetics. To prevent esthetic problem and maintain periodontal health, there should be atraumatic surgery, removal of local inflammation, optimal orthodontic force, and adequate width of attached gingiva.

유치원아동에서 고자당배지를 이용한 우식활성검사치와 우식경험유치면지수와의 상관성

이광희,김유정 大韓小兒齒科學會 1991 大韓小兒齒科學會誌 Vol.18 No.2

116 preschool-children were examined for caries activity and dmfs index.20% Sucrose-sulphasomidine-broth was used to cultivate plaque sample that was obtained from buccal side of maxillary posterior teeth. After incubation for 48 hours and 72 hours, acid production of Streptococcus mutans was evaluated by the color change of pH indicator(5% Bromcresol green) in the medium. 1.There was significant correlation between dmfs index and caries activity test scores(P<0.05). 2.Age and sex did not significantly affect caries activity test scores. 3.By cultivating plaque sample in 20% sucrose-sulphasomidine-broth over 72 hours caries-inactive children can be differentiated from caries-active children.

한국형 노인주거개발을 위한 이론적 고찰

박유복,최영선,김현정,오이진,박정희 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

According to the increase of the number and portion of the elderly people, the elderly housing is an important social welfare factor as the solution of the elderly problem. When we consider the elderly housing of Korea, it should be appropriate to Korean culture and emotion. This study aims to suggest two ways of Korean elderly housing: three-generation housing and the renovation of housing which one elderly person have lived in. Considering that family centrism is remained a lot in Korean consciousness, those two ways should be developed well so as to build a unique Korean housing culture for the elderly.

GT rotary file을 이용한 근관성형법과 충전방법의 비교

강유미,진정희,유미경,이세준,이광원 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.5

The purpose of this study was to compare the shaping time of two shaping methods and the leakage of three different obturation techniques. Ninty three canaled human molar teeth were used. which were randomly divided into two groups of forty teeth each and ten control teeth. After working length determination. the one group was prepared crowndown technique using rotary root canal instruments of GT rotary files .12/20, .10/20, .08/20 and .06/20 taper(Maillefer Instrument SA. Switzerland). The other group was instrumented with Gates Gildden burs(#1, #2 and #3) to coronal preparation and GT rotary files .08/20 and .06/20 taper to apical preparation. Shaping time was measured. After root canals were instrumented, they were divided to three subgroups and obturated as follows: Subgroup 1, obturated with single cone method : Subgroup 2, obturated with lateral condensation : Subgroup 3, obturated with continuous wave technique. Three subgroups were obturated using non-standardized gutta-percha cone(Diadent, Korea, 06 or .08 taper) and AH-26(Dentsply DeTrey, Germany) as a root canal cement. Ten unobturated teeth served as positive and negative controls. After immersion in 2% methylene blue solution for 1 month, the teeth were washed during 24h. The teeth were determineralized in 10% nitric aciid and dehydrated by immersion in 80, 90 and 100% ethyl alcohol. The teeth were finally cleared and stored in 100% methylsalicylate, and apical dye penetration was evaluated under stereomicroscope(Leica M420, LC, U.S.A) at (×) 8.75 magnification. Liner measurement of dye penetration was assessed with the use of digitalized image analysing system (analySIS, GmbH, Germany), The data were analysed statistically using independent T-test and Two-way ANOVA and Tukey test. The result were as follows: 1. In canal prepared with GT^Trotary file, shaphing time taked more than the group of using Gates Gildden drill to coronal preparation without statistical significant (p>0.05). 2. The group of single cone obturation using canal preparation of GT^TM rotary files showed significantly more apical leakage than those of lateral condensation and continuous wave technique regardless of shaping method (p<0.05). 3. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed significantly more apical leakage than those of continuous wave technique regardless of shaping method (p<0.05). 4. Regardless of shaping method. The group of continuous wave obturation showed less apical leakage than those of lateral condensation without statistical significance (p>0.05). 5. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed more apical leakage than the group of lateral condensation using sane shaping method without statistical significance (p>0.05).

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

바닐로이드 수용체 길항제로서의 (1R)-phenethyl thiocarbamic acid 0-[l-(4-hydroxy-3-methoxyphenoxymethyI)-3-phenylpropyl] ester 의 설계 및 합성

황유정,이현주,김희두 숙명여자대학교 약학연구소 2002 약학논문집-숙명여자대학교 Vol.18 No.-

(IR)- Phenethylthiocarbamic acid 0-[l-(4-hydroxy-3-methoxyphenoxymethyl)-3-phenylpropyl] ester (8) was designed and synthesized as a vanilloid receptor antagonist. Acetovanillone (1) was successively converted to the thiocarbamate 8 via 6-steps sequence including Baeyer-Villiger oxidation and copper(I)-catalyzed epoxide ring opening reaction.

시각장애학교 교사의 학교도서관 이용 및 활용수업 실태 : A Study on Teachers' Use of the School Library and School Library-Assisted Instruction at School for the Visually Impaired

고유진,정은희 이화여자대학교 특수교육연구소 2015 특수교육 Vol.14 No.3

연구목적: 본 연구는 시각장애학교 학교도서관 이용 및 활용수업 실태를 알아보고자 하였다. 연구방법: 시각장애 중·고등학교 교과 담당 교사 86명을 대상으로 한 조사연구를 실시하였다. 연구결과: 과반수정도가 도서관 활용수업을 진행한 적이 있다고 하였다. 국어교사는 대부분 경험이 있는 반면 다수의 수학교사는 경험이 없었으며, 활용수업을 실시하지 않는 이유로는 과목의 특성을 언급하였다. 도서관 활용수업은 교과수업의 질을 높이기 위해 실시한다고 하였고, 대부분의 교사가 시각장애학생에게 도서관 활용수업이 필요하며 교수학습 면에서도 중요하다고 하였다. 또한 학교도서관 활용수업을 통해 자기주도 학습능력, 정보 활용능력, 수업에 대한 관심과 흥미도가 모두 향상된다고 인식하고 있었다. 도서관 활용수업을 활성화시키기 위해서는 대체자료 및 보조공학기기의 보완, 편의시설이 필요하다고 하였다. 결론: 전담 사서교사의 배치를 통해 체계적인 지원 체계와 전문성을 확보하고 지속적인 연수를 통하여 학교도서관 활용수업에 대한 홍보, 교육과정과의 연계 및 다양한 프로그램과 교수매체의 개발이 필요하다. Purpose: This research examines teachers’ use of school library and their implementation of school library-assisted instruction at middle and high schools for the visually impaired. Method: A questionnaire was distributed to 86 middle and high school teachers for the visually impaired. Results: First, more than a half of the teachers had implemented school library-assisted instruction. While most teachers of Korean had taught library-assisted classes, most math teachers responded that they had not used school libraries because of the nature of the subject matter. Regarding the purpose of school library-assisted instruction, a majority of teachers mentioned the improvement of the quality of teaching and learning. Second, most teachers acknowledged the benefits of library-assisted instruction for visually impaired students and its importance in teaching and learning. The teachers expected that, by utilizing school libraries, they could enhance the visually impaired students’ self-initiated learning ability, information utilization ability, attention and interest in class. Lastly, teachers suggested that alternative materials and assistive technology should be made available for more effective utilization of school libraries. Conclusion: The research indicates that support systems are also necessary, including professional librarians, continual education on school library-assisted instruction, development of connected curriculum, and development of instructional media.

랫드에서 법제유황과 비법제유황의 독성비교

김근수, 정유리, 이남진, 홍성희, 유종훈, 정재황, 강종구 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

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