건선환자에서 피부각질층의 형태학적 변화에 관한 연구

함정희 梨花女子大學校 韓國生活科學硏究院 1992 韓國生活科學硏究院 論叢 Vol.50 No.-

Psoriasis, which affects 3% of the outpatients in Republic of Korea, is a common, chronic, recurrent, inflammatory disease of the skin characterized by rounded, circumscribed, erythematous dry scaling patches of various sizes, covered by grayish white or silvery white, imbricated and lamellar scales. The lesion in ordinary cases have predilectin for the scalp, nails, extensor surfaces of the limbs(especially the shins), the elbows, the knee, and the sacral region. The histologic picture of psoriasis vulgaris varies considerably with the stage of the lesion and near the margin of advancing plaques. In the fully developed lesions of psoriasis, as best seen at the margin of enlarging plaques, the histologic picture is characterized by (1) regular elongation of the rete ridges with thickening in their lower portion (2) elongation and edema of the papillae (3) thining of the suprapapillary portions of the stratum malpighii, with the occasional presence of granular cells (4) the absence of granular cells (5) parakeratosis (6) the presence of Munro microabscesses The purpose of this study is to evaluate pathophysiology of psoriasis observing the morphological changes of corneocytes in the epidermis by scanning electron microscope(SEM). All materials were taken from involved skin of six psoriatic patients, uninvolved skin of six psoriatic patients, six normal persons and treated psoriatic lesions by skin surface biopsy. The results were as follows : 1. There were no folding lines or microplications in the involved skin of psoriatic patients compared with stratum corneum of normal person. 2. There were more profuse villi and more prominent villous projections in the involved skin than uninvolved skin of psoriatic patients. 3. There were no villi in the corneocytes except a few in normal person. 4. Profuse villi and less prominent villous projections were seen on the treated psoriatic lesions without scales.

Flashlamp-Pumped Pulsed Dye Laser를 이용한 소아화염상모반의 치료효과에 관한 연구

함정희 (사)한국여자의사회 1994 한국여자의사회지 Vol.19 No.-

Flashlamp-Pumped Pulsed Dye Laser를 이용한 소아화염상모반의 치료효과에 관한 연구

함정희 梨花女子大學校 韓國生活科學硏究院 1992 韓國生活科學硏究院 論叢 Vol.50 No.-

Portwine stain(pws) is a congenital vascular malformation that occurs primarily on the face and neck, affecting approximately 0.3% to 0.5% of newborns. The major indication for therapy in most patients, regardless of age, is the psychosocial burden due to the portwine stain. Purpose of this study is to evaluate safety and efficacy of flashlamp-pumped pulsed dye laser for pws in children. Seventy-eight children, 5months to 15years of age, with portwine stains were treated with the flashlamp-pumped pulsed dye laser with an emission wavelength of 585nm, a pulse duration of 450 microseconds and 5mm spot size. More than 75% lightening of their lesion was achieved with an average of 5.9 treatments(±2.50) in 28 patients(35.8% of all patients). Children less than five years old required fewer sessions(mean±SD, 4.63±1.71) than older children(7.15±2.33 : P<0.05). Portwine stain lesion is found more frequently on the left side of the face. There was no evidence of depressed scars, atrophy and hyperpigmentation in the treated areas. The only side effect was transient hypopigmentation which occurred in 5 patients(6.4%), indicating the relative safety of this treatment modality.

肝吸蟲 感染者에 대한 間接螢光抗體反應(IFAT) 補體結合反應(CFT) 및 ELISA법의 比較 硏究

咸姃希,李駿商,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

Human colonorchiasis is one of the most common trematode diseases and of very important public health problem in Korea. A number of serological techniques have been applied to the diagnosis of parasitic diseases, and efforts in recent years have been made for the development of new promising serological techniques. In this study the sensitivity and the specificity of the indirect immunofluorescent antibody test(IFAT), the complement fixation test(CFT) and the enzyme-linked immunosorbent assay(ELISA) were investigated with 55 human clonorchiasis sera, 16 sera of other parasitic infections and 9 sera of non-infected human cases. The IFAT was performed using frozen sectioned antigen of adult Clonorchis sinensis, the CFT was performed with ether extracted antigen prepared from adult C.sinensis. The ELISA was performed with Clonorchis veronal buffered saline antigen, peroxidase conjugated antihuman Ig G and ortho-phenylenediamine as a substrate by micro-method. The results obtained were as follows: 1. The positive reactions in 34 (61.8%) out of 55 clonorchiasis sera at a dilution of 1/16 or below and in one (4.0%) out of 25 control sera were detected by the IFAT. 2. The positive reactions in 31 (56.4%) out of 55 clonorchiasis sera at a dilution of 1/8 or below and in 3 (12.0%) out of 25 control sera were detected by the CFT. 3. Fourty-three (78.2%) out of 55 clonorchiasis sera were positive at absorbance 1.000 or below by the ELISA. However, 25 control sera tested by the ELISA were negative. 4. Among the 43 Clonorchis positive sera detected by the ELISA, positive reactions were observed in 33 (76.7%) sera in the IFAT and 30 (69.8%) sera in the CFT. Among the 12 Clonorchis negative sera tested by the ELISA, one gave positive reaction by the IFAT and the CFT. 5. When the results were compared between the IFAT and the CFT using 55 human clonorchiasis sera showed that 50 (90.9%) out of the 55 clonorchiasis sera gave same reactions, and the titers of two immunological techniques were almost corresponding. These findings indicated that the ELISA was the most sensitive and specific in the diagnosis of human clonorchiasis among three serological tests.

최근 5년간 피부외과술로 치료받은 환자의 분석 : 1994. 1∼1998. 12

신정현,강민정,조소연,황규광,함정희 梨花女子大學校 醫科大學 醫科學硏究所 2000 EMJ (Ewha medical journal) Vol.23 No.2

연구 목적 : 1990년대 이후 국외 및 국내에서 피부외과의 영역이 넓어지고 있으나 현재 국내에서 시행되고 있는 피부외과적 수술에 대한 통계는 아직 보고되지 않아 그 현황이 잘 파악되지 않고 있다. 이에 저자들은 본교실 미용피부외과 클리닉에 내원하여 수술을 받은 환자 1,075명을 대상으로 통계적 분석을 시행하여 피부외과 환자의 분포, 경향을 파악하여 향후 발전의 토대로 삼고자 한다. 방법: 1994년 1월부터 1998년 12월까지 5년간 이화여자대학교 의과대학 부속 동대문병원 피부과 미용피부외과 클리닉에 내원하여 수술을 받은 환자 1,075명을 대상으로 성별, 연령별, 주거지역별 분포와 진단명 및 수술의 종류에 대하여 통계적 분석하였다. 결과: 1) 남녀비는 1 : 2.4였고, 연령은 10개월부터 87세까지로 다양하였으나 20, 30대가 66.0%로 가장 많고 평균연령은 남자 30.6세, 여자 30.2세였다. 환자의 주거지역별 분포는 서울시가 75%로 가장 많았고 서울시내 지역구별의 차이는 크지 않았다. 2) 환자 1명이 두 가지 이상의 질환을 가질 때 각 질환을 개개로 간주하여 총 1.354예의 질환을 수술하였으며 반흔(39.8%), 색소성 질환(30.8%), 악성/양성종양(21.2%), 기타질환(8.2%) 순이었다. 3) 수술은 총 2,334회 시행되었고 그 종류별 빈도는 화학박피수술 가장 많아 846예(36.2%)이었고 다음으로 냉동외과술 650예(27.8%), CO_2 레이저 255예(10.9%), 기계박피술 209예(8.9%), 외과적 절제술 113예(4.8%), Mohs 미세도식수술 61예(2.6%), 혈관응고술 50예(2.1%), 피판재건술 48예(2.0%)이었으며 그 외 모발이식 15예, 표피이식 13예, 자가지방이식 2예 등이 있었다. 4) 각 반흔의 종류에 따라 분류하면, 여드름반흔은 화학박피술(72.7%), CO_2 레이저(11.9%) 및 기계박피술(9.7%)로, 위축성반흔은 기계박피술(37.3%). CO_2 레이저(27.8%) 및 펀치상향술(11.9%)로, 비후성반흔은 냉동외과술(28.2%), 기계박피술(24.2%) 및 CO_2 레이저(22.7%)로 치료하였다. 5) 악성종양 및 일부 양성종양에 Mohs 미세도식수술을 시행하였으며 재건술로 총 61예 중 피판재건술을 시행한 예가 가장 많아 45.9%이었고, 단순봉합이 36.1%, 복합봉합은 18.0% 이었다. 결론: 피부외과적 수술환자는 여자가 남자보다 2.4배 많았으나 남자의 비율이 증가추세에 있고 남녀 모두 평균 연령은 30대였다. 수술질환은 반흔과 색소성 질환이 가장 많아 미용적인 관심이 매우 높음을 알 수 있었고 연도별 유의한 차이는 없었다 총 2,334회 수술 중 화학박피술, 냉동외과술이 50% 이상을 차지하였고 반흔의 종류에 따라 선호되는 수술이 달랐다. 악성종양은 모두 Mohs 미세도식 수술하였으며 주로 국소 피판술로 재건하였다. 이상의 분석으로 피부외과적 수술환자의 분포, 대상질환, 수술방법 등을 빈도별로 파악할 수 있었으며, 향후 각 질환별 혹은 수술별로 세분하여 수술성과 및 만족도 조사를 시행함으로써 피부외과 분야 및 본 크리닉의 발전 방향을 설정하는 가늠자 역할을 할 것으로 기대한다. Background : The field of dermatologic surgery has seen trementdous developments in the past few years. Objective : Our purpose was to discuss current statistical data on the dermatologic patients treated by surgical methods at our institute. Methods : We analyzed 2,334 cases of surgeries performed on 1,075 patients at the Department of Dermatology of Ewha Womans University Tongdaemun Hospital during a period of 5 years (1994. 1 - 1998. 12). Results & Conclusion : The results are summarized as folows: 1) Of the 2,334 cases of surgeries, 846 cases(36.2%) were chemical peelings, 650 cases(27.8%) cryosurgeries, 255 cases(10.9%) CO_2, lasers, 209 cases(8.9%) dermabrasions, 113 cases(4.8%) scalpel surgeries, 61 cases(2.6%) Mohs micrographic surgeries, 50 cases(21.1%) sclerotherapy, 48 cases(2.0%) flap repair surgeries, 35 cases(1.5%) punch elevations, 15 cases(0.6%) hair transplantations, 13 cases(0.5%) epidermal grafts, and 2 cases(0.1%) autologous fat/collagen transplantations. 2) The ratio of male to female was 1 : 2.4 and the mean age of patients was 30.3 years. 3) A total of 1,354 cases of diseases were managed surgically : among them, the most frequent disease was scar(39.8%), followed by pigmentary disorders(30.8%), and benign or malignant tumors(21.2%). 4) With respect to the types of scars, acne scar was treated most frequently by chemical peeling (72.7% of 580 cases), atrophic scar by dermabrasion(37.3% of 126 cases), and hypertrophic scar (including burn scars) by cryosurgery(35.3% of 85 cases).

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

지역여성단체 현황과 활성화 방안 연구

한정자,함인희 이화여자대학교 한국여성연구원 2000 여성학논집 Vol.17 No.-

This paper focuses on the actual conditions of the local women's organization. These organizations are regarded as the best vehicle for improving women's status in local areas. However, the survey results of current situation of local women's organization reveals the organization is to a large extent in a very poor condition. The survey covered all the women's organization located in the six biggest cities and six seats of the provincial government. Among the 1,082 organizations, survey questionnaires were delivered to the 1,054 organizations, and 422 questionnaires were returned from August 23 to September 15 in 1999. 400 questionnaire were included in the field analysis. If we briefly examine the results, 78.0% of the organizations are "registered", 61.5% are "chapters of the Center", 74.5% are "members of the Women's Organization Council" and 16.0% are "member of the Women's Organization Union". The size of the organization varies from very small one having less than 30 members with only one person in charge to huge one having more than 10,000 members with 16 board members. And 59.8% of the organizations have no paid staff. In case of facilities, only 52.8% of these organizations have their own office, 56% have their own telephone number, 39.6% have a fax machine, and 36.2% own a computer. Only 28(7%) of these organizations have a homepage. In terms of working expenses, there is a great dispanity among these organization. 48.3% of the organizations spend less than 5 million won costs of operation. 95% of the organizations depend heavily upon their membership fees to manage the organization. The main purposes of these local women's organizations are as follows; 'Community development and volunteer work'(66.5%); The enhancement of 'women's status'(13.8%), The improvement in 'the quality and well-being of its members'(9.8%) and 'Cultivating mutual friendship'(4.3%) etc.. In the second part of this study the problems which is supposed to be experienced by most local women's organization are analyzed. For the convenience of this analysis, we have divided our analysis into four sections: First, among the organization-related problems, 'the lack of administrative and financial support'(mean value 3.29) was pointed out as the most serious problem, then 'the members' activities for the organization do not pay back'(mean value 2.88), and 'lack of independence and self regulation of the local women's organization'(mean value 2.63), and so forth. Second, in regards to problems of the membership and leadership, the style of 'leadership'(mean value 3.07) was recognized as the most difficult problem, followed by 'underestimation of the leader's activities'(mean value 3.04), and the burden of role playing by members'(mean value 2.82) was regarded as the third barrier to activate the local women's organization etc.. Third, in regards to problems relating to organizational activities & program-related issues, 'too much emphasis on the volunteer work' and 'the lack shortage of the program satisfying members' cultural needs'(mean value 3.01) are selected at the same time as the most urgent problem the organization needs to solve. Another problem was the 'lack of programs dedicated to the improvement women's status' and a 'lack of public relations vis-a-vis organizational activities'(mean value 2.97). Fourth, in the area of the other activities, the mean value(3.29) of 'the financial support increased' shows the highest, and 'the space for the women's activities should be secured'(mean value 3.06) shows the second highest. In order to activate these local women's organizations, "The organization should continue to make an effort'; "The government should offer administrative and financial support'; 'Gain understanding and cooperation firm family members as well as the local community', 'Gain social rewards in their organizational activities' etc. are suggested.

퍼지알고리즘를 이용한 유도전동기 속도제어에 관한 연구

조정민,전기영,함년근,이승환,이훈구,한경희 명지대학교 대학원 1999 대학원논문집 Vol.3 No.-

The conventional PI controller are fragile in parameter variation and load-variation. Therefore, in this paper, a speed control algorithm based on the Fuzzy PI controller is proposed for the high performance speed control of a voltage ?? inverter to drive 3-phase induction motors. The computer simulation and experiment results show that the proposed controller are more excellent control characteristics than conventional PI controller in transient-state and steady-state response.

방광 소세포암:1예 보고

허정남,김용수,조온구,고병희,임현철,함창곡 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Small cell carcinoma(also known as oat cell carcinoma) of the urinary bladder is an extremely rare malignancy and is derived from neuroendocrine stem cells. It is usually biologically aggressive tumor with early vascular and muscle invasion, so it has poor prognosis. Radiological findings of small cell carcinoma are similar to other malignancies of urinary bladder, therefore it is impossible to distinguish small cell carcinoma from other malignancies. Pathologic study is an only useful method for differential diagnosis of bladder tumor. We report here the case of 74th years old woman presented with painless gross hematuria.

치료 저항성 환청을 나타내는 만성 정신분열병 환자에서 측두두정부 반복 경두개자기자극의 효과

정경희,최충식,박진수,이규항,함웅,이승환,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : It has been reported that repetitive transcranial magnetic stimulation (rTMS), which stimulate the focal region of brain may relieve auditory hallucination in patient with schizophrenia. This study was aimed to evaluate the effect of rTMS on left and right temporopahetal cortex in schizophrenic patients with treatment-resistant auditory hallucination. Methods : Twenty-six patients with chronic schizophrenia with treatment -resistant auditory hallucination were randomly a1-located to rTMS group on left and right temporoparietal head regions. The rTMS was applied to TP3/4 region by EEG 10-20 international system at 1 Hz for 20 minutes per day for 101reatment days. A Figure of eight TMS coil with a solid core was used for rTMS at 100% of individual motor threshold. Efficacy was evaluated with Auditory Hallucination Rating Scale (HRS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression (CGI) Scale on 5 and 10 days of treatment. Results : Ten days administration of l-Hz rTMS to temporopahetal cortex significant improved frequency (p<0.001) and attentional salience (p=0.038) of auditory hallucination, Positive (p<0.001) and negative symptom (p=0.02), and CGI-impro-vement (p<0.001). There were no significant differences between right and left side stimulations. Conclusion : These results suggest that the low frequency rTMS on temporopahetal cortex may be useful in treating Schizo-phrenic patients with treatment-resistant auditory hallucination and it could be a useful novel treatment option.