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RISS 인기검색어
- 검색키워드
- 저자 : ( Jen Nifer Lee ) (검색결과 2 건)
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( Jung Hee Koh ),( Sung Hwan Park ),( Jen Nifer Lee ),( Seung Min Jung ),( Seung Ki Kwok ),( Ji Hyeon Ju ),( Hong Ki Min ),( Jin Young Kang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN), and identified predictors for renal fi are. In cases of renal fi are during pregnancy, we assessed the long-term post-delivery renal outcome. Methods: We performed a retrospective analysis of 183 pregnancies managed at Seoul St. Mary`s Hospital, Seoul, Korea. Laboratory data, including blood chemistry, urinalysis, urinary protein, and complement levels were recorded at prepregnancy, during pregnancy, and at 1 month, 6 months, and 1 year post-delivery. Results: Pregnancies with preexisting LN had a more adverse obstetric outcome. Renal fi ares were predicted by uric acid level at conception (OR 2. 2; 95% confi dence interval, 1. 246-3. 884) and preexisting LN (OR 14. 272; 95% confi dence interval, 2. 738-74. 4). Persistent LN 1 year after delivery was observed in 37. 3% of pregnancies. Pregnancies with a =50% reduction protein levels at 6 months were signifi cantly lower in this group. The median post-delivery follow-up time was 61 months and chronic kidney disease (CKD) developed in 25% of pregnancies with renal fi are within 10 years. In patients with renal fi are, failing to achieve a =50% reduction in urine protein levels within 6 months and serum creatinine > 0. 9 mg/dL during the fi are predicted CKDdevelopment. Renal fi are during pregnancy might have long-term negative effects on renal function. Conclusions: Females with preexisting LN should achieve remission before pregnancy and reduction in proteinuria level within 6 months after delivery, when they experience renal fi are during pregnancy.
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( Hong Ki Min ),( Jin Young Kang ),( Jung Hee Koh ),( Seung Min Jung ),( Jen Nifer Lee ),( Ji Yeon Lee ),( Seung Ki Kwok ),( Ji Hyeon Ju ),( Wan Uk Kim ),( Sung Hwan Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We investigated radiographic progression of ankylosing spondylitis (AS) patients treated with TNF antagonist, continuous NSAID, and on demand treatment of NSAID. Methods: This retrospective single-center study included 41 Korean AS patients who fulfi lled the 1984 Modifi ed New York criteria for AS or 2009 ASAS criteria for classifi cation of spondyloarthritis from January 2006 to June 2014. Patients who had been checked lateral cervical and lumbar radiographs at baseline, after 4 years, and 8 years were included. Radiologic progressions were measured by calculating modifi ed Stokes AS spinal score (mSASSS) and number of syndesmophytes. Oneway analysis of variance and Kruskal-wallis test were used for assessing comparisons. Results: Patients in TNF antagonist (n=14), continuous NSAID (n=12), and on demand NSAID (n=15) did not show difference in baseline characteristics and radiologic status (mSASSS score and number of syndesmophyte). Laboratory datas of ESR were higher in TNF antagonist group when compared with continuous NSAID group and on demand NSAID group (TNF antagonist vs continuous NSAID; 39.0 (9.8-71.8) vs 6.0 (4.3- 13.6), p=0.002, TNF antagonist vs on demand NSAID; 39.0 (9.8-71.8) vs 7.0 (3.0-33.0), p=0.013). Radiographic progressions measured by mSASSS and number of syndesmophytes were differed signifi cantly between TNF antagonist group and continuous NSAID group at 8 years: 7.5 (3.8-16.2) mSASSS change in TNF antagonist group versus 5.0 (2.0-6.0) in continuous NSAID group (p=0.040), 2.0 (0-5.2) syndesmophyte change in TNF antagonist group versus 1.0 (0-3.0) in continuous NSAID group (p=0.038). Conclusions: In our study, continuous NSAID treatment group showed less radiographic progressions of AS than TNF antagonist treatment group. Continuous NSAID usage may have superior effect on blocking the progression of new bone formation in AS, hence physicians may consider continuous NSAID treatment regardless of patient`s symptoms.
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