광양항 컨테이너부두 배후부지 개발방향과 활성화방안

송성헌,김우제,장은령,이정욱 한국로지스틱스학회 1998 로지스틱스연구 Vol.6 No.2

이 논문의 목적은 광양항 컨테이너부두 배후부지의 개발방향과 활성화 방안을 제시하는 것이다. 이를 위해서 우선, 배후부지의 개발과 운영에 관련된 계획, 법규 및 국내외 사례를 검토한 후, 배후부지 유치대상 기능과 주요시설을 규명하고, 개발 기본구상도와 단계별 개발계획안을 제시한다. 배후부지 개발사업의 활성화를 위해 정부의 정책적 지원방안 및 관련조직간의 협조방안과 배후부지 입주업체의 유치방안을 제시한다. 아울러 배후부지 개발의 기대효과 및 최근 경제상황에 따른 건의사항을 제시한다. In this paper we try to make suggestions for the development and promotion for the hinterland of the Kwangyang container port. First, we investigated the development plan, the law and several cases related to the development and operation of the port hinterland. Then we propose a scheme to develop the hinterland and define major functions and facilities for the hinterland. For the promotion of the hinterland, we suggest several roles of the government organizations to activate functions of the hinterland and ideas to attract customers. Finally, we suggest an expected effect according to the development of the hinterland and propose a proper way of the development considering the recent Korean economic situation.

수지상세포의 방사선 저항성에 대한 연구

김은실,김종순,이명호,범희승,민정준,정환정,김성민,허영준,송호천,이제중 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.3

목적 : 림프구와 비교되는 수지상 세포의 방사선 민감성을 보기 위하여 본 연구를 시행하였다. 대상 및 방법 : 말초혈액에서 분리한 T 림프구에 0 Gy, 10 Gy, 30 Gy의 방사선을 조사하고 4시간 후에 유세포 분석기를 이용하여 선량별 세포고사 빈도를 관찰하였다. 또한 조혈모세포에서 미성숙 및 성숙 수지상 세포를 단계적으로 분리 배양하여 각각 0 Gy, 10 Gy, 30 Gy, 100 Gy의 방사선을 조사하고 4시간, 24시간 그리고 48 시간 후에 선량별 세포고사 빈도를 관찰하였다. 사이토스핀(cytospin)슬라이드에 림프구와 미성숙 및 성숙 수지상세포를 3×104개 씩 분주하고 May Grunwald-Giemsa 염색한 후, 광학 현미경 하에서 각각의 세포군 당 100개의 세포에서 세포 면적당 핵의 면적 비를 측정하였다. 결과 : 림프구에서는 방사선조사 선량별로 세포고사 빈도가 유의하게 증가하였으나, 수지상 세포에서는 그 분화정도나 방사선조사 선량에 따른 세포고사의 빈도차이가 없었다. 또한 수지상 세포는 방사선선량과 관계없이 용량에 의존적으로 강력한 T-세포 자극능을 보였다. 림프구의 세포에 대한 핵의 면적 비는 미성숙 및 성숙 수지상세포의 세포에 대한 핵의 면적 비보다 현저히 큰 반면, 두 가지 수지상세포간에 유의한 차이는 없었다. 결론 : 수지상세포는 그 분화도와 상관없이 림프구에 비하여 방사선 저항성을 나타내었고, 이는 세포의 형태적 차이에 따른 표적의 크기와 관련이 있을 것으로 생각되며, 향후 분자 생물학적인 연구의 기초 자료로 활용할 수 있을 것으로 생각된다. Purpose : To evaluate radiation sensitivity of dendritic cells in comparison with lymphocytes. Materials and methods : T lymphocytes captured from peripheral blood were irradiated by 0 Gy, 10 Gy, 30Gy. Apoptosis was measured by flowcytometry for staining of Annexin V 4 hours after irradiation. Immature and mature dendritic cells processed from blood hematopoietic stern cell were irradiated by 0 Gy, 10 Gy, 30 Gy, 100 Gy respectively and apoptosis was measured by flowcytometry with time difference as 4h, 24h and 48h after irradiation. Morphometric analysis by percent nucleus was measured in three cell groups, also. Results : Lymphocytes showed radiation sensitivity by increasing apoptotic fraction according to radiation dose. However, both mature and immature dendritic cells showed consistent fraction of apoptosis in spite of increasing radiation dose. Percent nucleus ratio is significantly higher in lymphocytes than that of mature or immature dendritic cells. Stimulation of T-cell by dendritic cells was not changed after irradiation. Conclusion : Dendritic cells showed radioresistance which was associated with small size of nucleus in comparison with lymphocytes and this result would be used as a basal data of radio-labelling for the cellular trafficking studies in nuclear medicine fields.

N値에 따른 地盤評價에 關한 硏究

박은규,류제천,김송만,박춘수 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.1

In this paper, parameters of soil which are estimated with N-value and the results from laboratory test with the sample in construntion field are compared and analyzed. As a result, modification methods caused by existed weight is nearly same with the Equation of Liao & Whitman. Under same existed weight, the difference of N'/N is 0.9~2.1 in the Equation of Peck & Bazzaraa and Gibbs & Holtz. The Equation of O-Ja-Ki (&?'§) is more accurate with average value than any other equations in estimating a angle of internal friction of sand. The result of laboratory test is similar to the Equation of terzaghi & Peck. When unconfined compression strength of clay is estimated, the equation, q_(u) ≒ N/0.722, may represent many suggested equations. Standard Penetration Test is one of the most popular method to estimate parameters of soil because of its simplicity. Correlation between N-value and parameters of soil has been studied by many people but the absurd is still remain and we can face it on the construction field. Therefore field investigation and understanding about N-value are required when engineers estimate parameters of soil with N-value. There should be more study to get high accuracy of N-value and trustable parameters of soil.

退行性關節炎 韓方治療에 對한 最近 硏究 動向 : 臨床硏究 方法論을 中心으로 Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals

서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.

식품 기준·규격의 합리적 관리 ·운영에 관한 연구(Ⅰ) : 두부,식용유지, 전분의 분말상 원료에 관하여 Powdered marerials of Tofu, Edible oil, Starch

김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.

한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

Dose- and Time-Related Effects of Pilocarpine Mouthwash on Salivation

Song, Je-Il,Park, Jo-Eun,Kim, Hye-Kyoung,Kim, Mee-Eun,Kim, Ki-Suk Korean Academy of Orofacial Pain and Oral Medicine 2017 Journal of Oral Medicine and Pain Vol.42 No.3

Purpose: Pilocarpine as a salivation stimulant in pill form has mostly been used to relieve oral dryness for xerostomic patients but its use may often be limited due to variable side effects from systemic absorption. Therefore, the purpose of this study was to investigate the effects of pilocarpine mouthwash on salivation according to the variable concentration and duration for healthy volunteers. Related adverse effects and subjective assessment on its effects on salivation were also examined. Methods: This study was performed as placebo-controlled, double-blind, randomized clinical trial. Thirty healthy volunteers (male=23, mean age=22.2 years) were randomly allocated to 6 groups with the different concentration of pilocarpine mouthwash (placebo, 0.1%, 0.5%, 1.0%, 1.5%, and 2.0%). The whole experiment consisted of 3 sessions according to the duration of mouthwash, i.e., 1, 3, and 5 minutes with the mean wash-out period ${\geq}2$ days between the sessions. Unstimulated whole saliva was collected before and after gargling with a mouthwash. Results: Salivation of the higher concentration groups ${\geq}1%$ significantly increased than those of lower concentration group. The application period of mouthwash did not cause any changes of salivary flow rate at the higher concentrations ${\geq}1.0%$. The lower concentrations of 0.5% and 0.1% had no effects on salivation even after 5-minute mouthwash. There was no significant difference between blood pressure and pulse rate before and after use of mouthwash. Conclusions: From the results of the current study, pilocarpine mouthwash with at least 1.0% concentration more than a minute might be clinically effective in salivation without any serious side effects. Dose of mouthwash rather than duration seems to be a critical factor to salivation.

Genetic polymorphism of Korean wild mice (KWM/1YSI) by microsatellite marker

Eun Ju Song,Jung Eun Lee,Je Kyung Seong 한국실험동물학회 2001 Laboratory Animal Research Vol.17 No.3

Survey of Adverse Events After The First Dose of The ChAdOx1 nCoV-19 Vaccine: A Single-Center Experience in Korea

Song Je Eun,Oh Gang-Bok,Park Hye Kyeong,Lee Sung-Soon,Kwak Yee Gyung 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3

Vaccination is an important strategy for controlling the coronavirus disease 2019 (COVID-19) pandemic. We conducted a web-based cross-sectional survey based on Google Forms to collect data on adverse events (AEs) after the first dose of the ChAdOx1 nCoV-19 vaccine for healthcare workers (HCWs). Among the 1,676 vaccinated HCWs, 59.5% (998/1,676) responded to the survey. In total, 809 (81.1%) respondents reported experiencing AEs. There were no serious AEs, such as anaphylaxis. The most common AE was pain at the injection site (76.2%), followed by fatigue (75.9%), myalgia (74.9%), and fever (58.4%). HCWs in the younger age group experienced significantly more AEs than in the older age group.

Poster Session : PS 0286 ; Gastroenterology : Clinical Usefulness of Visceral Fat in Fatty Liver Severity

( Eun Lee ),( Young Mo Kang ),( Bum Jin Jung ),( Young Jun Jo ),( Ji Suk Sung ),( Yong Moon Woo ),( Kyung Pyo Jo ),( Je Sung Lee ),( Hae Jin Tae ),( Suk Woo Kang ),( Jung Hoon Song ),( Eun Jung Jung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Obesity, especially central obesity is a risk factor of fatty liver. Whereas abdominal ultrasound is widely used to detect hepatic steatosis, it is unable to provide a precise information of hepatic fat content. Liver biopsy is not frequently performed because of its invasive nature although it is accurate. The aim of this study is to evaluate the relationship between histologic degree of fatty liver and visceral fat. Methods: Forty seven patients with fatty liver or fatty metamorphosis in liver biopsy fi nding were enrolled. They were diagnosed from January 2003 to July 2008. Abdominal computerized tomography (CT) was performed on all subjects within a month of liver biopsy. Biopsy specimens were reviewed by two pathologists. The degree of steatosis was graded as minimal, mild (grade 1), moderate (grade 2) and severe (grade 3). Grade 0 was defi ned when the patients had no evidence of fatty liver in biopsy specimenalthough they were diagnosed via imaging study (ultrasound or CT). Abdominal fat area (total fat, visceral fat, subcutaneous fat) were quantifi ed using abdominal CT. Liver fat content in biopsy specimen was also estimated quantitatively by morphometric analysis. Results: The grades of hepatic steatosis were 0 in 7, minimal in 7, mild in 22, and moderate to severe in 11 patients. Baseline characteristics between groups according to the histologic degree were not signifi cantly different. Visceral fat/total fat ratio correlated signifi cantly with the grades of steatosis (0. 43±0. 14, 0. 49±0. 05, 0. 52±0. 10, 0. 56±0. 05, respectively). The liver fat content measured by morphometry also correlated signifi cantly with visceral fat/total fat ratio. Conclusions: Visceral fat, as a marker of central obesity, was correlated signifi cantly with the histologic degree of hepatic steatosis. Measurement of abdominal fat area by CT will be clinically useful for prediction of histologic degree of fatty liver.