구개편도에 발생한 결핵

이병돈,강주원,장혁순,박철규,김장묵 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

Tonsillar tuberculosis, almost always secondary to pulmonary tuberculosis is very rare disease in otolaryngologic fields. Authors have experienced a case of tonsillar tuberculosis associated with miliary pulmonary tuberculosis. The patient had cough, sputum and sore throat for 1 month. On physical examinations, palatine tonsils were slightly hypertrophied, smoothly surfaced, but crypt ulceration or patches were not seen. Diffuse discrete nodules were seen in both lung fields by simple chest X-ray. In high resolution computed tomography, miliary tuberculosis was suspected and in pleural needle biopsy, granulomatous inflammaiton was diagnosed as tuberculosis. AFB smear of sputum was two positive. Histopatholoigic finding of right tonsil was consistent with tuberculosis. He was cured of it with antituberculosis medications for one year. We report the case with review of the literatures.

구리와 철분말의 사출성형 및 소결

이혁기,이동희,장경옥 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.2

The mixtures of Cu or Fe powders and microcrystalline wax as binder were extruded into the long wire by metal injection molding method and sintered after debinding at different conditions. In the case of coarse(33㎛) and irregular Cu powders, the mixture containing 50 vol% wax was suitable for the uniform mixing and forming when injected at 70℃. Binder in coarse Cu powder mixtures was removed at 300℃ for 10 hours. On the other hand, for the spherical and fine Fe powders(4㎛) 30 vol% wax was appropriate and 78% of wax was removed at 400℃ for 1 hour. The density of sintered Cu specimens reached up to 73% of full density when sintered at 1000℃ for 1 hour, but that of Fe specimens was observed to be as high as 97% when sintered at 1200℃ for 1 hour after the optimum debinding.

진균성 부비동염의 임상적 고찰

이승원,김장욱,박영진,송태현,이병돈,장혁순 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

The fungal sinusitis is relatively rare and mainly develops in immunocompromised hosts, but is sporadically appears in the immunocompetent patients, where its incidence tends to be increasing. Because the clinical features of this disease are similar to those of chronic suppurative sinusitis, this entity may be overlooked. We analysed thirteen fungal sinusitis from January 1997 through December 1999 based on clinical features, laboratory characteristics and operative findings. The results are as follows. 1)Fungal sinusitis occurred 3.3 times as frequently in female patients as in male patients and the peak age groups are 4th and 5th decades. 2) The time intervals between the onset of symptoms and the first hospital visit were as follows: 5 cases within 3 months, 1 case between 4 and 6 months, 3 cases between 7 and 12 months, and 4 cases over 1 year. 3) The chief complaints were nasal obstruction, postnasal drip, rhinorrhea, cheek pain, headache, ocular pain, sneezing. 4) The characteristic computerized tomographic findings were hyperattenuated lesions in the maxillary sinus and in the nasal cavity near the natural ostium. 5) The most common pathogen was Aspergillus(92.3%) 6) We performed Caldwell-Luc's operation only in 4 cases, Caldwell-Luc's operation with intranasal ethmoidectomy in 3 cases, Caldwell-Luc's operation with endoscopic sinus surgery in 3 cases and endoscopic sinus sugery only in 3 cases. 7) Most of the gross specimens revealed a fungus ball containing a black-brown necrotic debris or caseous material.

두경부 편평상피세포암 세포주의 VEGF 아형의 분포와 종양증식 및 이종이식성 : relation to xenotransplantability and tumor progression in mice.

김동욱,이종대,박진규,이재형,이병돈,장혁순 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Overexpression of vascular endothelial growth factor(VEGF) is related to tumor progression and xenotransplantability in various human solid tumors, but the specific impact of the VEGF-subtypes is still under discussion. The aim of this study was to analyse a possible association of the major VEGF-isoforms and the growth characteristics of xenotransplanted human head and neck squamous cell carcinoma tumors in nude mice. Seven squamous cell carcinoma cell lines were analysed by quantitative RT-PCR using the Taqman^(TM)-System. We investigated the expression of VEGF-total-mRNA and of the major subtypes VEGF-121, -165, and -189 by using subtype specific primers. The cell lines were xenotransplanted in three mice each, and the data of tumor growth and progression were correlated to the expression of VEGF-isoforms. We also investigated an "growth response rate" measured by tumor growth per detected VEGF-level. Six out of the seven cell lines analysed expressed all isoforms of VEGF in different quantities. One cell line expressed generally low levels of VEGF and no VEGF-189 at all, In this cell line xenotransplantation failed in one mice out of three. In a second cell line transplantation failed in one out of seven mice, too. Success rates for the other five cell lines were 100%. The cell lines with higher transplantation success were expressing higher VEGF-121/165-189 ratios comparing to those without success. In contrast, linearity of tumor growth and lack of necrosis were associated with a lower VEGF-121/165-189 ratio. The findings demonstrate a predominant expression of VEGF-165 and VEGF-189, compared VEGF-121. In highly proliferating tumors this rate appeared to be about 10 times higher than in low proliferating tumors. We conclude that the ratio between the VEGF-subtypes during tumor implantation and growth is a prerequisite for progression and hypothesize an individual and different response of each tumor cell line to VEGF.

Scleral Lens Applications Focused on Korean Patients with Various Corneal Disorders

Ko Eun Lee(Ko Eun Lee),Su Young Moon(Su Young Moon),Sanghyu Nam(Sanghyu Nam),Joon Hyuck Jang(Joon Hyuck Jang),Jae Yong Kim(Jae Yong Kim),Hungwon Tchah(Hungwon Tchah),Hun Lee(Hun Lee) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2

Purpose: We aimed to report on the clinical outcomes of scleral lens applications in Korean patients with various corneal disorders. Methods: This retrospective review was conducted for 62 eyes of 47 patients who had been fitted with scleral lenses for variouscorneal disorders. The patients were referred for inadequate spectacle-corrected visual acuity and rigid gas permeable(RGP) or soft contact lens intolerance. Uncorrected visual acuity, habitually corrected visual acuity, best lens-corrected visualacuity, topographic indices, keratometry indices, and lens parameters were evaluated. Results: Twenty-six eyes of 19 patients with keratoconus were enrolled. Other conditions included corneal scar (13 eyes of12 patients), phlyctenules (three eyes), laceration (four eyes), chemical burn (one eye), keratitis (one eye), Peters’ anomaly (oneeye), fibrous dysplasia (one eye), ocular graft-versus-host disease (two eyes of one patient), irregular astigmatism (18 eyes of12 patients), and corneal transplant status (five eyes of four patients). The mean topographic values of the eyes include flatkeratometric value (43.0 ± 6.1 diopters [D]), steep keratometric value (48.0 ± 7.4 D), and astigmatism (4.9 ± 3.6 D). Of the eyesfitted with scleral lenses, best lens-corrected visual acuity (0.10 ± 0.22 logarithm of the minimum angle of resolution [logMAR])was significantly better than the habitually corrected visual acuity (0.59 ± 0.62 logMAR, p < 0.001). Conclusions: Scleral contact lenses are a good alternative for patients with corneal abnormalities and those who are intolerableto RGP contact lenses, resulting in both successful visual outcomes and patient satisfaction, especially concerning keratoconus,corneal scar, and corneal transplant status.

Long-term cardiovascular events in hypertensive patients: full report of the Korean Hypertension Cohort

Jin Young Lee,Jean Kyung Bak,Mina Kim,Ho-Gyun Shin,Kyun-Ik Park,Seung-Pyo Lee,Hee-Sun Lee,Ju-Yeun Lee,Kwang-il Kim,Si-Hyuck Kang,Jang Hoon Lee,Se Yong Jang,Ju-Hee Lee,Kye Hun Kim,Jae Yeong Cho,Jae-Hye 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.1

Background/Aims: This study evaluated the long-term cardiovascular complications among Korean patients with hypertension and compared them with that of controls without hypertension. Methods: The Korean Hypertension Cohort (KHC) enrolled 11,043 patients with hypertension and followed them for more than 10 years. Age- and sex-matched controls without hypertension were enrolled at a 1:10 ratio. We compared the incidence of cardiovascular events and death among patients and controls without hypertension. Results: The mean age was 59 years, and 34.8% and 16.5% of the patients belonged to the high and moderate cardiovascular risk groups, respectively. During the 10-year follow-up, 1,591 cardiovascular events (14.4%) with 588 deaths (5.3%) occurred among patients with hypertension and 7,635 cardiovascular events (6.9%) with 4,826 deaths (4.4%) occurred among controls. Even the low-risk population with hypertension showed a higher cardiovascular event rate than the population without hypertension. Although blood pressure measurements in the clinic showed remarkable inaccuracy compared with those measured in the national health examinations, systolic blood pressure (SBP) ≥ 150 mmHg was significantly associated with a higher risk of cardiovascular events. Conclusions: This long-term follow-up study confirmed the cardiovascular event rates among Korean hypertensive patients were substantial, reaching 15% in 10 years. SBP levels ≥ 150 mmHg were highly associated with occurrence of cardiovascular event rates.

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma

Lee, Pureun-Haneul,Kim, Byeong-Gon,Lee, Sun-Hye,Lee, June-Hyuck,Park, Sung-Woo,Kim, Do-Jin,Park, Choon-Sik,Leikauf, George D.,Jang, An-Soo The Korean Academy of Asthma, Allergy and Clinical 2018 Allergy, Asthma & Immunology Research Vol.10 No.1

<P><B>Purpose</B></P><P>Claudin-4 has been reported to function as a paracellular sodium barrier and is one of the 3 major claudins expressed in lung alveolar epithelial cells. However, the possible role of claudin-4 in bronchial asthma has not yet been fully studied. In this study, we aimed to elucidate the role of claudin-4 in the pathogenesis of bronchial asthma.</P><P><B>Methods</B></P><P>We determined claudin-4 levels in blood from asthmatic patients. Moreover, using mice sensitized and challenged with OVA, as well as sensitized and challenged with saline, we investigated whether claudin-4 is involved in the pathogenesis of bronchial asthma. Der p1 induced the inflammatory cytokines in NHBE cells.</P><P><B>Results</B></P><P>We found that claudin-4 in blood from asthmatic patients was increased compared with that from healthy control subjects. Plasma claudin-4 levels were significantly higher in exacerbated patients than in control patients with bronchial asthma. The plasma claudin-4 level was correlated with eosinophils, total IgE, FEV1% pred, and FEV1/FVC. Moreover, lung tissues from the OVA-OVA mice showed significant increases in transcripts and proteins of claudin-4 as well as in TJ breaks and the densities of claudin-4 staining. When claudin-4 was knocked down by transfecting its siRNA, inflammatory cytokine expressions, which were induced by Der p1 treatment, were significantly increased.</P><P><B>Conclusions</B></P><P>These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma.</P>

Reduction of mycoplasmal lesions and clinical signs by vaccination against Mycoplasma hyorhinis

Lee, Jung-Ah,Hwang, Min-A,Han, Jang-Hyuck,Cho, Eun-Haeng,Lee, Joong-Bok,Park, Seung-Yong,Song, Chang-Seon,Choi, In-Soo,Lee, Sang-Won Elsevier 2018 Veterinary immunology and immunopathology Vol.196 No.-

<P>Porcine mycoplasmal pneumonia is a significant disease problem in the swine industry. The causative agents include Mycoplasma hyopneumoniae and Mycoplasma hyorhinis. M. hyopneumoniae is the major pathogen contributing to the porcine respiratory disease complex, but is difficult to isolate from the respiratory tract and tonsils, whereas M. hyorhinis is not. Although M. hyorhinis is commonly detected in the lungs, the role of M. hyorhinis as a cause of pneumonia remains unclear. Current vaccines for porcine mycoplasmal pneumonia only include M. hyopneumoniae, not M. hyorhinis. M. hyopneumoniae vaccines are widely used, but disease still occurs because of poor vaccine efficacy and possibly the presence of M. hyorhinis. In this study, an inactivated vaccine containing a mixture of M. hyorhinis and M. hyopneumoniae was generated and evaluated for safety, immunogenicity, and protective efficacy against challenge with M. hyorhinis in pigs. The inactivated vaccine induced an antibody response and reduced pneumonic lesions in the lungs and tracheas compared with the non vaccinated group.</P>

Clinicopathologic risk factors for the local recurrence of phyllodes tumors of the breast.

Jang, Jae Hyuck,Choi, Min-Young,Lee, Se Kyung,Kim, Sangmin,Kim, Jiyoung,Lee, Jeonghui,Jung, Seung Pil,Choe, Jun-Ho,Kim, Jung-Han,Kim, Jee Soo,Cho, Eun Yoon,Lee, Jeong Eon,Nam, Seok Jin,Yang, Jung-Hyun Raven Press 2012 Annals of surgical oncology Vol.19 No.8

<P>Phyllodes tumors (PTs) are rare breast tumors that usually occur in middle-aged women. Here we discuss our recent experiences in the diagnosis, surgical management, and clinical follow-up of this disease.</P>

TSC2 genetic variant and prognosis in non‐small cell lung cancer after curative surgery

Lee, Yong Hoon,Do, Sook Kyung,Lee, Shin Yup,Kang, Hyo‐,Gyoung,Choi, Jin Eun,Hong, Mi Jeong,Lee, Jang Hyuck,Lee, Eung Bae,Jeong, Ji Yun,Shin, Kyung Min,Lee, Won Kee,Seok, Yangki,Cho, Sukki,Yoo, S Wiley-Blackwells 2019 Thoracic Cancer Vol.10 No.2

<P>This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non‐small cell lung cancer (NSCLC) after surgical resection. Twenty‐three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease‐free survival (DFS) were analyzed. Among the 23 SNPs investigated, <I>TSC2</I> rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21–2.91, <I>P</I> = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15–2.38, <I>P</I> = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever‐smokers, and stage I, but not in adenocarcinoma, never‐smokers, and stage II–IIIA. The results suggest that <I>TSC2</I> rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.</P>