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만삭임신 및 만삭전 임신에서 음향자극후 태아심박동 각 변수의 변화
이재억,신호문,박문일,문형,김두상 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.1
Various fetal heart rate (FHR) tests including nonstress test (NST) have been used for antepartum fetal surveillance. The test using FHR response to externally applied sound, namely acoustic stimulation test (AST), is currently being used as an alternative tool of NST. However, there were only few reports regarding computerized FHR analysis in the AST. Individual subjective analysis of FHR tracings can be replaced with an automated computerized objective nalysis system and the accurate recording and analysis of FHR records is now possible using personal computers. In this study, the author prospectively analyzed the FHR response after acoustic stimulation using computerized FHR analysis system, HYFM-1. Sixty five normal term and preterm pregnancies entered to this study. After coustic stimulation with 90 Decibedl and 500 Hertz using programmable acoustic stimulator (8031-CPU, 70-120 Decibel of sound intensity level range, 10-10,000 Hertz of frequency range), the changes of baseline FHR, variability, number of fetal movements and loss of signal were analyzed using HYFM-1. In normal term pregnancies, the baseline FHR, variability, and number of fetal movements were significantly increased after acoustic stimulation. In preterm pregnancies, the baseline FHR and variability were also increased significantly exceptnumber of fetal movements, although absolute value of fetal movement was somewhat increased after acoustic stimulation. Using qualitative analysis of baseline FHR, 15 of 43term pregnancies (34.9%) revealed FHR increments more than 15bpm, however there were only 13.6% (3 of 22 patients)FHR increment over 15 bpm in preterm pregnancies. This difference was statistically significant. It would be suggested that the increment of baseline FHR reflect the central nervous system maturation of fetus at least in term pregnancies.
이윤영,김경태,이재억,유중배,김영오,황윤영 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.2
Three patients(1%) with recurrent molar pregnancy were managed arnong 317 registered molar pregnancies at the department of Obstetrics and Gynecology, Hanyang University Hospital between 197S and 1991. Reeurrent molar pregnancy seemed to be oaiated with a worsening histology and an increased incidence of proliferative trophoblastic sequelae in the successive episodes of hydatidiform mole. The treatment of recurrent mole is discussed and the literature regardmg recurrent rnolar pregnancy is reviewed.
에스트로겐과 활성형 비타민 D의 병합투여가 요추 골밀도에 미치는 영향
조석신,이재억,유중배,황윤영,조수현,문형 대한폐경학회 1996 대한폐경학회지 Vol.2 No.1
Administration of estrogen or vitamin D has been shown to increase bone mineral density in postmenopausal women. To evaluate any added beneficial effects of estrogen combined with vitamine D, 101 postmenopausal attending menopause clinic were allocated into two treatment group; group l,estrogen + progestin(n=72); group 2,estrogen + progestin + 1a-hydroxyvitamin D3 0.5ug/day(n=29). After 1 year of treatment, spinal bone mineral density(BMD) were increased 3.3% in all women. The percent increament of spinal BMD is higher in group 2 than in group 1(244±6.7 vs 5.7±9.8, p$lt; 0.05) and higher in women with osteopenia than normal BMD before treatment(3.4±2.4 vs 8.4±11.2, p$lt;0.05).The percent increasment of spinal BMD correlated with age(group 1; r=0.27, p=0.02, group 2;r=0.41, p=0.02) and menopausal duration in group 2(r=0.45, p=0.01). From the above results, it might be suggested that conbined therapy is more effective in postmenopausal women with osteopenia.
자궁경부암 원통형 및 거대내자궁병소에 대한 관해항암화학요법의 치료효과
조수현,이정한,김승룡,황정혜,조삼현,이재억,류기영,황윤영,공미숙,문형,김경태,이문휘 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.2
Objectives: This retrospective study was conducted to analyze the hypothesis that with neoadjuvant chemotherapy of vinblastine, bleomycin, and cisplatin followed by radical hysterectomy or radiation therapy and concurrent chemoradiation with cisplatin based regimen would improve survival in patients with barrel-shaped or bulky-endophytic (Diameter $gt; 4cm) cervical carcinomas than those of radiation alone or combined radiation and surgery. Study design: Eighty-eight patients with barrel-shaped or bulky-endophytic cervical carcinomas, treated at the Hanyang University Hospital from 1983 to 1997, were the subjects of this investigation. Fifty-six of these patients were treated by neoadjuvant chemotherapy followed by radical hysterectomy with bilateral pelvic lymphadenectomy ( Stage I b2, 8; IIa, 15; IIb, 20; III- IV, 13), twelve patients were treated by neoadjuvant chemotherapy followed by radiation therapy ( Stage IIb, 4; III-IV, 8), and twenty patients were treated by concurrent chemo-radiotherapy ( Stage IIb, 2; III-IV, 18). Results: The incidence of parametrial extension and pelvic lymphnode metastases was higher in patients with barrel-shaped or bulky-endophytic cervical carcinomas than non-barrel-shaped cervix (p=.025 : .001). 5-years disease free survival rate was determined for patients treated by neoadjuvant chemotherapy followed by radical hysterectomy with bilateral pelvic lymphadenectomy was 73.3 %. For patients treated by neoadjuvant chemotherapy followed by radiation therapy it was 45.7%. For patients treated by concurrent chemo-radiotherapy it was 46.1%. Conclusion: These data support an improvement in survival of patients with barrel-shaped or bulky-endophytic cervical carcinomas treated by neoadjuvant chemotherapy followed by radical hysterectomy or radiation therapy and concurrent chemo-radiotherapy.