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Bae, Jun-Hyeon,Cha, Jae-Min,Kim, Dae-Sung,Kim, Young-Seok,Ryu, Bong-Ki The Korean Ceramic Society 2018 한국세라믹학회지 Vol.55 No.2
The glass structure and antibacterial properties of $(65-x)ZnO-xB_2O_3-35P_2O_5$ glasses were investigated. Zinc borophosphate glasses were prepared using a conventional melt-quenching technique at $1000^{\circ}C$. Glass transition temperature and CTE were studied and the structure of zinc borophosphate glasses was evaluated by FTIR. The $Zn^{2+}$ state increase with increasing ZnO content was investigated by XPS and a single sharp Zn $2P_{3/2}$ peak was confirmed, showing that Zn $2P_{3/2}$ exists as $Zn^{2+}$. In order to to evaluate the antimicrobial activity, Escherichia coli (E. coli) was used following the Japanese Industrial Standard JIS Z 2801; the E. coli death rate was found to increase with increasing $Zn^{2+}$ content of glasses.
Recent Advancement of the Molecular Diagnosis in Pediatric Brain Tumor
Bae, Jeong-Mo,Won, Jae-Kyung,Park, Sung-Hye The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.3
Recent discoveries of brain tumor-related genes and fast advances in genomic testing technologies have led to the era of molecular diagnosis of brain tumor. Molecular profiling of brain tumor became the significant step in the diagnosis, the prediction of prognosis and the treatment of brain tumor. Because traditional molecular testing methods have limitations in time and cost for multiple gene tests, next-generation sequencing technologies are rapidly introduced into clinical practice. Targeted sequencing panels using these technologies have been developed for brain tumors. In this article, focused on pediatric brain tumor, key discoveries of brain tumor-related genes are reviewed and cancer panels used in the molecular profiling of brain tumor are discussed.
Sung Han Kim,Un Kyung Kim,Jae Jin Chae,Jeong In Baek,Soo Young Choi,Jae Woong Bae,Sang Hyun Kim,Hyo Soo Kim 한국유전학회 2008 Genes & Genomics Vol.30 No.5
Genetic polymorphisms at the apolipoprotein B have been associated with elevated plasma concentrations of LDL, atherosclerosis and increased risk of coronary artery disease. 106 individuals composed of 46 hypercholesterolemic patients and 60 controls were analyzed with Ins/Del length polymorphism, four RFLPs (HincII, PvuII, AluI, EcoRI) and 3`-VNTR to clarify the characteristics of the apolipoprotein B gene and to determine their influence on the lipid profile of hypercholesterolemic patients and controls in Korea. A total of 212 apolipoprotein B alleles from six markers were identified in this study. Heterozygosityranges from zero to 0.32, and the genotyope frequencies in the case of 3`-VNTR are significantly different between two groups. Analysis of linkage disequilibrium revealed paired nonrandom associations between four pairs of polymorphic sites of the apolipoprotein B gene (p<0.05). Moreover, addition of all 4 polymorphic sites provided the highest PIC value. This study also investigated the association of these polymorphisms with the patients and with variation in lipid levels. A significant association between 3`-VNTR genotypes and Lp(a) was observed in hypercholesterolemic patients (p<0.05). The results suggest that genotypes of six polymorphic markers were not significantly associated with TC, TG or LDL-chol level between the patients and controls in the Koreans.
Managing Soil Organic Matter and Salinity by Crop Cultivation in Saemangeum Reclaimed Tidal Land
Bae, Hui Su,Jang, Hyeonsoo,Hwang, Jae Bok,Park, Tae Seon,Lee, Kyo Suk,Lee, Dong Sung,Chung, Doug Young Korean Society of Soil Science and Fertilizer 2018 한국토양비료학회지 Vol.51 No.1
This study was to evaluate the effect of organic amendments incorporation on soil properties and plant growth under two different soil salinity levels and various cultivated crops at Saemangeum reclaimed tidal land for three years from 2012 to 2014. The soil texture of the experimental site was sandy loam. Four different crops, sesbania (Sesbania grandiflora), sorghum-sudangrass hybrid (Sorghum bicolor-Sorghum sudanense), rice (Oryza sativa L.) and barley (Hordeum vulgare) were cultivated at low (< $1dS\;m^{-1}$) and high (> $4dS\;m^{-1}$) soil salinity levels. The soil salinity was significantly lowered at the rice cultivation site compared to continuous upland crops cultivation site in high soil salinity level. But the soil salinity was increased as cultivating sesbania coutinuously in low soil salinity level. The soil organic matter content was increased with the incorporation of straw at the continuous site of rice and barley, and the average of soil organic matter was increased by $0.9g\;kg^{-1}$ per year which was effective in soil aggregate formation. The highest biomass yield plot was found in barley (high salinity level) and sesbania (low salinity level) cultivation site, respectively. Our research indicates that rice cultivation in paddy field with high salinity level was effective in lowering soil salinity and sesbania cultivation was useful to biomass production at upland with low salinity. In conclusion, soil salinity and organic matter content should be considered for multiple land use in newly reclaimed tidal land.
Jae Won Cha,Ye Jin Kim,Young Min Kim,Jun Ho Bae,Sung Hyuk Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2
Mg–Al–Zn–Ca–Y (SEN) alloys have been recently developed by adding small amounts of Ca and Y to commercial Mg–Al–Zn (AZ series) alloys. These alloys possess superior corrosion and ignition resistances to their commercial AZ seriescounterparts. Here, commercial AZ91 (Mg–9Al–0.8Zn, wt%) and developed SEN9 (Mg–9Al–0.8Zn–0.3Ca–0.2Y, wt%)alloys are extruded under the same conditions, and the microstructure, tensile properties, and high-cycle fatigue propertiesof the extruded alloys are compared. The extruded SEN9 alloy has a smaller average grain size and higher microstructuralhomogeneity than the extruded AZ91 alloy because the Al2Y,Al2Ca,and Al8Mn4Yparticles in the homogenized SEN9 billetpromote dynamic recrystallization during extrusion. Despite their different microstructures, the two alloys possess similartensile strengths because the strong precipitation hardening in the extruded AZ91 alloy is offset by strong grain-boundaryhardening in the extruded SEN9 alloy. However, the extruded SEN9 alloy exhibits higher tensile elongation because deformationtwinning is suppressed by the finer grains. The fatigue strength of the extruded SEN9 alloy (100 MPa) is slightlylower than that of the extruded AZ91 alloy (110 MPa). For the extruded AZ91 alloy, fatigue cracks initiate on the surfacein all specimens, whereas for the extruded SEN9 alloy, fatigue cracks initiate in an Al2Caor Al2Yparticle present on thesubsurface in some specimens, especially at low stress amplitudes. The Al2Caand Al2Yparticles are larger than the Mg17Al12precipitates, and considerably harder than the matrix. Consequently, local stress is highly concentrated in these particlesduring cyclic loading, which eventually causes premature fatigue cracking and decreased fatigue resistance.