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      • 항정신성 약물 사용에 따른 체중변화에 관한 연구

        변은하,김상훈,김재민,박상학,김학열,박찬원 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

        Objective : Weight gain is one of the common side effects of antipsychotics and it has been known that the quality of life is decreased by weight gain. Therefbre the purpose of this study is to compare weight gain among the antipsychotics, which are frequently used in the clinical practice. Methods : We performed a retrospective chart review of 124 patients with schizophrenia who were treated at least 12 weeks with typical antipsychotics (chlorpromazine and halopehdol) or atypical antipsychotics (risperidone, olanzapine, and clozapine). They were divided into three groups as treated with chlorpromazine (N=44), with haloperidol (N=60), and with atypical antipsychotics (N=20) and body weight and Body Mass Index (BMI) were compared at O (Baseline), 8 and 12 week between the three groups. Additionally, we examined possible correlations of changes in body weight with baseline factors. Results : 1) Significant change in body weight and BMI were found during 12 weeks in all groups, received different kinds of antipsychotics but there were no significant differences between three groups. 2) Weight gain was prominent within 8 weeks in the treatment, but not significant after then in all the three groups. 3) Lower body weight in baseline was correlated with more weight gain with the treatment with antipsychotics. Conclusions: Antipsychotics were associated with weight gain in patients with schizophrenia, Particularly in the early stage of treatment. Therefore to increase the quality of life and improve the compliance of medication in treatment of schizophrenia and other psychotic disorder, we must choice medication which are consistent with a individuality

      • 밀레니엄 광고세대의 커리어 행로(carrer path)에 관한 문헌연구

        최은하,김재영 남서울대학교 2004 남서울대학교 논문집 Vol.10 No.1

        This paper aims at study of the career path that is the most important decision factor of millennium generation's lifestyle. Because millennium generation will be new market indicator, of 21 century. For this study, this paper is based on generation Gap that is dealt with all social science. Where Traditionalists seek to build lifetime careers, Boomers to build stellar careers, and Xers to build portable careers, the career path ClashPoint for Millennials will be around parallel careers. Millennials' programmed live have made them true multitaskers. Millennials are already quite capable of learning several jobs simultaneously and performing them admirably. Millennials are throwing out the old model that you're either a waitress, a hostess, or running the register. In a tight labor market, making sure scarce Millennials can cover more than one position is a smart strategy. In a contracting economy, it's cost-effective to put Millennials' multitasking abilities to use rather than hire more employees. Plus, cross-training is a great retention strategy, which reduces the expense of turnover. Futurists predict that Millennials will experience as many as ten career changes in their lifetimes. That's career changes, not job changes-meaning they will recycle their skills and talents and personal preferences into new application again and again and again. Throughout their careers, this generation will be ready, willing, and able to adapt to an organization's evolving structure.

      • SCOPUSSCIEKCI등재

        터키안와 및 상부 종양의 임상적 고찰

        임재현,하은주,이종수,이승재,박효일 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.2

        Tumorous lesion of intra- and suprasellar area showed unique clinical pictures and also was very hazardous and difficult to remove surgically because of the surrounding important anatomical structures. Here, authors analyzed 28 confirmed tumor of this area during last two and half years retrospctively. Histopathologically, 28 cases were classified in 14 pituitary adenoma cased6 cases of non-functioning adenoma, 1 GH-secreting adenoma and 7 cases of prolactinoma), 7 craniopharyngioma cases, 3 meninigioma cases and each one case of germinoma, Rathke's cleft cyst, pituitary abscess and hamartoma. Sexual incidence was 6 : 22 in male vs female ratio. Twenty two cases were measured its diameter over 2cm and they extended to suprasellar area in all cases. Five cases of microadenoma were analyzed and they were all enclosed in sella turcica. Visual impairment was the most frequent and prominent clinical symptom. of which incidence was 78.57% (22 cases). The next frequent symptoms were headache and generalized lethargy. Diabetes insipidus was a presenting symptom in 4 cases and hydrocephalus was noted in 4 cases preoperatively. Surgical intervention was carried out in 23 cases, by the way, the performed type of surgery in 21 cases was a conventional transcranial frontotemporal(pterional) microsurgical method. Post-operatively, diabetes insipidus was complicated in 78.26 % and pituitary hypofunction was noted 34.78%. Two cases of intracranial hemorrhage was developed after surgery and one was died. Through 6 to 28 months follow up. 82.1 % of cases were improved in its clinical status including 7 cured cases.

      • KCI등재

        유색미의 첨가량과 발효방법에 따른 증편의 품질특성

        신은하,이재경 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.4

        This study was carried out to investigate the quality characteristics of Jeung-Pyun with respect to the addition ratio of pigmented rice and fermentation method. As the amount of pigmented rice was increased, the moisture content of the products added with yeast tended to increase more than those made in the traditional way. Regardless of fermentation method, L value and b value of Jeung-Pyun without pigmented rice were higher than those of Jeung-Pyun with pigmented rice, for which the values were significantly low. The samples with 5% or 10% pigmented rice had a high degree of expansion. The other samples showed no visible difference. The hardness, cohesiveness, springiness and chewiness tended to decrease. On the other hand, the adhesiveness was increased. In both fermentation methods, as the amount of pigmented rice was increased, the gelatinization degree was raised. In sensory evaluation, the characteristics of Jeung-Pyun with 30% pigmented rice were very poor, except for the characteristics on pore uniformity. The other samples and both fermentation methods were hardly different.

      • 생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

        류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

        Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

      • 회맹장 판막에 발생한 아니사키스증 1례

        이재익,박정하,김준영,조영완,진한영,강명주,정은욱,박석주,양성연 인제대학교 2006 仁濟醫學 Vol.27 No.-

        Anisakiasis refers to parasitic infestation by nematode larvae that belongs to the subfamily Anisakinae, and this condition is seen in people who eat inadequately prepared or raw salt-water fish. While gastric anisakiasis is commonly diagnosed by endoscopic technique, intestinal anisakiasis is rare because it is less common and the clinical and radiologic features are poorly understood. The authors report a case of human anisakiasis involving the ileocecal valve in 62-year-old man who had the history of eating raw cuttlefish.

      • 첨단·비첨단 신제품과 조화·부조화적 광고단서의 설득 효과

        최은하,김재영 남서울대학교 2004 남서울대학교 논문집 Vol.10 No.3

        The current research contributes to the literature by showing empirically that viewers could read advertising effects of new high-tech product according to their congruent, incongruent visual cues. Specifically, research findings indicate that, as an integral element in print advertising, (non)high-technology new products works with other ad elements-such as visual cues-to help "Complexity" a product and visual cues that frames the meanings communicated to a viewer. The results from the research are suggested as follows. Incongruent visual cues are to be more efficient persuading means in non-high tech products than in high-tech ones. Congruent visual cues, demonstrate their conjoined pacing effects with being restricted to purchasing intention.

      • KCI등재

        산재보상을 신청한 뇌심혈관질환의 특성 분석

        유재홍,하은희,김수근,김정연,김용규,이의철,이철호,손준석 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

        목적: 이 연구는 뇌 · 심혈관 질환으로 업무상재해를 신청한 사례 중에서 승인된 사례와 불승인된 사례의 특성을 비교하여 뇌 · 심혈관 질환의 업무상 재해여부를 판단하는데 필요한 기초 자료를 제공하고자 한다. 방법: 2000년부터 2004년까지 근로복지공단에 업무상 재해로 요양이 신청되어 승인여부가 결정된 뇌 · 심혈관 질환자 12,309명을 대상으로 하였다. 승인여부와 관련된 특성을 확인하기 위해 연도별, 업종별, 규모별, 직업별, 성별, 연령별, 질환별, 생존유무별 그리고 기존질환 유무에 대하여 카이제곱 검정과 다변량 로지스틱 회귀분석을 이용하였다. 결과: 다변량 로지스틱 분석에서 뇌 · 심혈관 질환의 불승인에 대한 승인의 비차비는 광업을 기준으로 하였을 때에 전기가스 상수도업이 4.18(95% CI=1.43~12.17), 건설업이 2.39 (95% CI=1.22~4.69), 제조업이 2.10 (95% CI=1.08~4.07)이었고, 장치기계조작원 및 조립원에 비하여 서비스 근로자 및 상점과 시장 판매근로자 군이 1.90(95% CI=1.47~2.47), 전문가 군이 1.83(95% CI=1.50~2.23), 기술공 및 준전문가 군이 1.63(95% CI=1.35~1.97), 입법 공무원과 고위 임직원 및 관리자 군이 1.62(95% CI=1.24~2.12)이었고, 여성이 남성에 비하여 1.31(95% CI=1.13~1.53), 심장질환에 비하여 뇌혈관질환이 2.75(95% CI=2.42~3.13), 사망한 경우가 생존한 경우에 비하여 6.01(95% CI=4.89~7.38)이었다. 결론: 우리나라에서 뇌심혈관질환으로 업무상 재해를 신청하는 건수는 증가하고 있고 승인율은 비교적 높았으며 승인에 영향을 미치는 요인으로는 업종, 규모, 직종, 성, 연령, 질환, 생존유무 등이 확인되었다. 특히 업종과 직종에 따라서 승인율의 차이가 큰 것이 어떠한 요인의 영향 때문인지에 대한 검토가 필요하고, 특히 뇌실질내 출혈의 경우에 다른 질환에 비하여 승인율이 매우 높았던 것은 업무수행성에 대한 인정기준의 잘못된 적용의 결과 이므로 시정이 필요하겠다. Objectives: This study was performed to provide fundamental data to judge whether or not cerebro and cardiovascular diseases are work-related, by comparing the characteristics between approved and non-approved cases among the worker's compensation claims. Methods: We collected 12,309 cerebro and cardiovascular disease claims based on the worker's compensation records of the Labor Welfare Corporation from 2000 to 2004. The approved and non-approved cases were analyzed according to factors such as the calendar year, industry, company size, occupation, gender, age group, classification of cerebro and cardiovascular diseases, fatality and underlying diseases. We used x²-test and multivariate logistic regression for the analysis. Results: According to multivariate logistic regression, electricity gas and water supply (OR=4.18, 95% CI=1.43~12.17), construction (OR=2.39, 95% CI=1.22~4.69) and manufacturing (OR=2.10, 95% CI=1.08~4.07) industries had a higher approval rate than mining and quarrying industries. Service workers and sales & marketing department workers (OR=1.90, 95% CI=1.47~2.47), professionals (OR=1.83, 95% CI=1.50~2.23), technicians and associate professionals (OR=1.63, 95% CI=1.35~1.97) and legislators and senior officials and managers (OR=l.62, 95% CI=1.24~2.12) had a higher approval rate than plant and machine operators and assemblers. Female workers had a higher approval rate (OR=1.31, 95% CI=1.13~1.53) than male workers. Cerebrovascular diseases had a higher approval rate (OR=2.75, 95% CI=2.42~3.13) than cardiovascular diseases. Fatal cases had a higher approval rate (OR=6.01, 95% CI=4.89~7.38) than surviving cases. Conclusion: For cerebro and cardiovascular diseases, workers' compensation claims are increasing, approval rates are relatively high and factors such as industry, company size, occupation, gender and fatality are related. A remarkable difference in the approval rate was found according to industry and occupation, suggesting the need for further study to identify which factors influence the approval rate. The approval rate for intracerebral hemorrhage arising in the course of employment (COE) was significantly higher than that arising out of employment (AOE), suggesting the need to correct the approval criteria.

      • 염산증기 흡입에 의해 발생한 화학성 폐렴 1예

        장재혁,원경준,권세훈,하성일,권용은,이승일,윤성호 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

        A 38-year-old man with dyspnea admitted to the emergency department after exposure to hydrochloric acid in pharmaceutical product manufacturer. Crackle was auscultated in both lung fields in initial physical examination. Chest radiograph showed consolidation and diffuse parenchymal infiltration in both lung fields. Arterial blood gas analysis showed severe hypoxia. This patient was treated by mechanical ventilation, corticosteroid, antibiotics and bronchodilators and was improved completely in a week after the admission. The authors report a rare case of chemical pneumonitis caused by hydrochloric acid.

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