체계적인 보안 정책 관리를 위한 계층적 보안 모델 설계

황윤철,엄남경,장재웅,이상호 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.1

인터넷 서비스의 다양화와 인터넷을 구성하는 네트워크의 대형화로 인해 다양한 특성을 갖는 구성요소와 환경 등의 요인으로 시스템간의 거래에 대한 보안정책 설정 및 제어가 어려운 문제로 등장하고 있다. 보안 정책 기술이란 인터넷상에서 정보보호 기능을 구현할 때 적용하는 정책들에 대한 검색, 접근제어, 분배 및 처리하는 기술을 의미한다. 이 논문에서는 이러한 현실적인 문제를 해결하기 위해 대형화되어 가는 인터넷 전체에 걸쳐 효율적으로 적용할 수 있는 계층적 구조의 보안 정책 모델을 설계한다. Security policy association and control about transaction between systems must be hard problem to solve because of the environment and composite factors with variable properties by diversity of internet service and enlarging a scale of organizing internet. Security policy technique means retrieval, access, control, distribute and process technique about adoptable policies when implementation is information security function on internet. In this paper, to solve this actual problems, Design of a hierarchical structure security policy model applicable to internet.

수술로 절제된 간의 국소 결절성 증식의 임상적 특징

황남철,최문석,이준혁,고광철,백승운,유병철,이종철,이광웅,조재원,박철근 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.2

목적: 간의 국소 결정성 과형성은 일반적으로 특별한 치료가 필요 없는 양성 종양이다. 그러나 드물지만 합병증이 발생한 경우와 진단이 불확실한 경우에는 수술을 시행하게 된다. 이에 저자들은 간절제술을 시행한 국소 결절성 과형성의 임상적, 영상학적 특징들을 알아보고자 하였다. 대상과 방법: 1995년부터 2003년까지 수술을 시행하여 조직을 확인한 국소 결절성 과형성 환자 10명을 대상으로 연령, 성별, 실험실 검사 및 영상 소견과 조직 소견을 분석하였다. 결과: 연령의 중앙값은 37.5세, 남녀 비는 1.5:1이었다. 5예에서는 간세포선종이나 간세포암종을 감별할 수 없어서 수술을 시행하였으며, 수술 후 우연히 진단된 예는 4예이었다. 간세포암종의 위험 인자를 가지고 있었던 예는 4예(B형 간염 바이러스 보유자 3예, 간경변 2예)이었다. CT검사가 시행되었던 6예 중 5예는 동맥기에서 조영 증강을 보였고 문맥기 및 지연기로 감에 따라 주변과 동일(4예)한 또는 감소(2예)되는 양상을 보여 간세포암종과의 감별이 어려웠다. 크기는 3.2±2.2㎝이었으며 위치는 간우엽의 후하구역(S6)에 가장 많았다(30.0%). 4예에서 수술 전 침생검을 시행하였으나 고분화 간세포암종이나 간세포선종과의 감별이 어려웠다. 결론: 임상상, 영상검사 및 간침생검으로도 간세포암종이나 간세포선종과의 감별이 어려운 경우 수술을 시행하였으며 수술 전에는 발견하지 못하였지만 다른 질환으로 인한 수술시 우연히 발견된 경우도 있어 국소 결절성 과형성의 수술 전 진단이 어려운 경우가 적지 않음을 알 수 있었다. Background/Aims: Focal nodular hyperplasia (FNH) is a benign hepatic tumor with few serious complications and no malignant transformation. However, differential diagnosis between FNH and other liver tumors, especially hepatocellular carcinoma, is often difficult. Methods: Clinical features of surgically resected FNH were reviewed. From January, 1995 to February, 2003, 10 patients with surgically resected FNH were enrolled. Their age, sex, results of laboratory examination, imaging studies and pathologic findings were evaluated. Results: Median age was 37.5 years and sex ratio (male:female) was 1.5:1. In 5 cases, resection to exclude hepatic adenoma or HCC was performed. Four cases were diagnosed incidentally after surgery. Four patients had risk factors for HCC, such as hepatitis B virus infection, liver cirrhosis or both. The size of FNH was 3.2 2.2 cm. The most common site of the tumor was segment 6 (30.0%). Differential diagnosis with HCC was difficult in 5 of six cases in whom CT was performed. Although needle biopsies were performed preoperatively in 4 cases, it was difficult to distinguish FNH from hepatic adenoma or HCC. Conclusions: FNH was resected due to uncertainty of diagnosis, or incidentally during hepatectomy in patients with other liver disease. In the former, differential diagnosis with hepatic adenoma or HCC was a major problem despite extensive work-up including dynamic CT or biopsy. (Korean J Hepatol 2004;10:135-141)

도시성장분석상 위성영상자료와 구역자료의 통합이용에 관한 연구

김재익,황국웅,정현욱,여창환 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3

위성영상은 도시의 물리적 확산 및 변화를 예측하는데 많이 활용되고 있다. 그러나 이 방법은 도시화된 지역이 어느 정도의 강도로 개발되었는지를 파악할 수 있는 밀도분석에는 적절치 못하다. 이는 위성영상이 미시적 공간단위로 토지이용 현황을 분석하는 반면 통계자료는 거시적 공간단위로 구축되어 있어 통계자료를 미시적인 공간단위에 적용하는데 어려웠기 때문이다. 본 연구는 위성영상자료와 통계청의 기초단위구라는 미시적 구역통계자료를 활용하여 도시성장분석상 이들 자료를 통합하여 활용하는 것이 유용함을 입증하고자 하였다. 연구대상지역은 대구광역시로 하였으며, 분석자료로 1985년과 2000년의 위성영상 Landsat TM틀 와 구역통계자료로 기초단위구를 이용하였다. 분석결과 위성영상자료는 도시의 확산 그리고 기초단위구는 밀도 분석이 용이하여 도시성장에 따른 확산과 밀도변화를 동시에 파악할 수 있었다. Nowadays, a satellite image is widely utilized in identifying and predicting urban spatial growth. It provides essential informations on horizontal expansion of urbanized areas. However, its usefulness becomes very limited in analyzing density of urban development. On the contrary, zonal data, typically census data, provides various density information such as population, number of houses, floor information within a given zone. The problem of the zonal data in analyzing urban growth is that the size of the zone is too big. The minimum administration unit, Dong, is too big to match the satellite images. This study tries to derive synergy effects by matching the merits of the two information sources-- image data and zonal data. For this purpose, basic statistical unit (census block size) is utilized as a zonal unit. By comparing the image and zonal data of 1985 and 2000 of Daegu metropolitan area, this study concludes that urban growth pattern is better explained when the two types of data are properly used.

人蔘이 닭의 血中葡萄糖 및 遊離脂肪酸濃度에 미치는 影響

李神雄,李載欣,黃炳斗,琴基昌 충남대학교 의과대학 지역사회의학연구소 1974 충남의대잡지 Vol.1 No.1

Effect of Panax Ginseng on the plasma glucose and free fatty acid levels of the normal chicken and experimentally induced-hyperglycemic chicken, and on the release of glucose and glycogen contents in the chicken liver slices was investigated. 1) Plasma glucose levels was not influenced, but plasma FFA level decreased significantly by intravenous administration of Panax Ginseng in the normal chicken. 2) Epinephrine-induced hyperglycemic and hyperlipemic response and hyperglycemia induced by pancreatic ligation were inhibited by Panax Ginseng, and in the glucose tolerance test, Ginseng shortened the recovery time to normal glucose level. 3) In the chicken liver slices, Panax Ginseng inhibited the release of glucose from the specimen, but did not affect glycogen contents of the tissue.

급성 호흡곤란으로 내원한 성대기능이상 1례

함초롬,박경일,박혜연,황철웅,김종연,김태년,진재용,이성순 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Vocal cord dysfunction (VCD) is a respiratory disorder characterized by the abnormal adduction of the vocal cords upon inspiration, expiration, or both, leading to a diverse array of acute obstructive airway signs and symptoms (wheezing, chest tightness, shortness of breath, and cough). VCD frequently mimics or confounds asthma. Misdiagnosis as asthma has led to inappropriate treatment, most notably with high-dose corticosteroids. Mistaken for anaphylaxis or angioedema, VCD has led to intubation and tracheostomy. VCD should be suspected in patients who are treated aggressively for asthma but continue to experience dyspnea. The diagnosis of VCD is made from direct visualization of the vocal cords during an attack. Inspiratory, anterior vocal cord closure with a posterior glottic chink is seen. On pulmonary function testing, a pattern of "saw-toothing", or fluttering of the inspiratory limb, representing fluctuations in the abnormal cord motion is seen in VCD patient. Treatment includes discussion of the diagnosis with the patients, discontinuing unnecessary medications, using of a helium-oxygen mixture in acute attack. Speech therapy and psychotherapy are the mainstays of long-term treatment. Here in we report a case of VCD in company with asthma.

진단 초음파를 이용한 정상 성인의 정중신경 측정

이정아,임길병,이홍재,정웅태,황현오 최신의학사 2003 最新醫學 Vol.46 No.11-12

Development and External Validation of Survival Prediction Model for Pancreatic Cancer Using Two Nationwide Databases: Surveillance, Epidemiology and End Results (SEER) and Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP)

( Jae Seung Kang ),( Lydia Mok ),( Jin Seok Heo ),( In Woong Han ),( Sang Hyun Shin ),( Yoo-seok Yoon ),( Ho-seong Han ),( Dae Wook Hwang ),( Jae Hoon Lee ),( Woo Jung Lee ),( Sang Jae Park ),( Joon S 대한간학회 2021 Gut and Liver Vol.15 No.6

Background/Aims: Several prediction models for evaluating the prognosis of nonmetastatic resected pancreatic ductal adenocarcinoma (PDAC) have been developed, and their performances were reported to be superior to that of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system. We developed a prediction model to evaluate the prognosis of resected PDAC and externally validated it with data from a nationwide Korean database. Methods: Data from the Surveillance, Epidemiology and End Results (SEER) database were utilized for model development, and data from the Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP) database were used for external validation. Potential candidate variables for model development were age, sex, histologic differentiation, tumor location, adjuvant chemotherapy, and the AJCC 8th staging system T and N stages. For external validation, the concordance index (C-index) and time-dependent area under the receiver operating characteristic curve (AUC) were evaluated. Results: Between 2004 and 2016, data from 9,624 patients were utilized for model development, and data from 3,282 patients were used for external validation. In the multivariate Cox proportional hazard model, age, sex, tumor location, T and N stages, histologic differentiation, and adjuvant chemotherapy were independent prognostic factors for resected PDAC. After an exhaustive search and 10-fold cross validation, the best model was finally developed, which included all prognostic variables. The C-index, 1-year, 2-year, 3-year, and 5-year time-dependent AUCs were 0.628, 0.650, 0.665, 0.675, and 0.686, respectively. Conclusions: The survival prediction model for resected PDAC could provide quantitative survival probabilities with reliable performance. External validation studies with other nationwide databases are needed to evaluate the performance of this model. (Gut Liver 2021;15:912-921)

Transgenic Efficiency of FoxN1-targeted Pig Parthenogenetic Embryos

Jae-Hoon Yeo,In-Sul Hwang,Jae Kyung Park,Dae-Jin Kwon,Seoki Im,Eung-Woo Park,Jeong-Woong Lee,Choon-Keun Park,Seongsoo Hwang 한국수정란이식학회 2014 한국동물생명공학회지 Vol.29 No.4

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein (Cas9) system can be applied to produce transgenic pigs. Therefore, we applied CRISPR/Cas9 system to generate FoxN1-targeted pig parthenogenetic embryos. Using single guided RNA targeted to pig FoxN1 genes was injected into cytoplasm of in vitro matured oocyte before electrical activation. In results, regardless of the concentrations of vector, the cleavage rate were significantly (p<0.05) decreased (4 ng/μl, 51.24%; 8 ng/μl, 40.88%; and 16 ng/μl; 45.22%) compared to no injection group (70.44%). The blastocyst formation rates were also decreased in vector injected 3 groups (4 ng/μl, 7.96%; 8 ng/μl, 6.4%; and 16 ng/μl; 9.04%) compared to no injection group (29.07%). In addition, the blastocyst formation rates between sham injected group (13.51%) and no injection group (29.07%) also showed significant difference (p<0.05). The mutation rates were comparable between groups (4 ng/μl, 18.4%; 8 ng/μl, 12.5%; and 16 ng/μl; 20.0%). The sequencing analysis showed that blastocysts derived from each group were successfully mutated in FoxN1 loci regardless of the vector concentrations. However, the deletion patterns were higher than the patterns of point mutation and insertion regardless of the vector concentrations. In conclusion, we described that cytoplasmic microinjection of FoxN1-targeted CRISPR/Cas9 vector could efficiently generate transgenic pig parthenogenetic embryos in one-step.

The Association Between Unexplained Second - Trimester Human Chorionic Gonadotropin Elevations and Pregnancy Outcome

(Jae Woong Hwang),(Seong Un Jeong),(Jeong Wook Seo),(Yun Seok Yang),(Jun Sook Park) 대한산부인과학회 1998 춘계학술대회 Vol.- No.-

Indole-3-Carbinol Prevents H₂O ₂-Induced Inhibition of Gap Junctional Intercellular Communication by Inactivation of PKB/Akt

HWANG, Jae-Woong,JUNG, Ji-Won,LEE, Yong-Soon,KANG, Kyung-Sun JAPANESE SOCIETY OF VETERINARY SCIENCE 2008 The Journal of veterinary medical science Vol.70 No.10

<P>Indole-3-carbinol (I3C) is a phytochemical found in cruciferous vegetables and possesses a variety of biological and biochemical effects. Despite a wealth of data about the chemopreventive properties of I3C, its effects on gap junctional intercellular communication (GJIC), which is associated with the promotion and progression phases of the multi-stage process of carcinogenesis, has not been studied. In this study, we examined the ability of I3C to prevent H<SUB>2</SUB>O <SUB>2</SUB>-induced inhibition of GJIC in WB-F344 rat liver epithelial cells (WB cells). The cells were preincubated with I3C for 48 hr, and then treated with 1 mM H<SUB>2</SUB>O<SUB>2</SUB> for 1 hr. We found that I3C could prevent the H<SUB>2</SUB>O<SUB>2</SUB>-induced inhibition of GJIC through prevention of the phosphorylated state of gap junction protein connexin 43 (Cx43) phosphorylation. Prevention of GJIC by I3C was dependent upon inactivation of Akt, but not MAPK, although inhibition of GJIC by H<SUB>2</SUB>O<SUB>2</SUB> leads to activation of both. Similar to I3C, modulation of Akt activation through the phosphoinositide-3 kinase inhibitor, LY294002, could also prevent H<SUB>2</SUB>O<SUB>2</SUB>-induced inhibition of GJIC and phosphorylation of Cx43. Our results suggest that I3C might exert its dietary chemopreventive effects by interfering with the Akt signaling pathway, which appears to be linked to modulating GJIC, a cellular mechanisms regulating cell proliferation, differentiation and apoptosis.</P>