바터 팽대부에 생긴 유암종 1예

강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-

Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.

글라스 아이오노머 수복재의 불소 유리 및 재흡수 양상

배익현,김재문,정태성,김신 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.1

이차 우식은 수복 실패의 주된 원인 중 하나로 지목되고 있으며, 이로 인해 빈번히 재수복을 하게 된다. 이차 우식은 항우식 작용이 있는 불소를 함유한 수복물을 사용하여 예방될 수 있다. 구강내에서 불소를 유리하는 것으로 알려진 글라스 아이오노머 수복재는 불소를 장기간 유리할 뿐 아니라 불소의 재충전 및 재유리 능력이 있어 불소의 저장소 역할을 할 수 있다. 따라서 본 연구는 통상의 글라스 아이오노머와 고점도 글라스 아이오노머 및 복합 레진을 대상으로 불소의 유리 양상과 불소도포를 통한 재흡수 후 유리 양상을 알아봄으로써 기존의 수복재와 새로운 수복재간의 임상적 유용성을 평가할 목적으로 시행하였다. 4종의 수복재를 대상으로 불소 유리량 및 2% NaF로 재충전 후 불소 유리량을 각각 측정하여 다음과 같은 결과를 얻었다. 1. 실험 대상의 모든 글라스 아이오노머 수복재는 초기에 다량의 불소를 유리하고 이후 점차 감소하는 경향을 보였다. 2. 2% NaF 용액을 통한 재충전 후의 유리량은 Fuji IX, Ketac Fil, Ketac Molar, Z-100의 순으로 나타났다. 3. Fuji IX을 제외한 모든 실험 대상의 수복재에서 수분의 영향으로 표면 경도는 유의하게 감소하였고 불소 재충전 후 유리량은 수분 흡수와 비례하였다(P<0.05). 4. Fuji IX이 초기 유리량에 비해 재충전 후 더 많은 불소를 유리였다(P<0.05). The replacement of dental restorations due to secondary caries is a continuing problem in restorative dentistry. The secondary caries can be partly prevented by using fluoride containing dental materials such as glass ionomer cement, which releases and be recharged with fluoride ion acting as a fluoride reservoir. For the purpose of investigating the behaviors of fluoride release and recharge of conventional and high viscosity glass ionomer cements, the experiment was performed on the seven specimens each from 4 kinds of materials; 1 kind of conventional glass ionomer cement, 2 kinds of high viscosity glass ionomer cements and 1 kind of composite resin. The amount of fluoride release was measured over 7 days with pH/ion meter and fluoride specific electrode. After measuring daily fluoride release, the specimens were recharged with 2% NaF solutions for 4 minutes and measured for 3 days with recharging repeated two consecutive times. The results were as follows : 1. Significantly more fluoride was released at first day after recharge in all materials except Z-100. 2. High viscosity glass ionomer cements released more or nearly equal amount of fluoride after recharge compared with the initial release(P<0.05). 3. The fluoride release after recharge with 2% NaF solution was in order of Fuji IX, Ketac Fil, Ketac Molar, Z-100.

랫드 배양배아에서 ginsenosides가 superoxide dismutase 유전자 발현에 미치는 영향

김재승, 이세라, 김연, 연정민, 백인정, 안병우, 김윤배, 이범준, 윤영원, 남상윤 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

본태성 고혈압에서 염산에포니디핀 (NZ-105, 핀테20정�)의 유효성 및 안전성 : 제3상 다기관 임상시험 The phaseⅢ multicenter open trial

배종화,손일석,강흥선,조정휘,강재헌,김성원,이선영,양윤준,김영식,선우성 대한간질학회 2003 대한간질학회지 Vol.9 No.1

Sarcoma-180 세포를 이용한 고등균류의 항암효과

배만종,이재성,김선희,박무희 경산대학교 생명자원개발연구소 1998 생명자원과 산업 Vol.2 No.-

상황버섯과 버들송이 균사체를 중심으로 하여 이들 균사체로부터 열수 추출된 세포내다당류와 배양액에서 회수된 다당류를 이용하여 sarcoma180에 대한 항암효과를 실험한 결과는 다음과 같다. Sarcoma-180 cell-line으로 복수임을 유발시킨 mice에 균사체와 배양액으로부터 회수한 다당체를 50㎍/㎏ 투여시의 체중증가량은 대조군에 비하여, 현저하게 체중증가량이 감소하였으며, 균사체에서 보다 배양액에서의 다당류에서 더욱 효과 있는 것으로 나타났다. 수명연장 효과를 살펴본 결과는 대조군에 비하여 상황과 버들송이 균사체의 세포외단백다당체에서 각각 47.8%, 69.6%, 32.2% 및 23.9%의 생존율을 나타내었다. In vitro에서의 S-180에 대한 증식 억제효과는 대조군에 비하여 모든 군에서 억제효과가 나타났으며, 시료의 농도에 비례하여 억제되는 것으로 나타났다. This study examine antitumor effects, the intracellular and extracellular, extracts from the liquid culture of the Phellinius igniarius and the Agrocybe cylindracea by using sarcoma180 tumor cells. The experimented was carred out by mice body weight increation, the life prolongation and tumor cell groth inhibition in vitro. The resultes obtained from the experiment as follows; Total body weight of mice, inoculated with sarcoma-180ascites tumor cells challenge, were decreased significantly in experimental groups, intracellular and extracellular polysaccharide extracts from the liquid culture of the Phellinius igniarius and the Agrocybe cylindracea than control groups. The life prolongation effects were 47.8%, 69.6%, 32.2% and 23.9%, respectively when intracellular and extracellular, extracts from the liquid culture of the Phellinius igniarius and the Agrocy cylindracea were administrated to the mice. Inhibitory efect on the growth rate of the sarcoma-180 was stronger in intracellular and extracellular, extracts from the liquid culture of the Phellinius igniarius and the Agrocybe cylindracea than control group. The growth rates of the sarcoma-180 in medium containing samples were inhibited gradually to a significant degree in proportion to the increase of the samples concentration in vitro.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

가령에 따른 백서 악관절 원판의 형태 및 미세구조적 변화

배용철,성재현,경희문,서혜경 대한치과교정학회 1994 대한치과교정학회지 Vol.24 No.2

백서에 있어서 가령에 따라 악관절 원판에 가하여지는 기계적 부하의 변화에 따른 악관절 원판의 형태, 탄성섬유 및 세포의 미세구조의 적응등의 변화양상을 관찰하기 위하여, 생후 1일, 7일, 17일, 27일, 55일, 1년 이상군의 백서의 악관절 부위를 적출하여 광학 및 전자현미경으로 관찰하여 다음과 같은 결론을 얻었다. 악관절 원판의 형태는 1일 및 7일군에서는 중앙부의 얇은 부위가 전후방으로 상당히 길게 뻗쳐 있고 전부 및 후부의 최대 풍융부를 향한 경사가 완만하여 하악와 및 하악과두에 적합되지 않는 양상을 보였으나, 17일군부터는 전부 및 후부가 하악와쪽으로 풍융해짐과 동시에 중앙부의 얇은 부위가 전후방으로 좁아지고 전부 및 후부의 최대 풍융부를 향한 경사가 급하여져, 악관절 원판이 하악과두를 감싸는 형태를 취하여 하악와 및 하악과두에 적합되어 가는 양상을 보였다. 가령에 따라 세포밀도는 점점 감소하였으며, 1일 및7일군에서는 세포내 골지장치, 과립성 내형질망, 유리 리보솜 등의 세포질 및 세포간 기질을 활발하게 합성하는 세포 소기관들이 발달 되어 있었으나 세포질내 세사는 발달되어 있지 않았다. 17일, 27일 및 55일에서는 기질합성에 관여하는 세포 소기관의 발달과 아울러 손가락 모양의 세포돌기, 용해소체, 사립체등의 세포간 기질의 개조에 관여하는 세포 소기관이 발달된 세포가 다수 관찰되었으며, 가령에 따라서 세포질내 세사가 점점 축적되어지는 양상을 보였고, 섬유성 물질에 둘러 싸인 chondroid cell들이 증가하였다. 1년이상군에서는 대부분이 세포가 chondroid cell로 구성되어 있었으며 세포질내의 대부분을 세사가 차지하고 세포내 소기관이 거의 발달되지 않는 등 대사 활동이 미약하며 주로 기계적 부하에 적응하기 위한 구조로 이루어져 있었으며 때로는 변성과정에 있는 세포도 다소 관찰되었다. The purpose of this study was to investigate changes in the shape and ultrastructrue of the articular disc of the rat mandibular joint with aging. Mechanical stress applied to the articular disc changes during neonatal, suckling, juvenile, adult and senile stages. Mandibular joints of 6 groups of rats (1-,7-,17-,27-,55-day and over-1-year groups) were removed en bloc and processed for light and electro microscopic study. The changes in the shape of articular disc were examined by light microscope in each group. Structural and ultrastructural changes in the articular disc were examined by light and electron microscope in each group. The results were as follows: In the 1-day and 7-day groups, the articular disc was long and slender in shape and the articular disc was not fitted with the shape of the mandibular fossa and condyle. However, after that time, the anterior and posterior portions of the articular disc were more bulged and the middle portion was shorter and biconcave. Thus the articuler disc was well fitted with the shape of the mandibular fossa and condyle. The cell density decreased wth aging. In the 1-day and 7-day groups, the Golgi apparatus, rough endoplasmic reticulum and free ribosome, which are involved in the synthesis of intracellular and extracellular matrix. were developed. In the 17-day, 27-day and 55-day groups, not only the cell organelles involved in the synthesis of the intracellular and exracellular matrix but also the cell organelles involved in the remodeling of the extracellular matrix(i.e., finger-like cell process, lysosome and mitochondria) were well developed. With advancing age, intracytoplasmic microfilaments were more accumulated and condroid cells increased. In the over-1-year group, the majority of cells of the articular disc were chondroid cells. The majority of cytoplasmic compartment were filled with intracytoplasmic microfilaments and cell organelles were not developed. Therefore, metabolic activites of the cell was markedly reduced and cells contained structures enduring mechanical stress, and cells which were in the process of degeneration were observed occasionally.

격자변형 분석법에 의한 성인 두부방사선 규격 사진학적 계측

배세복,성재현 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.1

The Moorrees mesh is a valuable diagnostic adjunct in evaluation dentofacial deformity. The purposes of this study intended to calculate the cephalometric norms of Korean adults by the mesh diagram analysis. Lateral cephalograms were obtained from 41 males and 36 females. Results of this study were obtained as follows 1. Norms of Korean adult male and female were calculated. 2. The size of upper face in male was larger than that of female. 3. Linear measurements of each landmarks in male were larger than those of female, but there were no significant sexual difference in proportionate measurements. 4. In the stability of reference line, FH line and natural head position were more stable than SN line. There was no significant difference between FH line and natural head position, but natural head position was slightly more stable than FH plane. 5. As upper facial height increased, LFH/UFH ratio was decreased. J. Kyungpook Univ. Sch. Dent. Vol. 7, No. 1,99∼110, 1990

水産專門大學 漁業科 敎育課程 開發硏究

裵錫悌,宋之浩,李吉來,鄭興基,洪聖根,趙鳳坤,朴種洙 군산대학교 1983 群山水産專門大學 硏究報告 Vol.17 No.1

In order to develop the curriculum of the fishery department in the fisheries Jr. college, We have collected and analyzed the domistic and foreign data adquated to the fishey department under the international trend, also we gathered the opinion from the inquiring paper investigation and consultation to the industrial field, concerned college and graduate during the 6 month from September 1982. The fishery department curriculum in fisheries Jr. college will be industrialized with the concerned technics and knowledge in relation to speciality of maritime affairs. Accordingly, we have developed the adquate curriculum which is practical and can be cultivated the technician to adopt in the industrial society.

정자기장과 맥동전자기장이 MC3T3-E1 세포의 ALP 및 DNA 활성도에 미치는 영향

배성민,성재현,손정희 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

정자기장과 맥동전자기장이 배양 조골세포에 미치는 영향을 알아보고자 MC3T3-E1세포를 각 자기장하에서 배양하여 ALP활성도와 DNA의 합성능을 평가한 결과 다음과 같은 결과를 얻었다. 1. 정자기장을 가한 군에서 자석을 1,2,3개 가한 군(51~114.8mT)에서 대조군에 비하여 ALP의 유의성있는 증가가 나타났으며(p<0.05), 자석을 4개, 5개 가한 군(150mT)에서는 대조군에 비하여 ALP활성도에 차이가 나타나지 않았다. 2. 맥동성 전자기장에서는 대조군에 비하여 ALP활성도에 유의한 차이가 나타나지 않았다. 3. DNA합성능은 정자기장과 맥동성 전자기장을 가한 군 모두 대조군에 비하여 유의한 차이가 나타나지 않았다. 이상의 결과 정자기장에 의한 교정력은 골세포의 대사과정에 변화를 줄 수 있으므로, 치아이동에 어떠한 영향을 줄 수 있을 것으로 사료된다. The purpose of this study was to evaluate the effect of magnetic field on cellular activity of MC3T3-E1 cells. The celular activity was monitored by alkaline phosphatase and DNA synthetic activity in control, static magnetic field and pulsed electromagnetic field groups. A static magnetic field and pulsed electromagnetic field groups. A static magnetic field was applied to the cell by placing one, two, three, foue, and five samarium-cobalt magnets above and below each cell plate for 24hours per day. A pulsed electromagnetic field with a frequency of 100 herz was applied for 10 hours per day. After 10 days of magnetic field exposure, there were increase of alkaline phosphatase activity in static magnetic field groups consisted of one, two and three magnetic groups. Alkaline phosphaatase activities were not significant increase in alkaline phosphatase activity compared to control. DNA synthetic activity in both static and pulsed electromagnetic field group were not significantly different from that in control group. The result of this study suggest that magnetic field could have effect on the metabolism of bone cells related to the cellular metabolic process.