서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

랫드 배양배아에서 ginsenosides가 superoxide dismutase 유전자 발현에 미치는 영향

김재승, 이세라, 김연, 연정민, 백인정, 안병우, 김윤배, 이범준, 윤영원, 남상윤 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

펄프 고해과정중 발생되는 미세섬유의 구조(II) : 활엽수 펄프 Hardwood pulp

윤승락,김재경,김사익,조종수,노정관 진주산업대학교 2000 산업과학기술연구소보 Vol.- No.7

Freeness occurrence and types of deciduous fine fibers depending on beating time were examined to evaluate morphological characteristics of fine fibers produced by beating of Kraft pulp(KP) processes. The results were as foltows; As the beating time was increased, freeness and occurrence of fine fibers were gradually increased. The fibrillation of fiber was started at 20 minutes(22˚ SR) after beating, and the cell wall was destroyed or cut after 70 minutes(67˚ SR). Fine fibers produced during beating were composed of microfibrils from wood fibers, fragments caused by vessel destruction, and parenchyma cells. At initial stage of beating, the primary and secondary walls of fine fibers were coexisted, but as the beating was more processed, fine fibers which were composed of secondary wall were increased, indicating of destruction of secondary cell wall. The morphological change of parenchyma cell was not occurred by beating.

오존처리·추출처리후 섬유벽내의 탈리그닌

尹承洛,金在慶 진주산업대학교 환경문제연구소 1998 環境硏究論文集 Vol.2 No.-

추출조작중 알칼리용액 추출이 물에 의한 추출보다 탈리그닌, 강도적 성질이 우수하다는 원인을 구명하기 위하여 자외선 현미경을 이용하여 섬유벽내의 리그닌 분포 및 탈리그닌 정도를 관찰한 결과는 다음과 같다. 1. 물과 1% NaOH 용액에 의한 추출처리에서 용액에 따라 탈리그닌 영역이 다르다. 2. 오존에 의해 산화 분해된 섬유내 리그닌의 용출은 물보다 1% NaOH 용액이 효과적이었다. 이런 이유로 물에 의한 추출보다 1% NaOH 용액으로 추출한 펄프의 강도적 특성이 우수하다. 3. 고온(70℃)에서 추출처리를 행하면 섬유표면과 루멘측의 리그닌이 동시에 용출된다. 섬유로 부터의 리그닌 용출은 실온보다 고온에서 처리하는 것이 효과적이다. In order to evaluate the delignification in cell wall by alkali extraction treatment after ozonation, the lignin distribution and delignification degree was determined by UV microscope. The delignification area was differentiated depending on extractants such as water or 1% NaOH. The content of oxidized gushing out lignin in fiber was higher by 1% NaOH extraction than by water, therefore, the strength properties of pulp extracted with 1% NaOH was better. When the extraction treatment was carried out at high temperature(70℃), the lignin was simultaneously gushed out in the surface of fiber and lumen, therefore the treatment at high temperature was preferred for the purpose of lignin gushing out from fiber.

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

펄프 叩解科程中 發生되는 微細纖維의 構造(I) : 針葉樹 펄프 Softwood Pulp

尹承洛,金在慶,金思翼,趙鍾洙 진주산업대학교 1998 산업과학기술연구소보 Vol.- No.5

펄프 고해과정중 발생되는 微細織維를 究明하기 위하여 시간별로 TMP, KP를 고해하여 濾水度 변화, 微細織維발생량 및 형태에 대하여 검토한 결과는 다음과 같다. 1.고해시간이 길어지면 濾水度, 微細織維 발생량은 증가되고, 섬유의 朶軟性 차이로 KP보다 TMP가 높았다. 2.고해에 의해 발생되는 微細織維는 절단된 朶細胞 破片과 細胞壁 2次壁의 마이크로휘브릴이다. 3.TMP, KP에서 발생된 微細細胞의 종류는 同하지만, 형태에서는 差異點을 보이고 있다. 印解가 진행되면 朶細胞는 小片化되고, 마이크로휘브릴은 切斷, 細分化된다. 4.印解初期에 발생된 微細織維는 1, 2次壁이 共存하지만, 印解가 더 진행되면, 1, 2次壁이 分離되었다. The freeness variation, the fine fibers occurrence and type were examined to investigate characteristics of fine fibers produced by beating during TMP(Thermomechanical Pulp) and KP(Kraft Pulp)processes. According to increased the beating time, the freeness and the fine fibers occurrence were gradually increased, and TMP showed higher freeness and occurrence than KP due to the difference on fiber softness. In addition, the fine fibers produced by beating were generally cut parenchyma cell and microfibrils of secondary wall. The kindness of fine fibers produced by TMP and KP processes were similar, but the types were different. At initial stage of besting, the primary and secondary walls of fine were coexisted. but as the beating was more processed, those primary and secondary walls were separated each other.

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

Mepirizole 유도 십이지장 궤양에 관한 실험적 연구

윤재승 圓光大學校 醫科學硏究所 1987 圓光醫科學 Vol.3 No.2

To make an experimental model of the duodenal ulcer is necessary to investigate the mechanism of the duodenal ulcer and the efficacy of the drugs for the duodenal ulcer. The author tried an experimental study of mepirizole - induced duodenal ulcer. Mepirizole ( [1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-mehyyl-5-methoxy pyrazole] ) is a sort of an antiinflammatory drugs. Various doses of mepirizole (50, 100, 200, and 300㎎/㎏) were administered orally as a single dose to rats, and then changes of the morphology of the stomach and duodenum and the gastric acidity were observed. 1. Morphologic changes On gross examination of the stomach and duodenum of the rats that were fasted for 24 hours after various amount of mepirizole administration, mepirizole-induced ulcer was confined to the duodenum, and the gastric mucosa was only erosive but not ulcerative. The size of duodenal ulcer was proportional to the administered dose of mepirizole. In 200 and 300 ㎎/㎏ of mepirizole administered groups, all animals showed duodenal ulcer, and perforation rate of duodenal ulcer were 25% and 75%, respectively. But the mortality rate was relatively low (5% in 200 ㎎/㎏ - groups, and 10% in 300 ㎎/㎏-group). Histologically, necrotic lesions were confined to the duodenal mucosa in 50 and 100㎎/㎏- groups, but in 200 and 300 ㎎/㎏- groups, most of experimental animals showed duodenal ulcer which penetrated musculoserosal layer. Desquamation and necrosis of the gastric mucosal cells were noted in groups of large doses of mepirizole (more than 100㎎/㎏). 2. Gastric acidity An increase of gastric acidity was dependent to the dosage and the time interval of mepirizole treatment. According to these results, mepirizole is an excellent agent for an experimental duodenal ulcer and the effective dose is about 200㎎/㎏. Nothing per oral for 24 hours after mepirizole administration is mandatory. Increased gastric acidity might be a major role in the mechanisms of mepirizole- induced duodenal ulcer.

군산 구(舊)조계지의 필지변화와 주거건축에 관한 연구

윤도선,홍승재 대한건축학회 2004 대한건축학회논문집 Vol.20 No.1

The characteristic and change of dwelling architecture of Japanese and plot transition were analyzed with the old international settlement in Gunsan. By learning about one side of modern history that was broken off in the historical form of dwelling and observing the dwelling environment that have been changing historically, it can be significant as the basic material of observing our dwelling today. Along with prior investigations and studies related to the late 19th century (opening of port period) urban dwellings, the urban tissue was analyzed through documents about the history of Gunsan city and other cities that were occupied by Japan. In addition, along with survey investigation based on the cadastral map, construction management register and aerial map, I also worked on drawing up dwellings and urban tissue. As for the time range, the urban tissue of Gunsan, before opening of port, and after opening of port from 1899 to 1945 during the Japanese Occupation, was studied. And, the urban tissue was studied up to the current 2002, where the plot transition is changing or continuously maintained. As for the district subjected for study, the established international settlement district of Gunsan during the early stage of opening of port, was established as spacial range, focusing on Yeonghwa-dong which was the center of international settlement district, which was abolished in 1913. This was the first district in Gunsan to be planned with grid streets structure, and this could be said to be the main dwelling that keeps the characteristic of Japanese dwellings. The old international settlement of Gunsan has become the center of urban tissue development of the current Gunsan, and the initially established street pattern influenced the form and plot of dwellings. The dwellings have been changing with correlation to the current plot. As the plot line is fixed according to the line divided within a long building(長屋), the form is changed through a small scale of subdivided plots combining, in the process of new construction by removing the existing structures again. The plot is changing of possessing one-way improvement only by facing the street, as the bare grounds (alleyway) disappeared. The dwellings in this district, long buildings or machiyas(町屋), have developed with precedent pattern according to the street, and the dwellings have developed in the direction of inner household. In addition, as for the dwelling space, there was change in the use and extension, due to the factors such as difference in style, change in life style and modernization of accommodation system.

十全大補湯이 癌轉移 抑制에 미치는 影響

윤재호,최승훈,안규석 대한한방종양학회 1998 대한한방종양학회지 Vol.4 No.1

To examine the effect of Shiquandabutang on the metastasis of cancer, the following experiments were made. Before the main experiments, the cytotoxieity was measured by putting Shiquandabutang sample in HT1080, Then zymography was made to examine the change of gelatinolytic activity. And western blotting was carried out to examine the changes of Fos, Jun, Ets, the transcription factors of MMP-2. MMP-9, and Erk. JNK on signal transduction pathway to AP-1, Third, in vitro invasion assay with tranwells coated by collagen and matrigel was carried out. From the results of the above the following conclusions were obtained. 1. The experimental result about cytotoxicity of Shiquandabutang against HT1080 was as below. The stained cell count after being treated by Shiquandabutang sample 400ug/ml for 24 hours was 0.9% of total cells. and the stained cell count by Shiquandabutang sample 100ug/ml was 1.5% of total cells. Both were near the level ot control groupwhich showed 0.6% stained. 2. The restlt of collagenase assay was as bclow. In shiquandanbutang sample 400ug/ml, MMP-2 was reduced as compared with TPA control group. and the band of MMP-9 induced by TPA disappeared. In Shiquandabutang sample 800ug/ml. both bands of MMP-2 and MMP-9 disappeared. 3. The reasults of western blots for Jun, Fos, Ets, Erk, JNK were as below. In Shiwaandabutang sample 200ug/ml, Ets was reduced, and Jun, Fos were increased. 4. The result of invasion assay was as below. The number of cells which migrated across transwell membrane in shiquandabutang-lteated group was less than that of +TPA control group. From the above results, it was concluded that Shiquandabutang might control the appearting and acting of collagenase not by the MMP-2, -9 promoter but by other way.