치성 각화성 낭종에 대한 고찰

송승희,이선재,조갑주,서영진,고부일,유기준,박영주,안병근 한림대학교의료원 1994 人間科學 Vol.18 No.11

우리나라의 農作業 災害實態에 관한 考察

송경환,양재성 順天大學校 1997 論文集 人文社會科學篇 Vol.16 No.-

ABSTRACT The main focus this study is the countermeasure of after agricultural work disaster. In this study, The countermeasure of after agricultural work disaster is to present the extension of industrial disaster insurance Many factory works accept the benefit of social insurance, industrial insurance, medical care insurace, national pension, employment insurance etc. But Agricultural business works accept only medical care insurance and national pension, in spite of lower income then their. Actually, Agricultural work disaster is to happen work course considerably. In order to solve such problem, the govenment must extend social insurance to agricultural work disaster.

RAPD 분석에 의한 굴참나무 집단의 유전변이 연구

송정호,김남수,이용섭,김영중,송재모,이재선 한국유전학회 2002 Genes & Genomics Vol.24 No.2

Quercus variabilis is one of the most important tree species in both utilization of forest resources and management of forest ecosystem in Korea. To obtain the basic information for the establishment of breeding strategy and efficient management of genetic resources, five populations of Q. variabilis from 89 selected plus trees were studied using POPGENE and AMOVA analysis based on DNA markers focussing on the genetic diversity and variation among populations. The overall polymorphic amplicons were 78.6% and levels of genetic diversity within 5 populations were similar each other (Shannon's Index : 0.289∼0.423 [mean 0.366]). The values of total genetic diversity (H_t) and average gene diversity within population (H_S) were 0.265 and 0.239, respectively. The degree of genetic differentiation (G_st : 0.098) was relatively high compared with those of other tree species. Based on the cluster analysis of UPGMA, genetic relationships among 5 populations were not coincided with the pattern of geographic distribution.

역위 매복된 상악 중절치의 외과적 재위치 후 치근 발육 정지

송제선,최병재,최형준,김성오,손흥규,이제호 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

상악 중절치의 매복은 소아 환자의 심미적 사회적 기능적 문제를 일으킬 수 있어 적절한 치료를 통해 바로잡아 주어야 한다. 상악 중절치 매복의 치료로 외과적 노출 후 교정적 견인이 어려울 경우 발치하기에 앞서 외과적 재위치(surgical repositioning) 혹은 치조 내 자가치아이식(intra-alveolar autotransplantation)을 고려해 볼 수 있다. 본 증례는 5세 9개월 된 남아의 역위 매복된 상악 우측 중절치를 치근 발육 초기인 Nolla's stage 6.5에 부분 맹출된 위치로 외과적 재위치를 시행하여 자발적 맹출을 기대하였으나 21개월 간의 추적 검사 결과 치관 발육 및 맹출이 정지된 증례이다. 그 원인으로서 수술 시 치배를 발거하고 치조와를 적합하는 과정에서 Hertwig's epithelial root sheath(HERS)가 손상 받았기 때문으로 생각된다. 매복 치아의 외과적 재위치 시에는 본 증례와 같이 합병증 발생 가능성이 있으므로 신중한 적응증의 선택, 치근 발달 정도를 고려한 적절한 치료 시기의 결정, 최소한의 손상을 주는 외과적 술식 등의 노력이 필요할 것이다. Impaction of the maxillary central incisor may cause social, esthetic, and functional problems in children. There are various means of treatment for the inverted maxillary central incisor, such as extraction, surgical opening followed by orthodontic traction, surgical repositioning or intra-alveolar autotransplantation prior to extraction. In this case, we surgically repositioned the inverted maxillary central incisor to normal semi-erupted position in a 5-year-old boy. The developmental stage of the inverted tooth was Nolla’ s 6.5, which indicates formation of less than one third of the root. After surgical reposition, we did follow-up for 21 months, expecting spontaneous growth. Unfortunately, poor prognosis was noted : further root was not observed. Such failure seems to originate from possible injury on Hertwig’ s epithelial root sheath by surgical trauma. We performed surgical repositioning to retain the tooth instead of extraction. However, arrest of root development occurred, which is one of the critical complications. In order to increase the success rate of the surgical reposition procedure, minimal surgical trauma is required as well as selection of adequate indication and decision of proper time of treatment considering the stage of root development.

지역사회획득 폐렴의 치료지침 권고안

송재훈,정기석,강문원,김도진,배현주,서지영,심태선,안중현,안철민,우준희,이남용,이동건,이미숙,이상무,이영선,이혁민,정두련,지역사회획득 폐렴 치료지침 제정위원회 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

A successful therapy of community-acquired pneumonia requires appropriate empirical antimicrobial therapy. Etiology and antimicrobial susceptibility of major pathogens of pneumonia can differ by country. Therefore, an ideal treatment guideline of community-acquired pneumonia should be based on the studies performed in each country. We developed a treatment guideline for community-acquired pneumonia in immunocompetent adults in Korea. This guideline was developed by the joint committee of the Korean Society for Chemotherapy, the Korean Society of Infectious Diseases, and the Korean Academy of Tuberculosis and Respiratory diseases.

Treacher Collins 증후군 환아의 증례보고

박지현,김승혜,송제선,김성오,이제호 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

Treacher Collins 증후군(TCS)은 25,000명에서 50,000명당 1명의 빈도로 비교적 드물게 발생하는 난치성 질환이다. 이 질환은 정상적인 부모에게서 돌연변이로 발생하거나 상염색체 우성으로 유전된다고 알려져 있다. 하악과 상악, 협골의 발육 부전, 부정교합, 양측성 이개 기형, 안검렬의 반몽고증 사면(antimongoloid slant)이 특징적이며, 종종 구순열, 구개열, 외이도 폐쇄, 중이와 내이의 기형에 의한 청각소실, 왜소증, 심장과 골격의 이상 등을 동반한다. 또한, 인두의 형성부전, 소구, 거설증, 악골의 기형에 기인하여 수면 중 무호흡증, 만성 폐쇄성 무호흡증 등의 호흡 장애가 있을 수 있으며, 전신마취 유도 시에 기관내 삽관이 어렵다고 보고된 바 있다. 치과의사는 관련 신드롬에 대한 충분한 이해를 통해 환자에게 보다 안전하게 치료를 제공해야 하며 구강 건강 관리 및 선천성 안면 기형에 대한 문제 해결을 돕기 위해 적절한 치료 및 안면 수술에 관련된 가이드를 제시해야 한다. 본 증례는 전반적인 치아우식을 주소로 연세대학교 치과병원 소아치과에 내원하여 외래에서 치아우식 치료를 받은 TCS 환아에 대한 것으로, 문헌 고찰을 통해 얻은 다소의 지견을 함께 보고하는 바이다. Treacher Collins syndrome(TCS) is a rare, incurable condition occurring in approximately 1 of 25,000 to 50,000 births. It may occur as a spontaneous mutation out of genetically normal parents or it may be manifested as an autosomal dominant pattern. TCS is characterized by facial deformities such as, underdevelopment of the maxilla, mandible and zygoma, malocclusion, bilateral deformities of auricles, antimongoloid slant of the palpebral fissures. The syndrome is often associated with cleft lip and palate, ear malformations and hearing loss, short stature, and anomalies of the heart and skeleton. Respiratory difficulty associated with air way obstruction may also be observed, and there is considerable difficulty in airway management during general anesthesia. It is necessary that dentists provide safe dental treatments and guidelines to TCS patients by providing adequate understanding about the characteristics of the syndrome and proper ways of managements. The purpose of this study is to report the dental and medical characteristics of the patient who visited the Department of Pediatric Dentistry, Yonsei University for multiple dental caries treatment and to review the literatures of TCS.

비호지킨림프종 환자에서 발생한 폐 효모균증 1예

장재혁,송치원,심병용,이동건,변재호,정정임,이교영,홍영선,신완식,김춘추,이경식 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

저자들은 비호지킨씨 림프종 환자에서 항암 치료 후 질환의 진행성 병변과 감별을 요했던 우폐 중엽의 단발성 종괴를 흉강경하 생검으로 폐 효모균증을 확진하고 amphotericin B와 fluconazole로 치료한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Non-Hodgkin's lymphoma is monoclonal expansion of malignant B or T cells. The immunocompromised status in this disease is accompanied by many infections. The cryptococcosis, caused by Cryptococcus neoformans, frequently occurs in leukemia, Hodgkin's disease, sarcoidosis, diabetes mellitus, tuberculosis, and long-term steroid-using patients. Recent increasing incidence of fungal infection could be due to the spread of AIDS and transplantation. We experienced one patient with lung mass in Non-Hodgkin's lymphoma after three cycles of chemotherapy, which could not be discriminated from the newly developed lymphoma mass. Cryptococcus neoformans was isolated from the lung tissue obtained by thoracoscopic biopsy. Herein we report this case with brief review of pertinent literature.

안면 골절의 후유증으로 인한 치아의 맹출장애 및 안모 비대칭 : A possible complication of facial fracture in child

이선재,유기준,송승희,서영진,조갑주,고부일,박영주,안병근 한림대학교의료원 1994 人間科學 Vol.18 No.11

特用資源植物의 硏究 : 한국임학회지에 게재된 논문을 중심으로 Based on the Articles Published in the Journal of Korean Forestry

이재선,김철우,배찬호,송재모,강효진,황석인,문흥규 江原大學校 森林科學硏究所 2003 Journal of Forest Science Vol.19 No.-

한국임학회지 (1962년의 1호~2002년의 91권 6호)에 게재된 특용자원식물 관련 논문에서 식·음용식물, 약용식물, 사료식물, 조경식물, 섬유식물, 산업용식물 및 밀원식물로 분류하고 그 내용에 따라 입지환경, 생태, 생리, 번식, 조림(또는 무육, 재배), 유전·육종, 분류(또는 식별), 병·충해와 방제, 동물피해와 방제, 성분분석, 식생정보, 생물공학, 경영·경제 및 총설로 나누었다. 총 1,434편의 발표 논문 중 유용식물자원을 대상으로 한 논문은 27.6%를 차지하는 396편이었고, 내용은 식생정보 60편(15.2%), 생리 56편(14.1%), 유전·육종 56편(14.1%), 번식 53편(13.4%) 및 생태 37편(9.3%)이었다. 조림(무육·재배)은 11편(2.8%)으로 특용자원식물의 규모경영이 이루어지지 않고 있음을 시사하고 있으며, 이것은 경영·경제 분야가 6편(1.5%)인 것과 맥을 같이 하고 있었다. 연구대상 식물은 잣나무(42편), 아까시나무(23편), 밤나무(14편) 및 은행나무(14편) 순으로 높았고, 이 식물들과 관련한 연구내용은 번식, 생리, 유전·육종, 생태 및 병·충해 순이었다. 연구의 목적, 내용, 결과 및 대상식물 등을 고려하여 보면, 1) 초본식물에 대한 보다 많은 연구, 2) 타산업 또는 학분 분야와의 공동연구, 3) 자원 보전적 연구 및 4) 연구주체자 간의 연구결과의 공유 등이 매우 요망된다. The articles, published in the Journal of Korean Forestry from Number 1(1962) to number 6, Volume 91(2002), were surveyed and investigated for the research trend analysis about resource-plants for special use or purpose, i.e edible plants, medicinal plants, feed resource, landscape plants, fiber plants, industrial usage, and bee plants. If the purpose or subject matter of the research was construction or furniture timber production, mushrooms and/or pulp and Paper, such research was not included in this study. These articles were classified again depending on the content of research into 14 categories : habitat environment, ecology, physiology, propagation, silviculture(tending and culture), genetics and breeding, identification, insect and disease control, animal-related research, cemponent analysis, vegetation survey, biotechnology, management, and review. Among the total 1,434 articles published, 396 ones (27,6%) were related with plants for special use or purpose. Vegetation survey was 60(15.2%) ; physiology 56(04.1%) ; genetics and breeding 56(14.1%) ; propagation 53(13.4%) ; and ecology 37(9.3%). Siviculture research field included 11 articles (2.8%), which indicates that the management of resource-plants is to far from economic income as seen in the low number of management research filed articles, i. e., only 6 reports(1.5%). Korean white Pine was most popular for research and included 42 articles ; Robinia pseudoacacia 23 Castanea crenata 14 : and ginkgo tree 14, Research related with these species had focused mainly or propagation, physiotogy, genetics and breeding, ecology and pest control. Based on this survey and analysis, the followings are suggested : 1. More research is required on forest herbaceous plants. 2. Cooperative research work with other industrial and/or scientific area is recommendable for commercialization including medicine, cosmetics, and food etc. 3. Research resource-plant conservation. which includes biology, social education and policy, should be supported for next generation. 4. Mutual correspondence and information exchange about the research results between researchers and institutes is more necessary than now.

환경 오염물질의 진보된 독성 평가 기법

류재천,최윤정,김연정,김형태,방형애,송윤선 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.1

Recently, several new methods for the detection of genetic damages in vitro and in vivo based on molecular biological techniques were introduced according to the rapid progress in toxicology combined with cellular and molecular biology. Among these methods, mouse lymphoma thymidine kanase (tk) gene forward mutation assay, single cell gel electrophoresis (comet assay) and transgenic animal and cell line model as a target gene of lac I (Big Blue) and lac Z (Muta Mouse) gene mutation are newly introduced based on molecular toxicological approaches. The mouse lymphoma tk^(+/-) gene assay (MOLY) using L5178Y tk+i- mouse lymphoma cell line is one of the mammalian forward mutation assays, and has many advantages and more sensitive than hprt assay. The target gene of MOLY is a heterozygous tk^(+/-) gene located in 11 chromosome, so it is able to detect the wide range of genetic changes like point mutation, deletion, rearrangement, and mitotic recombination within tk gene or deletion of entire chromosome 11. The comet assay is a rapid, simple, visual and sensitive technique for measuring and analysing DNA breakages in mammalian cells. Also, transgenic animal and cell line models, which have exogenous DNA incorporated into their genome, carry recoverable shuttle vector containing reporter genes to assess endogenous effects or alteration in specific genes related to disease process, are powerful tools to study the mechanism of mutation in vivo and in vitro, respectively. Also in vivo acridine orange supravital staining micronucleus assay by using mouse peripheral reticulocytes was introduced as an alternative of bone marrow micronucleus assay. In this respect, there was an International workshop on genotoxicity procedure (IWGTP) supported by OECD and EMS (Environmental Mutagen Society) at Washington D, C, in March 25-26, 1999. The objective of IWGTP is to harmonize the testing procedures internationally, and to extend to finalization of OECD guideline, and to the agreement of new guidelines under the International Conference of Harmonization (ICH) for these methods mentioned above. Therefore, we introduce and review the principle, detailed procedure, and application of MOLY, comet assay, transgenic mutagenesis assay and supravital staining micronucleus assay.